User:Neal.shah.bc/LDLR Protein 8

Wikipedia Proposal: Low density lipoprotein receptor-related protein 8

Dinesh Vannan, Neal Shah, and Eric Mlodzinski

Introduction

This is a proposal for the project to improve and expand the article Low density lipoprotein receptor-related protein 8. This collaborative effort will be carried out over the course of this semester. The work shall be split up as best seen fit by the group members. We shall be having weekly meetings to better collaborate out work.

Low density lipoprotein receptor-related protein 8 (also known as ApoE2) is a cell-surface protein that is part of the LDL receptor family. These receptors regulate the transport of cholesterol, but have recently been seen to have functions beyond cholesterol metabolism. LRP 8 has been observed to play a role during the development of the mammalian brain, specifically affecting the layering of neurons in the cerebral cortex.

Structure

Apolipoprotein E (ApoE) is contains 299 amino acid. 35 kDa glycoprotein constituent of lipoproteins in the plasma and brain. It is closely related to many other proteins in the LDLR family.

Function

• talk about role in both cholesterol metabolism and in neuronal activity
• closely associated with VLDLR
• neuronal layering in development
• plays a large role in delivery and clean up of cholesterol and plasma lipids

Signaling Pathways

• Low density lipoprotein receptor-related protein 8 is involved in the signaling pathways of Dab1 and reelin.
• The mechanism is incompletely understood.

Clinical Significance

References

1. Cooper, J., and B. Howell. "Lipoprotein ReceptorsSignaling Functions in the Brain?" Cell 97.6 (1999): 671-74. Web. 16 Sept. 2012. <http://www.sciencedirect.com/science/article/pii/S0092867400807783>.
2. De Groot, P., R. Derksen, and R. Urbanus. "The Role of LRP8 (ApoER2') in the Pathophysiology of the Antiphospholipid Syndrome." Lupus 19.4 (2010): 389-93. Web. 16 Sept. 2012.
3. Harris-White, M. E., and S. A. Frautschy. "Low Density Lipoprotein Receptor-Related Proteins (LRPs), Alzheimer’s and Cognition." Current Drug Targets-CNS & Neurological Disorders 4.5 (2005): 469-80. UCLA.edu. Web. 12 Sept. 2012. <http://alzheimer.neurology.ucla.edu/pubs/Harris-White_CDT-CNS%26ND%20copy.pdf>.
4. May, Petra, and Joachim Herz. "LDL Receptor-Related Proteins in Neurodevelopment." Traffic 4.5 (2003): 291-301. Web. 16 Sept. 2012. <http://onlinelibrary.wiley.com/doi/10.1034/j.1600-0854.2003.00086_4_5.x/full>.
5. Myant, Nicholas B. "Reelin and Apolipoprotein E Receptor 2 in the Embryonic and Mature Brain: Effects of an Evolutionary Change in the ApoER2 Gene." Reelin and Apolipoprotein E Receptor 2 in the Embryonic and Mature Brain: Effects of an Evolutionary Change in the ApoER2 Gene. Proceedings of the Royal Society, n.d. Web. 16 Sept. 2012. <http://rspb.royalsocietypublishing.org/content/277/1680/345.full>.
6. Qiu, S., K. Korwek, and E. Weeber. "A Fresh Look at an Ancient Receptor Family: Emerging Roles for Low Density Lipoprotein Receptors in Synaptic Plasticity and Memory Formation." Neurobiology of Learning and Memory 85.1 (2006): 16-29. Web. 16 Sept. 2012. <http://www.sciencedirect.com/science/article/pii/S1074742705000766>.