- INFO: Beginning work on GPR143... {November 25, 2007 7:39:30 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 7:40:08 PM PST}
- CREATED: Created new protein page: GPR143 {November 25, 2007 7:40:17 PM PST}
- INFO: Beginning work on HTR4... {November 25, 2007 7:23:00 PM PST}
- REDIRECT: Protein Redirected to: HTR4 {November 25, 2007 7:23:23 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 25, 2007 7:23:25 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 25, 2007 7:23:25 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 25, 2007 7:23:25 PM PST}
- UPDATED: Updated protein page: HTR4 {November 25, 2007 7:23:33 PM PST}
- INFO: Beginning work on HTR5A... {November 25, 2007 7:23:33 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 7:24:11 PM PST}
- CREATED: Created new protein page: HTR5A {November 25, 2007 7:24:19 PM PST}
- INFO: Beginning work on HTR6... {November 25, 2007 7:24:19 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 7:25:00 PM PST}
- CREATED: Created new protein page: HTR6 {November 25, 2007 7:25:08 PM PST}
- INFO: Beginning work on HTR7... {November 25, 2007 7:25:08 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:26:38 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)
| HGNCid = 5302
| Symbol = HTR7
| AltSymbols =; 5-HT7
| OMIM = 182137
| ECnumber =
| Homologene = 20244
| MGIid = 99841
| GeneAtlas_image1 = PBB_GE_HTR7_207818_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_HTR7_216098_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_HTR7_207927_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004977 |text = melanocortin receptor activity}} {{GNF_GO|id=GO:0004993 |text = serotonin receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007187 |text = G-protein signaling, coupled to cyclic nucleotide second messenger}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007623 |text = circadian rhythm}} {{GNF_GO|id=GO:0008015 |text = circulation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3363
| Hs_Ensembl = ENSG00000148680
| Hs_RefseqProtein = NP_000863
| Hs_RefseqmRNA = NM_000872
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 92490558
| Hs_GenLoc_end = 92607651
| Hs_Uniprot = P34969
| Mm_EntrezGene = 15566
| Mm_Ensembl = ENSMUSG00000024798
| Mm_RefseqmRNA = NM_008315
| Mm_RefseqProtein = NP_032341
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 36025416
| Mm_GenLoc_end = 36122492
| Mm_Uniprot = Q14A50
}}
}}
'''5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)''', also known as '''HTR7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HTR7 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3363| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends.<ref name="entrez">{{cite web | title = Entrez Gene: HTR7 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3363| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hoyer D, Hannon JP, Martin GR |title=Molecular, pharmacological and functional diversity of 5-HT receptors. |journal=Pharmacol. Biochem. Behav. |volume=71 |issue= 4 |pages= 533-54 |year= 2002 |pmid= 11888546 |doi= }}
*{{cite journal | author=Raymond JR, Mukhin YV, Gelasco A, ''et al.'' |title=Multiplicity of mechanisms of serotonin receptor signal transduction. |journal=Pharmacol. Ther. |volume=92 |issue= 2-3 |pages= 179-212 |year= 2002 |pmid= 11916537 |doi= }}
*{{cite journal | author=Gelernter J, Rao PA, Pauls DL, ''et al.'' |title=Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with Tourette syndrome. |journal=Genomics |volume=26 |issue= 2 |pages= 207-9 |year= 1995 |pmid= 7601444 |doi= }}
*{{cite journal | author=Ullmer C, Schmuck K, Kalkman HO, Lübbert H |title=Expression of serotonin receptor mRNAs in blood vessels. |journal=FEBS Lett. |volume=370 |issue= 3 |pages= 215-21 |year= 1995 |pmid= 7656980 |doi= }}
*{{cite journal | author=Bard JA, Zgombick J, Adham N, ''et al.'' |title=Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. |journal=J. Biol. Chem. |volume=268 |issue= 31 |pages= 23422-6 |year= 1993 |pmid= 8226867 |doi= }}
*{{cite journal | author=Lovenberg TW, Baron BM, de Lecea L, ''et al.'' |title=A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms. |journal=Neuron |volume=11 |issue= 3 |pages= 449-58 |year= 1993 |pmid= 8398139 |doi= }}
*{{cite journal | author=Heidmann DE, Metcalf MA, Kohen R, Hamblin MW |title=Four 5-hydroxytryptamine7 (5-HT7) receptor isoforms in human and rat produced by alternative splicing: species differences due to altered intron-exon organization. |journal=J. Neurochem. |volume=68 |issue= 4 |pages= 1372-81 |year= 1997 |pmid= 9084407 |doi= }}
*{{cite journal | author=Erdmann J, Nöthen MM, Shimron-Abarbanell D, ''et al.'' |title=The human serotonin 7 (5-HT7) receptor gene: genomic organization and systematic mutation screening in schizophrenia and bipolar affective disorder. |journal=Mol. Psychiatry |volume=1 |issue= 5 |pages= 392-7 |year= 1997 |pmid= 9154233 |doi= }}
*{{cite journal | author=Jasper JR, Kosaka A, To ZP, ''et al.'' |title=Cloning, expression and pharmacology of a truncated splice variant of the human 5-HT7 receptor (h5-HT7b). |journal=Br. J. Pharmacol. |volume=122 |issue= 1 |pages= 126-32 |year= 1997 |pmid= 9298538 |doi= 10.1038/sj.bjp.0701336 }}
*{{cite journal | author=Lassig JP, Vachirasomtoon K, Hartzell K, ''et al.'' |title=Physical mapping of the serotonin 5-HT(7) receptor gene (HTR7) to chromosome 10 and pseudogene (HTR7P) to chromosome 12, and testing of linkage disequilibrium between HTR7 and autistic disorder. |journal=Am. J. Med. Genet. |volume=88 |issue= 5 |pages= 472-5 |year= 1999 |pmid= 10490701 |doi= }}
*{{cite journal | author=Krobert KA, Levy FO |title=The human 5-HT7 serotonin receptor splice variants: constitutive activity and inverse agonist effects. |journal=Br. J. Pharmacol. |volume=135 |issue= 6 |pages= 1563-71 |year= 2002 |pmid= 11906971 |doi= 10.1038/sj.bjp.0704588 }}
*{{cite journal | author=Norum JH, Hart K, Levy FO |title=Ras-dependent ERK activation by the human G(s)-coupled serotonin receptors 5-HT4(b) and 5-HT7(a). |journal=J. Biol. Chem. |volume=278 |issue= 5 |pages= 3098-104 |year= 2003 |pmid= 12446729 |doi= 10.1074/jbc.M206237200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Slominski A, Pisarchik A, Zbytek B, ''et al.'' |title=Functional activity of serotoninergic and melatoninergic systems expressed in the skin. |journal=J. Cell. Physiol. |volume=196 |issue= 1 |pages= 144-53 |year= 2003 |pmid= 12767050 |doi= 10.1002/jcp.10287 }}
