- INFO: Beginning work on FFAR1... {November 25, 2007 7:03:02 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 7:03:27 PM PST}
- CREATED: Created new protein page: FFAR1 {November 25, 2007 7:03:36 PM PST}
- INFO: Beginning work on FFAR2... {November 25, 2007 7:04:50 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 7:05:30 PM PST}
- CREATED: Created new protein page: FFAR2 {November 25, 2007 7:05:38 PM PST}
- INFO: Beginning work on FFAR3... {November 25, 2007 7:03:36 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 7:03:56 PM PST}
- CREATED: Created new protein page: FFAR3 {November 25, 2007 7:04:03 PM PST}
- INFO: Beginning work on GPR42... {November 25, 2007 7:04:03 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 7:04:41 PM PST}
- CREATED: Created new protein page: GPR42 {November 25, 2007 7:04:50 PM PST}
- INFO: Beginning work on GRM1... {November 25, 2007 7:05:38 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:06:20 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GRM1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ewk.
| PDB = {{PDB2|1ewk}}, {{PDB2|1ewt}}, {{PDB2|1ewv}}, {{PDB2|1isr}}, {{PDB2|1iss}}
| Name = Glutamate receptor, metabotropic 1
| HGNCid = 4593
| Symbol = GRM1
| AltSymbols =; GPRC1A; GRM1A; MGLUR1; MGLUR1A; mGlu1
| OMIM = 604473
| ECnumber =
| Homologene = 649
| MGIid = 1351338
| GeneAtlas_image1 = PBB_GE_GRM1_207299_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_GRM1_210939_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_GRM1_210940_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008067 |text = metabotropic glutamate, GABA-B-like receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0030425 |text = dendrite}}
| Process = {{GNF_GO|id=GO:0000186 |text = activation of MAPKK activity}} {{GNF_GO|id=GO:0000187 |text = activation of MAPK activity}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007626 |text = locomotory behavior}} {{GNF_GO|id=GO:0043408 |text = regulation of MAPKKK cascade}} {{GNF_GO|id=GO:0051930 |text = regulation of sensory perception of pain}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2911
| Hs_Ensembl = ENSG00000152822
| Hs_RefseqProtein = NP_000829
| Hs_RefseqmRNA = NM_000838
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 146390611
| Hs_GenLoc_end = 146800427
| Hs_Uniprot = Q13255
| Mm_EntrezGene = 14816
| Mm_Ensembl = ENSMUSG00000019828
| Mm_RefseqmRNA = XM_976537
| Mm_RefseqProtein = XP_981631
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 10378793
| Mm_GenLoc_end = 10772495
| Mm_Uniprot = Q3V0U2
}}
}}
'''Glutamate receptor, metabotropic 1''', also known as '''GRM1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GRM1 glutamate receptor, metabotropic 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2911| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of the GRM1 gene have been described but their full-length nature has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: GRM1 glutamate receptor, metabotropic 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2911| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bockaert J, Pin JP |title=Molecular tinkering of G protein-coupled receptors: an evolutionary success. |journal=EMBO J. |volume=18 |issue= 7 |pages= 1723-9 |year= 1999 |pmid= 10202136 |doi= 10.1093/emboj/18.7.1723 }}
*{{cite journal | author=King JE, Eugenin EA, Buckner CM, Berman JW |title=HIV tat and neurotoxicity. |journal=Microbes Infect. |volume=8 |issue= 5 |pages= 1347-57 |year= 2006 |pmid= 16697675 |doi= 10.1016/j.micinf.2005.11.014 }}
*{{cite journal | author=Desai MA, Burnett JP, Mayne NG, Schoepp DD |title=Cloning and expression of a human metabotropic glutamate receptor 1 alpha: enhanced coupling on co-transfection with a glutamate transporter. |journal=Mol. Pharmacol. |volume=48 |issue= 4 |pages= 648-57 |year= 1995 |pmid= 7476890 |doi= }}
*{{cite journal | author=Scherer SW, Duvoisin RM, Kuhn R, ''et al.'' |title=Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q. |journal=Genomics |volume=31 |issue= 2 |pages= 230-3 |year= 1997 |pmid= 8824806 |doi= 10.1006/geno.1996.0036 }}
*{{cite journal | author=Brakeman PR, Lanahan AA, O'Brien R, ''et al.'' |title=Homer: a protein that selectively binds metabotropic glutamate receptors. |journal=Nature |volume=386 |issue= 6622 |pages= 284-8 |year= 1997 |pmid= 9069287 |doi= 10.1038/386284a0 }}
*{{cite journal | author=Stephan D, Bon C, Holzwarth JA, ''et al.'' |title=Human metabotropic glutamate receptor 1: mRNA distribution, chromosome localization and functional expression of two splice variants. |journal=Neuropharmacology |volume=35 |issue= 12 |pages= 1649-60 |year= 1997 |pmid= 9076744 |doi= }}
*{{cite journal | author=Makoff AJ, Phillips T, Pilling C, Emson P |title=Expression of a novel splice variant of human mGluR1 in the cerebellum. |journal=Neuroreport |volume=8 |issue= 13 |pages= 2943-7 |year= 1997 |pmid= 9376535 |doi= }}
*{{cite journal | author=Francesconi A, Duvoisin RM |title=Role of the second and third intracellular loops of metabotropic glutamate receptors in mediating dual signal transduction activation. |journal=J. Biol. Chem. |volume=273 |issue= 10 |pages= 5615-24 |year= 1998 |pmid= 9488690 |doi= }}
*{{cite journal | author=Okamoto T, Sekiyama N, Otsu M, ''et al.'' |title=Expression and purification of the extracellular ligand binding region of metabotropic glutamate receptor subtype 1. |journal=J. Biol. Chem. |volume=273 |issue= 21 |pages= 13089-96 |year= 1998 |pmid= 9582347 |doi= }}
*{{cite journal | author=Snow BE, Hall RA, Krumins AM, ''et al.'' |title=GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain. |journal=J. Biol. Chem. |volume=273 |issue= 28 |pages= 17749-55 |year= 1998 |pmid= 9651375 |doi= }}
*{{cite journal | author=Xiao B, Tu JC, Petralia RS, ''et al.'' |title=Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. |journal=Neuron |volume=21 |issue= 4 |pages= 707-16 |year= 1998 |pmid= 9808458 |doi= }}
*{{cite journal | author=Tu JC, Xiao B, Yuan JP, ''et al.'' |title=Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. |journal=Neuron |volume=21 |issue= 4 |pages= 717-26 |year= 1998 |pmid= 9808459 |doi= }}
*{{cite journal | author=Ciruela F, Robbins MJ, Willis AC, McIlhinney RA |title=Interactions of the C terminus of metabotropic glutamate receptor type 1alpha with rat brain proteins: evidence for a direct interaction with tubulin. |journal=J. Neurochem. |volume=72 |issue= 1 |pages= 346-54 |year= 1999 |pmid= 9886087 |doi= }}
*{{cite journal | author=Robbins MJ, Ciruela F, Rhodes A, McIlhinney RA |title=Characterization of the dimerization of metabotropic glutamate receptors using an N-terminal truncation of mGluR1alpha. |journal=J. Neurochem. |volume=72 |issue= 6 |pages= 2539-47 |year= 1999 |pmid= 10349865 |doi= }}
*{{cite journal | author=Mody N, Hermans E, Nahorski SR, Challiss RA |title=Inhibition of N-linked glycosylation of the human type 1alpha metabotropic glutamate receptor by tunicamycin: effects on cell-surface receptor expression and function. |journal=Neuropharmacology |volume=38 |issue= 10 |pages= 1485-92 |year= 1999 |pmid= 10530810 |doi= }}
*{{cite journal | author=Francesconi A, Duvoisin RM |title=Opposing effects of protein kinase C and protein kinase A on metabotropic glutamate receptor signaling: selective desensitization of the inositol trisphosphate/Ca2+ pathway by phosphorylation of the receptor-G protein-coupling domain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 11 |pages= 6185-90 |year= 2000 |pmid= 10823959 |doi= }}
*{{cite journal | author=Ganesh S, Amano K, Yamakawa K |title=Assignment of the gene GRM1 coding for metabotropic glutamate receptor 1 to human chromosome band 6q24 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 3-4 |pages= 314-5 |year= 2000 |pmid= 10828618 |doi= }}
*{{cite journal | author=Ray K, Hauschild BC |title=Cys-140 is critical for metabotropic glutamate receptor-1 dimerization. |journal=J. Biol. Chem. |volume=275 |issue= 44 |pages= 34245-51 |year= 2000 |pmid= 10945991 |doi= 10.1074/jbc.M005581200 }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GRM2... {November 25, 2007 7:06:20 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:07:11 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Glutamate receptor, metabotropic 2
| HGNCid = 4594
| Symbol = GRM2
| AltSymbols =; GLUR2; GPRC1B; MGLUR2; mGlu2
| OMIM = 604099
| ECnumber =
| Homologene = 20229
| MGIid =
| GeneAtlas_image1 = PBB_GE_GRM2_208465_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0008067 |text = metabotropic glutamate, GABA-B-like receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007194 |text = negative regulation of adenylate cyclase activity}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2912
| Hs_Ensembl = ENSG00000164082
| Hs_RefseqProtein = NP_000830
| Hs_RefseqmRNA = NM_000839
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 51716118
| Hs_GenLoc_end = 51727663
| Hs_Uniprot = Q14416
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Glutamate receptor, metabotropic 2''', also known as '''GRM2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GRM2 glutamate receptor, metabotropic 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2912| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.<ref name="entrez">{{cite web | title = Entrez Gene: GRM2 glutamate receptor, metabotropic 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2912| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Flor PJ, Lindauer K, Püttner I, ''et al.'' |title=Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2. |journal=Eur. J. Neurosci. |volume=7 |issue= 4 |pages= 622-9 |year= 1995 |pmid= 7620613 |doi= }}
