- INFO: Beginning work on CXCR3... {November 25, 2007 6:41:04 PM PST}
- SEARCH REDIRECT: Control Box Found: CXCR3 {November 25, 2007 6:41:53 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 25, 2007 6:41:56 PM PST}
- SKIP SUMMARY: Skipping Summary, No Errors. {November 25, 2007 6:41:56 PM PST}
- SKIP CITATIONS: Skipping Citations, No Errors. {November 25, 2007 6:41:56 PM PST}
- UPDATED: Updated protein page: CXCR3 {November 25, 2007 6:42:01 PM PST}
- INFO: Beginning work on GPR12... {November 25, 2007 6:42:30 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 6:43:17 PM PST}
- CREATED: Created new protein page: GPR12 {November 25, 2007 6:43:25 PM PST}
- INFO: Beginning work on GPR15... {November 25, 2007 6:43:52 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 6:44:38 PM PST}
- CREATED: Created new protein page: GPR15 {November 25, 2007 6:44:46 PM PST}
- INFO: Beginning work on GPR17... {November 25, 2007 6:44:46 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 6:45:44 PM PST}
- CREATED: Created new protein page: GPR17 {November 25, 2007 6:45:52 PM PST}
- INFO: Beginning work on GPR18... {November 25, 2007 6:45:52 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 6:46:39 PM PST}
- CREATED: Created new protein page: GPR18 {November 25, 2007 6:46:46 PM PST}
- INFO: Beginning work on GPR19... {November 25, 2007 6:46:46 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 6:47:26 PM PST}
- CREATED: Created new protein page: GPR19 {November 25, 2007 6:47:34 PM PST}
- INFO: Beginning work on GPR20... {November 25, 2007 6:47:34 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 6:48:08 PM PST}
- CREATED: Created new protein page: GPR20 {November 25, 2007 6:48:16 PM PST}
- INFO: Beginning work on GPR21... {November 25, 2007 6:48:16 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 6:48:48 PM PST}
- CREATED: Created new protein page: GPR21 {November 25, 2007 6:48:56 PM PST}
- INFO: Beginning work on GPR22... {November 25, 2007 6:48:56 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 6:49:31 PM PST}
- CREATED: Created new protein page: GPR22 {November 25, 2007 6:49:38 PM PST}
- INFO: Beginning work on GPR23... {November 25, 2007 6:49:38 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 6:50:32 PM PST}
- CREATED: Created new protein page: GPR23 {November 25, 2007 6:50:39 PM PST}
- INFO: Beginning work on GPR25... {November 25, 2007 6:51:33 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 6:52:06 PM PST}
- CREATED: Created new protein page: GPR25 {November 25, 2007 6:52:15 PM PST}
- INFO: Beginning work on GPR26... {November 25, 2007 6:52:15 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 6:53:15 PM PST}
- CREATED: Created new protein page: GPR26 {November 25, 2007 6:53:27 PM PST}
- INFO: Beginning work on GPR27... {November 25, 2007 6:53:27 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 6:54:09 PM PST}
- CREATED: Created new protein page: GPR27 {November 25, 2007 6:54:16 PM PST}
- INFO: Beginning work on GPR30... {November 25, 2007 6:54:16 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 6:54:52 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = G protein-coupled receptor 30
| HGNCid = 4485
| Symbol = GPR30
| AltSymbols =; CMKRL2; DRY12; FEG-1; GPCR-Br; LERGU; LERGU2; LyGPR; MGC99678
| OMIM = 601805
| ECnumber =
| Homologene = 15855
| MGIid = 1924104
| GeneAtlas_image1 = PBB_GE_GPR30_210640_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_GPR30_211829_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0045028 |text = purinergic nucleotide receptor activity, G-protein coupled}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2852
| Hs_Ensembl = ENSG00000164850
| Hs_RefseqProtein = NP_001035055
| Hs_RefseqmRNA = NM_001039966
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 1093038
| Hs_GenLoc_end = 1099977
| Hs_Uniprot = Q99527
| Mm_EntrezGene = 76854
| Mm_Ensembl = ENSMUSG00000053647
| Mm_RefseqmRNA = NM_029771
| Mm_RefseqProtein = NP_084047
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 139676821
| Mm_GenLoc_end = 139681430
| Mm_Uniprot = Q8BMP4
}}
}}
