- INFO: Beginning work on EMR3... {November 26, 2007 2:59:26 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 26, 2007 2:59:58 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Egf-like module containing, mucin-like, hormone receptor-like 3
| HGNCid = 23647
| Symbol = EMR3
| AltSymbols =;
| OMIM = 606101
| ECnumber =
| Homologene = 50009
| MGIid =
| GeneAtlas_image1 = PBB_GE_EMR3_210724_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 84658
| Hs_Ensembl = ENSG00000131355
| Hs_RefseqProtein = NP_115960
| Hs_RefseqmRNA = NM_032571
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 14570918
| Hs_GenLoc_end = 14646810
| Hs_Uniprot = Q9BY15
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Egf-like module containing, mucin-like, hormone receptor-like 3''', also known as '''EMR3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EMR3 egf-like module containing, mucin-like, hormone receptor-like 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84658| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses.<ref name="entrez">{{cite web | title = Entrez Gene: EMR3 egf-like module containing, mucin-like, hormone receptor-like 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84658| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Stacey M, Lin HH, Hilyard KL, ''et al.'' |title=Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 18863-70 |year= 2001 |pmid= 11279179 |doi= 10.1074/jbc.M101147200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal | author=Bjarnadóttir TK, Fredriksson R, Höglund PJ, ''et al.'' |title=The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. |journal=Genomics |volume=84 |issue= 1 |pages= 23-33 |year= 2005 |pmid= 15203201 |doi= 10.1016/j.ygeno.2003.12.004 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Matmati M, Pouwels W, van Bruggen R, ''et al.'' |title=The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes. |journal=J. Leukoc. Biol. |volume=81 |issue= 2 |pages= 440-8 |year= 2007 |pmid= 17108056 |doi= 10.1189/jlb.0406276 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GNRHR2... {November 26, 2007 3:02:04 PM PST}
- CREATE: Found no pages, creating new page. {November 26, 2007 3:02:21 PM PST}
- CREATED: Created new protein page: GNRHR2 {November 26, 2007 3:02:28 PM PST}
- INFO: Beginning work on GPR101... {November 26, 2007 2:52:27 PM PST}
- CREATE: Found no pages, creating new page. {November 26, 2007 2:53:08 PM PST}
- CREATED: Created new protein page: GPR101 {November 26, 2007 2:53:17 PM PST}
- INFO: Beginning work on GPR103... {November 26, 2007 2:56:21 PM PST}
- CREATE: Found no pages, creating new page. {November 26, 2007 2:56:55 PM PST}
- CREATED: Created new protein page: GPR103 {November 26, 2007 2:57:04 PM PST}
- INFO: Beginning work on GPR123... {November 26, 2007 2:57:04 PM PST}
- CREATE: Found no pages, creating new page. {November 26, 2007 2:57:25 PM PST}
- CREATED: Created new protein page: GPR123 {November 26, 2007 2:57:33 PM PST}
- INFO: Beginning work on GPR128... {November 26, 2007 2:59:59 PM PST}
- CREATE: Found no pages, creating new page. {November 26, 2007 3:01:24 PM PST}
- CREATED: Created new protein page: GPR128 {November 26, 2007 3:01:32 PM PST}
- INFO: Beginning work on GPR146... {November 26, 2007 3:02:28 PM PST}
- CREATE: Found no pages, creating new page. {November 26, 2007 3:02:49 PM PST}
- CREATED: Created new protein page: GPR146 {November 26, 2007 3:02:57 PM PST}
- INFO: Beginning work on GPR174... {November 26, 2007 2:58:41 PM PST}
- CREATE: Found no pages, creating new page. {November 26, 2007 2:59:17 PM PST}
- CREATED: Created new protein page: GPR174 {November 26, 2007 2:59:25 PM PST}
- INFO: Beginning work on GPR61... {November 26, 2007 2:54:45 PM PST}
- CREATE: Found no pages, creating new page. {November 26, 2007 2:55:11 PM PST}