*{{cite journal | author=Simonin F, Karcher P, Boeuf JJ, ''et al.'' |title=Identification of a novel family of G protein-coupled receptor associated sorting proteins. |journal=J. Neurochem. |volume=89 |issue= 3 |pages= 766-75 |year= 2004 |pmid= 15086532 |doi= 10.1111/j.1471-4159.2004.02411.x }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Brüss M, Kiel S, Bönisch H, ''et al.'' |title=Decreased agonist, but not antagonist, binding to the naturally occurring Thr92Lys variant of the h5-HT7(a) receptor. |journal=Neurochem. Int. |volume=47 |issue= 3 |pages= 196-203 |year= 2005 |pmid= 15896881 |doi= 10.1016/j.neuint.2005.03.003 }}
*{{cite journal | author=Ikeda M, Iwata N, Kitajima T, ''et al.'' |title=Positive association of the serotonin 5-HT7 receptor gene with schizophrenia in a Japanese population. |journal=Neuropsychopharmacology |volume=31 |issue= 4 |pages= 866-71 |year= 2006 |pmid= 16192982 |doi= 10.1038/sj.npp.1300901 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on IL8RA... {November 25, 2007 7:26:38 PM PST}
- REDIRECT: Protein Redirected to: IL8RA {November 25, 2007 7:27:01 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 25, 2007 7:27:03 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 25, 2007 7:27:03 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 25, 2007 7:27:03 PM PST}
- UPDATED: Updated protein page: IL8RA {November 25, 2007 7:27:09 PM PST}
- INFO: Beginning work on IL8RB... {November 25, 2007 7:27:09 PM PST}
- REDIRECT: Protein Redirected to: IL8RB {November 25, 2007 7:27:27 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 25, 2007 7:27:29 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 25, 2007 7:27:29 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 25, 2007 7:27:29 PM PST}
- UPDATED: Updated protein page: IL8RB {November 25, 2007 7:27:36 PM PST}
- INFO: Beginning work on LHCGR... {November 25, 2007 7:27:36 PM PST}
- SEARCH REDIRECT: Control Box Found: Luteinizing hormone/choriogonadotropin receptor {November 25, 2007 7:28:06 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 25, 2007 7:28:09 PM PST}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {November 25, 2007 7:28:09 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 25, 2007 7:28:09 PM PST}
- UPDATED: Updated protein page: Luteinizing hormone/choriogonadotropin receptor {November 25, 2007 7:28:17 PM PST}
- INFO: Beginning work on MAS1... {November 25, 2007 7:28:17 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:28:55 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = MAS1 oncogene
| HGNCid = 6899
| Symbol = MAS1
| AltSymbols =; MAS; MGC119966
| OMIM = 165180
| ECnumber =
| Homologene = 1782
| MGIid = 96918
| GeneAtlas_image1 = PBB_GE_MAS1_208210_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004945 |text = angiotensin type II receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4142
| Hs_Ensembl = ENSG00000130368
| Hs_RefseqProtein = NP_002368
| Hs_RefseqmRNA = NM_002377
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 160247712
| Hs_GenLoc_end = 160249098
| Hs_Uniprot = P04201
| Mm_EntrezGene = 17171
| Mm_Ensembl = ENSMUSG00000068037
| Mm_RefseqmRNA = XM_622557
| Mm_RefseqProtein = XP_622557
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 12684492
| Mm_GenLoc_end = 12685466
| Mm_Uniprot = Q0VB49
}}
}}
'''MAS1 oncogene''', also known as '''MAS1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MAS1 MAS1 oncogene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4142| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects.<ref name="entrez">{{cite web | title = Entrez Gene: MAS1 MAS1 oncogene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4142| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hanley MR |title=Molecular and cell biology of angiotensin receptors. |journal=J. Cardiovasc. Pharmacol. |volume=18 Suppl 2 |issue= |pages= S7-13 |year= 1992 |pmid= 1725048 |doi= }}
*{{cite journal | author=Hanley MR, Cheung WT, Hawkins P, ''et al.'' |title=The mas oncogene as a neural peptide receptor: expression, regulation and mechanism of action. |journal=Ciba Found. Symp. |volume=150 |issue= |pages= 23-38; discussion 38-46 |year= 1990 |pmid= 2197067 |doi= }}
*{{cite journal | author=Rabin M, Birnbaum D, Young D, ''et al.'' |title=Human ros1 and mas1 oncogenes located in regions of chromosome 6 associated with tumor-specific rearrangements. |journal=Oncogene Res. |volume=1 |issue= 2 |pages= 169-78 |year= 1988 |pmid= 3329713 |doi= }}
*{{cite journal | author=Jackson TR, Blair LA, Marshall J, ''et al.'' |title=The mas oncogene encodes an angiotensin receptor. |journal=Nature |volume=335 |issue= 6189 |pages= 437-40 |year= 1988 |pmid= 3419518 |doi= 10.1038/335437a0 }}
*{{cite journal | author=Young D, Waitches G, Birchmeier C, ''et al.'' |title=Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains. |journal=Cell |volume=45 |issue= 5 |pages= 711-9 |year= 1986 |pmid= 3708691 |doi= }}
*{{cite journal | author=Riesewijk AM, Schepens MT, Mariman EM, ''et al.'' |title=The MAS proto-oncogene is not imprinted in humans. |journal=Genomics |volume=35 |issue= 2 |pages= 380-2 |year= 1996 |pmid= 8661154 |doi= 10.1006/geno.1996.0372 }}
*{{cite journal | author=Xu X, Quiambao AB, Roveri L, ''et al.'' |title=Degeneration of cone photoreceptors induced by expression of the Mas1 protooncogene. |journal=Exp. Neurol. |volume=163 |issue= 1 |pages= 207-19 |year= 2000 |pmid= 10785460 |doi= 10.1006/exnr.2000.7370 }}
*{{cite journal | author=Alenina N, Baranova T, Smirnow E, ''et al.'' |title=Cell type-specific expression of the Mas proto-oncogene in testis. |journal=J. Histochem. Cytochem. |volume=50 |issue= 5 |pages= 691-6 |year= 2002 |pmid= 11967280 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Santos RA, Simoes e Silva AC, Maric C, ''et al.'' |title=Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 14 |pages= 8258-63 |year= 2003 |pmid= 12829792 |doi= 10.1073/pnas.1432869100 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Canals M, Jenkins L, Kellett E, Milligan G |title=Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS. |journal=J. Biol. Chem. |volume=281 |issue= 24 |pages= 16757-67 |year= 2006 |pmid= 16611642 |doi= 10.1074/jbc.M601121200 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MC1R... {November 25, 2007 7:28:56 PM PST}