*{{cite journal | author=Scherer SW, Duvoisin RM, Kuhn R, ''et al.'' |title=Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q. |journal=Genomics |volume=31 |issue= 2 |pages= 230-3 |year= 1997 |pmid= 8824806 |doi= 10.1006/geno.1996.0036 }}
*{{cite journal | author=Gomeza J, Mary S, Brabet I, ''et al.'' |title=Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists. |journal=Mol. Pharmacol. |volume=50 |issue= 4 |pages= 923-30 |year= 1996 |pmid= 8863838 |doi= }}
*{{cite journal | author=Snow BE, Hall RA, Krumins AM, ''et al.'' |title=GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain. |journal=J. Biol. Chem. |volume=273 |issue= 28 |pages= 17749-55 |year= 1998 |pmid= 9651375 |doi= }}
*{{cite journal | author=Malherbe P, Knoflach F, Broger C, ''et al.'' |title=Identification of essential residues involved in the glutamate binding pocket of the group II metabotropic glutamate receptor. |journal=Mol. Pharmacol. |volume=60 |issue= 5 |pages= 944-54 |year= 2001 |pmid= 11641422 |doi= }}
*{{cite journal | author=Martí SB, Cichon S, Propping P, Nöthen M |title=Human metabotropic glutamate receptor 2 gene (GRM2): chromosomal sublocalization (3p21.1-p21.2) and genomic organization. |journal=Am. J. Med. Genet. |volume=114 |issue= 1 |pages= 12-4 |year= 2002 |pmid= 11840499 |doi= }}
*{{cite journal | author=Krampfl K, Schlesinger F, Zörner A, ''et al.'' |title=Control of kinetic properties of GluR2 flop AMPA-type channels: impact of R/G nuclear editing. |journal=Eur. J. Neurosci. |volume=15 |issue= 1 |pages= 51-62 |year= 2002 |pmid= 11860506 |doi= }}
*{{cite journal | author=Dietrich D, Kral T, Clusmann H, ''et al.'' |title=Presynaptic group II metabotropic glutamate receptors reduce stimulated and spontaneous transmitter release in human dentate gyrus. |journal=Neuropharmacology |volume=42 |issue= 3 |pages= 297-305 |year= 2002 |pmid= 11897108 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Kuwabara T, Hsieh J, Nakashima K, ''et al.'' |title=A small modulatory dsRNA specifies the fate of adult neural stem cells. |journal=Cell |volume=116 |issue= 6 |pages= 779-93 |year= 2004 |pmid= 15035981 |doi= }}
*{{cite journal | author=Tang FR, Chia SC, Chen PM, ''et al.'' |title=Metabotropic glutamate receptor 2/3 in the hippocampus of patients with mesial temporal lobe epilepsy, and of rats and mice after pilocarpine-induced status epilepticus. |journal=Epilepsy Res. |volume=59 |issue= 2-3 |pages= 167-80 |year= 2004 |pmid= 15246118 |doi= 10.1016/j.eplepsyres.2004.04.002 }}
*{{cite journal | author=Anneser JM, Chahli C, Ince PG, ''et al.'' |title=Glial proliferation and metabotropic glutamate receptor expression in amyotrophic lateral sclerosis. |journal=J. Neuropathol. Exp. Neurol. |volume=63 |issue= 8 |pages= 831-40 |year= 2004 |pmid= 15330338 |doi= }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Cube RV, Vernier JM, Hutchinson JH, ''et al.'' |title=3-(2-Ethoxy-4-{4-[3-hydroxy-2-methyl-4-(3-methylbutanoyl)phenoxy]butoxy}phenyl)propanoic acid: a brain penetrant allosteric potentiator at the metabotropic glutamate receptor 2 (mGluR2). |journal=Bioorg. Med. Chem. Lett. |volume=15 |issue= 9 |pages= 2389-93 |year= 2005 |pmid= 15837331 |doi= 10.1016/j.bmcl.2005.02.078 }}
*{{cite journal | author=Rodd ZA, McKinzie DL, Bell RL, ''et al.'' |title=The metabotropic glutamate 2/3 receptor agonist LY404039 reduces alcohol-seeking but not alcohol self-administration in alcohol-preferring (P) rats. |journal=Behav. Brain Res. |volume=171 |issue= 2 |pages= 207-15 |year= 2006 |pmid= 16678921 |doi= 10.1016/j.bbr.2006.03.032 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GRM3... {November 25, 2007 7:07:11 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein GRM3 image.jpg {November 25, 2007 7:07:50 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:08:07 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GRM3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2e4u.
| PDB = {{PDB2|2e4u}}, {{PDB2|2e4v}}, {{PDB2|2e4w}}, {{PDB2|2e4x}}, {{PDB2|2e4y}}
| Name = Glutamate receptor, metabotropic 3
| HGNCid = 4595
| Symbol = GRM3
| AltSymbols =; GLUR3; GPRC1C; MGLUR3; mGlu3
| OMIM = 601115
| ECnumber =
| Homologene = 651
| MGIid = 1351340
| GeneAtlas_image1 = PBB_GE_GRM3_205814_at_tn.png
| Function = {{GNF_GO|id=GO:0001641 |text = group II metabotropic glutamate receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005246 |text = calcium channel regulator activity}} {{GNF_GO|id=GO:0008067 |text = metabotropic glutamate, GABA-B-like receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0030424 |text = axon}} {{GNF_GO|id=GO:0042734 |text = presynaptic membrane}} {{GNF_GO|id=GO:0043197 |text = dendritic spine}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007194 |text = negative regulation of adenylate cyclase activity}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2913
| Hs_Ensembl = ENSG00000198822
| Hs_RefseqProtein = NP_000831
| Hs_RefseqmRNA = NM_000840
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 86111160
| Hs_GenLoc_end = 86332127
| Hs_Uniprot = Q14832
| Mm_EntrezGene = 108069
| Mm_Ensembl = ENSMUSG00000003974
| Mm_RefseqmRNA = NM_181850
| Mm_RefseqProtein = NP_862898
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 9491242
| Mm_GenLoc_end = 9731358
| Mm_Uniprot = Q14DJ9
}}
}}
'''Glutamate receptor, metabotropic 3''', also known as '''GRM3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GRM3 glutamate receptor, metabotropic 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2913| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.<ref name="entrez">{{cite web | title = Entrez Gene: GRM3 glutamate receptor, metabotropic 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2913| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Scherer SW, Duvoisin RM, Kuhn R, ''et al.'' |title=Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q. |journal=Genomics |volume=31 |issue= 2 |pages= 230-3 |year= 1997 |pmid= 8824806 |doi= 10.1006/geno.1996.0036 }}
*{{cite journal | author=Makoff A, Volpe F, Lelchuk R, ''et al.'' |title=Molecular characterization and localization of human metabotropic glutamate receptor type 3. |journal=Brain Res. Mol. Brain Res. |volume=40 |issue= 1 |pages= 55-63 |year= 1997 |pmid= 8840013 |doi= }}
*{{cite journal | author=Emile L, Mercken L, Apiou F, ''et al.'' |title=Molecular cloning, functional expression, pharmacological characterization and chromosomal localization of the human metabotropic glutamate receptor type 3. |journal=Neuropharmacology |volume=35 |issue= 5 |pages= 523-30 |year= 1997 |pmid= 8887960 |doi= }}
*{{cite journal | author=Corti C, Sala CF, Yang F, ''et al.'' |title=Genomic organization of the human metabotropic glutamate receptor subtype 3. |journal=J. Neurogenet. |volume=14 |issue= 4 |pages= 207-25, 271 |year= 2001 |pmid= 11342382 |doi= }}
*{{cite journal | author=Corti C, Xuereb JH, Corsi M, Ferraguti F |title=Identification and characterization of the promoter region of the GRM3 gene. |journal=Biochem. Biophys. Res. Commun. |volume=286 |issue= 2 |pages= 381-7 |year= 2001 |pmid= 11500049 |doi= 10.1006/bbrc.2001.5391 }}
*{{cite journal | author=Tomiyama M, Kimura T, Maeda T, ''et al.'' |title=Expression of metabotropic glutamate receptor mRNAs in the human spinal cord: implications for selective vulnerability of spinal motor neurons in amyotrophic lateral sclerosis. |journal=J. Neurol. Sci. |volume=189 |issue= 1-2 |pages= 65-9 |year= 2001 |pmid= 11535235 |doi= }}
*{{cite journal | author=Rosemond E, Peltekova V, Naples M, ''et al.'' |title=Molecular determinants of high affinity binding to group III metabotropic glutamate receptors. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7333-40 |year= 2002 |pmid= 11744707 |doi= 10.1074/jbc.M110476200 }}
*{{cite journal | author=Martí SB, Cichon S, Propping P, Nöthen M |title=Metabotropic glutamate receptor 3 (GRM3) gene variation is not associated with schizophrenia or bipolar affective disorder in the German population. |journal=Am. J. Med. Genet. |volume=114 |issue= 1 |pages= 46-50 |year= 2002 |pmid= 11840505 |doi= }}
*{{cite journal | author=Kitano J, Kimura K, Yamazaki Y, ''et al.'' |title=Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins. |journal=J. Neurosci. |volume=22 |issue= 4 |pages= 1280-9 |year= 2002 |pmid= 11850456 |doi= }}
*{{cite journal | author=Hirbec H, Perestenko O, Nishimune A, ''et al.'' |title=The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15221-4 |year= 2002 |pmid= 11891216 |doi= 10.1074/jbc.C200112200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal | author=Fujii Y, Shibata H, Kikuta R, ''et al.'' |title=Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia. |journal=Psychiatr. Genet. |volume=13 |issue= 2 |pages= 71-6 |year= 2004 |pmid= 12782962 |doi= 10.1097/01.ypg.0000056682.82896.b0 }}
*{{cite journal | author=Aronica E, Gorter JA, Ijlst-Keizers H, ''et al.'' |title=Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins. |journal=Eur. J. Neurosci. |volume=17 |issue= 10 |pages= 2106-18 |year= 2003 |pmid= 12786977 |doi= }}
*{{cite journal | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal | author=Flajolet M, Rakhilin S, Wang H, ''et al.'' |title=Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 26 |pages= 16006-11 |year= 2004 |pmid= 14663150 |doi= 10.1073/pnas.2136600100 }}