- CREATED: Created new protein page: GPR61 {November 26, 2007 2:55:19 PM PST}
- INFO: Beginning work on GPR63... {November 26, 2007 2:49:25 PM PST}
- CREATE: Found no pages, creating new page. {November 26, 2007 2:50:03 PM PST}
- CREATED: Created new protein page: GPR63 {November 26, 2007 2:50:14 PM PST}
- INFO: Beginning work on GPR98... {November 26, 2007 2:55:19 PM PST}
- REDIRECT: Protein Redirected to: GPR98 {November 26, 2007 2:56:11 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 26, 2007 2:56:14 PM PST}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {November 26, 2007 2:56:14 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 26, 2007 2:56:14 PM PST}
- UPDATED: Updated protein page: GPR98 {November 26, 2007 2:56:21 PM PST}
- INFO: Beginning work on KISS1R... {November 26, 2007 2:58:12 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 26, 2007 2:58:41 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = KISS1 receptor
| HGNCid = 4510
| Symbol = KISS1R
| AltSymbols =; AXOR12; GPR54; HOT7T175
| OMIM = 604161
| ECnumber =
| Homologene = 11411
| MGIid = 2148793
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008188 |text = neuropeptide receptor activity}}
| Component = {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007610 |text = behavior}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0030336 |text = negative regulation of cell migration}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 84634
| Hs_Ensembl = ENSG00000116014
| Hs_RefseqProtein = NP_115940
| Hs_RefseqmRNA = NM_032551
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 868358
| Hs_GenLoc_end = 872013
| Hs_Uniprot = Q969F8
| Mm_EntrezGene = 114229
| Mm_Ensembl = ENSMUSG00000035773
| Mm_RefseqmRNA = NM_053244
| Mm_RefseqProtein = NP_444474
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 79320100
| Mm_GenLoc_end = 79325312
| Mm_Uniprot = Q91V45
}}
}}
'''KISS1 receptor''', also known as '''KISS1R''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KISS1R KISS1 receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84634| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a galanin-like G protein-coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the expressed gene suggests that it is involved in the regulation of endocrine function, and this is supported by the finding that this gene appears to play a role in the onset of puberty.<ref name="entrez">{{cite web | title = Entrez Gene: KISS1R KISS1 receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84634| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Colledge WH |title=GPR54 and puberty. |journal=Trends Endocrinol. Metab. |volume=15 |issue= 9 |pages= 448-53 |year= 2005 |pmid= 15519892 |doi= 10.1016/j.tem.2004.09.008 }}
*{{cite journal | author=Kaiser UB, Kuohung W |title=KiSS-1 and GPR54 as new players in gonadotropin regulation and puberty. |journal=Endocrine |volume=26 |issue= 3 |pages= 277-84 |year= 2006 |pmid= 16034182 |doi= }}
*{{cite journal | author=Seminara SB |title=Metastin and its G protein-coupled receptor, GPR54: critical pathway modulating GnRH secretion. |journal=Frontiers in neuroendocrinology |volume=26 |issue= 3-4 |pages= 131-8 |year= 2006 |pmid= 16309735 |doi= 10.1016/j.yfrne.2005.10.001 }}
*{{cite journal | author=Tena-Sempere M |title=GPR54 and kisspeptin in reproduction. |journal=Hum. Reprod. Update |volume=12 |issue= 5 |pages= 631-9 |year= 2006 |pmid= 16731583 |doi= 10.1093/humupd/dml023 }}
*{{cite journal | author=Cerrato F, Seminara SB |title=Human genetics of GPR54. |journal=Reviews in endocrine & metabolic disorders |volume=8 |issue= 1 |pages= 47-55 |year= 2007 |pmid= 17334928 |doi= 10.1007/s11154-007-9027-3 }}
*{{cite journal | author=Lee DK, Nguyen T, O'Neill GP, ''et al.'' |title=Discovery of a receptor related to the galanin receptors. |journal=FEBS Lett. |volume=446 |issue= 1 |pages= 103-7 |year= 1999 |pmid= 10100623 |doi= }}
