- INFO: Beginning work on CHRM5... {October 10, 2007 6:09:59 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {October 10, 2007 6:10:16 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cholinergic receptor, muscarinic 5
| HGNCid = 1954
| Symbol = CHRM5
| AltSymbols =; HM5; MGC41838
| OMIM = 118496
| ECnumber =
| Homologene = 22697
| MGIid = 109248
| GeneAtlas_image1 = PBB_GE_CHRM5_221347_at_tn.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004435 |text = phosphoinositide phospholipase C activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004981 |text = muscarinic acetylcholine receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007197 |text = muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway}} {{GNF_GO|id=GO:0007213 |text = acetylcholine receptor signaling, muscarinic pathway}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1133
| Hs_Ensembl = ENSG00000184984
| Hs_RefseqProtein = NP_036257
| Hs_RefseqmRNA = NM_012125
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 32142129
| Hs_GenLoc_end = 32144579
| Hs_Uniprot = P08912
| Mm_EntrezGene = 213788
| Mm_Ensembl = ENSMUSG00000074939
| Mm_RefseqmRNA = NM_205783
| Mm_RefseqProtein = NP_991352
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 112280010
| Mm_GenLoc_end = 112281608
| Mm_Uniprot = Q0VBI9
}}
}}
'''Cholinergic receptor, muscarinic 5''', also known as '''CHRM5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, stimulation of this receptor is known to increase cyclic AMP levels.<ref>{{cite web | title = Entrez Gene: CHRM5 cholinergic receptor, muscarinic 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1133| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Brann MR, Ellis J, Jørgensen H, ''et al.'' |title=Muscarinic acetylcholine receptor subtypes: localization and structure/function. |journal=Prog. Brain Res. |volume=98 |issue= |pages= 121-7 |year= 1994 |pmid= 8248499 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on EGR1... {October 10, 2007 6:10:16 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {October 10, 2007 6:10:53 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB = {{PDB2|1a1f}}, {{PDB2|1a1g}}, {{PDB2|1a1h}}, {{PDB2|1a1i}}, {{PDB2|1a1j}}, {{PDB2|1a1k}}, {{PDB2|1a1l}}, {{PDB2|1aay}}, {{PDB2|1f2i}}, {{PDB2|1jk1}}, {{PDB2|1jk2}}, {{PDB2|1p47}}, {{PDB2|1zaa}}
| Name = Early growth response 1
| HGNCid = 3238
| Symbol = EGR1
| AltSymbols =; AT225; G0S30; KROX-24; NGFI-A; TIS8; ZIF-268; ZNF225
| OMIM = 128990
| ECnumber =
| Homologene = 56394
| MGIid = 95295
| GeneAtlas_image1 = PBB_GE_EGR1_201694_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_EGR1_201693_s_at_tn.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0030217 |text = T cell differentiation}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1958
| Hs_Ensembl = ENSG00000120738
| Hs_RefseqProtein = NP_001955
| Hs_RefseqmRNA = NM_001964
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 137829338
| Hs_GenLoc_end = 137831669
| Hs_Uniprot = P18146
| Mm_EntrezGene = 13653
| Mm_Ensembl = ENSMUSG00000038418
| Mm_RefseqmRNA = NM_007913
| Mm_RefseqProtein = NP_031939
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 18
| Mm_GenLoc_start = 34987181
| Mm_GenLoc_end = 34990930
| Mm_Uniprot = Q3UM09
}}
}}
'''Early growth response 1''', also known as '''EGR1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene.<ref>{{cite web | title = Entrez Gene: EGR1 early growth response 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1958| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Heath RG |title=Brain function and behavior. I. Emotion and sensory phenomena in psychotic patients and in experimental animals. |journal=J. Nerv. Ment. Dis. |volume=160 |issue= 3 |pages= 159-75 |year= 1975 |pmid= 1090709 |doi= }}
*{{cite journal | author=Silverman ES, Collins T |title=Pathways of Egr-1-mediated gene transcription in vascular biology. |journal=Am. J. Pathol. |volume=154 |issue= 3 |pages= 665-70 |year= 1999 |pmid= 10079243 |doi= }}
*{{cite journal | author=Adamson ED, Mercola D |title=Egr1 transcription factor: multiple roles in prostate tumor cell growth and survival. |journal=Tumour Biol. |volume=23 |issue= 2 |pages= 93-102 |year= 2002 |pmid= 12065847 |doi= }}
*{{cite journal | author=Blaschke F, Bruemmer D, Law RE |title=Egr-1 is a major vascular pathogenic transcription factor in atherosclerosis and restenosis. |journal=Reviews in endocrine & metabolic disorders |volume=5 |issue= 3 |pages= 249-54 |year= 2004 |pmid= 15211096 |doi= 10.1023/B:REMD.0000032413.88756.ee }}
*{{cite journal | author=Abdulkadir SA |title=Mechanisms of prostate tumorigenesis: roles for transcription factors Nkx3.1 and Egr1. |journal=Ann. N. Y. Acad. Sci. |volume=1059 |issue= |pages= 33-40 |year= 2006 |pmid= 16382041 |doi= 10.1196/annals.1339.018 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GPR88... {October 10, 2007 6:11:52 PM PDT}
- CREATE: Found no pages, creating new page. {October 10, 2007 6:12:06 PM PDT}
- CREATED: Created new protein page: GPR88 {October 10, 2007 6:12:14 PM PDT}
- INFO: Beginning work on NXF1... {October 10, 2007 6:11:27 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {October 10, 2007 6:11:52 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB = {{PDB2|1fo1}}, {{PDB2|1ft8}}, {{PDB2|1go5}}, {{PDB2|1jkg}}, {{PDB2|1jn5}}, {{PDB2|1koh}}, {{PDB2|1koo}}, {{PDB2|1oai}}
| Name = Nuclear RNA export factor 1
| HGNCid = 8071
| Symbol = NXF1
| AltSymbols =; TAP; DKFZp667O0311; MEX67
| OMIM = 602647
| ECnumber =
| Homologene = 38176
| MGIid = 1858330
| GeneAtlas_image1 = PBB_GE_NXF1_208922_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_NXF1_220934_s_at_tn.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003729 |text = mRNA binding}} {{GNF_GO|id=GO:0005487 |text = nucleocytoplasmic transporter activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005643 |text = nuclear pore}} {{GNF_GO|id=GO:0042405 |text = nuclear inclusion body}}
| Process = {{GNF_GO|id=GO:0006405 |text = RNA export from nucleus}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0016973 |text = poly(A)+ mRNA export from nucleus}} {{GNF_GO|id=GO:0051028 |text = mRNA transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 10482
| Hs_Ensembl = ENSG00000162231
| Hs_RefseqProtein = NP_001074960
| Hs_RefseqmRNA = NM_001081491
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 62316220
| Hs_GenLoc_end = 62329529
| Hs_Uniprot = Q9UBU9
| Mm_EntrezGene = 53319
| Mm_Ensembl = ENSMUSG00000010097
| Mm_RefseqmRNA = NM_016813
| Mm_RefseqProtein = NP_058093
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 8824148
| Mm_GenLoc_end = 8837955
| Mm_Uniprot = Q3TJA5
}}
}}
'''Nuclear RNA export factor 1''', also known as '''NXF1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants.<ref>{{cite web | title = Entrez Gene: NXF1 nuclear RNA export factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10482| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PITPNA... {October 10, 2007 6:10:53 PM PDT}
- CREATE: Found no pages, creating new page. {October 10, 2007 6:11:15 PM PDT}
- CREATED: Created new protein page: PITPNA {October 10, 2007 6:11:27 PM PDT}
end log.