*{{cite journal | author=Yao Y, Koo JC, Wells JW, Hampson DR |title=Expression of a truncated secreted form of the mGluR3 subtype of metabotropic glutamate receptor. |journal=Biochem. Biophys. Res. Commun. |volume=319 |issue= 2 |pages= 622-8 |year= 2004 |pmid= 15178451 |doi= 10.1016/j.bbrc.2004.05.032 }}
*{{cite journal | author=Tang FR, Chia SC, Chen PM, ''et al.'' |title=Metabotropic glutamate receptor 2/3 in the hippocampus of patients with mesial temporal lobe epilepsy, and of rats and mice after pilocarpine-induced status epilepticus. |journal=Epilepsy Res. |volume=59 |issue= 2-3 |pages= 167-80 |year= 2004 |pmid= 15246118 |doi= 10.1016/j.eplepsyres.2004.04.002 }}
*{{cite journal | author=Egan MF, Straub RE, Goldberg TE, ''et al.'' |title=Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 34 |pages= 12604-9 |year= 2004 |pmid= 15310849 |doi= 10.1073/pnas.0405077101 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GRM4... {November 25, 2007 7:08:07 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:08:49 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Glutamate receptor, metabotropic 4
| HGNCid = 4596
| Symbol = GRM4
| AltSymbols =; GPRC1D; MGLUR4; mGlu4
| OMIM = 604100
| ECnumber =
| Homologene = 20230
| MGIid = 1351341
| GeneAtlas_image1 = PBB_GE_GRM4_210234_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0008067 |text = metabotropic glutamate, GABA-B-like receptor activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0031410 |text = cytoplasmic vesicle}}
| Process = {{GNF_GO|id=GO:0000187 |text = activation of MAPK activity}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007194 |text = negative regulation of adenylate cyclase activity}} {{GNF_GO|id=GO:0007196 |text = metabotropic glutamate receptor, adenylate cyclase inhibiting pathway}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007269 |text = neurotransmitter secretion}} {{GNF_GO|id=GO:0007612 |text = learning}} {{GNF_GO|id=GO:0043410 |text = positive regulation of MAPKKK cascade}} {{GNF_GO|id=GO:0043526 |text = neuroprotection}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2914
| Hs_Ensembl = ENSG00000124493
| Hs_RefseqProtein = NP_000832
| Hs_RefseqmRNA = NM_000841
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 34097606
| Hs_GenLoc_end = 34231377
| Hs_Uniprot = Q14833
| Mm_EntrezGene = 268934
| Mm_Ensembl = ENSMUSG00000063239
| Mm_RefseqmRNA = NM_001013385
| Mm_RefseqProtein = NP_001013403
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 27149976
| Mm_GenLoc_end = 27230893
| Mm_Uniprot =
}}
}}
'''Glutamate receptor, metabotropic 4''', also known as '''GRM4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GRM4 glutamate receptor, metabotropic 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2914| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.<ref name="entrez">{{cite web | title = Entrez Gene: GRM4 glutamate receptor, metabotropic 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2914| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Flor PJ, Lukic S, Rüegg D, ''et al.'' |title=Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 4. |journal=Neuropharmacology |volume=34 |issue= 2 |pages= 149-55 |year= 1995 |pmid= 7617140 |doi= }}
*{{cite journal | author=Makoff A, Lelchuk R, Oxer M, ''et al.'' |title=Molecular characterization and localization of human metabotropic glutamate receptor type 4. |journal=Brain Res. Mol. Brain Res. |volume=37 |issue= 1-2 |pages= 239-48 |year= 1996 |pmid= 8738157 |doi= }}
*{{cite journal | author=Scherer SW, Duvoisin RM, Kuhn R, ''et al.'' |title=Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q. |journal=Genomics |volume=31 |issue= 2 |pages= 230-3 |year= 1997 |pmid= 8824806 |doi= 10.1006/geno.1996.0036 }}
*{{cite journal | author=Gomeza J, Mary S, Brabet I, ''et al.'' |title=Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists. |journal=Mol. Pharmacol. |volume=50 |issue= 4 |pages= 923-30 |year= 1996 |pmid= 8863838 |doi= }}
*{{cite journal | author=Wu S, Wright RA, Rockey PK, ''et al.'' |title=Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells. |journal=Brain Res. Mol. Brain Res. |volume=53 |issue= 1-2 |pages= 88-97 |year= 1998 |pmid= 9473604 |doi= }}
*{{cite journal | author=Fu M, Wang C, Reutens AT, ''et al.'' |title=p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation. |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20853-60 |year= 2000 |pmid= 10779504 |doi= 10.1074/jbc.M000660200 }}
*{{cite journal | author=Barbon A, Ferraboli S, Barlati S |title=Assignment of the human metabotropic glutamate receptor gene GRM4 to chromosome 6 band p21.3 by radiation hybrid mapping. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 3-4 |pages= 210 |year= 2000 |pmid= 10828590 |doi= }}
*{{cite journal | author=Ohtsuki T, Toru M, Arinami T |title=Mutation screening of the metabotropic glutamate receptor mGluR4 (GRM4) gene in patients with schizophrenia. |journal=Psychiatr. Genet. |volume=11 |issue= 2 |pages= 79-83 |year= 2002 |pmid= 11525421 |doi= }}
*{{cite journal | author=Erdemir T, Bilican B, Oncel D, ''et al.'' |title=DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX). |journal=J. Cell. Sci. |volume=115 |issue= Pt 1 |pages= 207-16 |year= 2002 |pmid= 11801738 |doi= }}
*{{cite journal | author=Collard CD, Park KA, Montalto MC, ''et al.'' |title=Neutrophil-derived glutamate regulates vascular endothelial barrier function. |journal=J. Biol. Chem. |volume=277 |issue= 17 |pages= 14801-11 |year= 2002 |pmid= 11847215 |doi= 10.1074/jbc.M110557200 }}
*{{cite journal | author=Enz R |title=The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7. |journal=FEBS Lett. |volume=514 |issue= 2-3 |pages= 184-8 |year= 2002 |pmid= 11943148 |doi= }}
*{{cite journal | author=Gaughan L, Logan IR, Cook S, ''et al.'' |title=Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor. |journal=J. Biol. Chem. |volume=277 |issue= 29 |pages= 25904-13 |year= 2002 |pmid= 11994312 |doi= 10.1074/jbc.M203423200 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Iacovelli L, Capobianco L, Iula M, ''et al.'' |title=Regulation of mGlu4 metabotropic glutamate receptor signaling by type-2 G-protein coupled receptor kinase (GRK2). |journal=Mol. Pharmacol. |volume=65 |issue= 5 |pages= 1103-10 |year= 2004 |pmid= 15102938 |doi= 10.1124/mol.65.5.1103 }}
*{{cite journal | author=Hermit MB, Greenwood JR, Bräuner-Osborne H |title=Mutation-induced quisqualic acid and ibotenic acid affinity at the metabotropic glutamate receptor subtype 4: ligand selectivity results from a synergy of several amino acid residues. |journal=J. Biol. Chem. |volume=279 |issue= 33 |pages= 34811-7 |year= 2004 |pmid= 15184361 |doi= 10.1074/jbc.M404109200 }}
*{{cite journal | author=Yoo BC, Jeon E, Hong SH, ''et al.'' |title=Metabotropic glutamate receptor 4-mediated 5-Fluorouracil resistance in a human colon cancer cell line. |journal=Clin. Cancer Res. |volume=10 |issue= 12 Pt 1 |pages= 4176-84 |year= 2005 |pmid= 15217955 |doi= 10.1158/1078-0432.CCR-1114-03 }}
*{{cite journal | author=Chang HJ, Yoo BC, Lim SB, ''et al.'' |title=Metabotropic glutamate receptor 4 expression in colorectal carcinoma and its prognostic significance. |journal=Clin. Cancer Res. |volume=11 |issue= 9 |pages= 3288-95 |year= 2005 |pmid= 15867225 |doi= 10.1158/1078-0432.CCR-04-1912 }}
*{{cite journal | author=Mathiesen JM, Ramirez MT |title=The metabotropic glutamate receptor 4 is internalized and desensitized upon protein kinase C activation. |journal=Br. J. Pharmacol. |volume=148 |issue= 3 |pages= 279-90 |year= 2006 |pmid= 16582932 |doi= 10.1038/sj.bjp.0706733 }}
*{{cite journal | author=Iacovelli L, Arcella A, Battaglia G, ''et al.'' |title=Pharmacological activation of mGlu4 metabotropic glutamate receptors inhibits the growth of medulloblastomas. |journal=J. Neurosci. |volume=26 |issue= 32 |pages= 8388-97 |year= 2006 |pmid= 16899734 |doi= 10.1523/JNEUROSCI.2285-06.2006 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GRM5... {November 25, 2007 7:08:49 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:09:47 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Glutamate receptor, metabotropic 5
| HGNCid = 4597
| Symbol = GRM5
| AltSymbols =; GPRC1E; MGLUR5; MGLUR5A; MGLUR5B; mGlu5
| OMIM = 604102
| ECnumber =
| Homologene = 37354
| MGIid = 1351342
| GeneAtlas_image1 = PBB_GE_GRM5_207235_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008067 |text = metabotropic glutamate, GABA-B-like receptor activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007206 |text = metabotropic glutamate receptor, phospholipase C activating pathway}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007612 |text = learning}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2915
| Hs_Ensembl = ENSG00000168959
| Hs_RefseqProtein = NP_000833
| Hs_RefseqmRNA = NM_000842
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 87881006
| Hs_GenLoc_end = 88420838
| Hs_Uniprot = P41594
| Mm_EntrezGene = 108071
| Mm_Ensembl = ENSMUSG00000049583
| Mm_RefseqmRNA = XM_983330
| Mm_RefseqProtein = XP_988424
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 87477812
| Mm_GenLoc_end = 88006270
| Mm_Uniprot =
}}
}}
'''Glutamate receptor, metabotropic 5''', also known as '''GRM5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GRM5 glutamate receptor, metabotropic 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2915| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of GRM8 have been described but their full-length nature has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: GRM5 glutamate receptor, metabotropic 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2915| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Minakami R, Katsuki F, Sugiyama H |title=A variant of metabotropic glutamate receptor subtype 5: an evolutionally conserved insertion with no termination codon. |journal=Biochem. Biophys. Res. Commun. |volume=194 |issue= 2 |pages= 622-7 |year= 1993 |pmid= 7688218 |doi= 10.1006/bbrc.1993.1866 }}