*{{cite journal | author=Ohtaki T, Shintani Y, Honda S, ''et al.'' |title=Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. |journal=Nature |volume=411 |issue= 6837 |pages= 613-7 |year= 2001 |pmid= 11385580 |doi= 10.1038/35079135 }}
*{{cite journal | author=Muir AI, Chamberlain L, Elshourbagy NA, ''et al.'' |title=AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 28969-75 |year= 2001 |pmid= 11387329 |doi= 10.1074/jbc.M102743200 }}
*{{cite journal | author=Clements MK, McDonald TP, Wang R, ''et al.'' |title=FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54. |journal=Biochem. Biophys. Res. Commun. |volume=284 |issue= 5 |pages= 1189-93 |year= 2001 |pmid= 11414709 |doi= 10.1006/bbrc.2001.5098 }}
*{{cite journal | author=Kotani M, Detheux M, Vandenbogaerde A, ''et al.'' |title=The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. |journal=J. Biol. Chem. |volume=276 |issue= 37 |pages= 34631-6 |year= 2001 |pmid= 11457843 |doi= 10.1074/jbc.M104847200 }}
*{{cite journal | author=Hori A, Honda S, Asada M, ''et al.'' |title=Metastin suppresses the motility and growth of CHO cells transfected with its receptor. |journal=Biochem. Biophys. Res. Commun. |volume=286 |issue= 5 |pages= 958-63 |year= 2001 |pmid= 11527393 |doi= 10.1006/bbrc.2001.5470 }}
*{{cite journal | author=Ringel MD, Hardy E, Bernet VJ, ''et al.'' |title=Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 5 |pages= 2399 |year= 2002 |pmid= 11994395 |doi= }}
*{{cite journal | author=Janneau JL, Maldonado-Estrada J, Tachdjian G, ''et al.'' |title=Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 11 |pages= 5336-9 |year= 2002 |pmid= 12414911 |doi= }}
*{{cite journal | author=Bo-Abbas Y, Acierno JS, Shagoury JK, ''et al.'' |title=Autosomal recessive idiopathic hypogonadotropic hypogonadism: genetic analysis excludes mutations in the gonadotropin-releasing hormone (GnRH) and GnRH receptor genes. |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue= 6 |pages= 2730-7 |year= 2003 |pmid= 12788881 |doi= }}
*{{cite journal | author=Ikeguchi M, Hirooka Y, Kaibara N |title=Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in hepatocellular carcinoma. |journal=J. Cancer Res. Clin. Oncol. |volume=129 |issue= 9 |pages= 531-5 |year= 2003 |pmid= 12898236 |doi= 10.1007/s00432-003-0469-z }}
*{{cite journal | author=de Roux N, Genin E, Carel JC, ''et al.'' |title=Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 19 |pages= 10972-6 |year= 2003 |pmid= 12944565 |doi= 10.1073/pnas.1834399100 }}
*{{cite journal | author=Seminara SB, Messager S, Chatzidaki EE, ''et al.'' |title=The GPR54 gene as a regulator of puberty. |journal=N. Engl. J. Med. |volume=349 |issue= 17 |pages= 1614-27 |year= 2003 |pmid= 14573733 |doi= 10.1056/NEJMoa035322 }}
*{{cite journal | author=Ikeguchi M, Yamaguchi K, Kaibara N |title=Clinical significance of the loss of KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma. |journal=Clin. Cancer Res. |volume=10 |issue= 4 |pages= 1379-83 |year= 2004 |pmid= 14977840 |doi= }}
*{{cite journal | author=Bilban M, Ghaffari-Tabrizi N, Hintermann E, ''et al.'' |title=Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts. |journal=J. Cell. Sci. |volume=117 |issue= Pt 8 |pages= 1319-28 |year= 2004 |pmid= 15020672 |doi= 10.1242/jcs.00971 }}
*{{cite journal | author=Grimwood J, Gordon LA, Olsen A, ''et al.'' |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529-35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MAS1L... {November 26, 2007 3:02:57 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 26, 2007 3:03:28 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = MAS1 oncogene-like
| HGNCid = 13961
| Symbol = MAS1L
| AltSymbols =; MRG; MAS-L; MGC119987; dJ994E9.2
| OMIM = 607235
| ECnumber =