- SEARCH REDIRECT: Control Box Found: MC1R {November 25, 2007 7:29:17 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 25, 2007 7:29:21 PM PST}
- SKIP SUMMARY: Skipping Summary, No Errors. {November 25, 2007 7:29:21 PM PST}
- SKIP CITATIONS: Skipping Citations, No Errors. {November 25, 2007 7:29:21 PM PST}
- UPDATED: Updated protein page: MC1R {November 25, 2007 7:29:27 PM PST}
- INFO: Beginning work on MC2R... {November 25, 2007 7:29:27 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 7:30:28 PM PST}
- CREATED: Created new protein page: MC2R {November 25, 2007 7:30:37 PM PST}
- INFO: Beginning work on MC3R... {November 25, 2007 7:30:37 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 7:31:14 PM PST}
- CREATED: Created new protein page: MC3R {November 25, 2007 7:31:23 PM PST}
- INFO: Beginning work on MC4R... {November 25, 2007 7:31:23 PM PST}
- REDIRECT: Protein Redirected to: MC4R {November 25, 2007 7:31:39 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 25, 2007 7:31:41 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 25, 2007 7:31:41 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 25, 2007 7:31:41 PM PST}
- UPDATED: Updated protein page: MC4R {November 25, 2007 7:31:48 PM PST}
- INFO: Beginning work on MC5R... {November 25, 2007 7:31:48 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 7:32:27 PM PST}
- CREATED: Created new protein page: MC5R {November 25, 2007 7:32:35 PM PST}
- INFO: Beginning work on MTNR1A... {November 25, 2007 7:32:35 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 7:33:12 PM PST}
- CREATED: Created new protein page: MTNR1A {November 25, 2007 7:33:23 PM PST}
- INFO: Beginning work on MTNR1B... {November 25, 2007 7:33:23 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:34:04 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Melatonin receptor 1B
| HGNCid = 7464
| Symbol = MTNR1B
| AltSymbols =; MT2; MEL-1B-R
| OMIM = 600804
| ECnumber =
| Homologene = 4350
| MGIid = 2181726
| GeneAtlas_image1 = PBB_GE_MTNR1B_208516_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0008502 |text = melatonin receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007187 |text = G-protein signaling, coupled to cyclic nucleotide second messenger}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4544
| Hs_Ensembl = ENSG00000134640
| Hs_RefseqProtein = NP_005950
| Hs_RefseqmRNA = NM_005959
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 92342437
| Hs_GenLoc_end = 92355596
| Hs_Uniprot = P49286
| Mm_EntrezGene = 244701
| Mm_Ensembl = ENSMUSG00000050901
| Mm_RefseqmRNA = NM_145712
| Mm_RefseqProtein = NP_663758
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 15613060
| Mm_GenLoc_end = 15624853
| Mm_Uniprot = P70329
}}
}}
'''Melatonin receptor 1B''', also known as '''MTNR1B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MTNR1B melatonin receptor 1B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4544| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin.<ref name="entrez">{{cite web | title = Entrez Gene: MTNR1B melatonin receptor 1B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4544| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Brzezinski A |title=Melatonin in humans. |journal=N. Engl. J. Med. |volume=336 |issue= 3 |pages= 186-95 |year= 1997 |pmid= 8988899 |doi= }}
*{{cite journal | author=Reppert SM, Godson C, Mahle CD, ''et al.'' |title=Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 19 |pages= 8734-8 |year= 1995 |pmid= 7568007 |doi= }}
*{{cite journal | author=Reppert SM, Weaver DR, Ebisawa T, ''et al.'' |title=Cloning of a melatonin-related receptor from human pituitary. |journal=FEBS Lett. |volume=386 |issue= 2-3 |pages= 219-24 |year= 1996 |pmid= 8647286 |doi= }}
*{{cite journal | author=Niles LP, Wang J, Shen L, ''et al.'' |title=Melatonin receptor mRNA expression in human granulosa cells. |journal=Mol. Cell. Endocrinol. |volume=156 |issue= 1-2 |pages= 107-10 |year= 2000 |pmid= 10612428 |doi= }}
*{{cite journal | author=Ebisawa T, Uchiyama M, Kajimura N, ''et al.'' |title=Genetic polymorphisms of human melatonin 1b receptor gene in circadian rhythm sleep disorders and controls. |journal=Neurosci. Lett. |volume=280 |issue= 1 |pages= 29-32 |year= 2000 |pmid= 10696804 |doi= }}
*{{cite journal | author=Roy D, Angelini NL, Fujieda H, ''et al.'' |title=Cyclical regulation of GnRH gene expression in GT1-7 GnRH-secreting neurons by melatonin. |journal=Endocrinology |volume=142 |issue= 11 |pages= 4711-20 |year= 2001 |pmid= 11606436 |doi= }}
*{{cite journal | author=Ayoub MA, Couturier C, Lucas-Meunier E, ''et al.'' |title=Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer. |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 21522-8 |year= 2002 |pmid= 11940583 |doi= 10.1074/jbc.M200729200 }}
*{{cite journal | author=Yuan L, Collins AR, Dai J, ''et al.'' |title=MT(1) melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells. |journal=Mol. Cell. Endocrinol. |volume=192 |issue= 1-2 |pages= 147-56 |year= 2003 |pmid= 12088876 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Slominski A, Pisarchik A, Zbytek B, ''et al.'' |title=Functional activity of serotoninergic and melatoninergic systems expressed in the skin. |journal=J. Cell. Physiol. |volume=196 |issue= 1 |pages= 144-53 |year= 2003 |pmid= 12767050 |doi= 10.1002/jcp.10287 }}
*{{cite journal | author=Ayoub MA, Levoye A, Delagrange P, Jockers R |title=Preferential formation of MT1/MT2 melatonin receptor heterodimers with distinct ligand interaction properties compared with MT2 homodimers. |journal=Mol. Pharmacol. |volume=66 |issue= 2 |pages= 312-21 |year= 2004 |pmid= 15266022 |doi= 10.1124/mol.104.000398 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Mazna P, Berka K, Jelinkova I, ''et al.'' |title=Ligand binding to the human MT2 melatonin receptor: the role of residues in transmembrane domains 3, 6, and 7. |journal=Biochem. Biophys. Res. Commun. |volume=332 |issue= 3 |pages= 726-34 |year= 2005 |pmid= 15913560 |doi= 10.1016/j.bbrc.2005.05.017 }}
*{{cite journal | author=Ha E, Choe BK, Jung KH, ''et al.'' |title=Positive relationship between melatonin receptor type 1B polymorphism and rheumatoid factor in rheumatoid arthritis patients in the Korean population. |journal=J. Pineal Res. |volume=39 |issue= 2 |pages= 201-5 |year= 2005 |pmid= 16098099 |doi= 10.1111/j.1600-079X.2005.00237.x }}