*{{cite journal | author=Minakami R, Katsuki F, Yamamoto T, ''et al.'' |title=Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5. |journal=Biochem. Biophys. Res. Commun. |volume=199 |issue= 3 |pages= 1136-43 |year= 1994 |pmid= 7908515 |doi= 10.1006/bbrc.1994.1349 }}
*{{cite journal | author=Daggett LP, Sacaan AI, Akong M, ''et al.'' |title=Molecular and functional characterization of recombinant human metabotropic glutamate receptor subtype 5. |journal=Neuropharmacology |volume=34 |issue= 8 |pages= 871-86 |year= 1996 |pmid= 8532169 |doi= }}
*{{cite journal | author=Brakeman PR, Lanahan AA, O'Brien R, ''et al.'' |title=Homer: a protein that selectively binds metabotropic glutamate receptors. |journal=Nature |volume=386 |issue= 6622 |pages= 284-8 |year= 1997 |pmid= 9069287 |doi= 10.1038/386284a0 }}
*{{cite journal | author=Minakami R, Jinnai N, Sugiyama H |title=Phosphorylation and calmodulin binding of the metabotropic glutamate receptor subtype 5 (mGluR5) are antagonistic in vitro. |journal=J. Biol. Chem. |volume=272 |issue= 32 |pages= 20291-8 |year= 1997 |pmid= 9242710 |doi= }}
*{{cite journal | author=Snow BE, Hall RA, Krumins AM, ''et al.'' |title=GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain. |journal=J. Biol. Chem. |volume=273 |issue= 28 |pages= 17749-55 |year= 1998 |pmid= 9651375 |doi= }}
*{{cite journal | author=Xiao B, Tu JC, Petralia RS, ''et al.'' |title=Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. |journal=Neuron |volume=21 |issue= 4 |pages= 707-16 |year= 1998 |pmid= 9808458 |doi= }}
*{{cite journal | author=Enz R |title=The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7. |journal=FEBS Lett. |volume=514 |issue= 2-3 |pages= 184-8 |year= 2002 |pmid= 11943148 |doi= }}
*{{cite journal | author=Saugstad JA, Yang S, Pohl J, ''et al.'' |title=Interaction between metabotropic glutamate receptor 7 and alpha tubulin. |journal=J. Neurochem. |volume=80 |issue= 6 |pages= 980-8 |year= 2002 |pmid= 11953448 |doi= }}
*{{cite journal | author=Nash MS, Schell MJ, Atkinson PJ, ''et al.'' |title=Determinants of metabotropic glutamate receptor-5-mediated Ca2+ and inositol 1,4,5-trisphosphate oscillation frequency. Receptor density versus agonist concentration. |journal=J. Biol. Chem. |volume=277 |issue= 39 |pages= 35947-60 |year= 2002 |pmid= 12119301 |doi= 10.1074/jbc.M205622200 }}
*{{cite journal | author=Bates B, Xie Y, Taylor N, ''et al.'' |title=Characterization of mGluR5R, a novel, metabotropic glutamate receptor 5-related gene. |journal=Brain Res. Mol. Brain Res. |volume=109 |issue= 1-2 |pages= 18-33 |year= 2003 |pmid= 12531512 |doi= }}
*{{cite journal | author=Malherbe P, Kew JN, Richards JG, ''et al.'' |title=Identification and characterization of a novel splice variant of the metabotropic glutamate receptor 5 gene in human hippocampus and cerebellum. |journal=Brain Res. Mol. Brain Res. |volume=109 |issue= 1-2 |pages= 168-78 |year= 2003 |pmid= 12531526 |doi= }}
*{{cite journal | author=O'Malley KL, Jong YJ, Gonchar Y, ''et al.'' |title=Activation of metabotropic glutamate receptor mGlu5 on nuclear membranes mediates intranuclear Ca2+ changes in heterologous cell types and neurons. |journal=J. Biol. Chem. |volume=278 |issue= 30 |pages= 28210-9 |year= 2003 |pmid= 12736269 |doi= 10.1074/jbc.M300792200 }}
*{{cite journal | author=Corti C, Clarkson RW, Crepaldi L, ''et al.'' |title=Gene structure of the human metabotropic glutamate receptor 5 and functional analysis of its multiple promoters in neuroblastoma and astroglioma cells. |journal=J. Biol. Chem. |volume=278 |issue= 35 |pages= 33105-19 |year= 2003 |pmid= 12783878 |doi= 10.1074/jbc.M212380200 }}
*{{cite journal | author=Aronica E, Gorter JA, Ijlst-Keizers H, ''et al.'' |title=Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins. |journal=Eur. J. Neurosci. |volume=17 |issue= 10 |pages= 2106-18 |year= 2003 |pmid= 12786977 |doi= }}
*{{cite journal | author=Uchino M, Sakai N, Kashiwagi K, ''et al.'' |title=Isoform-specific phosphorylation of metabotropic glutamate receptor 5 by protein kinase C (PKC) blocks Ca2+ oscillation and oscillatory translocation of Ca2+-dependent PKC. |journal=J. Biol. Chem. |volume=279 |issue= 3 |pages= 2254-61 |year= 2004 |pmid= 14561742 |doi= 10.1074/jbc.M309894200 }}
*{{cite journal | author=Anneser JM, Ince PG, Shaw PJ, Borasio GD |title=Differential expression of mGluR5 in human lumbosacral motoneurons. |journal=Neuroreport |volume=15 |issue= 2 |pages= 271-3 |year= 2004 |pmid= 15076751 |doi= }}
*{{cite journal | author=Pacheco R, Ciruela F, Casadó V, ''et al.'' |title=Group I metabotropic glutamate receptors mediate a dual role of glutamate in T cell activation. |journal=J. Biol. Chem. |volume=279 |issue= 32 |pages= 33352-8 |year= 2004 |pmid= 15184389 |doi= 10.1074/jbc.M401761200 }}
*{{cite journal | author=Kim CH, Braud S, Isaac JT, Roche KW |title=Protein kinase C phosphorylation of the metabotropic glutamate receptor mGluR5 on Serine 839 regulates Ca2+ oscillations. |journal=J. Biol. Chem. |volume=280 |issue= 27 |pages= 25409-15 |year= 2005 |pmid= 15894802 |doi= 10.1074/jbc.M502644200 }}
*{{cite journal | author=Cabello N, Remelli R, Canela L, ''et al.'' |title=Actin-binding protein alpha-actinin-1 interacts with the metabotropic glutamate receptor type 5b and modulates the cell surface expression and function of the receptor. |journal=J. Biol. Chem. |volume=282 |issue= 16 |pages= 12143-53 |year= 2007 |pmid= 17311919 |doi= 10.1074/jbc.M608880200 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GRM6... {November 25, 2007 7:09:47 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:10:31 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Glutamate receptor, metabotropic 6
| HGNCid = 4598
| Symbol = GRM6
| AltSymbols =; CSNB1B; DKFZp686H1993; GPRC1F; MGLUR6; mGlu6
| OMIM = 604096
| ECnumber =
| Homologene = 20232
| MGIid =
| GeneAtlas_image1 = PBB_GE_GRM6_208035_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0008067 |text = metabotropic glutamate, GABA-B-like receptor activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007216 |text = metabotropic glutamate receptor signaling pathway}} {{GNF_GO|id=GO:0009584 |text = detection of visible light}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2916
| Hs_Ensembl = ENSG00000113262
| Hs_RefseqProtein = NP_000834
| Hs_RefseqmRNA = NM_000843
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 178324702
| Hs_GenLoc_end = 178354730
| Hs_Uniprot = O15303
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Glutamate receptor, metabotropic 6''', also known as '''GRM6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GRM6 glutamate receptor, metabotropic 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2916| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.<ref name="entrez">{{cite web | title = Entrez Gene: GRM6 glutamate receptor, metabotropic 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2916| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hashimoto T, Inazawa J, Okamoto N, ''et al.'' |title=The whole nucleotide sequence and chromosomal localization of the gene for human metabotropic glutamate receptor subtype 6. |journal=Eur. J. Neurosci. |volume=9 |issue= 6 |pages= 1226-35 |year= 1997 |pmid= 9215706 |doi= }}
*{{cite journal | author=Dhingra A, Lyubarsky A, Jiang M, ''et al.'' |title=The light response of ON bipolar neurons requires G[alpha]o. |journal=J. Neurosci. |volume=20 |issue= 24 |pages= 9053-8 |year= 2001 |pmid= 11124982 |doi= }}
*{{cite journal | author=Valerio A, Ferraboli S, Paterlini M, ''et al.'' |title=Identification of novel alternatively-spliced mRNA isoforms of metabotropic glutamate receptor 6 gene in rat and human retina. |journal=Gene |volume=262 |issue= 1-2 |pages= 99-106 |year= 2001 |pmid= 11179672 |doi= }}
*{{cite journal | author=Dryja TP, McGee TL, Berson EL, ''et al.'' |title=Night blindness and abnormal cone electroretinogram ON responses in patients with mutations in the GRM6 gene encoding mGluR6. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 13 |pages= 4884-9 |year= 2005 |pmid= 15781871 |doi= 10.1073/pnas.0501233102 }}
*{{cite journal | author=Zeitz C, van Genderen M, Neidhardt J, ''et al.'' |title=Mutations in GRM6 cause autosomal recessive congenital stationary night blindness with a distinctive scotopic 15-Hz flicker electroretinogram. |journal=Invest. Ophthalmol. Vis. Sci. |volume=46 |issue= 11 |pages= 4328-35 |year= 2005 |pmid= 16249515 |doi= 10.1167/iovs.05-0526 }}
*{{cite journal | author=Zeitz C, Forster U, Neidhardt J, ''et al.'' |title=Night blindness-associated mutations in the ligand-binding, cysteine-rich, and intracellular domains of the metabotropic glutamate receptor 6 abolish protein trafficking. |journal=Hum. Mutat. |volume=28 |issue= 8 |pages= 771-80 |year= 2007 |pmid= 17405131 |doi= 10.1002/humu.20499 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GRM7... {November 25, 2007 7:10:31 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein GRM7 image.jpg {November 25, 2007 7:11:09 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:11:27 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GRM7_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2e4z.