| Homologene = 50478
| MGIid =
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 116511
| Hs_Ensembl = ENSG00000204687
| Hs_RefseqProtein = NP_443199
| Hs_RefseqmRNA = NM_052967
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 29562522
| Hs_GenLoc_end = 29563658
| Hs_Uniprot = P35410
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''MAS1 oncogene-like''', also known as '''MAS1L''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MAS1L MAS1 oncogene-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=116511| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Monnot C, Weber V, Stinnakre J, ''et al.'' |title=Cloning and functional characterization of a novel mas-related gene, modulating intracellular angiotensin II actions. |journal=Mol. Endocrinol. |volume=5 |issue= 10 |pages= 1477-87 |year= 1992 |pmid= 1723144 |doi= }}
*{{cite journal | author=Dong X, Han S, Zylka MJ, ''et al.'' |title=A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. |journal=Cell |volume=106 |issue= 5 |pages= 619-32 |year= 2001 |pmid= 11551509 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MCHR2... {November 26, 2007 2:57:33 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 26, 2007 2:58:12 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Melanin-concentrating hormone receptor 2
| HGNCid = 20867
| Symbol = MCHR2
| AltSymbols =; MCH2; GPR145; MCH2R; SLT
| OMIM = 606111
| ECnumber =
| Homologene = 50004
| MGIid =
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 84539
| Hs_Ensembl = ENSG00000152034
| Hs_RefseqProtein = NP_001035269
| Hs_RefseqmRNA = NM_001040179
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 100474507
| Hs_GenLoc_end = 100548820
| Hs_Uniprot = Q969V1
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Melanin-concentrating hormone receptor 2''', also known as '''MCHR2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MCHR2 melanin-concentrating hormone receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84539| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hill J, Duckworth M, Murdock P, ''et al.'' |title=Molecular cloning and functional characterization of MCH2, a novel human MCH receptor. |journal=J. Biol. Chem. |volume=276 |issue= 23 |pages= 20125-9 |year= 2001 |pmid= 11274220 |doi= 10.1074/jbc.M102068200 }}
*{{cite journal | author=Mori M, Harada M, Terao Y, ''et al.'' |title=Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor. |journal=Biochem. Biophys. Res. Commun. |volume=283 |issue= 5 |pages= 1013-8 |year= 2001 |pmid= 11355873 |doi= 10.1006/bbrc.2001.4893 }}
*{{cite journal | author=Sailer AW, Sano H, Zeng Z, ''et al.'' |title=Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 13 |pages= 7564-9 |year= 2001 |pmid= 11404457 |doi= 10.1073/pnas.121170598 }}
*{{cite journal | author=An S, Cutler G, Zhao JJ, ''et al.'' |title=Identification and characterization of a melanin-concentrating hormone receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 13 |pages= 7576-81 |year= 2001 |pmid= 11416225 |doi= 10.1073/pnas.131200698 }}
*{{cite journal | author=Wang S, Behan J, O'Neill K, ''et al.'' |title=Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, mch-r2. |journal=J. Biol. Chem. |volume=276 |issue= 37 |pages= 34664-70 |year= 2001 |pmid= 11459838 |doi= 10.1074/jbc.M102601200 }}
*{{cite journal | author=Bednarek MA, Feighner SD, Hreniuk DL, ''et al.'' |title=Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2. |journal=Biochemistry |volume=40 |issue= 31 |pages= 9379-86 |year= 2001 |pmid= 11478907 |doi= }}
*{{cite journal | author=Bednarek MA, Tan C, Hreniuk DL, ''et al.'' |title=Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13821-6 |year= 2002 |pmid= 11839762 |doi= 10.1074/jbc.M200563200 }}
