User:Postaire/Pierre Corvol

New article name goes here new article content ... Pierre Corvol, born on August 18, 1941 in Boulogne-Billancourt, is a doctor and researcher in biology 1. He was a director of the Collège de France from 2006 to August 2012, when Serge Haroche succeeded him.

Biography

Pierre Corvol was a student at the Lycée Condorcet. He is a former intern at the Paris hospitals (1964) and a post-doctoral fellow at the National Institutes of Health in Bethesda, USA, in 1969. He became an associate professor at the CHU Broussais Hôtel-Dieu in 1976. In 1983, he took over the management of Inserm's U36 (Vascular Pathology and Renal Endocrinology) and was elected to the chair of experimental medicine at the Collège de France in 1989, a position he held until 2012.

Pierre Corvol chaired the Scientific Council of the Foundation for Medical Research (1995-1998), the Scientific Council of Inserm (1999-2003), the Board of Directors of the École normale supérieure (2001-2004), the Scientific Council of the Assistance public-Hôpitaux de Paris (2004-2006). He was a member of Inserm's Scientific Steering Committee from 1985 to 1992 and played a major role in the creation of Clinical Investigation Centres (1990-1992), which allow clinical research in hospitals 2.

Pierre Corvol has been a full member of the Academy of Sciences since 1995. He was elected a member of the American Academy of Arts and Sciences in 2000. Since 9 December 2008, he has been a full member of the National Academy of Medicine 1. He is an honorary doctorate from the Universities of Lausanne (1997), Geneva (2006) and Semmelweis University of Budapest (2012).

In 2016, he was commissioned by Thierry Mandon to submit a report on scientific integrity 3,4,5, following which numerous measures were taken for scientific integrity in France, including the creation in 2017 of the French Office for Scientific Integrity 6,7. Scientific contribution If this blindfold is no longer relevant, remove it. Click to see other models. This article or section does not rely, or not enough, on secondary or tertiary sources (November 2018).

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Pierre Corvol is a leading researcher in the field of endocrine regulation of blood pressure and hypertension. In particular, he was one of the discoverers[necessary referent] of the hormone regulatory system, the renin angiotensin system, and the angiotensin converting enzyme 8.

His work has contributed very largely 9 to the development of therapeutics blocking the renin-angiotensin-aldosterone system, the importance of which he has shown 10. These drugs are widely used 11 in the treatment of high blood pressure, heart failure and kidney failure in diabetics.

He was one of the pioneers Insufficient Source 12 of the genetics of high blood pressure in humans. He has shown the importance of genetic markers in the renin system for predisposition to hypertension, cardiovascular disease and renal complications in diabetics 13.

Publications

   Dr. Knock's return: cardiovascular risk trials with Nicloas Postel-Vinay. Odile Jacob. Paris 2000
   The vascular tree, with Nicolas Postel-Vinay, Odile Jacob, Paris, 2008
   Sortir de l'eau, le passage de la vie aquatique à la vie terrestre (collective work), Odile Jacob, Paris 2011
   Les élèves de Claude Bernard avec Jean-Gaël Barbara (collective work), Hermann, Paris 2012.

And many publications, the main ones are as follows:

1- Panthier J.J., Foote S., Chambraud B., Strosberg A.D., Corvol P. and Rougeon F. Complete amino-acid sequence and maturation of the mouse submaxillary gland renin precursor. Nature 298: 90-92, 1982. 2- Galen F.X., Corvol M.T., Devaux C., Gubler M.C., Mounier F., Camilleri J.P., Houot A.M., Ménard J. and Corvol P. Renin biosynthesis by human tumoral juxtaglomerular cells: evidence for a renin precursor. J. Clin. Invest. 73 : 1144-1155, 1984. 3- Soubrier F., Alhenc-Gelas F., Hubert C., Allegrini J., John M., Tregear G. and Corvol P. Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning. Proc. Natl. Acad. Sci. USA 85: 9386-9390, 1988. 4- Rigat B., Hubert C., Alhenc-Gelas F., Cambien F., Corvol P. and Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J. Clin. Invest. 86: 1343-1346, 1990. 5- Jeunemaitre X. Soubrier F., Kotelevtsev Y., Lifton R., Williams C., Charru A., Hunt S., Hopkins P., Williams R., Lalouel J.M. and Corvol P. Molecular basis of human hypertension: Role of angiotensinogen. Cell 71 : 169-180, 1992. 6- Rousseau A., Michaud A., Chauvet M-T., Lenfant M. and Corvol P. The hemoregulatory peptide Acetyl-N-Ser-Asp-Lys-Pro is a natural and specific substrate of the N-terminal active site of human angiotensin-converting enzyme. J. Biol. Chem. 270 : 3656-3661, 1995 7- Dive V., Cotton J., Yiotakis A., Michaud A., Vissiliou S., Jiracek J., Vazeux G., Chauvet M-T., Cuniasse P. and Corvol P. RXP407, a phosphinic peptide, is a potent inhibitor of angiotensin I converting enzyme able to differentiate between its two active sites. Proc. Natl. Acad. Sci. USA 96 : 4330-4335, 1999. 8- Cole J., Ertoy D., Lin H., Sutliff R.L., Ezan E., Guyene T.T., Capecchi M., Corvol P. and Bernstein K.E. Lack of angiotensin II-facilitated erythropoiesis causes anemia in angiotensin-converting enzyme-deficient mice. J. Clin. Invest. 106 : 1391-1398, 2001. 9- Billet S., Bardin S., Verp S., Baudrie V., Michaud A., Conchon S., Muffat-Joly M., Escoubet B., Souil E., Harmard G., Bernstein K.E., Gasc J-M., Elghozi J-L., Corvol P. and Clauser E. Gain-of-function mutant of angiotensin II recepor, type 1A, causes hypertension and cardiovascular fibrosis in mice. J. Clin. Invest. 117 : 1914-1925, 2007. 10- Michaud A., Bur D., Gribouval O., Muller L., Iturrioz X., Clemessy M., Gasc J-M., Gubler M-C. and Corvol P. Loss-of-function point mutations associated with renal tubular dysgenesis provide insights about renin function and cellular trafficking. Hum. Mol. Genet. 20 : 301-311, 2011.

Distinctions

1973: Award for research on high blood pressure. National High Blood Pressure League

   1980: Claude Bernard Grand Prize, City of Paris
   1980: Young researcher Award, International Society of Hypertension
   1981: Jeanine Courrier Prize from the Academy of Sciences, Institut de France
   1982: AC Corcoran Lecture Award, Council for High Blood Pressure Research,     Cleveland
   1982: American Heart Association
   1983: Recipient of the Laurence B. Ellis Reading. Haravard Medical School
   1984: European Society of Clinical Inverstigation Award
   1985: Ciba award for hypertension research. Council for high blood pressure research.
   1985: Grand prix scientifique de la Ville de Paris
   1990: European Medal, British Society of Endocrinology
   1993: Humboldt Prize
   2004: Robert Tigerstedt Award, American society of hypertension
   2006: Grand Prize for Medical Research at INSERM.
   2008: Commander of the Legion of Honour
   2017: Grand Officer of the National Order of Merit

External links

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