*{{cite journal | author=Savaskan E, Jockers R, Ayoub M, ''et al.'' |title=The MT2 melatonin receptor subtype is present in human retina and decreases in Alzheimer's disease. |journal=Current Alzheimer research |volume=4 |issue= 1 |pages= 47-51 |year= 2007 |pmid= 17316165 |doi= }}
*{{cite journal | author=Suzuki S, Masui Y, Ohnuki M, ''et al.'' |title=Induction of metallothionein synthesis by cilostazol in mice and in human cultured neuronal cell lines. |journal=Biol. Pharm. Bull. |volume=30 |issue= 4 |pages= 791-4 |year= 2007 |pmid= 17409522 |doi= }}
*{{cite journal | author=Qiu XS, Tang NL, Yeung HY, ''et al.'' |title=Melatonin receptor 1B (MTNR1B) gene polymorphism is associated with the occurrence of adolescent idiopathic scoliosis. |journal=Spine |volume=32 |issue= 16 |pages= 1748-53 |year= 2007 |pmid= 17632395 |doi= 10.1097/BRS.0b013e3180b9f0ff }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NMBR... {November 25, 2007 7:34:05 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:34:57 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Neuromedin B receptor
| HGNCid = 7843
| Symbol = NMBR
| AltSymbols =;
| OMIM = 162341
| ECnumber =
| Homologene = 20560
| MGIid = 1100525
| GeneAtlas_image1 = PBB_GE_NMBR_207333_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004946 |text = bombesin receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007200 |text = G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4829
| Hs_Ensembl = ENSG00000135577
| Hs_RefseqProtein = NP_002502
| Hs_RefseqmRNA = NM_002511
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 142438438
| Hs_GenLoc_end = 142451629
| Hs_Uniprot = P28336
| Mm_EntrezGene = 18101
| Mm_Ensembl = ENSMUSG00000019865
| Mm_RefseqmRNA = NM_008703
| Mm_RefseqProtein = NP_032729
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 14450487
| Mm_GenLoc_end = 14460754
| Mm_Uniprot = Q0VEH1
}}
}}
'''Neuromedin B receptor''', also known as '''NMBR''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NMBR neuromedin B receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4829| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Neuromedin B receptor binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal epithelial tissue.<ref name="entrez">{{cite web | title = Entrez Gene: NMBR neuromedin B receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4829| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Corjay MH, Dobrzanski DJ, Way JM, ''et al.'' |title=Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells. |journal=J. Biol. Chem. |volume=266 |issue= 28 |pages= 18771-9 |year= 1991 |pmid= 1655761 |doi= }}
*{{cite journal | author=Wu JM, Hoang DO, Feldman RI |title=Differential activation of human gastrin-releasing peptide receptor-mediated responses by bombesin analogs. |journal=Mol. Pharmacol. |volume=47 |issue= 4 |pages= 871-81 |year= 1995 |pmid= 7723750 |doi= }}
*{{cite journal | author=Benya RV, Kusui T, Pradhan TK, ''et al.'' |title=Expression and characterization of cloned human bombesin receptors. |journal=Mol. Pharmacol. |volume=47 |issue= 1 |pages= 10-20 |year= 1995 |pmid= 7838118 |doi= }}
*{{cite journal | author=Bitar KN, Zhu XX |title=Expression of bombesin-receptor subtypes and their differential regulation of colonic smooth muscle contraction. |journal=Gastroenterology |volume=105 |issue= 6 |pages= 1672-80 |year= 1994 |pmid= 8253343 |doi= }}
*{{cite journal | author=Giladi E, Nagalla SR, Spindel ER |title=Molecular cloning and characterization of receptors for the mammalian bombesin-like peptides. |journal=J. Mol. Neurosci. |volume=4 |issue= 1 |pages= 41-54 |year= 1993 |pmid= 8391296 |doi= }}
*{{cite journal | author=Fathi Z, Benya RV, Shapira H, ''et al.'' |title=The fifth transmembrane segment of the neuromedin B receptor is critical for high affinity neuromedin B binding. |journal=J. Biol. Chem. |volume=268 |issue= 20 |pages= 14622-6 |year= 1993 |pmid= 8392057 |doi= }}
*{{cite journal | author=Kane MA, Toi-Scott M, Johnson GL, ''et al.'' |title=Bombesin-like peptide receptors in human bronchial epithelial cells. |journal=Peptides |volume=17 |issue= 1 |pages= 111-8 |year= 1996 |pmid= 8822519 |doi= }}
*{{cite journal | author=Sainz E, Akeson M, Mantey SA, ''et al.'' |title=Four amino acid residues are critical for high affinity binding of neuromedin B to the neuromedin B receptor. |journal=J. Biol. Chem. |volume=273 |issue= 26 |pages= 15927-32 |year= 1998 |pmid= 9632639 |doi= }}
*{{cite journal | author=Lee S, Kim Y |title=Solution structure of neuromedin B by (1)H nuclear magnetic resonance spectroscopy. |journal=FEBS Lett. |volume=460 |issue= 2 |pages= 263-9 |year= 1999 |pmid= 10544247 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Matusiak D, Glover S, Nathaniel R, ''et al.'' |title=Neuromedin B and its receptor are mitogens in both normal and malignant epithelial cells lining the colon. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=288 |issue= 4 |pages= G718-28 |year= 2005 |pmid= 15528253 |doi= 10.1152/ajpgi.00156.2004 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NPY1R... {November 25, 2007 7:34:57 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 7:35:43 PM PST}
- CREATED: Created new protein page: NPY1R {November 25, 2007 7:35:52 PM PST}
- INFO: Beginning work on NPY2R... {November 25, 2007 7:35:52 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 7:36:55 PM PST}
- CREATED: Created new protein page: NPY2R {November 25, 2007 7:37:03 PM PST}
- INFO: Beginning work on NPY5R... {November 25, 2007 7:37:31 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 7:38:07 PM PST}
- CREATED: Created new protein page: NPY5R {November 25, 2007 7:38:17 PM PST}
- INFO: Beginning work on NPY6R... {November 25, 2007 7:37:03 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 7:37:24 PM PST}
- CREATED: Created new protein page: NPY6R {November 25, 2007 7:37:31 PM PST}
- INFO: Beginning work on NTSR1... {November 25, 2007 7:38:17 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:39:30 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Neurotensin receptor 1 (high affinity)
| HGNCid = 8039
| Symbol = NTSR1
| AltSymbols =; NTR
| OMIM = 162651
| ECnumber =
| Homologene = 68261
| MGIid = 97386