*{{cite journal | author=Audinot V, Lahaye C, Suply T, ''et al.'' |title=SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor. |journal=Biochem. Biophys. Res. Commun. |volume=295 |issue= 4 |pages= 841-8 |year= 2002 |pmid= 12127971 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Logan DW, Bryson-Richardson RJ, Pagán KE, ''et al.'' |title=The structure and evolution of the melanocortin and MCH receptors in fish and mammals. |journal=Genomics |volume=81 |issue= 2 |pages= 184-91 |year= 2003 |pmid= 12620396 |doi= }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Vitale RM, Pedone C, De Benedetti PG, Fanelli F |title=Structural features of the inactive and active states of the melanin-concentrating hormone receptors: insights from molecular simulations. |journal=Proteins |volume=56 |issue= 3 |pages= 430-48 |year= 2004 |pmid= 15229878 |doi= 10.1002/prot.20125 }}
*{{cite journal | author=Hawes BE, Green B, O'Neill K, ''et al.'' |title=Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2. |journal=Obes. Res. |volume=12 |issue= 8 |pages= 1327-34 |year= 2004 |pmid= 15340116 |doi= }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MRGPRD... {November 26, 2007 3:03:28 PM PST}
- CREATE: Found no pages, creating new page. {November 26, 2007 3:03:56 PM PST}
- CREATED: Created new protein page: MRGPRD {November 26, 2007 3:04:17 PM PST}
- INFO: Beginning work on MRGPRE... {November 26, 2007 3:04:17 PM PST}
- CREATE: Found no pages, creating new page. {November 26, 2007 3:05:02 PM PST}
- CREATED: Created new protein page: MRGPRE {November 26, 2007 3:05:11 PM PST}
- INFO: Beginning work on MRGPRX2... {November 26, 2007 3:05:11 PM PST}
- CREATE: Found no pages, creating new page. {November 26, 2007 3:05:31 PM PST}
- CREATED: Created new protein page: MRGPRX2 {November 26, 2007 3:05:40 PM PST}
- INFO: Beginning work on MRGPRX3... {November 26, 2007 3:05:40 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 26, 2007 3:06:06 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = MAS-related GPR, member X3
| HGNCid = 17980
| Symbol = MRGPRX3
| AltSymbols =; GPCR; MRGX3; SNSR1
| OMIM = 607229
| ECnumber =
| Homologene = 79615
| MGIid = 3644999
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 117195
| Hs_Ensembl = ENSG00000179826
| Hs_RefseqProtein = NP_473372
| Hs_RefseqmRNA = NM_054031
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 18115326
| Hs_GenLoc_end = 18116294
| Hs_Uniprot = Q96LB0
| Mm_EntrezGene = 668725
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_001003331
| Mm_RefseqProtein = XP_001003331
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''MAS-related GPR, member X3''', also known as '''MRGPRX3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MRGPRX3 MAS-related GPR, member X3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=117195| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Dong X, Han S, Zylka MJ, ''et al.'' |title=A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. |journal=Cell |volume=106 |issue= 5 |pages= 619-32 |year= 2001 |pmid= 11551509 |doi= }}
*{{cite journal | author=Lembo PM, Grazzini E, Groblewski T, ''et al.'' |title=Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs. |journal=Nat. Neurosci. |volume=5 |issue= 3 |pages= 201-9 |year= 2002 |pmid= 11850634 |doi= 10.1038/nn815 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Kaisho Y, Watanabe T, Nakata M, ''et al.'' |title=Transgenic rats overexpressing the human MrgX3 gene show cataracts and an abnormal skin phenotype. |journal=Biochem. Biophys. Res. Commun. |volume=330 |issue= 3 |pages= 653-7 |year= 2005 |pmid= 15809047 |doi= 10.1016/j.bbrc.2005.03.027 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OPN4... {November 26, 2007 3:01:32 PM PST}
- SEARCH REDIRECT: Control Box Found: Melanopsin {November 26, 2007 3:01:56 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 26, 2007 3:01:58 PM PST}