| PDB = {{PDB2|2e4z}}
| Name = Glutamate receptor, metabotropic 7
| HGNCid = 4599
| Symbol = GRM7
| AltSymbols =; GLUR7; FLJ40498; GPRC1G; MGLUR7; mGlu7
| OMIM = 604101
| ECnumber =
| Homologene = 20233
| MGIid = 1351344
| GeneAtlas_image1 = PBB_GE_GRM7_217008_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0008067 |text = metabotropic glutamate, GABA-B-like receptor activity}} {{GNF_GO|id=GO:0030165 |text = PDZ domain binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}} {{GNF_GO|id=GO:0048787 |text = active zone presynaptic plasma membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007194 |text = negative regulation of adenylate cyclase activity}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0042596 |text = fear response}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2917
| Hs_Ensembl = ENSG00000196277
| Hs_RefseqProtein = NP_000835
| Hs_RefseqmRNA = NM_000844
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 6878076
| Hs_GenLoc_end = 7710342
| Hs_Uniprot = Q14831
| Mm_EntrezGene = 108073
| Mm_Ensembl = ENSMUSG00000056755
| Mm_RefseqmRNA = NM_177328
| Mm_RefseqProtein = NP_796302
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 110611645
| Mm_GenLoc_end = 111461678
| Mm_Uniprot = Q80T39
}}
}}
'''Glutamate receptor, metabotropic 7''', also known as '''GRM7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GRM7 glutamate receptor, metabotropic 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2917| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of GRM8 have been described but their full-length nature has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: GRM7 glutamate receptor, metabotropic 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2917| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Okamoto N, Hori S, Akazawa C, ''et al.'' |title=Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction. |journal=J. Biol. Chem. |volume=269 |issue= 2 |pages= 1231-6 |year= 1994 |pmid= 8288585 |doi= }}
*{{cite journal | author=Scherer SW, Duvoisin RM, Kuhn R, ''et al.'' |title=Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q. |journal=Genomics |volume=31 |issue= 2 |pages= 230-3 |year= 1997 |pmid= 8824806 |doi= 10.1006/geno.1996.0036 }}
*{{cite journal | author=Makoff A, Pilling C, Harrington K, Emson P |title=Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS. |journal=Brain Res. Mol. Brain Res. |volume=40 |issue= 1 |pages= 165-70 |year= 1997 |pmid= 8840028 |doi= }}
*{{cite journal | author=Flor PJ, Van Der Putten H, Rüegg D, ''et al.'' |title=A novel splice variant of a metabotropic glutamate receptor, human mGluR7b. |journal=Neuropharmacology |volume=36 |issue= 2 |pages= 153-9 |year= 1997 |pmid= 9144652 |doi= }}
*{{cite journal | author=Wu S, Wright RA, Rockey PK, ''et al.'' |title=Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells. |journal=Brain Res. Mol. Brain Res. |volume=53 |issue= 1-2 |pages= 88-97 |year= 1998 |pmid= 9473604 |doi= }}
*{{cite journal | author=Nakajima Y, Yamamoto T, Nakayama T, Nakanishi S |title=A relationship between protein kinase C phosphorylation and calmodulin binding to the metabotropic glutamate receptor subtype 7. |journal=J. Biol. Chem. |volume=274 |issue= 39 |pages= 27573-7 |year= 1999 |pmid= 10488094 |doi= }}
*{{cite journal | author=O'Connor V, El Far O, Bofill-Cardona E, ''et al.'' |title=Calmodulin dependence of presynaptic metabotropic glutamate receptor signaling. |journal=Science |volume=286 |issue= 5442 |pages= 1180-4 |year= 1999 |pmid= 10550060 |doi= }}
*{{cite journal | author=Barbon A, Ferraboli S, Barlati S |title=Assignment of the human metabotropic glutamate receptor gene GRM7 to chromosome 3p26.1-->p25.2 by radiation hybrid mapping. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 3-4 |pages= 288 |year= 2000 |pmid= 10828612 |doi= }}
*{{cite journal | author=Dev KK, Nakajima Y, Kitano J, ''et al.'' |title=PICK1 interacts with and regulates PKC phosphorylation of mGLUR7. |journal=J. Neurosci. |volume=20 |issue= 19 |pages= 7252-7 |year= 2001 |pmid= 11007882 |doi= }}
*{{cite journal | author=Bolonna AA, Kerwin RW, Munro J, ''et al.'' |title=Polymorphisms in the genes for mGluR types 7 and 8: association studies with schizophrenia. |journal=Schizophr. Res. |volume=47 |issue= 1 |pages= 99-103 |year= 2001 |pmid= 11163549 |doi= }}
*{{cite journal | author=Hirbec H, Perestenko O, Nishimune A, ''et al.'' |title=The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15221-4 |year= 2002 |pmid= 11891216 |doi= 10.1074/jbc.C200112200 }}
*{{cite journal | author=Enz R |title=The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7. |journal=FEBS Lett. |volume=514 |issue= 2-3 |pages= 184-8 |year= 2002 |pmid= 11943148 |doi= }}
*{{cite journal | author=Saugstad JA, Yang S, Pohl J, ''et al.'' |title=Interaction between metabotropic glutamate receptor 7 and alpha tubulin. |journal=J. Neurochem. |volume=80 |issue= 6 |pages= 980-8 |year= 2002 |pmid= 11953448 |doi= }}
*{{cite journal | author=Schulz HL, Stohr H, Weber BH |title=Characterization of three novel isoforms of the metabotrobic glutamate receptor 7 (GRM7). |journal=Neurosci. Lett. |volume=326 |issue= 1 |pages= 37-40 |year= 2002 |pmid= 12052533 |doi= }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Kobayashi Y, Akiyoshi J, Kanehisa M, ''et al.'' |title=Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder. |journal=Psychiatr. Genet. |volume=17 |issue= 1 |pages= 9 |year= 2007 |pmid= 17167337 |doi= 10.1097/YPG.0b013e32801118bc }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GRM8... {November 25, 2007 7:11:28 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:11:57 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Glutamate receptor, metabotropic 8
| HGNCid = 4600
| Symbol = GRM8
| AltSymbols =; FLJ41058; GLUR8; GPRC1H; MGC126724; MGLUR8; mGlu8
| OMIM = 601116
| ECnumber =
| Homologene = 654
| MGIid = 1351345
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0008067 |text = metabotropic glutamate, GABA-B-like receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007194 |text = negative regulation of adenylate cyclase activity}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0030818 |text = negative regulation of cAMP biosynthetic process}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2918
| Hs_Ensembl =
| Hs_RefseqProtein = NP_000836
| Hs_RefseqmRNA = NM_000845
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 14823
| Mm_Ensembl = ENSMUSG00000024211
| Mm_RefseqmRNA = NM_008174
| Mm_RefseqProtein = NP_032200
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 27225655
| Mm_GenLoc_end = 28076135
| Mm_Uniprot = Q05BD6
}}
}}
'''Glutamate receptor, metabotropic 8''', also known as '''GRM8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GRM8 glutamate receptor, metabotropic 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2918| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of GRM8 have been described but their full-length nature has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: GRM8 glutamate receptor, metabotropic 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2918| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Scherer SW, Duvoisin RM, Kuhn R, ''et al.'' |title=Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q. |journal=Genomics |volume=31 |issue= 2 |pages= 230-3 |year= 1997 |pmid= 8824806 |doi= 10.1006/geno.1996.0036 }}
*{{cite journal | author=Scherer SW, Soder S, Duvoisin RM, ''et al.'' |title=The human metabotropic glutamate receptor 8 (GRM8) gene: a disproportionately large gene located at 7q31.3-q32.1. |journal=Genomics |volume=44 |issue= 2 |pages= 232-6 |year= 1997 |pmid= 9299241 |doi= 10.1006/geno.1997.4842 }}
*{{cite journal | author=Wu S, Wright RA, Rockey PK, ''et al.'' |title=Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells. |journal=Brain Res. Mol. Brain Res. |volume=53 |issue= 1-2 |pages= 88-97 |year= 1998 |pmid= 9473604 |doi= }}
*{{cite journal | author=Malherbe P, Kratzeisen C, Lundstrom K, ''et al.'' |title=Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8. |journal=Brain Res. Mol. Brain Res. |volume=67 |issue= 2 |pages= 201-10 |year= 1999 |pmid= 10216218 |doi= }}
*{{cite journal | author=Thomas NK, Wright RA, Howson PA, ''et al.'' |title=(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. |journal=Neuropharmacology |volume=40 |issue= 3 |pages= 311-8 |year= 2001 |pmid= 11166323 |doi= }}
*{{cite journal | author=Enz R |title=The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7. |journal=FEBS Lett. |volume=514 |issue= 2-3 |pages= 184-8 |year= 2002 |pmid= 11943148 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Tang Z, El Far O, Betz H, Scheschonka A |title=Pias1 interaction and sumoylation of metabotropic glutamate receptor 8. |journal=J. Biol. Chem. |volume=280 |issue= 46 |pages= 38153-9 |year= 2006 |pmid= 16144832 |doi= 10.1074/jbc.M508168200 }}
*{{cite journal | author=Kobayashi Y, Akiyoshi J, Kanehisa M, ''et al.'' |title=Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder. |journal=Psychiatr. Genet. |volume=17 |issue= 1 |pages= 9 |year= 2007 |pmid= 17167337 |doi= 10.1097/YPG.0b013e32801118bc }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GRPR... {November 25, 2007 7:11:57 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:12:33 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Gastrin-releasing peptide receptor
| HGNCid = 4609
| Symbol = GRPR
| AltSymbols =;
| OMIM = 305670
| ECnumber =
| Homologene = 21098
| MGIid = 95836
| GeneAtlas_image1 = PBB_GE_GRPR_207929_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004946 |text = bombesin receptor activity}} {{GNF_GO|id=GO:0008528 |text = peptide receptor activity, G-protein coupled}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0042127 |text = regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2925
| Hs_Ensembl = ENSG00000126010
| Hs_RefseqProtein = NP_005305
| Hs_RefseqmRNA = NM_005314
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 16051345
| Hs_GenLoc_end = 16081562
| Hs_Uniprot = P30550
| Mm_EntrezGene = 14829
| Mm_Ensembl = ENSMUSG00000031364
| Mm_RefseqmRNA = NM_008177
| Mm_RefseqProtein = NP_032203
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 158858009
| Mm_GenLoc_end = 158893752
| Mm_Uniprot = Q53WV4
}}
}}
