Vince DiFrancesca (1922 – May 21, 2007) was a college football player and coach in the United States. His total career coaching record was 106 wins, 71 losses, and 7 ties.

DiFrancesca was the eighth head college football coach for the Western Illinois University Leathernecks located in Macomb, Illinois and he held that position for five seasons, from 1949 until 1953. His career coaching record at Western Illinois was 38 wins, 7 losses, and 1 ties. As of completion of the 2007 season, this ranks him seventh at Western Illinois in total wins and first at Western Illinois in winning percentage.[1] Under DiFrancesca's leadership, Western's team was ranked among the best offensive and defensive teams in the nation for five years.[2]

DiFrancesco was also the head coach at Iowa State University from 1954 to 1958.[3] he was the 21st head coach for the Cyclones in Ames, Iowa. His coaching record at Iowa state was 6 wins, 21 losses, and 1 ties. As of completion of the 2007 season, this ranks him 19th at Iowa state in total wins and 28th at Iowa state in winning percentage.[4]

His final head coaching job was as the 22nd head college football coach for the Carroll College (Wisconsin) Pioneers located in Waukesha, Wisconsin and he held that position for thirteen seasons, from 1959 until 1971. His record at Carroll College was a more successful 62 wins, 43 losses, and 5 ties. As of completion of the 2006 season, this ranks him second at Carroll College in total wins and tenth at Carroll College in winning percentage.[3]

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