- SKIP SUMMARY: Skipping Summary, No Errors. {November 26, 2007 3:01:58 PM PST}
- SKIP CITATIONS: Skipping Citations, No Errors. {November 26, 2007 3:01:58 PM PST}
- UPDATED: Updated protein page: Melanopsin {November 26, 2007 3:02:04 PM PST}
- INFO: Beginning work on OR12D3... {November 26, 2007 2:51:40 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 26, 2007 2:52:27 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 12, subfamily D, member 3
| HGNCid = 13963
| Symbol = OR12D3
| AltSymbols =; MGC119267; MGC125888; hs6M1-27
| OMIM =
| ECnumber =
| Homologene = 12811
| MGIid = 2177492
| GeneAtlas_image1 = PBB_GE_OR12D3_221431_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 81797
| Hs_Ensembl = ENSG00000204692
| Hs_RefseqProtein = NP_112221
| Hs_RefseqmRNA = NM_030959
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 29449179
| Hs_GenLoc_end = 29525854
| Hs_Uniprot = Q9UGF7
| Mm_EntrezGene = 258832
| Mm_Ensembl = ENSMUSG00000029184
| Mm_RefseqmRNA = NM_146835
| Mm_RefseqProtein = NP_667046
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 37074261
| Mm_GenLoc_end = 37075205
| Mm_Uniprot =
}}
}}
'''Olfactory receptor, family 12, subfamily D, member 3''', also known as '''OR12D3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR12D3 olfactory receptor, family 12, subfamily D, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81797| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR12D3 olfactory receptor, family 12, subfamily D, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81797| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Volz A, Ehlers A, Younger R, ''et al.'' |title=Complex transcription and splicing of odorant receptor genes. |journal=J. Biol. Chem. |volume=278 |issue= 22 |pages= 19691-701 |year= 2003 |pmid= 12637542 |doi= 10.1074/jbc.M212424200 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi= }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OR2B2... {November 26, 2007 2:50:58 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 26, 2007 2:51:40 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 2, subfamily B, member 2
| HGNCid = 13966
| Symbol = OR2B2
| AltSymbols =; OR2B2Q; OR2B9; OR6-1; dJ193B12.4; hs6M1-10
| OMIM =
| ECnumber =
| Homologene = 11056
| MGIid = 3031193
| GeneAtlas_image1 = PBB_GE_OR2B2_216408_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 81697
| Hs_Ensembl = ENSG00000168131
| Hs_RefseqProtein = NP_149046
| Hs_RefseqmRNA = NM_033057
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 27987003
| Hs_GenLoc_end = 27988076
| Hs_Uniprot = Q9GZK3
| Mm_EntrezGene = 258067
| Mm_Ensembl = ENSMUSG00000057727
| Mm_RefseqmRNA = NM_001011820
| Mm_RefseqProtein = NP_001011820
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 21710468
| Mm_GenLoc_end = 21711409
| Mm_Uniprot =
}}
}}
'''Olfactory receptor, family 2, subfamily B, member 2''', also known as '''OR2B2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR2B2 olfactory receptor, family 2, subfamily B, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81697| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR2B2 olfactory receptor, family 2, subfamily B, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81697| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OR5V1... {November 26, 2007 2:50:14 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 26, 2007 2:50:58 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 5, subfamily V, member 1
| HGNCid = 13972
| Symbol = OR5V1
| AltSymbols =; 6M1-21; hs6M1-21
| OMIM =
| ECnumber =
| Homologene = 73968
| MGIid = 2177493
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 81696
| Hs_Ensembl = ENSG00000112461
| Hs_RefseqProtein = NP_110503
| Hs_RefseqmRNA = NM_030876
| Hs_GenLoc_db =
| Hs_GenLoc_chr = c6_COX
| Hs_GenLoc_start = 29466976
| Hs_GenLoc_end = 29467941
| Hs_Uniprot = Q9UGF6