'''Gastrin-releasing peptide receptor''', also known as '''GRPR''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GRPR gastrin-releasing peptide receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2925| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.<ref name="entrez">{{cite web | title = Entrez Gene: GRPR gastrin-releasing peptide receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2925| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Corjay MH, Dobrzanski DJ, Way JM, ''et al.'' |title=Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells. |journal=J. Biol. Chem. |volume=266 |issue= 28 |pages= 18771-9 |year= 1991 |pmid= 1655761 |doi= }}
*{{cite journal | author=Alitalo T, Francis F, Kere J, ''et al.'' |title=A 6-Mb YAC contig in Xp22.1-p22.2 spanning the DXS69E, XE59, GLRA2, PIGA, GRPR, CALB3, and PHKA2 genes. |journal=Genomics |volume=25 |issue= 3 |pages= 691-700 |year= 1995 |pmid= 7759104 |doi= }}
*{{cite journal | author=Benya RV, Kusui T, Pradhan TK, ''et al.'' |title=Expression and characterization of cloned human bombesin receptors. |journal=Mol. Pharmacol. |volume=47 |issue= 1 |pages= 10-20 |year= 1995 |pmid= 7838118 |doi= }}
*{{cite journal | author=Giladi E, Nagalla SR, Spindel ER |title=Molecular cloning and characterization of receptors for the mammalian bombesin-like peptides. |journal=J. Mol. Neurosci. |volume=4 |issue= 1 |pages= 41-54 |year= 1993 |pmid= 8391296 |doi= }}
*{{cite journal | author=Maslen GL, Boyd Y |title=Comparative mapping of the Grpr locus on the X chromosomes of man and mouse. |journal=Genomics |volume=17 |issue= 1 |pages= 106-9 |year= 1993 |pmid= 8406441 |doi= 10.1006/geno.1993.1290 }}
*{{cite journal | author=Ishikawa-Brush Y, Powell JF, Bolton P, ''et al.'' |title=Autism and multiple exostoses associated with an X;8 translocation occurring within the GRPR gene and 3' to the SDC2 gene. |journal=Hum. Mol. Genet. |volume=6 |issue= 8 |pages= 1241-50 |year= 1997 |pmid= 9259269 |doi= }}
*{{cite journal | author=Heidary G, Hampton LL, Schanen NC, ''et al.'' |title=Exclusion of the gastrin-releasing peptide receptor (GRPR) locus as a candidate gene for Rett syndrome. |journal=Am. J. Med. Genet. |volume=78 |issue= 2 |pages= 173-5 |year= 1998 |pmid= 9674911 |doi= }}
*{{cite journal | author=Shriver SP, Bourdeau HA, Gubish CT, ''et al.'' |title=Sex-specific expression of gastrin-releasing peptide receptor: relationship to smoking history and risk of lung cancer. |journal=J. Natl. Cancer Inst. |volume=92 |issue= 1 |pages= 24-33 |year= 2000 |pmid= 10620630 |doi= }}
*{{cite journal | author=Xiao D, Wang J, Hampton LL, Weber HC |title=The human gastrin-releasing peptide receptor gene structure, its tissue expression and promoter. |journal=Gene |volume=264 |issue= 1 |pages= 95-103 |year= 2001 |pmid= 11245983 |doi= }}
*{{cite journal | author=Carroll RE, Matkowskyj K, Saunthararajah Y, ''et al.'' |title=Contribution of gastrin-releasing peptide and its receptor to villus development in the murine and human gastrointestinal tract. |journal=Mech. Dev. |volume=113 |issue= 2 |pages= 121-30 |year= 2002 |pmid= 11960700 |doi= }}
*{{cite journal | author=Qu X, Xiao D, Weber HC |title=Human gastrin-releasing peptide receptor mediates sustained CREB phosphorylation and transactivation in HuTu 80 duodenal cancer cells. |journal=FEBS Lett. |volume=527 |issue= 1-3 |pages= 109-13 |year= 2002 |pmid= 12220644 |doi= }}
*{{cite journal | author=Xiao D, Qu X, Weber HC |title=GRP receptor-mediated immediate early gene expression and transcription factor Elk-1 activation in prostate cancer cells. |journal=Regul. Pept. |volume=109 |issue= 1-3 |pages= 141-8 |year= 2003 |pmid= 12409226 |doi= }}
*{{cite journal | author=Uchida K, Kojima A, Morokawa N, ''et al.'' |title=Expression of progastrin-releasing peptide and gastrin-releasing peptide receptor mRNA transcripts in tumor cells of patients with small cell lung cancer. |journal=J. Cancer Res. Clin. Oncol. |volume=128 |issue= 12 |pages= 633-40 |year= 2003 |pmid= 12474049 |doi= 10.1007/s00432-002-0392-8 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Shumyatsky GP, Tsvetkov E, Malleret G, ''et al.'' |title=Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear. |journal=Cell |volume=111 |issue= 6 |pages= 905-18 |year= 2003 |pmid= 12526815 |doi= }}
*{{cite journal | author=Glover SC, Tretiakova MS, Carroll RE, Benya RV |title=Increased frequency of gastrin-releasing peptide receptor gene mutations during colon-adenocarcinoma progression. |journal=Mol. Carcinog. |volume=37 |issue= 1 |pages= 5-15 |year= 2003 |pmid= 12720295 |doi= 10.1002/mc.10117 }}
*{{cite journal | author=Waters CM, MacKinnon AC, Cummings J, ''et al.'' |title=Increased gastrin-releasing peptide (GRP) receptor expression in tumour cells confers sensitivity to [Arg6,D-Trp7,9,NmePhe8]-substance P (6-11)-induced growth inhibition. |journal=Br. J. Cancer |volume=88 |issue= 11 |pages= 1808-16 |year= 2003 |pmid= 12771999 |doi= 10.1038/sj.bjc.6600957 }}
*{{cite journal | author=Scott N, Millward E, Cartwright EJ, ''et al.'' |title=Gastrin releasing peptide and gastrin releasing peptide receptor expression in gastrointestinal carcinoid tumours. |journal=J. Clin. Pathol. |volume=57 |issue= 2 |pages= 189-92 |year= 2004 |pmid= 14747448 |doi= }}
*{{cite journal | author=Chen PW, Kroog GS |title=Alterations in receptor expression or agonist concentration change the pathways gastrin-releasing peptide receptor uses to regulate extracellular signal-regulated kinase. |journal=Mol. Pharmacol. |volume=66 |issue= 6 |pages= 1625-34 |year= 2005 |pmid= 15361544 |doi= 10.1124/mol.104.001206 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HCRTR1... {November 25, 2007 7:12:33 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 7:13:13 PM PST}
- CREATED: Created new protein page: HCRTR1 {November 25, 2007 7:13:21 PM PST}
- INFO: Beginning work on HCRTR2... {November 25, 2007 7:13:21 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 7:14:00 PM PST}
- CREATED: Created new protein page: HCRTR2 {November 25, 2007 7:14:08 PM PST}
- INFO: Beginning work on HRH1... {November 25, 2007 7:14:08 PM PST}
- REDIRECT: Protein Redirected to: HRH1 {November 25, 2007 7:14:37 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 25, 2007 7:14:39 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 25, 2007 7:14:39 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 25, 2007 7:14:39 PM PST}
- UPDATED: Updated protein page: HRH1 {November 25, 2007 7:14:46 PM PST}
- INFO: Beginning work on HRH2... {November 25, 2007 7:14:46 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:15:05 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Histamine receptor H2
| HGNCid = 5183
| Symbol = HRH2
| AltSymbols =; H2R
| OMIM = 142703
| ECnumber =
| Homologene = 40613
| MGIid = 108482
| GeneAtlas_image1 = PBB_GE_HRH2_220805_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004969 |text = histamine receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007187 |text = G-protein signaling, coupled to cyclic nucleotide second messenger}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3274
| Hs_Ensembl = ENSG00000113749
| Hs_RefseqProtein = NP_071640
| Hs_RefseqmRNA = NM_022304
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 175017637
| Hs_GenLoc_end = 175045847
| Hs_Uniprot = P25021
| Mm_EntrezGene = 15466
| Mm_Ensembl = ENSMUSG00000034987
| Mm_RefseqmRNA = NM_001010973
| Mm_RefseqProtein = NP_001010973
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 54201750
| Mm_GenLoc_end = 54232053
| Mm_Uniprot = Q3ZB30
}}
}}
'''Histamine receptor H2''', also known as '''HRH2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HRH2 histamine receptor H2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3274| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation.<ref name="entrez">{{cite web | title = Entrez Gene: HRH2 histamine receptor H2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3274| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hill SJ, Ganellin CR, Timmerman H, ''et al.'' |title=International Union of Pharmacology. XIII. Classification of histamine receptors. |journal=Pharmacol. Rev. |volume=49 |issue= 3 |pages= 253-78 |year= 1997 |pmid= 9311023 |doi= }}
*{{cite journal | author=Del Valle J, Gantz I |title=Novel insights into histamine H2 receptor biology. |journal=Am. J. Physiol. |volume=273 |issue= 5 Pt 1 |pages= G987-96 |year= 1997 |pmid= 9374694 |doi= }}
*{{cite journal | author=Gantz I, Munzert G, Tashiro T, ''et al.'' |title=Molecular cloning of the human histamine H2 receptor. |journal=Biochem. Biophys. Res. Commun. |volume=178 |issue= 3 |pages= 1386-92 |year= 1991 |pmid= 1714721 |doi= }}
*{{cite journal | author=Vannier E, Dinarello CA |title=Histamine enhances interleukin (IL)-1-induced IL-6 gene expression and protein synthesis via H2 receptors in peripheral blood mononuclear cells. |journal=J. Biol. Chem. |volume=269 |issue= 13 |pages= 9952-6 |year= 1994 |pmid= 7511596 |doi= }}
*{{cite journal | author=Smit MJ, Timmerman H, Alewijnse AE, ''et al.'' |title=Visualization of agonist-induced internalization of histamine H2 receptors. |journal=Biochem. Biophys. Res. Commun. |volume=214 |issue= 3 |pages= 1138-45 |year= 1995 |pmid= 7575521 |doi= }}
*{{cite journal | author=Nishi T, Koike T, Oka T, ''et al.'' |title=Identification of the promoter region of the human histamine H2-receptor gene. |journal=Biochem. Biophys. Res. Commun. |volume=210 |issue= 2 |pages= 616-23 |year= 1995 |pmid= 7755641 |doi= 10.1006/bbrc.1995.1703 }}
*{{cite journal | author=Traiffort E, Vizuete ML, Tardivel-Lacombe J, ''et al.'' |title=The guinea pig histamine H2 receptor: gene cloning, tissue expression and chromosomal localization of its human counterpart. |journal=Biochem. Biophys. Res. Commun. |volume=211 |issue= 2 |pages= 570-7 |year= 1995 |pmid= 7794271 |doi= }}
*{{cite journal | author=Orange PR, Heath PR, Wright SR, Pearson RC |title=Allelic variations of the human histamine H2 receptor gene. |journal=Neuroreport |volume=7 |issue= 7 |pages= 1293-6 |year= 1996 |pmid= 8817552 |doi= }}
*{{cite journal | author=Elenkov IJ, Webster E, Papanicolaou DA, ''et al.'' |title=Histamine potently suppresses human IL-12 and stimulates IL-10 production via H2 receptors. |journal=J. Immunol. |volume=161 |issue= 5 |pages= 2586-93 |year= 1998 |pmid= 9725260 |doi= }}