'''G protein-coupled receptor 30''', also known as '''GPR30''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPR30 G protein-coupled receptor 30| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2852| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized.<ref name="entrez">{{cite web | title = Entrez Gene: GPR30 G protein-coupled receptor 30| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2852| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Filardo EJ |title=Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer. |journal=J. Steroid Biochem. Mol. Biol. |volume=80 |issue= 2 |pages= 231-8 |year= 2002 |pmid= 11897506 |doi= }}
*{{cite journal | author=Filardo EJ, Thomas P |title=GPR30: a seven-transmembrane-spanning estrogen receptor that triggers EGF release. |journal=Trends Endocrinol. Metab. |volume=16 |issue= 8 |pages= 362-7 |year= 2005 |pmid= 16125968 |doi= 10.1016/j.tem.2005.08.005 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
*{{cite journal | author=Owman C, Blay P, Nilsson C, Lolait SJ |title=Cloning of human cDNA encoding a novel heptahelix receptor expressed in Burkitt's lymphoma and widely distributed in brain and peripheral tissues. |journal=Biochem. Biophys. Res. Commun. |volume=228 |issue= 2 |pages= 285-92 |year= 1996 |pmid= 8920907 |doi= 10.1006/bbrc.1996.1654 }}
*{{cite journal | author=Feng Y, Gregor P |title=Cloning of a novel member of the G protein-coupled receptor family related to peptide receptors. |journal=Biochem. Biophys. Res. Commun. |volume=231 |issue= 3 |pages= 651-4 |year= 1997 |pmid= 9070864 |doi= 10.1006/bbrc.1997.6161 }}
*{{cite journal | author=Kvingedal AM, Smeland EB |title=A novel putative G-protein-coupled receptor expressed in lung, heart and lymphoid tissue. |journal=FEBS Lett. |volume=407 |issue= 1 |pages= 59-62 |year= 1997 |pmid= 9141481 |doi= }}
*{{cite journal | author=Carmeci C, Thompson DA, Ring HZ, ''et al.'' |title=Identification of a gene (GPR30) with homology to the G-protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer. |journal=Genomics |volume=45 |issue= 3 |pages= 607-17 |year= 1998 |pmid= 9367686 |doi= 10.1006/geno.1997.4972 }}
*{{cite journal | author=Takada Y, Kato C, Kondo S, ''et al.'' |title=Cloning of cDNAs encoding G protein-coupled receptor expressed in human endothelial cells exposed to fluid shear stress. |journal=Biochem. Biophys. Res. Commun. |volume=240 |issue= 3 |pages= 737-41 |year= 1998 |pmid= 9398636 |doi= 10.1006/bbrc.1997.7734 }}
*{{cite journal | author=O'Dowd BF, Nguyen T, Marchese A, ''et al.'' |title=Discovery of three novel G-protein-coupled receptor genes. |journal=Genomics |volume=47 |issue= 2 |pages= 310-3 |year= 1998 |pmid= 9479505 |doi= 10.1006/geno.1998.5095 }}
*{{cite journal | author=Filardo EJ, Quinn JA, Bland KI, Frackelton AR |title=Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF. |journal=Mol. Endocrinol. |volume=14 |issue= 10 |pages= 1649-60 |year= 2001 |pmid= 11043579 |doi= }}
*{{cite journal | author=Filardo EJ, Quinn JA, Frackelton AR, Bland KI |title=Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis. |journal=Mol. Endocrinol. |volume=16 |issue= 1 |pages= 70-84 |year= 2002 |pmid= 11773440 |doi= }}
*{{cite journal | author=Ahola TM, Purmonen S, Pennanen P, ''et al.'' |title=Progestin upregulates G-protein-coupled receptor 30 in breast cancer cells. |journal=Eur. J. Biochem. |volume=269 |issue= 10 |pages= 2485-90 |year= 2002 |pmid= 12027886 |doi= }}
*{{cite journal | author=Ahola TM, Manninen T, Alkio N, Ylikomi T |title=G protein-coupled receptor 30 is critical for a progestin-induced growth inhibition in MCF-7 breast cancer cells. |journal=Endocrinology |volume=143 |issue= 9 |pages= 3376-84 |year= 2002 |pmid= 12193550 |doi= }}
*{{cite journal | author=Ahola TM, Alkio N, Manninen T, Ylikomi T |title=Progestin and G protein-coupled receptor 30 inhibit mitogen-activated protein kinase activity in MCF-7 breast cancer cells. |journal=Endocrinology |volume=143 |issue= 12 |pages= 4620-6 |year= 2002 |pmid= 12446589 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal | author=Hamza A, Sarma MH, Sarma RH |title=Plausible interaction of an alpha-fetoprotein cyclopeptide with the G-protein-coupled receptor model GPR30: docking study by molecular dynamics simulated annealing. |journal=J. Biomol. Struct. Dyn. |volume=20 |issue= 6 |pages= 751-8 |year= 2004 |pmid= 12744705 |doi= }}