| Mm_EntrezGene = 258325
| Mm_Ensembl = ENSMUSG00000046078
| Mm_RefseqmRNA = NM_146328
| Mm_RefseqProtein = NP_666440
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 37106706
| Mm_GenLoc_end = 37107659
| Mm_Uniprot =
}}
}}
'''Olfactory receptor, family 5, subfamily V, member 1''', also known as '''OR5V1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR5V1 olfactory receptor, family 5, subfamily V, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81696| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR5V1 olfactory receptor, family 5, subfamily V, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81696| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Volz A, Ehlers A, Younger R, ''et al.'' |title=Complex transcription and splicing of odorant receptor genes. |journal=J. Biol. Chem. |volume=278 |issue= 22 |pages= 19691-701 |year= 2003 |pmid= 12637542 |doi= 10.1074/jbc.M212424200 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TAAR8... {November 26, 2007 2:53:17 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 26, 2007 2:54:20 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Trace amine associated receptor 8
| HGNCid = 14964
| Symbol = TAAR8
| AltSymbols =; GPR102; TA5; TAR5; TRAR5
| OMIM = 606927
| ECnumber =
| Homologene = 14242
| MGIid = 2685076
| GeneAtlas_image1 = PBB_GE_TAAR8_gnf1h01258_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 83551
| Hs_Ensembl = ENSG00000146385
| Hs_RefseqProtein = NP_444508
| Hs_RefseqmRNA = NM_053278
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 132915525
| Hs_GenLoc_end = 132916553
| Hs_Uniprot = Q969N4
| Mm_EntrezGene = 215859
| Mm_Ensembl = ENSMUSG00000050804
| Mm_RefseqmRNA = NM_001010830
| Mm_RefseqProtein = NP_001010830
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 23765916
| Mm_GenLoc_end = 23766950
| Mm_Uniprot = Q5QD07
}}
}}
'''Trace amine associated receptor 8''', also known as '''TAAR8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TAAR8 trace amine associated receptor 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83551| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: TAAR8 trace amine associated receptor 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83551| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Borowsky B, Adham N, Jones KA, ''et al.'' |title=Trace amines: identification of a family of mammalian G protein-coupled receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 16 |pages= 8966-71 |year= 2001 |pmid= 11459929 |doi= 10.1073/pnas.151105198 }}
*{{cite journal | author=Lee DK, Nguyen T, Lynch KR, ''et al.'' |title=Discovery and mapping of ten novel G protein-coupled receptor genes. |journal=Gene |volume=275 |issue= 1 |pages= 83-91 |year= 2001 |pmid= 11574155 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Lindemann L, Ebeling M, Kratochwil NA, ''et al.'' |title=Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. |journal=Genomics |volume=85 |issue= 3 |pages= 372-85 |year= 2005 |pmid= 15718104 |doi= 10.1016/j.ygeno.2004.11.010 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TAS1R3... {November 26, 2007 2:54:20 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 26, 2007 2:54:45 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Taste receptor, type 1, member 3
| HGNCid = 15661
| Symbol = TAS1R3
| AltSymbols =; T1R3
| OMIM = 605865
| ECnumber =
| Homologene = 12890
| MGIid = 1933547
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0008067 |text = metabotropic glutamate, GABA-B-like receptor activity}} {{GNF_GO|id=GO:0008527 |text = taste receptor activity}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}} {{GNF_GO|id=GO:0050916 |text = sensory perception of sweet taste}} {{GNF_GO|id=GO:0050917 |text = sensory perception of umami taste}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 83756