| GeneAtlas_image1 = PBB_GE_NTSR1_207360_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0016492 |text = neurotensin receptor activity, G-protein coupled}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0008344 |text = adult locomotory behavior}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4923
| Hs_Ensembl = ENSG00000101188
| Hs_RefseqProtein = NP_002522
| Hs_RefseqmRNA = NM_002531
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 60810634
| Hs_GenLoc_end = 60864568
| Hs_Uniprot = P30989
| Mm_EntrezGene = 18216
| Mm_Ensembl = ENSMUSG00000027568
| Mm_RefseqmRNA = XM_989244
| Mm_RefseqProtein = XP_994338
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 180429384
| Mm_GenLoc_end = 180474387
| Mm_Uniprot = Q9QZQ2
}}
}}
'''Neurotensin receptor 1 (high affinity)''', also known as '''NTSR1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NTSR1 neurotensin receptor 1 (high affinity)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4923| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion.<ref name="entrez">{{cite web | title = Entrez Gene: NTSR1 neurotensin receptor 1 (high affinity)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4923| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Vincent JP |title=Neurotensin receptors: binding properties, transduction pathways, and structure. |journal=Cell. Mol. Neurobiol. |volume=15 |issue= 5 |pages= 501-12 |year= 1996 |pmid= 8719037 |doi= }}
*{{cite journal | author=Vincent JP, Mazella J, Kitabgi P |title=Neurotensin and neurotensin receptors. |journal=Trends Pharmacol. Sci. |volume=20 |issue= 7 |pages= 302-9 |year= 1999 |pmid= 10390649 |doi= }}
*{{cite journal | author=Laurent P, Clerc P, Mattei MG, ''et al.'' |title=Chromosomal localization of mouse and human neurotensin receptor genes. |journal=Mamm. Genome |volume=5 |issue= 5 |pages= 303-6 |year= 1994 |pmid= 8075503 |doi= }}
*{{cite journal | author=Vita N, Laurent P, Lefort S, ''et al.'' |title=Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor. |journal=FEBS Lett. |volume=317 |issue= 1-2 |pages= 139-42 |year= 1993 |pmid= 8381365 |doi= }}
*{{cite journal | author=Le F, Groshan K, Zeng XP, Richelson E |title=Characterization of the genomic structure, promoter region, and a tetranucleotide repeat polymorphism of the human neurotensin receptor gene. |journal=J. Biol. Chem. |volume=272 |issue= 2 |pages= 1315-22 |year= 1997 |pmid= 8995438 |doi= }}
*{{cite journal | author=Boudin H, Pélaprat D, Rostène W, ''et al.'' |title=Correlative ultrastructural distribution of neurotensin receptor proteins and binding sites in the rat substantia nigra. |journal=J. Neurosci. |volume=18 |issue= 20 |pages= 8473-84 |year= 1998 |pmid= 9763490 |doi= }}
*{{cite journal | author=Ye X, Mehlen P, Rabizadeh S, ''et al.'' |title=TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. |journal=J. Biol. Chem. |volume=274 |issue= 42 |pages= 30202-8 |year= 1999 |pmid= 10514511 |doi= }}
*{{cite journal | author=Wang L, Friess H, Zhu Z, ''et al.'' |title=Neurotensin receptor-1 mRNA analysis in normal pancreas and pancreatic disease. |journal=Clin. Cancer Res. |volume=6 |issue= 2 |pages= 566-71 |year= 2000 |pmid= 10690540 |doi= }}
*{{cite journal | author=Cusack B, Jansen K, McCormick DJ, ''et al.'' |title=A single amino acid of the human and rat neurotensin receptors (subtype 1) determining the pharmacological profile of a species-selective neurotensin agonist. |journal=Biochem. Pharmacol. |volume=60 |issue= 6 |pages= 793-801 |year= 2000 |pmid= 10930533 |doi= }}
*{{cite journal | author=Oakley RH, Laporte SA, Holt JA, ''et al.'' |title=Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19452-60 |year= 2001 |pmid= 11279203 |doi= 10.1074/jbc.M101450200 }}
*{{cite journal | author=Leplatois P, Josse A, Guillemot M, ''et al.'' |title=Neurotensin induces mating in Saccharomyces cerevisiae cells that express human neurotensin receptor type 1 in place of the endogenous pheromone receptor. |journal=Eur. J. Biochem. |volume=268 |issue= 18 |pages= 4860-7 |year= 2001 |pmid= 11559354 |doi= }}
*{{cite journal | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal | author=Lundquist JT, Büllesbach EE, Golden PL, Dix TA |title=Topography of the neurotensin (NT)(8-9) binding site of human NT receptor-1 probed with NT(8-13) analogs. |journal=J. Pept. Res. |volume=59 |issue= 2 |pages= 55-61 |year= 2002 |pmid= 11906607 |doi= }}
*{{cite journal | author=Somaï S, Gompel A, Rostène W, Forgez P |title=Neurotensin counteracts apoptosis in breast cancer cells. |journal=Biochem. Biophys. Res. Commun. |volume=295 |issue= 2 |pages= 482-8 |year= 2002 |pmid= 12150975 |doi= }}
*{{cite journal | author=Martin S, Navarro V, Vincent JP, Mazella J |title=Neurotensin receptor-1 and -3 complex modulates the cellular signaling of neurotensin in the HT29 cell line. |journal=Gastroenterology |volume=123 |issue= 4 |pages= 1135-43 |year= 2002 |pmid= 12360476 |doi= }}
*{{cite journal | author=Toy-Miou-Leong M, Cortes CL, Beaudet A, ''et al.'' |title=Receptor trafficking via the perinuclear recycling compartment accompanied by cell division is necessary for permanent neurotensin cell sensitization and leads to chronic mitogen-activated protein kinase activation. |journal=J. Biol. Chem. |volume=279 |issue= 13 |pages= 12636-46 |year= 2004 |pmid= 14699144 |doi= 10.1074/jbc.M303384200 }}
*{{cite journal | author=Magazin M, Poszepczynska-Guigné E, Bagot M, ''et al.'' |title=Sezary syndrome cells unlike normal circulating T lymphocytes fail to migrate following engagement of NT1 receptor. |journal=J. Invest. Dermatol. |volume=122 |issue= 1 |pages= 111-8 |year= 2004 |pmid= 14962098 |doi= 10.1046/j.0022-202X.2003.22131.x }}
*{{cite journal | author=Brun P, Mastrotto C, Beggiao E, ''et al.'' |title=Neuropeptide neurotensin stimulates intestinal wound healing following chronic intestinal inflammation. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=288 |issue= 4 |pages= G621-9 |year= 2005 |pmid= 15764810 |doi= 10.1152/ajpgi.00140.2004 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OPRD1... {November 25, 2007 7:40:17 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:40:38 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Opioid receptor, delta 1
| HGNCid = 8153
| Symbol = OPRD1
| AltSymbols =; OPRD
| OMIM = 165195
| ECnumber =
| Homologene = 20252
| MGIid = 97438