*{{cite journal | author=Kanda N, Watanabe S |title=17Beta-estradiol enhances the production of nerve growth factor in THP-1-derived macrophages or peripheral blood monocyte-derived macrophages. |journal=J. Invest. Dermatol. |volume=121 |issue= 4 |pages= 771-80 |year= 2003 |pmid= 14632195 |doi= 10.1046/j.1523-1747.2003.12487.x }}
*{{cite journal | author=Kanda N, Watanabe S |title=17beta-estradiol inhibits oxidative stress-induced apoptosis in keratinocytes by promoting Bcl-2 expression. |journal=J. Invest. Dermatol. |volume=121 |issue= 6 |pages= 1500-9 |year= 2004 |pmid= 14675202 |doi= 10.1111/j.1523-1747.2003.12617.x }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GPR31... {November 25, 2007 6:54:52 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 6:55:30 PM PST}
- CREATED: Created new protein page: GPR31 {November 25, 2007 6:55:38 PM PST}
- INFO: Beginning work on GPR32... {November 25, 2007 6:55:38 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 6:56:10 PM PST}
- CREATED: Created new protein page: GPR32 {November 25, 2007 6:56:17 PM PST}
- INFO: Beginning work on GPR33... {November 25, 2007 6:56:18 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 6:56:33 PM PST}
- CREATED: Created new protein page: GPR33 {November 25, 2007 6:56:39 PM PST}
- INFO: Beginning work on GPR34... {November 25, 2007 6:56:40 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 6:57:00 PM PST}
- CREATED: Created new protein page: GPR34 {November 25, 2007 6:57:10 PM PST}
- INFO: Beginning work on GPR35... {November 25, 2007 6:57:10 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 6:57:51 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = G protein-coupled receptor 35
| HGNCid = 4492
| Symbol = GPR35
| AltSymbols =;
| OMIM = 602646
| ECnumber =
| Homologene = 3874
| MGIid = 1929509
| GeneAtlas_image1 = PBB_GE_GPR35_210264_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2859
| Hs_Ensembl = ENSG00000178623
| Hs_RefseqProtein = NP_005292
| Hs_RefseqmRNA = NM_005301
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 241215523
| Hs_GenLoc_end = 241219342
| Hs_Uniprot = Q9HC97
| Mm_EntrezGene = 64095
| Mm_Ensembl = ENSMUSG00000026271
| Mm_RefseqmRNA = NM_022320
| Mm_RefseqProtein = NP_071715
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 94617360
| Mm_GenLoc_end = 94816797
| Mm_Uniprot = Q3TBY9
}}
}}
'''G protein-coupled receptor 35''', also known as '''GPR35''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPR35 G protein-coupled receptor 35| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2859| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Fauci AS, Balow JE, Pratt KR |title=Human bone marrow lymphocytes. Cytotoxic effector cells in the bone marrow of normal individuals. |journal=J. Clin. Invest. |volume=57 |issue= 4 |pages= 826-35 |year= 1976 |pmid= 947955 |doi= }}
*{{cite journal | author=O'Dowd BF, Nguyen T, Marchese A, ''et al.'' |title=Discovery of three novel G-protein-coupled receptor genes. |journal=Genomics |volume=47 |issue= 2 |pages= 310-3 |year= 1998 |pmid= 9479505 |doi= 10.1006/geno.1998.5095 }}
*{{cite journal | author=Horikawa Y, Oda N, Cox NJ, ''et al.'' |title=Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. |journal=Nat. Genet. |volume=26 |issue= 2 |pages= 163-75 |year= 2000 |pmid= 11017071 |doi= 10.1038/79876 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Okumura S, Baba H, Kumada T, ''et al.'' |title=Cloning of a G-protein-coupled receptor that shows an activity to transform NIH3T3 cells and is expressed in gastric cancer cells. |journal=Cancer Sci. |volume=95 |issue= 2 |pages= 131-5 |year= 2004 |pmid= 14965362 |doi= }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GPR37... {November 25, 2007 6:57:51 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 6:58:57 PM PST}
- CREATED: Created new protein page: GPR37 {November 25, 2007 6:59:06 PM PST}
- INFO: Beginning work on GPR39... {November 25, 2007 6:59:42 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 7:00:25 PM PST}
