this is oalnafo1's sandbox. testing 1,2.
Five pillars summary
editOnline encyclopedia As objective as possible ##incomplete
Summary of characteristics of target article
editOur article should be between B and GA article quality ratings.
B
editA B-rated article is suitably referenced, shows reasonable coverage, structured, reasonably well-written, contains illustrations, presented for a relatively general audience. More information on this rating can be found here.
GA
editGA stands for "good article" and is characterized by the following: well-written, verifiable with no original research, broad in its coverage, neutral, stable, and illustrated. A more detailed description can be found here.
Differences between B and GA
editThe main difference between the two ratings is stage of development with B-rated articles being just below the complete and GA-rated articles attaining completeness through peer-review and polishing.
Aging and Mitochondria
editThere are many links between physiological aging and mitochondrial. One link is found in people with Hutchinson-Gilford progeria who experience symptoms that resemble the normal aging phenotype; the gene responsible for the syndrome, progerin, has been shown to cause mitochondrial dysfunction in human skin fibroblasts and mouse models[1]. Additionally, it has been shown that dietary restriction, a widely-supported method of lifespan extension, attenuates the loss of mitochondrial biogenesis associated with aging[2]. Hutchinson-Gilford progeria express decreased abundances of mitochondria which also suggests reduced mitochondrial biogenesis in that syndrome[1]. More investigation into this association is required because the role of mitochondrial biogenesis may not be causative.
Notes
edit- ^ a b Rivera-Torres, J.; Acín-Perez, R.; Cabezas-Sánchez, P.; Osorio, FG.; Gonzalez-Gómez, C.; Megias, D.; Cámara, C.; López-Otín, C.; Enríquez, JA. (Aug 2013). "Identification of mitochondrial dysfunction in Hutchinson-Gilford progeria syndrome through use of stable isotope labeling with amino acids in cell culture". J Proteomics. 91C: 466–477. doi:10.1016/j.jprot.2013.08.008. PMID 23969228.
{{cite journal}}: Invalid|display-authors=9(help)CS1 maint: date and year (link) - ^ Picca, A.; Pesce, V.; Fracasso, F.; Joseph, AM.; Leeuwenburgh, C.; Lezza, AM. (2013). "Aging and Calorie Restriction Oppositely Affect Mitochondrial Biogenesis through TFAM Binding at Both Origins of Mitochondrial DNA Replication in Rat Liver". PLOS ONE. 8 (9): e74644. doi:10.1371/journal.pone.0074644. PMC 3772924. PMID 24058615.