*{{cite journal | author=Murakami H, Sun-Wada GH, Matsumoto M, ''et al.'' |title=Human histamine H2 receptor gene: multiple transcription initiation and tissue-specific expression. |journal=FEBS Lett. |volume=451 |issue= 3 |pages= 327-31 |year= 1999 |pmid= 10371214 |doi= }}
*{{cite journal | author=Wang LD, Wang M, Todisco A, ''et al.'' |title=The human histamine H(2) receptor regulates c-jun and c-fos in a differential manner. |journal=Am. J. Physiol., Cell Physiol. |volume=278 |issue= 6 |pages= C1246-55 |year= 2000 |pmid= 10837353 |doi= }}
*{{cite journal | author=Suh BC, Lee H, Jun DJ, ''et al.'' |title=Inhibition of H2 histamine receptor-mediated cation channel opening by protein kinase C in human promyelocytic cells. |journal=J. Immunol. |volume=167 |issue= 3 |pages= 1663-71 |year= 2001 |pmid= 11466390 |doi= }}
*{{cite journal | author=Brew OB, Sullivan MH |title=Localisation of mRNAs for diamine oxidase and histamine receptors H1 and H2, at the feto-maternal interface of human pregnancy. |journal=Inflamm. Res. |volume=50 |issue= 9 |pages= 449-52 |year= 2002 |pmid= 11603849 |doi= }}
*{{cite journal | author=Shayo C, Fernandez N, Legnazzi BL, ''et al.'' |title=Histamine H2 receptor desensitization: involvement of a select array of G protein-coupled receptor kinases. |journal=Mol. Pharmacol. |volume=60 |issue= 5 |pages= 1049-56 |year= 2001 |pmid= 11641433 |doi= }}
*{{cite journal | author=Tanimoto A, Murata Y, Nomaguchi M, ''et al.'' |title=Histamine increases the expression of LOX-1 via H2 receptor in human monocytic THP-1 cells. |journal=FEBS Lett. |volume=508 |issue= 3 |pages= 345-9 |year= 2001 |pmid= 11728449 |doi= }}
*{{cite journal | author=Gutzmer R, Langer K, Lisewski M, ''et al.'' |title=Expression and function of histamine receptors 1 and 2 on human monocyte-derived dendritic cells. |journal=J. Allergy Clin. Immunol. |volume=109 |issue= 3 |pages= 524-31 |year= 2002 |pmid= 11898002 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Esbenshade TA, Kang CH, Krueger KM, ''et al.'' |title=Differential activation of dual signaling responses by human H1 and H2 histamine receptors. |journal=J. Recept. Signal Transduct. Res. |volume=23 |issue= 1 |pages= 17-31 |year= 2003 |pmid= 12680587 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HTR1A... {November 25, 2007 7:15:05 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:15:38 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = 5-hydroxytryptamine (serotonin) receptor 1A
| HGNCid = 5286
| Symbol = HTR1A
| AltSymbols =; 5-HT1A; 5HT1a; ADRB2RL1; ADRBRL1
| OMIM = 109760
| ECnumber =
| Homologene = 20148
| MGIid = 96273
| GeneAtlas_image1 = PBB_GE_HTR1A_221351_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004993 |text = serotonin receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007610 |text = behavior}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3350
| Hs_Ensembl = ENSG00000178394
| Hs_RefseqProtein = NP_000515
| Hs_RefseqmRNA = NM_000524
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 63292034
| Hs_GenLoc_end = 63293302
| Hs_Uniprot = P08908
| Mm_EntrezGene = 15550
| Mm_Ensembl = ENSMUSG00000021721
| Mm_RefseqmRNA = NM_008308
| Mm_RefseqProtein = NP_032334
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 106564148
| Mm_GenLoc_end = 106568501
| Mm_Uniprot = Q8BGS4
}}
}}
'''5-hydroxytryptamine (serotonin) receptor 1A''', also known as '''HTR1A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HTR1A 5-hydroxytryptamine (serotonin) receptor 1A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3350| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=el Mestikawy S, Fargin A, Raymond JR, ''et al.'' |title=The 5-HT1A receptor: an overview of recent advances. |journal=Neurochem. Res. |volume=16 |issue= 1 |pages= 1-10 |year= 1991 |pmid= 2052135 |doi= }}
*{{cite journal | author=Hensler JG |title=Regulation of 5-HT1A receptor function in brain following agonist or antidepressant administration. |journal=Life Sci. |volume=72 |issue= 15 |pages= 1665-82 |year= 2003 |pmid= 12559389 |doi= }}
*{{cite journal | author=Van Oekelen D, Luyten WH, Leysen JE |title=5-HT2A and 5-HT2C receptors and their atypical regulation properties. |journal=Life Sci. |volume=72 |issue= 22 |pages= 2429-49 |year= 2003 |pmid= 12650852 |doi= }}
*{{cite journal | author=Lesch KP, Gutknecht L |title=Focus on The 5-HT1A receptor: emerging role of a gene regulatory variant in psychopathology and pharmacogenetics. |journal=Int. J. Neuropsychopharmacol. |volume=7 |issue= 4 |pages= 381-5 |year= 2005 |pmid= 15683551 |doi= 10.1017/S1461145704004845 }}
*{{cite journal | author=Kalipatnapu S, Chattopadhyay A |title=Membrane protein solubilization: recent advances and challenges in solubilization of serotonin1A receptors. |journal=IUBMB Life |volume=57 |issue= 7 |pages= 505-12 |year= 2006 |pmid= 16081372 |doi= 10.1080/15216540500167237 }}
*{{cite journal | author=Varrault A, Bockaert J, Waeber C |title=Activation of 5-HT1A receptors expressed in NIH-3T3 cells induces focus formation and potentiates EGF effect on DNA synthesis. |journal=Mol. Biol. Cell |volume=3 |issue= 9 |pages= 961-9 |year= 1992 |pmid= 1330092 |doi= }}
*{{cite journal | author=Levy FO, Gudermann T, Perez-Reyes E, ''et al.'' |title=Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype. |journal=J. Biol. Chem. |volume=267 |issue= 11 |pages= 7553-62 |year= 1992 |pmid= 1559993 |doi= }}
*{{cite journal | author=Melmer G, Sherrington R, Mankoo B, ''et al.'' |title=A cosmid clone for the 5HT1A receptor (HTR1A) reveals a TaqI RFLP that shows tight linkage to dna loci D5S6, D5S39, and D5S76. |journal=Genomics |volume=11 |issue= 3 |pages= 767-9 |year= 1992 |pmid= 1685484 |doi= }}
*{{cite journal | author=Parks CL, Chang LS, Shenk T |title=A polymerase chain reaction mediated by a single primer: cloning of genomic sequences adjacent to a serotonin receptor protein coding region. |journal=Nucleic Acids Res. |volume=19 |issue= 25 |pages= 7155-60 |year= 1992 |pmid= 1766875 |doi= }}
*{{cite journal | author=Gilliam TC, Freimer NB, Kaufmann CA, ''et al.'' |title=Deletion mapping of DNA markers to a region of chromosome 5 that cosegregates with schizophrenia. |journal=Genomics |volume=5 |issue= 4 |pages= 940-4 |year= 1990 |pmid= 2591972 |doi= }}
*{{cite journal | author=Kobilka BK, Frielle T, Collins S, ''et al.'' |title=An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins. |journal=Nature |volume=329 |issue= 6134 |pages= 75-9 |year= 1987 |pmid= 3041227 |doi= 10.1038/329075a0 }}
*{{cite journal | author=Fargin A, Raymond JR, Lohse MJ, ''et al.'' |title=The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor. |journal=Nature |volume=335 |issue= 6188 |pages= 358-60 |year= 1988 |pmid= 3138543 |doi= 10.1038/335358a0 }}
*{{cite journal | author=Nakhai B, Nielsen DA, Linnoila M, Goldman D |title=Two naturally occurring amino acid substitutions in the human 5-HT1A receptor: glycine 22 to serine 22 and isoleucine 28 to valine 28. |journal=Biochem. Biophys. Res. Commun. |volume=210 |issue= 2 |pages= 530-6 |year= 1995 |pmid= 7755630 |doi= }}
*{{cite journal | author=Aune TM, McGrath KM, Sarr T, ''et al.'' |title=Expression of 5HT1a receptors on activated human T cells. Regulation of cyclic AMP levels and T cell proliferation by 5-hydroxytryptamine. |journal=J. Immunol. |volume=151 |issue= 3 |pages= 1175-83 |year= 1993 |pmid= 8393041 |doi= }}
*{{cite journal | author=Parks CL, Shenk T |title=The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1. |journal=J. Biol. Chem. |volume=271 |issue= 8 |pages= 4417-30 |year= 1996 |pmid= 8626793 |doi= }}
*{{cite journal | author=Stockmeier CA, Shapiro LA, Dilley GE, ''et al.'' |title=Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activity. |journal=J. Neurosci. |volume=18 |issue= 18 |pages= 7394-401 |year= 1998 |pmid= 9736659 |doi= }}
*{{cite journal | author=Kawanishi Y, Harada S, Tachikawa H, ''et al.'' |title=Novel mutations in the promoter and coding region of the human 5-HT1A receptor gene and association analysis in schizophrenia. |journal=Am. J. Med. Genet. |volume=81 |issue= 5 |pages= 434-9 |year= 1998 |pmid= 9754630 |doi= }}
*{{cite journal | author=Price JC, Kelley DE, Ryan CM, ''et al.'' |title=Evidence of increased serotonin-1A receptor binding in type 2 diabetes: a positron emission tomography study. |journal=Brain Res. |volume=927 |issue= 1 |pages= 97-103 |year= 2002 |pmid= 11814436 |doi= }}
*{{cite journal | author=Salim K, Fenton T, Bacha J, ''et al.'' |title=Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15482-5 |year= 2002 |pmid= 11854302 |doi= 10.1074/jbc.M201539200 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HTR1B... {November 25, 2007 7:15:38 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:16:10 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = 5-hydroxytryptamine (serotonin) receptor 1B
| HGNCid = 5287
| Symbol = HTR1B
| AltSymbols =; 5-HT1B; 5-HT1DB; HTR1D2; HTR1DB; S12
| OMIM = 182131
| ECnumber =
| Homologene = 669
| MGIid = 96274
| GeneAtlas_image1 = PBB_GE_HTR1B_210799_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004993 |text = serotonin receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007187 |text = G-protein signaling, coupled to cyclic nucleotide second messenger}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3351
| Hs_Ensembl = ENSG00000135312
| Hs_RefseqProtein = NP_000854
| Hs_RefseqmRNA = NM_000863
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 78228641
| Hs_GenLoc_end = 78229900
| Hs_Uniprot = P28222
| Mm_EntrezGene = 15551
| Mm_Ensembl = ENSMUSG00000049511
| Mm_RefseqmRNA = NM_010482
| Mm_RefseqProtein = NP_034612
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 81428110
| Mm_GenLoc_end = 81429270
| Mm_Uniprot = Q0VES5
}}
}}
'''5-hydroxytryptamine (serotonin) receptor 1B''', also known as '''HTR1B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HTR1B 5-hydroxytryptamine (serotonin) receptor 1B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3351| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Olivier B, van Oorschot R |title=5-HT1B receptors and aggression: a review. |journal=Eur. J. Pharmacol. |volume=526 |issue= 1-3 |pages= 207-17 |year= 2006 |pmid= 16310769 |doi= 10.1016/j.ejphar.2005.09.066 }}