- CREATED: Created new protein page: GPR39 {November 25, 2007 7:00:34 PM PST}
- INFO: Beginning work on MCHR1... {November 25, 2007 6:50:39 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 6:51:33 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Melanin-concentrating hormone receptor 1
| HGNCid = 4479
| Symbol = MCHR1
| AltSymbols =; GPR24; MCH1R; MGC32129; SLC1
| OMIM = 601751
| ECnumber =
| Homologene = 21097
| MGIid = 2180756
| GeneAtlas_image1 = PBB_GE_MCHR1_221354_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0008188 |text = neuropeptide receptor activity}} {{GNF_GO|id=GO:0030273 |text = melanin-concentrating hormone receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006091 |text = generation of precursor metabolites and energy}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007193 |text = G-protein signaling, adenylate cyclase inhibiting pathway}} {{GNF_GO|id=GO:0007204 |text = elevation of cytosolic calcium ion concentration}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}} {{GNF_GO|id=GO:0007631 |text = feeding behavior}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2847
| Hs_Ensembl = ENSG00000128285
| Hs_RefseqProtein = NP_005288
| Hs_RefseqmRNA = NM_005297
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 22
| Hs_GenLoc_start = 39405045
| Hs_GenLoc_end = 39407878
| Hs_Uniprot = Q99705
| Mm_EntrezGene = 207911
| Mm_Ensembl = ENSMUSG00000050164
| Mm_RefseqmRNA = NM_145132
| Mm_RefseqProtein = NP_660114
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 81062824
| Mm_GenLoc_end = 81065367
| Mm_Uniprot = Q3UY93
}}
}}
'''Melanin-concentrating hormone receptor 1''', also known as '''MCHR1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MCHR1 melanin-concentrating hormone receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2847| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin.<ref name="entrez">{{cite web | title = Entrez Gene: MCHR1 melanin-concentrating hormone receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2847| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kolakowski LF, Jung BP, Nguyen T, ''et al.'' |title=Characterization of a human gene related to genes encoding somatostatin receptors. |journal=FEBS Lett. |volume=398 |issue= 2-3 |pages= 253-8 |year= 1997 |pmid= 8977118 |doi= }}
*{{cite journal | author=Chambers J, Ames RS, Bergsma D, ''et al.'' |title=Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1. |journal=Nature |volume=400 |issue= 6741 |pages= 261-5 |year= 1999 |pmid= 10421367 |doi= 10.1038/22313 }}
*{{cite journal | author=Saito Y, Nothacker HP, Wang Z, ''et al.'' |title=Molecular characterization of the melanin-concentrating-hormone receptor. |journal=Nature |volume=400 |issue= 6741 |pages= 265-9 |year= 1999 |pmid= 10421368 |doi= 10.1038/22321 }}
*{{cite journal | author=Shimomura Y, Mori M, Sugo T, ''et al.'' |title=Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor. |journal=Biochem. Biophys. Res. Commun. |volume=261 |issue= 3 |pages= 622-6 |year= 1999 |pmid= 10441476 |doi= 10.1006/bbrc.1999.1104 }}
*{{cite journal | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal | author=Macdonald D, Murgolo N, Zhang R, ''et al.'' |title=Molecular characterization of the melanin-concentrating hormone/receptor complex: identification of critical residues involved in binding and activation. |journal=Mol. Pharmacol. |volume=58 |issue= 1 |pages= 217-25 |year= 2000 |pmid= 10860944 |doi= }}
*{{cite journal | author=An S, Cutler G, Zhao JJ, ''et al.'' |title=Identification and characterization of a melanin-concentrating hormone receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 13 |pages= 7576-81 |year= 2001 |pmid= 11416225 |doi= 10.1073/pnas.131200698 }}
*{{cite journal | author=Bednarek MA, Feighner SD, Hreniuk DL, ''et al.'' |title=Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2. |journal=Biochemistry |volume=40 |issue= 31 |pages= 9379-86 |year= 2001 |pmid= 11478907 |doi= }}
*{{cite journal | author=Bednarek MA, Tan C, Hreniuk DL, ''et al.'' |title=Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13821-6 |year= 2002 |pmid= 11839762 |doi= 10.1074/jbc.M200563200 }}