| GeneAtlas_image1 = PBB_GE_OPRD1_207792_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004986 |text = delta-opioid receptor activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007187 |text = G-protein signaling, coupled to cyclic nucleotide second messenger}} {{GNF_GO|id=GO:0007193 |text = G-protein signaling, adenylate cyclase inhibiting pathway}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}} {{GNF_GO|id=GO:0007600 |text = sensory perception}} {{GNF_GO|id=GO:0008344 |text = adult locomotory behavior}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4985
| Hs_Ensembl = ENSG00000116329
| Hs_RefseqProtein = NP_000902
| Hs_RefseqmRNA = NM_000911
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 29011241
| Hs_GenLoc_end = 29062795
| Hs_Uniprot = P41143
| Mm_EntrezGene = 18386
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_973497
| Mm_RefseqProtein = XP_978591
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Opioid receptor, delta 1''', also known as '''OPRD1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OPRD1 opioid receptor, delta 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4985| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Narita M, Funada M, Suzuki T |title=Regulations of opioid dependence by opioid receptor types. |journal=Pharmacol. Ther. |volume=89 |issue= 1 |pages= 1-15 |year= 2001 |pmid= 11316510 |doi= }}
*{{cite journal | author=Evans CJ, Keith DE, Morrison H, ''et al.'' |title=Cloning of a delta opioid receptor by functional expression. |journal=Science |volume=258 |issue= 5090 |pages= 1952-5 |year= 1993 |pmid= 1335167 |doi= }}
*{{cite journal | author=Offermanns S, Schultz G, Rosenthal W |title=Evidence for opioid receptor-mediated activation of the G-proteins, Go and Gi2, in membranes of neuroblastoma x glioma (NG108-15) hybrid cells. |journal=J. Biol. Chem. |volume=266 |issue= 6 |pages= 3365-8 |year= 1991 |pmid= 1671672 |doi= }}
*{{cite journal | author=Simonin F, Befort K, Gavériaux-Ruff C, ''et al.'' |title=The human delta-opioid receptor: genomic organization, cDNA cloning, functional expression, and distribution in human brain. |journal=Mol. Pharmacol. |volume=46 |issue= 6 |pages= 1015-21 |year= 1995 |pmid= 7808419 |doi= }}
*{{cite journal | author=Befort K, Mattéi MG, Roeckel N, Kieffer B |title=Chromosomal localization of the delta opioid receptor gene to human 1p34.3-p36.1 and mouse 4D bands by in situ hybridization. |journal=Genomics |volume=20 |issue= 1 |pages= 143-5 |year= 1994 |pmid= 8020949 |doi= }}
*{{cite journal | author=Knapp RJ, Malatynska E, Fang L, ''et al.'' |title=Identification of a human delta opioid receptor: cloning and expression. |journal=Life Sci. |volume=54 |issue= 25 |pages= PL463-9 |year= 1994 |pmid= 8201839 |doi= }}
*{{cite journal | author=Georgoussi Z, Carr C, Milligan G |title=Direct measurements of in situ interactions of rat brain opioid receptors with the guanine nucleotide-binding protein Go. |journal=Mol. Pharmacol. |volume=44 |issue= 1 |pages= 62-9 |year= 1993 |pmid= 8393523 |doi= }}
*{{cite journal | author=Bzdega T, Chin H, Kim H, ''et al.'' |title=Regional expression and chromosomal localization of the delta opiate receptor gene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 20 |pages= 9305-9 |year= 1993 |pmid= 8415697 |doi= }}
*{{cite journal | author=Ho MK, Wong YH |title=Functional role of amino-terminal serine16 and serine27 of G alphaZ in receptor and effector coupling. |journal=J. Neurochem. |volume=68 |issue= 6 |pages= 2514-22 |year= 1997 |pmid= 9166747 |doi= }}
*{{cite journal | author=Hedin KE, Bell MP, Kalli KR, ''et al.'' |title=Delta-opioid receptors expressed by Jurkat T cells enhance IL-2 secretion by increasing AP-1 complexes and activity of the NF-AT/AP-1-binding promoter element. |journal=J. Immunol. |volume=159 |issue= 11 |pages= 5431-40 |year= 1998 |pmid= 9548483 |doi= }}
*{{cite journal | author=Jordan BA, Devi LA |title=G-protein-coupled receptor heterodimerization modulates receptor function. |journal=Nature |volume=399 |issue= 6737 |pages= 697-700 |year= 1999 |pmid= 10385123 |doi= 10.1038/21441 }}
*{{cite journal | author=Petaja-Repo UE, Hogue M, Laperriere A, ''et al.'' |title=Export from the endoplasmic reticulum represents the limiting step in the maturation and cell surface expression of the human delta opioid receptor. |journal=J. Biol. Chem. |volume=275 |issue= 18 |pages= 13727-36 |year= 2000 |pmid= 10788493 |doi= }}
*{{cite journal | author=Gelernter J, Kranzler HR |title=Variant detection at the delta opioid receptor (OPRD1) locus and population genetics of a novel variant affecting protein sequence. |journal=Hum. Genet. |volume=107 |issue= 1 |pages= 86-8 |year= 2000 |pmid= 10982041 |doi= }}
*{{cite journal | author=Guo J, Wu Y, Zhang W, ''et al.'' |title=Identification of G protein-coupled receptor kinase 2 phosphorylation sites responsible for agonist-stimulated delta-opioid receptor phosphorylation. |journal=Mol. Pharmacol. |volume=58 |issue= 5 |pages= 1050-6 |year= 2000 |pmid= 11040053 |doi= }}
*{{cite journal | author=Gomes I, Jordan BA, Gupta A, ''et al.'' |title=Heterodimerization of mu and delta opioid receptors: A role in opiate synergy. |journal=J. Neurosci. |volume=20 |issue= 22 |pages= RC110 |year= 2001 |pmid= 11069979 |doi= }}
*{{cite journal | author=Xu W, Chen C, Huang P, ''et al.'' |title=The conserved cysteine 7.38 residue is differentially accessible in the binding-site crevices of the mu, delta, and kappa opioid receptors. |journal=Biochemistry |volume=39 |issue= 45 |pages= 13904-15 |year= 2000 |pmid= 11076532 |doi= }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
*{{cite journal | author=Saeed RW, Stefano GB, Murga JD, ''et al.'' |title=Expression of functional delta opioid receptors in vascular smooth muscle. |journal=Int. J. Mol. Med. |volume=6 |issue= 6 |pages= 673-7 |year= 2001 |pmid= 11078827 |doi= }}
*{{cite journal | author=Xiang B, Yu GH, Guo J, ''et al.'' |title=Heterologous activation of protein kinase C stimulates phosphorylation of delta-opioid receptor at serine 344, resulting in beta-arrestin- and clathrin-mediated receptor internalization. |journal=J. Biol. Chem. |volume=276 |issue= 7 |pages= 4709-16 |year= 2001 |pmid= 11085981 |doi= 10.1074/jbc.M006187200 }}