*{{cite journal | author=Hamblin MW, Metcalf MA, McGuffin RW, Karpells S |title=Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity. |journal=Biochem. Biophys. Res. Commun. |volume=184 |issue= 2 |pages= 752-9 |year= 1992 |pmid= 1315531 |doi= }}
*{{cite journal | author=Veldman SA, Bienkowski MJ |title=Cloning and pharmacological characterization of a novel human 5-hydroxytryptamine1D receptor subtype. |journal=Mol. Pharmacol. |volume=42 |issue= 3 |pages= 439-44 |year= 1992 |pmid= 1328844 |doi= }}
*{{cite journal | author=Jin H, Oksenberg D, Ashkenazi A, ''et al.'' |title=Characterization of the human 5-hydroxytryptamine1B receptor. |journal=J. Biol. Chem. |volume=267 |issue= 9 |pages= 5735-8 |year= 1992 |pmid= 1348246 |doi= }}
*{{cite journal | author=Demchyshyn L, Sunahara RK, Miller K, ''et al.'' |title=A human serotonin 1D receptor variant (5HT1D beta) encoded by an intronless gene on chromosome 6. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 12 |pages= 5522-6 |year= 1992 |pmid= 1351684 |doi= }}
*{{cite journal | author=Levy FO, Gudermann T, Perez-Reyes E, ''et al.'' |title=Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype. |journal=J. Biol. Chem. |volume=267 |issue= 11 |pages= 7553-62 |year= 1992 |pmid= 1559993 |doi= }}
*{{cite journal | author=Weinshank RL, Zgombick JM, Macchi MJ, ''et al.'' |title=Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 8 |pages= 3630-4 |year= 1992 |pmid= 1565658 |doi= }}
*{{cite journal | author=Mochizuki D, Yuyama Y, Tsujita R, ''et al.'' |title=Cloning and expression of the human 5-HT1B-type receptor gene. |journal=Biochem. Biophys. Res. Commun. |volume=185 |issue= 2 |pages= 517-23 |year= 1992 |pmid= 1610347 |doi= }}
*{{cite journal | author=Nöthen MM, Erdmann J, Shimron-Abarbanell D, Propping P |title=Identification of genetic variation in the human serotonin 1D beta receptor gene. |journal=Biochem. Biophys. Res. Commun. |volume=205 |issue= 2 |pages= 1194-200 |year= 1995 |pmid= 7802650 |doi= }}
*{{cite journal | author=Ng GY, George SR, Zastawny RL, ''et al.'' |title=Human serotonin1B receptor expression in Sf9 cells: phosphorylation, palmitoylation, and adenylyl cyclase inhibition. |journal=Biochemistry |volume=32 |issue= 43 |pages= 11727-33 |year= 1993 |pmid= 8218242 |doi= }}
*{{cite journal | author=Bouchelet I, Cohen Z, Case B, ''et al.'' |title=Differential expression of sumatriptan-sensitive 5-hydroxytryptamine receptors in human trigeminal ganglia and cerebral blood vessels. |journal=Mol. Pharmacol. |volume=50 |issue= 2 |pages= 219-23 |year= 1996 |pmid= 8700126 |doi= }}
*{{cite journal | author=Sanders AR, Cao Q, Taylor J, ''et al.'' |title=Genetic diversity of the human serotonin receptor 1B (HTR1B) gene. |journal=Genomics |volume=72 |issue= 1 |pages= 1-14 |year= 2001 |pmid= 11247661 |doi= 10.1006/geno.2000.6411 }}
*{{cite journal | author=Varnäs K, Hall H, Bonaventure P, Sedvall G |title=Autoradiographic mapping of 5-HT(1B) and 5-HT(1D) receptors in the post mortem human brain using [(3)H]GR 125743. |journal=Brain Res. |volume=915 |issue= 1 |pages= 47-57 |year= 2001 |pmid= 11578619 |doi= }}
*{{cite journal | author=Salim K, Fenton T, Bacha J, ''et al.'' |title=Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15482-5 |year= 2002 |pmid= 11854302 |doi= 10.1074/jbc.M201539200 }}
*{{cite journal | author=Hasegawa Y, Higuchi S, Matsushita S, Miyaoka H |title=Association of a polymorphism of the serotonin 1B receptor gene and alcohol dependence with inactive aldehyde dehydrogenase-2. |journal=Journal of neural transmission (Vienna, Austria : 1996) |volume=109 |issue= 4 |pages= 513-21 |year= 2002 |pmid= 11956970 |doi= 10.1007/s007020200042 }}
*{{cite journal | author=Hawi Z, Dring M, Kirley A, ''et al.'' |title=Serotonergic system and attention deficit hyperactivity disorder (ADHD): a potential susceptibility locus at the 5-HT(1B) receptor gene in 273 nuclear families from a multi-centre sample. |journal=Mol. Psychiatry |volume=7 |issue= 7 |pages= 718-25 |year= 2003 |pmid= 12192616 |doi= 10.1038/sj.mp.4001048 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Huang YY, Oquendo MA, Friedman JM, ''et al.'' |title=Substance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism. |journal=Neuropsychopharmacology |volume=28 |issue= 1 |pages= 163-9 |year= 2003 |pmid= 12496953 |doi= 10.1038/sj.npp.1300000 }}
*{{cite journal | author=Quist JF, Barr CL, Schachar R, ''et al.'' |title=The serotonin 5-HT1B receptor gene and attention deficit hyperactivity disorder. |journal=Mol. Psychiatry |volume=8 |issue= 1 |pages= 98-102 |year= 2003 |pmid= 12556913 |doi= 10.1038/sj.mp.4001244 }}
*{{cite journal | author=Sinha R, Cloninger CR, Parsian A |title=Linkage disequilibrium and haplotype analysis between serotonin receptor 1B gene variations and subtypes of alcoholism. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=121 |issue= 1 |pages= 83-8 |year= 2003 |pmid= 12898580 |doi= 10.1002/ajmg.b.20064 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HTR1D... {November 25, 2007 7:16:10 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:16:57 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = 5-hydroxytryptamine (serotonin) receptor 1D
| HGNCid = 5289
| Symbol = HTR1D
| AltSymbols =; 5-HT1D; HT1DA; HTR1DA; HTRL; RDC4
| OMIM = 182133
| ECnumber =
| Homologene = 20240
| MGIid = 96276
| GeneAtlas_image1 = PBB_GE_HTR1D_207368_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004993 |text = serotonin receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007187 |text = G-protein signaling, coupled to cyclic nucleotide second messenger}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3352
| Hs_Ensembl = ENSG00000179546
| Hs_RefseqProtein = NP_000855
| Hs_RefseqmRNA = NM_000864
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 23389580
| Hs_GenLoc_end = 23393809
| Hs_Uniprot = P28221
| Mm_EntrezGene = 15552
| Mm_Ensembl = ENSMUSG00000070687
| Mm_RefseqmRNA = NM_008309
| Mm_RefseqProtein = NP_032335
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 135695602
| Mm_GenLoc_end = 135715840
| Mm_Uniprot = Q3ZB48
}}
}}
'''5-hydroxytryptamine (serotonin) receptor 1D''', also known as '''HTR1D''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HTR1D 5-hydroxytryptamine (serotonin) receptor 1D| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3352| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hamblin MW, Metcalf MA, McGuffin RW, Karpells S |title=Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity. |journal=Biochem. Biophys. Res. Commun. |volume=184 |issue= 2 |pages= 752-9 |year= 1992 |pmid= 1315531 |doi= }}
*{{cite journal | author=Weinshank RL, Zgombick JM, Macchi MJ, ''et al.'' |title=Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 8 |pages= 3630-4 |year= 1992 |pmid= 1565658 |doi= }}
*{{cite journal | author=Hamblin MW, Metcalf MA |title=Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor. |journal=Mol. Pharmacol. |volume=40 |issue= 2 |pages= 143-8 |year= 1991 |pmid= 1652050 |doi= }}
*{{cite journal | author=Libert F, Passage E, Parmentier M, ''et al.'' |title=Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor. |journal=Genomics |volume=11 |issue= 1 |pages= 225-7 |year= 1992 |pmid= 1662665 |doi= }}
*{{cite journal | author=Libert F, Parmentier M, Lefort A, ''et al.'' |title=Selective amplification and cloning of four new members of the G protein-coupled receptor family. |journal=Science |volume=244 |issue= 4904 |pages= 569-72 |year= 1989 |pmid= 2541503 |doi= }}
*{{cite journal | author=Cargill M, Altshuler D, Ireland J, ''et al.'' |title=Characterization of single-nucleotide polymorphisms in coding regions of human genes. |journal=Nat. Genet. |volume=22 |issue= 3 |pages= 231-8 |year= 1999 |pmid= 10391209 |doi= 10.1038/10290 }}
*{{cite journal | author=Salim K, Fenton T, Bacha J, ''et al.'' |title=Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15482-5 |year= 2002 |pmid= 11854302 |doi= 10.1074/jbc.M201539200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Bergen AW, van den Bree MB, Yeager M, ''et al.'' |title=Candidate genes for anorexia nervosa in the 1p33-36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa. |journal=Mol. Psychiatry |volume=8 |issue= 4 |pages= 397-406 |year= 2004 |pmid= 12740597 |doi= 10.1038/sj.mp.4001318 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal | author=Li J, Zhang X, Wang Y, ''et al.'' |title=The serotonin 5-HT1D receptor gene and attention-deficit hyperactivity disorder in Chinese Han subjects. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=141 |issue= 8 |pages= 874-6 |year= 2007 |pmid= 17099886 |doi= 10.1002/ajmg.b.30364 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HTR1E... {November 25, 2007 7:16:57 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 7:17:36 PM PST}
- CREATED: Created new protein page: HTR1E {November 25, 2007 7:17:44 PM PST}
- INFO: Beginning work on HTR1F... {November 25, 2007 7:17:44 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 7:18:25 PM PST}
- CREATED: Created new protein page: HTR1F {November 25, 2007 7:18:33 PM PST}
- INFO: Beginning work on HTR2A... {November 25, 2007 7:18:33 PM PST}
- SEARCH REDIRECT: Control Box Found: 5-HT2A receptor {November 25, 2007 7:19:03 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 25, 2007 7:19:06 PM PST}
- SKIP SUMMARY: Skipping Summary, No Errors. {November 25, 2007 7:19:06 PM PST}
- SKIP CITATIONS: Skipping Citations, No Errors. {November 25, 2007 7:19:06 PM PST}
- UPDATED: Updated protein page: 5-HT2A receptor {November 25, 2007 7:19:13 PM PST}
- INFO: Beginning work on HTR2B... {November 25, 2007 7:19:14 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 7:20:01 PM PST}
- CREATED: Created new protein page: HTR2B {November 25, 2007 7:20:09 PM PST}
- INFO: Beginning work on HTR2C... {November 25, 2007 7:20:09 PM PST}
- REDIRECT: Protein Redirected to: HTR2C {November 25, 2007 7:20:37 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 25, 2007 7:20:39 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 25, 2007 7:20:39 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 25, 2007 7:20:39 PM PST}
- UPDATED: Updated protein page: HTR2C {November 25, 2007 7:20:45 PM PST}
end log.