*{{cite journal | author=Audinot V, Lahaye C, Suply T, ''et al.'' |title=SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor. |journal=Biochem. Biophys. Res. Commun. |volume=295 |issue= 4 |pages= 841-8 |year= 2002 |pmid= 12127971 |doi= }}
*{{cite journal | author=Hoogduijn MJ, Ancans J, Suzuki I, ''et al.'' |title=Melanin-concentrating hormone and its receptor are expressed and functional in human skin. |journal=Biochem. Biophys. Res. Commun. |volume=296 |issue= 3 |pages= 698-701 |year= 2002 |pmid= 12176038 |doi= }}
*{{cite journal | author=Bächner D, Kreienkamp HJ, Richter D |title=MIZIP, a highly conserved, vertebrate specific melanin-concentrating hormone receptor 1 interacting zinc-finger protein. |journal=FEBS Lett. |volume=526 |issue= 1-3 |pages= 124-8 |year= 2002 |pmid= 12208518 |doi= }}
*{{cite journal | author=Verlaet M, Adamantidis A, Coumans B, ''et al.'' |title=Human immune cells express ppMCH mRNA and functional MCHR1 receptor. |journal=FEBS Lett. |volume=527 |issue= 1-3 |pages= 205-10 |year= 2002 |pmid= 12220661 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Logan DW, Bryson-Richardson RJ, Pagán KE, ''et al.'' |title=The structure and evolution of the melanocortin and MCH receptors in fish and mammals. |journal=Genomics |volume=81 |issue= 2 |pages= 184-91 |year= 2003 |pmid= 12620396 |doi= }}
*{{cite journal | author=Pissios P, Trombly DJ, Tzameli I, Maratos-Flier E |title=Melanin-concentrating hormone receptor 1 activates extracellular signal-regulated kinase and synergizes with G(s)-coupled pathways. |journal=Endocrinology |volume=144 |issue= 8 |pages= 3514-23 |year= 2003 |pmid= 12865333 |doi= }}
*{{cite journal | author=Gottumukkala RV, Waterman EA, Herd LM, ''et al.'' |title=Autoantibodies in vitiligo patients recognize multiple domains of the melanin-concentrating hormone receptor. |journal=J. Invest. Dermatol. |volume=121 |issue= 4 |pages= 765-70 |year= 2003 |pmid= 14632194 |doi= 10.1046/j.1523-1747.2003.12494.x }}
*{{cite journal | author=Gibson WT, Pissios P, Trombly DJ, ''et al.'' |title=Melanin-concentrating hormone receptor mutations and human obesity: functional analysis. |journal=Obes. Res. |volume=12 |issue= 5 |pages= 743-9 |year= 2004 |pmid= 15166293 |doi= }}
*{{cite journal | author=Hawes BE, Green B, O'Neill K, ''et al.'' |title=Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2. |journal=Obes. Res. |volume=12 |issue= 8 |pages= 1327-34 |year= 2004 |pmid= 15340116 |doi= }}
*{{cite journal | author=Collins JE, Wright CL, Edwards CA, ''et al.'' |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MLNR... {November 25, 2007 6:59:06 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 6:59:42 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Motilin receptor
| HGNCid = 4495
| Symbol = MLNR
| AltSymbols =; GPR38; MTLR1
| OMIM = 602885
| ECnumber =
| Homologene = 74398
| MGIid =
| GeneAtlas_image1 = PBB_GE_MLNR_221365_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0016520 |text = growth hormone-releasing hormone receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006939 |text = smooth muscle contraction}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007586 |text = digestion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2862
| Hs_Ensembl = ENSG00000102539
| Hs_RefseqProtein = NP_001498
| Hs_RefseqmRNA = NM_001507
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 13
| Hs_GenLoc_start = 48692475
| Hs_GenLoc_end = 48694514
| Hs_Uniprot = O43193
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Motilin receptor''', also known as '''MLNR''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MLNR motilin receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2862| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Smith RG, Leonard R, Bailey AR, ''et al.'' |title=Growth hormone secretagogue receptor family members and ligands. |journal=Endocrine |volume=14 |issue= 1 |pages= 9-14 |year= 2001 |pmid= 11322507 |doi= }}
*{{cite journal | author=McKee KK, Tan CP, Palyha OC, ''et al.'' |title=Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors. |journal=Genomics |volume=46 |issue= 3 |pages= 426-34 |year= 1998 |pmid= 9441746 |doi= 10.1006/geno.1997.5069 }}