*{{cite journal | author=Yeo A, Samways DS, Fowler CE, ''et al.'' |title=Coincident signalling between the Gi/Go-coupled delta-opioid receptor and the Gq-coupled m3 muscarinic receptor at the level of intracellular free calcium in SH-SY5Y cells. |journal=J. Neurochem. |volume=76 |issue= 6 |pages= 1688-700 |year= 2001 |pmid= 11259487 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OPRK1... {November 25, 2007 7:40:38 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:41:34 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Opioid receptor, kappa 1
| HGNCid = 8154
| Symbol = OPRK1
| AltSymbols =; KOR; OPRK
| OMIM = 165196
| ECnumber =
| Homologene = 20253
| MGIid = 97439
| GeneAtlas_image1 = PBB_GE_OPRK1_207553_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004987 |text = kappa-opioid receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007193 |text = G-protein signaling, adenylate cyclase inhibiting pathway}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007600 |text = sensory perception}} {{GNF_GO|id=GO:0007610 |text = behavior}} {{GNF_GO|id=GO:0019079 |text = viral genome replication}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4986
| Hs_Ensembl = ENSG00000082556
| Hs_RefseqProtein = NP_000903
| Hs_RefseqmRNA = NM_000912
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 54300829
| Hs_GenLoc_end = 54326747
| Hs_Uniprot = P41145
| Mm_EntrezGene = 18387
| Mm_Ensembl = ENSMUSG00000025905
| Mm_RefseqmRNA = NM_011011
| Mm_RefseqProtein = NP_035141
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 5578574
| Mm_GenLoc_end = 5592947
| Mm_Uniprot = Q14AL5
}}
}}
'''Opioid receptor, kappa 1''', also known as '''OPRK1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OPRK1 opioid receptor, kappa 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4986| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hatzoglou A, Bakogeorgou E, Kampa M, ''et al.'' |title=Somatostatin and opioid receptors in mammary tissue. Role in cancer cell growth. |journal=Adv. Exp. Med. Biol. |volume=480 |issue= |pages= 55-63 |year= 2000 |pmid= 10959409 |doi= }}
*{{cite journal | author=Narita M, Funada M, Suzuki T |title=Regulations of opioid dependence by opioid receptor types. |journal=Pharmacol. Ther. |volume=89 |issue= 1 |pages= 1-15 |year= 2001 |pmid= 11316510 |doi= }}
*{{cite journal | author=Simonin F, Gavériaux-Ruff C, Befort K, ''et al.'' |title=kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 15 |pages= 7006-10 |year= 1995 |pmid= 7624359 |doi= }}
*{{cite journal | author=Zhu J, Chen C, Xue JC, ''et al.'' |title=Cloning of a human kappa opioid receptor from the brain. |journal=Life Sci. |volume=56 |issue= 9 |pages= PL201-7 |year= 1995 |pmid= 7869844 |doi= }}
*{{cite journal | author=Wang JB, Johnson PS, Wu JM, ''et al.'' |title=Human kappa opiate receptor second extracellular loop elevates dynorphin's affinity for human mu/kappa chimeras. |journal=J. Biol. Chem. |volume=269 |issue= 42 |pages= 25966-9 |year= 1994 |pmid= 7929306 |doi= }}
*{{cite journal | author=Mansson E, Bare L, Yang D |title=Isolation of a human kappa opioid receptor cDNA from placenta. |journal=Biochem. Biophys. Res. Commun. |volume=202 |issue= 3 |pages= 1431-7 |year= 1994 |pmid= 8060324 |doi= }}
*{{cite journal | author=Yasuda K, Espinosa R, Takeda J, ''et al.'' |title=Localization of the kappa opioid receptor gene to human chromosome band 8q11.2. |journal=Genomics |volume=19 |issue= 3 |pages= 596-7 |year= 1994 |pmid= 8188308 |doi= 10.1006/geno.1994.1117 }}
*{{cite journal | author=Chao CC, Gekker G, Hu S, ''et al.'' |title=kappa opioid receptors in human microglia downregulate human immunodeficiency virus 1 expression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 15 |pages= 8051-6 |year= 1996 |pmid= 8755601 |doi= }}
*{{cite journal | author=Lee JW, Joshi S, Chan JS, Wong YH |title=Differential coupling of mu-, delta-, and kappa-opioid receptors to G alpha16-mediated stimulation of phospholipase C. |journal=J. Neurochem. |volume=70 |issue= 5 |pages= 2203-11 |year= 1998 |pmid= 9572309 |doi= }}
*{{cite journal | author=Chatzaki E, Margioris AN, Makrigiannakis A, ''et al.'' |title=Kappa opioids and TGFbeta1 interact in human endometrial cells. |journal=Mol. Hum. Reprod. |volume=6 |issue= 7 |pages= 602-9 |year= 2000 |pmid= 10871647 |doi= }}
*{{cite journal | author=Gomes I, Jordan BA, Gupta A, ''et al.'' |title=Heterodimerization of mu and delta opioid receptors: A role in opiate synergy. |journal=J. Neurosci. |volume=20 |issue= 22 |pages= RC110 |year= 2001 |pmid= 11069979 |doi= }}
*{{cite journal | author=Mathieu-Kia AM, Fan LQ, Kreek MJ, ''et al.'' |title=Mu-, delta- and kappa-opioid receptor populations are differentially altered in distinct areas of postmortem brains of Alzheimer's disease patients. |journal=Brain Res. |volume=893 |issue= 1-2 |pages= 121-34 |year= 2001 |pmid= 11223000 |doi= }}
*{{cite journal | author=Lokensgard JR, Gekker G, Peterson PK |title=Kappa-opioid receptor agonist inhibition of HIV-1 envelope glycoprotein-mediated membrane fusion and CXCR4 expression on CD4(+) lymphocytes. |journal=Biochem. Pharmacol. |volume=63 |issue= 6 |pages= 1037-41 |year= 2002 |pmid= 11931835 |doi= }}
*{{cite journal | author=Li JG, Chen C, Liu-Chen LY |title=Ezrin-radixin-moesin-binding phosphoprotein-50/Na+/H+ exchanger regulatory factor (EBP50/NHERF) blocks U50,488H-induced down-regulation of the human kappa opioid receptor by enhancing its recycling rate. |journal=J. Biol. Chem. |volume=277 |issue= 30 |pages= 27545-52 |year= 2002 |pmid= 12004055 |doi= 10.1074/jbc.M200058200 }}
*{{cite journal | author=Suzuki S, Chuang LF, Yau P, ''et al.'' |title=Interactions of opioid and chemokine receptors: oligomerization of mu, kappa, and delta with CCR5 on immune cells. |journal=Exp. Cell Res. |volume=280 |issue= 2 |pages= 192-200 |year= 2002 |pmid= 12413885 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=McLaughlin JP, Xu M, Mackie K, Chavkin C |title=Phosphorylation of a carboxyl-terminal serine within the kappa-opioid receptor produces desensitization and internalization. |journal=J. Biol. Chem. |volume=278 |issue= 36 |pages= 34631-40 |year= 2003 |pmid= 12815037 |doi= 10.1074/jbc.M304022200 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OPRL1... {November 25, 2007 7:41:34 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 7:42:03 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Opiate receptor-like 1
| HGNCid = 8155
| Symbol = OPRL1
| AltSymbols =; KOR-3; MGC34578; NOCIR; OOR; ORL1
| OMIM = 602548
| ECnumber =
| Homologene = 22609
