User:Oconnedp/Glia Limitans

At the top of our page we will begin by providing a general description of the glia limitans and a basic definition. For more technical terms, we will insert links to the wikipedia pages describing the meanings of those terms. Our introduction will include information such as that which is outlined below:

The glia limitans, or the glial limiting membrane, is made up of the end foot processes extending from fibrous astrocytes, which are the astrocytes found primarily in white matter. The glia limitans is covered by the basal lamina, which is beneath the pia mater. The space between the pia and the glial limitans is the subpial space. The glia limitans seals the surface of the central nervous system acting as a protective layer, acting in concert with the capillaries around which it forms. It does not act alone in controlling diffusion of small molecules and water but rather works with several other components including the blood brain barrier.

We will also include a picture of the glia limitans and any other pictures that we feel will enhance an individual's understanding of the glia limitans. After our introduction, there will be a table of contents for the page, breaking up our information into a variety of subcategories. Some of the subcategories we have chosen so far are:

Formation

This section will include a great deal of information on astrocytes, particularly their foot processes and how they come together to form the glia limitans.

Glial limiting membrane
GFAP-expressing astrocytes shown in co-localization with Cu/Zn SOD in the glia limitans
Microglial cells and endothelium (arrow), identified with tomato lectin histochemistry were found to be negative for Cu/Zn SOD
Details
Parts	Astrocyte, Basal lamina
Identifiers
Latin	Glia limitans
Anatomical terms of neuroanatomy

Structure

We will discuss not only the structure of the glia limitans but where exactly it is situated within the brain and its relationship with surrounding structures.

Types

Superficial vs. Perivascular

Relationship with Blood Brain Barrier

Astrocytic foot processes not only form the glia limitans but they also provide the base structure for the relationship between astroctyes and the blood brain barrier.

Diseases

This subcategory will include information about what diseases can arise from problems/damage to the glia limitans and about diseases that affect the glia limitans.

Glia limitans breach is associated with Fukuyama-type Congenital Muscular Dystrophy (FCMD)

Current Research

Ransom, Bruce R.; Kettenmann, Helmut (2005). Neuroglia. Oxford [Oxfordshire]: Oxford University Press. ISBN 0-19-515222-0.{{cite book}}: CS1 maint: multiple names: authors list (link)

References

Intended references currently:

Brodal, Per. "Glia." The Central Nervous System: Structure and Function. 4th ed. New York: Oxford UP, 2010.

Fibrous astrocytes contain large quantities of this protein; they occur in tracts of nerve fibers and near the surface of the brain. Many of the cytoplasmic processes abut as end-feet on the basal laminae of capillary blood vessels. Astrocytic end-feet also form the thin external glial limiting membrane at the outside surface of the brain and spinal cord and around the larger blood vessels. There is a similar internal glial limiting membrane, subjacent to the ependyma.

Possible Sources
http://www.jstor.org/pss/4291646
http://www.ncbi.nlm.nih.gov/pubmed/3171612
http://jcb.rupress.org/content/88/3/660.full.pdf
http://www.springerlink.com/content/vp31272216753856/
http://books.google.com/books?id=8B5UuFNFbqoC&pg=PA19&lpg=PA19&dq=internal+glia+limitans&source=bl&ots=nMPJvzDFyD&sig=vNxuLRqn7aN9av4HBm1R5-3FsB8&hl=en&ei=ajmGTcT5IIuO0QH4r_nZCA&sa=X&oi=book_result&ct=result&resnum=9&ved=0CE0Q6AEwCA#v=onepage&q=internal%20glia%20limitans&f=false
http://cercor.oxfordjournals.org.proxy.bc.edu/content/11/6/498.full.pdf+html
http://onlinelibrary.wiley.com.proxy.bc.edu/doi/10.1002/cne.21238/abstract
http://www.sciencedirect.com.proxy.bc.edu/science?_ob=MImg&_imagekey=B6T01-3Y44S8G-16-1&_cdi=4849&_user=521319&_pii=073657489500040N&_origin=gateway&_coverDate=10%2F31%2F1995&_sk=999869993&view=c&wchp=dGLbVlb-zSkzk&md5=563e64630f5c6cb86f79626c339788e2&ie=/sdarticle.pdf
http://cercor.oxfordjournals.org.proxy.bc.edu/content/11/6/498.full.pdf+html
http://onlinelibrary.wiley.com.proxy.bc.edu/doi/10.1046/j.1460-9568.2000.00909.x/full
http://www.journalarchive.jst.go.jp/jnlpdf.php?cdjournal=jvms1939&cdvol=50&noissue=1&startpage=115&lang=en&from=jnlabstract

Castle Moat: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039833/