*{{cite journal | author=Feighner SD, Tan CP, McKee KK, ''et al.'' |title=Receptor for motilin identified in the human gastrointestinal system. |journal=Science |volume=284 |issue= 5423 |pages= 2184-8 |year= 1999 |pmid= 10381885 |doi= }}
*{{cite journal | author=Miller P, Roy A, St-Pierre S, ''et al.'' |title=Motilin receptors in the human antrum. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=278 |issue= 1 |pages= G18-23 |year= 2000 |pmid= 10644557 |doi= }}
*{{cite journal | author=Thielemans L, Depoortere I, Van Assche G, ''et al.'' |title=Demonstration of a functional motilin receptor in TE671 cells from human cerebellum. |journal=Brain Res. |volume=895 |issue= 1-2 |pages= 119-28 |year= 2001 |pmid= 11259768 |doi= }}
*{{cite journal | author=Coulie B, Matsuura B, Dong M, ''et al.'' |title=Identification of peptide ligand-binding domains within the human motilin receptor using photoaffinity labeling. |journal=J. Biol. Chem. |volume=276 |issue= 38 |pages= 35518-22 |year= 2001 |pmid= 11461914 |doi= 10.1074/jbc.M104489200 }}
*{{cite journal | author=Thielemans L, Depoortere I, Vanden Broeck J, Peeters TL |title=The motilin pharmacophore in CHO cells expressing the human motilin receptor. |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 4 |pages= 1223-7 |year= 2002 |pmid= 12054506 |doi= 10.1016/S0006-291X(02)00356-X }}
*{{cite journal | author=Depoortere I, Thijs T, Thielemans L, ''et al.'' |title=Interaction of the growth hormone-releasing peptides ghrelin and growth hormone-releasing peptide-6 with the motilin receptor in the rabbit gastric antrum. |journal=J. Pharmacol. Exp. Ther. |volume=305 |issue= 2 |pages= 660-7 |year= 2003 |pmid= 12606621 |doi= 10.1124/jpet.102.047563 }}
*{{cite journal | author=Dunham A, Matthews LH, Burton J, ''et al.'' |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522-8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 }}
*{{cite journal | author=Matsuura B, Dong M, Naik S, ''et al.'' |title=Differential contributions of motilin receptor extracellular domains for peptide and non-peptidyl agonist binding and activity. |journal=J. Biol. Chem. |volume=281 |issue= 18 |pages= 12390-6 |year= 2006 |pmid= 16531413 |doi= 10.1074/jbc.M511921200 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PRLHR... {November 25, 2007 6:42:01 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 6:42:30 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Prolactin releasing hormone receptor
| HGNCid = 4464
| Symbol = PRLHR
| AltSymbols =; GPR10; GR3; MGC126539; MGC126541; PrRPR
| OMIM = 600895
| ECnumber =
| Homologene = 3134
| MGIid = 2135956
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004983 |text = neuropeptide Y receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007565 |text = female pregnancy}} {{GNF_GO|id=GO:0007631 |text = feeding behavior}} {{GNF_GO|id=GO:0042445 |text = hormone metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2834
| Hs_Ensembl = ENSG00000119973
| Hs_RefseqProtein = NP_004239
| Hs_RefseqmRNA = NM_004248
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 120342951
| Hs_GenLoc_end = 120344746
| Hs_Uniprot = P49683
| Mm_EntrezGene = 226278
| Mm_Ensembl = ENSMUSG00000045052
| Mm_RefseqmRNA = NM_201615
| Mm_RefseqProtein = NP_963909
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 60521677
| Mm_GenLoc_end = 60522789
| Mm_Uniprot = Q059H6
}}
}}
'''Prolactin releasing hormone receptor''', also known as '''PRLHR''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PRLHR prolactin releasing hormone receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2834| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = PRLHR is a 7-transmembrane domain receptor for prolactin-releasing hormone (PRLH; MIM 602663) that is highly expressed in anterior pituitary (Ozawa et al., 2002).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: PRLHR prolactin releasing hormone receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2834| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hinuma S, Onda H, Fujino M |title=The quest for novel bioactive peptides utilizing orphan seven-transmembrane-domain receptors. |journal=J. Mol. Med. |volume=77 |issue= 6 |pages= 495-504 |year= 1999 |pmid= 10475064 |doi= }}