| MGIid = 97440
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0015051 |text = X-opioid receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007193 |text = G-protein signaling, adenylate cyclase inhibiting pathway}} {{GNF_GO|id=GO:0007204 |text = elevation of cytosolic calcium ion concentration}} {{GNF_GO|id=GO:0007600 |text = sensory perception}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4987
| Hs_Ensembl =
| Hs_RefseqProtein = XP_001131314
| Hs_RefseqmRNA = XM_001131314
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 18389
| Mm_Ensembl = ENSMUSG00000027584
| Mm_RefseqmRNA = NM_011012
| Mm_RefseqProtein = NP_035142
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 181644448
| Mm_GenLoc_end = 181650381
| Mm_Uniprot = Q542U1
}}
}}
'''Opiate receptor-like 1''', also known as '''OPRL1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OPRL1 opiate receptor-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4987| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a G protein-coupled receptor whose expression can be induced by phytohemagglutinin. The encoded integral membrane protein is a receptor for the 17 aa neuropeptide nociceptin/orphanin FQ. This gene may be involved in the regulation of numerous brain activities, particularly instinctive and emotional behaviors. A promoter for this gene also functions as a promoter for another gene, regulator of G-protein signalling 19 (RGS19), located on the opposite strand. Two transcript variants encoding the same protein have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: OPRL1 opiate receptor-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4987| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Mollereau C, Mouledous L |title=Tissue distribution of the opioid receptor-like (ORL1) receptor. |journal=Peptides |volume=21 |issue= 7 |pages= 907-17 |year= 2000 |pmid= 10998524 |doi= }}
*{{cite journal | author=New DC, Wong YH |title=The ORL1 receptor: molecular pharmacology and signalling mechanisms. |journal=Neurosignals |volume=11 |issue= 4 |pages= 197-212 |year= 2003 |pmid= 12393946 |doi= }}
*{{cite journal | author=Zaveri N |title=Peptide and nonpeptide ligands for the nociceptin/orphanin FQ receptor ORL1: research tools and potential therapeutic agents. |journal=Life Sci. |volume=73 |issue= 6 |pages= 663-78 |year= 2003 |pmid= 12801588 |doi= }}
*{{cite journal | author=Wick MJ, Minnerath SR, Roy S, ''et al.'' |title=Expression of alternate forms of brain opioid 'orphan' receptor mRNA in activated human peripheral blood lymphocytes and lymphocytic cell lines. |journal=Brain Res. Mol. Brain Res. |volume=32 |issue= 2 |pages= 342-7 |year= 1996 |pmid= 7500847 |doi= }}
*{{cite journal | author=Meunier JC, Mollereau C, Toll L, ''et al.'' |title=Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. |journal=Nature |volume=377 |issue= 6549 |pages= 532-5 |year= 1995 |pmid= 7566152 |doi= 10.1038/377532a0 }}
*{{cite journal | author=Mollereau C, Parmentier M, Mailleux P, ''et al.'' |title=ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization. |journal=FEBS Lett. |volume=341 |issue= 1 |pages= 33-8 |year= 1994 |pmid= 8137918 |doi= }}
*{{cite journal | author=Yung LY, Joshi SA, Chan RY, ''et al.'' |title=GalphaL1 (Galpha14) couples the opioid receptor-like1 receptor to stimulation of phospholipase C. |journal=J. Pharmacol. Exp. Ther. |volume=288 |issue= 1 |pages= 232-8 |year= 1999 |pmid= 9862775 |doi= }}
*{{cite journal | author=Feild JA, Foley JJ, Testa TT, ''et al.'' |title=Cloning and characterization of a rabbit ortholog of human Galpha16 and mouse G(alpha)15. |journal=FEBS Lett. |volume=460 |issue= 1 |pages= 53-6 |year= 1999 |pmid= 10571060 |doi= }}
*{{cite journal | author=Mouledous L, Topham CM, Moisand C, ''et al.'' |title=Functional inactivation of the nociceptin receptor by alanine substitution of glutamine 286 at the C terminus of transmembrane segment VI: evidence from a site-directed mutagenesis study of the ORL1 receptor transmembrane-binding domain. |journal=Mol. Pharmacol. |volume=57 |issue= 3 |pages= 495-502 |year= 2000 |pmid= 10692489 |doi= }}
*{{cite journal | author=Yung LY, Tsim KW, Pei G, Wong YH |title=Immunoglobulin G1 Fc fragment-tagged human opioid receptor-like receptor retains the ability to inhibit cAMP accumulation. |journal=Biological signals and receptors |volume=9 |issue= 5 |pages= 240-7 |year= 2000 |pmid= 10965058 |doi= }}
*{{cite journal | author=Ito E, Xie G, Maruyama K, Palmer PP |title=A core-promoter region functions bi-directionally for human opioid-receptor-like gene ORL1 and its 5'-adjacent gene GAIP. |journal=J. Mol. Biol. |volume=304 |issue= 3 |pages= 259-70 |year= 2000 |pmid= 11090272 |doi= 10.1006/jmbi.2000.4212 }}
*{{cite journal | author=Okada K, Sujaku T, Chuman Y, ''et al.'' |title=Highly potent nociceptin analog containing the Arg-Lys triple repeat. |journal=Biochem. Biophys. Res. Commun. |volume=278 |issue= 2 |pages= 493-8 |year= 2001 |pmid= 11097863 |doi= 10.1006/bbrc.2000.3822 }}
*{{cite journal | author=Serhan CN, Fierro IM, Chiang N, Pouliot M |title=Cutting edge: nociceptin stimulates neutrophil chemotaxis and recruitment: inhibition by aspirin-triggered-15-epi-lipoxin A4. |journal=J. Immunol. |volume=166 |issue= 6 |pages= 3650-4 |year= 2001 |pmid= 11238602 |doi= }}
*{{cite journal | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal | author=Mandyam CD, Thakker DR, Christensen JL, Standifer KM |title=Orphanin FQ/nociceptin-mediated desensitization of opioid receptor-like 1 receptor and mu opioid receptors involves protein kinase C: a molecular mechanism for heterologous cross-talk. |journal=J. Pharmacol. Exp. Ther. |volume=302 |issue= 2 |pages= 502-9 |year= 2002 |pmid= 12130708 |doi= 10.1124/jpet.102.033159 }}
*{{cite journal | author=Thakker DR, Standifer KM |title=Orphanin FQ/nociceptin blocks chronic morphine-induced tyrosine hydroxylase upregulation. |journal=Brain Res. Mol. Brain Res. |volume=105 |issue= 1-2 |pages= 38-46 |year= 2003 |pmid= 12399106 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Spampinato S, Di Toro R, Alessandri M, Murari G |title=Agonist-induced internalization and desensitization of the human nociceptin receptor expressed in CHO cells. |journal=Cell. Mol. Life Sci. |volume=59 |issue= 12 |pages= 2172-83 |year= 2003 |pmid= 12568343 |doi= }}
}}
{{refend}}
{{protein-stub}}
end log.