*{{cite journal | author=Marchese A, Heiber M, Nguyen T, ''et al.'' |title=Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors. |journal=Genomics |volume=29 |issue= 2 |pages= 335-44 |year= 1996 |pmid= 8666380 |doi= }}
*{{cite journal | author=Hinuma S, Habata Y, Fujii R, ''et al.'' |title=A prolactin-releasing peptide in the brain. |journal=Nature |volume=393 |issue= 6682 |pages= 272-6 |year= 1998 |pmid= 9607765 |doi= 10.1038/30515 }}
*{{cite journal | author=Fujii R, Fukusumi S, Hosoya M, ''et al.'' |title=Tissue distribution of prolactin-releasing peptide (PrRP) and its receptor. |journal=Regul. Pept. |volume=83 |issue= 1 |pages= 1-10 |year= 1999 |pmid= 10498338 |doi= }}
*{{cite journal | author=Langmead CJ, Szekeres PG, Chambers JK, ''et al.'' |title=Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor. |journal=Br. J. Pharmacol. |volume=131 |issue= 4 |pages= 683-8 |year= 2000 |pmid= 11030716 |doi= 10.1038/sj.bjp.0703617 }}
*{{cite journal | author=Lin SH, Arai AC, Wang Z, ''et al.'' |title=The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering. |journal=Mol. Pharmacol. |volume=60 |issue= 5 |pages= 916-23 |year= 2001 |pmid= 11641419 |doi= }}
*{{cite journal | author=Ozawa A, Yamada M, Satoh T, ''et al.'' |title=Transcriptional regulation of the human PRL-releasing peptide (PrRP) receptor gene by a dopamine 2 Receptor agonist: cloning and characterization of the human PrRP receptor gene and its promoter region. |journal=Mol. Endocrinol. |volume=16 |issue= 4 |pages= 785-98 |year= 2002 |pmid= 11923475 |doi= }}
*{{cite journal | author=Takahashi K, Totsune K, Murakami O, ''et al.'' |title=Expression of prolactin-releasing peptide and its receptor in the human adrenal glands and tumor tissues of adrenocortical tumors, pheochromocytomas and neuroblastomas. |journal=Peptides |volume=23 |issue= 6 |pages= 1135-40 |year= 2003 |pmid= 12126742 |doi= }}
*{{cite journal | author=Kemp DM, Lin JC, Ubeda M, Habener JF |title=NRSF/REST confers transcriptional repression of the GPR10 gene via a putative NRSE/RE-1 located in the 5' promoter region. |journal=FEBS Lett. |volume=531 |issue= 2 |pages= 193-8 |year= 2002 |pmid= 12417311 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Bhattacharyya S, Luan J, Challis B, ''et al.'' |title=Association of polymorphisms in GPR10, the gene encoding the prolactin-releasing peptide receptor with blood pressure, but not obesity, in a U.K. Caucasian population. |journal=Diabetes |volume=52 |issue= 5 |pages= 1296-9 |year= 2003 |pmid= 12716769 |doi= }}
*{{cite journal | author=Deloukas P, Earthrowl ME, Grafham DV, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375-81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Ellacott KL, Donald EL, Clarkson P, ''et al.'' |title=Characterization of a naturally-occurring polymorphism in the UHR-1 gene encoding the putative rat prolactin-releasing peptide receptor. |journal=Peptides |volume=26 |issue= 4 |pages= 675-81 |year= 2005 |pmid= 15752583 |doi= 10.1016/j.peptides.2004.11.020 }}
*{{cite journal | author=Lagerström MC, Fredriksson R, Bjarnadóttir TK, ''et al.'' |title=Origin of the prolactin-releasing hormone (PRLH) receptors: evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution. |journal=Genomics |volume=85 |issue= 6 |pages= 688-703 |year= 2005 |pmid= 15885496 |doi= 10.1016/j.ygeno.2005.02.007 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on UTS2R... {November 25, 2007 6:43:25 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 6:43:52 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Urotensin 2 receptor
| HGNCid = 4468
| Symbol = UTS2R
| AltSymbols =; GPR14; UTR; UTR2
| OMIM = 600896
| ECnumber =
| Homologene = 10345
| MGIid = 2183450
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0001604 |text = urotensin II receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0008015 |text = circulation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2837
| Hs_Ensembl = ENSG00000181408
| Hs_RefseqProtein = NP_061822
| Hs_RefseqmRNA = NM_018949
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 77925490
| Hs_GenLoc_end = 77926659
| Hs_Uniprot = Q9UKP6
| Mm_EntrezGene = 217369
| Mm_Ensembl = ENSMUSG00000039321
| Mm_RefseqmRNA = NM_145440
| Mm_RefseqProtein = NP_663415
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 120976361
| Mm_GenLoc_end = 120978063
| Mm_Uniprot = Q05AD1
}}
}}
'''Urotensin 2 receptor''', also known as '''UTS2R''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UTS2R urotensin 2 receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2837| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Marchese A, Heiber M, Nguyen T, ''et al.'' |title=Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors. |journal=Genomics |volume=29 |issue= 2 |pages= 335-44 |year= 1996 |pmid= 8666380 |doi= }}
*{{cite journal | author=Coulouarn Y, Lihrmann I, Jegou S, ''et al.'' |title=Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 26 |pages= 15803-8 |year= 1999 |pmid= 9861051 |doi= }}
*{{cite journal | author=Ames RS, Sarau HM, Chambers JK, ''et al.'' |title=Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. |journal=Nature |volume=401 |issue= 6750 |pages= 282-6 |year= 1999 |pmid= 10499587 |doi= 10.1038/45809 }}
*{{cite journal | author=Liu Q, Pong SS, Zeng Z, ''et al.'' |title=Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14. |journal=Biochem. Biophys. Res. Commun. |volume=266 |issue= 1 |pages= 174-8 |year= 2000 |pmid= 10581185 |doi= 10.1006/bbrc.1999.1796 }}
*{{cite journal | author=Protopopov A, Kashuba V, Podowski R, ''et al.'' |title=Assignment of the GPR14 gene coding for the G-protein-coupled receptor 14 to human chromosome 17q25.3 by fluorescent in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 3-4 |pages= 312-3 |year= 2000 |pmid= 10828617 |doi= }}
*{{cite journal | author=Maguire JJ, Kuc RE, Davenport AP |title=Orphan-receptor ligand human urotensin II: receptor localization in human tissues and comparison of vasoconstrictor responses with endothelin-1. |journal=Br. J. Pharmacol. |volume=131 |issue= 3 |pages= 441-6 |year= 2001 |pmid= 11015293 |doi= 10.1038/sj.bjp.0703601 }}
*{{cite journal | author=Sugo T, Murakami Y, Shimomura Y, ''et al.'' |title=Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain. |journal=Biochem. Biophys. Res. Commun. |volume=310 |issue= 3 |pages= 860-8 |year= 2003 |pmid= 14550283 |doi= }}
*{{cite journal | author=Birker-Robaczewska M, Boukhadra C, Studer R, ''et al.'' |title=The expression of urotensin II receptor (U2R) is up-regulated by interferon-gamma. |journal=J. Recept. Signal Transduct. Res. |volume=23 |issue= 4 |pages= 289-305 |year= 2004 |pmid= 14753294 |doi= }}
*{{cite journal | author=Bousette N, Patel L, Douglas SA, ''et al.'' |title=Increased expression of urotensin II and its cognate receptor GPR14 in atherosclerotic lesions of the human aorta. |journal=Atherosclerosis |volume=176 |issue= 1 |pages= 117-23 |year= 2004 |pmid= 15306183 |doi= 10.1016/j.atherosclerosis.2004.03.023 }}
*{{cite journal | author=Suzuki S, Wenyi Z, Hirai M, ''et al.'' |title=Genetic variations at urotensin II and urotensin II receptor genes and risk of type 2 diabetes mellitus in Japanese. |journal=Peptides |volume=25 |issue= 10 |pages= 1803-8 |year= 2005 |pmid= 15476949 |doi= 10.1016/j.peptides.2004.03.030 }}
*{{cite journal | author=Qi JS, Minor LK, Smith C, ''et al.'' |title=Characterization of functional urotensin II receptors in human skeletal muscle myoblasts: comparison with angiotensin II receptors. |journal=Peptides |volume=26 |issue= 4 |pages= 683-90 |year= 2005 |pmid= 15752584 |doi= 10.1016/j.peptides.2004.11.018 }}
*{{cite journal | author=Lehner U, Velić A, Schroter R, ''et al.'' |title=Ligands and signaling of the G-protein-coupled receptor GPR14, expressed in human kidney cells. |journal=Cell. Physiol. Biochem. |volume=20 |issue= 1-4 |pages= 181-92 |year= 2007 |pmid= 17595527 |doi= 10.1159/000104165 }}
*{{cite journal | author=Segain JP, Rolli-Derkinderen M, Gervois N, ''et al.'' |title=Urotensin II is a new chemotactic factor for UT receptor-expressing monocytes. |journal=J. Immunol. |volume=179 |issue= 2 |pages= 901-9 |year= 2007 |pmid= 17617581 |doi= }}
}}
{{refend}}
{{protein-stub}}
end log.