| Hs_Ensembl = ENSG00000169962
| Hs_RefseqProtein = NP_689414
| Hs_RefseqmRNA = NM_152228
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 1256557
| Hs_GenLoc_end = 1260549
| Hs_Uniprot = Q7RTX0
| Mm_EntrezGene = 83771
| Mm_Ensembl = ENSMUSG00000029072
| Mm_RefseqmRNA = NM_031872
| Mm_RefseqProtein = NP_114078
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 154703073
| Mm_GenLoc_end = 154707162
| Mm_Uniprot = Q925D8
}}
}}
'''Taste receptor, type 1, member 3''', also known as '''TAS1R3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TAS1R3 taste receptor, type 1, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83756| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The TAS1R3 gene encodes the human homolog of mouse Sac, a major determinant of differences between sweet-sensitive and -insensitive mouse strains in their responsiveness to sucrose, saccharine, and other sweeteners.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: TAS1R3 taste receptor, type 1, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83756| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Chandrashekar J, Hoon MA, Ryba NJ, Zuker CS |title=The receptors and cells for mammalian taste. |journal=Nature |volume=444 |issue= 7117 |pages= 288-94 |year= 2007 |pmid= 17108952 |doi= 10.1038/nature05401 }}
*{{cite journal | author=Montmayeur JP, Liberles SD, Matsunami H, Buck LB |title=A candidate taste receptor gene near a sweet taste locus. |journal=Nat. Neurosci. |volume=4 |issue= 5 |pages= 492-8 |year= 2001 |pmid= 11319557 |doi= 10.1038/87440 }}
*{{cite journal | author=Max M, Shanker YG, Huang L, ''et al.'' |title=Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. |journal=Nat. Genet. |volume=28 |issue= 1 |pages= 58-63 |year= 2001 |pmid= 11326277 |doi= 10.1038/88270 }}
*{{cite journal | author=Nelson G, Chandrashekar J, Hoon MA, ''et al.'' |title=An amino-acid taste receptor. |journal=Nature |volume=416 |issue= 6877 |pages= 199-202 |year= 2002 |pmid= 11894099 |doi= 10.1038/nature726 }}
*{{cite journal | author=Li X, Staszewski L, Xu H, ''et al.'' |title=Human receptors for sweet and umami taste. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 7 |pages= 4692-6 |year= 2002 |pmid= 11917125 |doi= 10.1073/pnas.072090199 }}
*{{cite journal | author=Spadaccini R, Trabucco F, Saviano G, ''et al.'' |title=The mechanism of interaction of sweet proteins with the T1R2-T1R3 receptor: evidence from the solution structure of G16A-MNEI. |journal=J. Mol. Biol. |volume=328 |issue= 3 |pages= 683-92 |year= 2003 |pmid= 12706725 |doi= }}
*{{cite journal | author=Ariyasu T, Matsumoto S, Kyono F, ''et al.'' |title=Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose. |journal=In Vitro Cell. Dev. Biol. Anim. |volume=39 |issue= 1-2 |pages= 80-8 |year= 2004 |pmid= 12892531 |doi= 10.1290/1543-706X(2003)039<0080:TRTIAE>2.0.CO;2 }}
*{{cite journal | author=Jiang P, Ji Q, Liu Z, ''et al.'' |title=The cysteine-rich region of T1R3 determines responses to intensely sweet proteins. |journal=J. Biol. Chem. |volume=279 |issue= 43 |pages= 45068-75 |year= 2004 |pmid= 15299024 |doi= 10.1074/jbc.M406779200 }}
*{{cite journal | author=Xu H, Staszewski L, Tang H, ''et al.'' |title=Different functional roles of T1R subunits in the heteromeric taste receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 39 |pages= 14258-63 |year= 2005 |pmid= 15353592 |doi= 10.1073/pnas.0404384101 }}
*{{cite journal | author=Taniguchi K |title=Expression of the sweet receptor protein, T1R3, in the human liver and pancreas. |journal=J. Vet. Med. Sci. |volume=66 |issue= 11 |pages= 1311-4 |year= 2005 |pmid= 15585941 |doi= }}
*{{cite journal | author=Jiang P, Cui M, Zhao B, ''et al.'' |title=Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste. |journal=J. Biol. Chem. |volume=280 |issue= 15 |pages= 15238-46 |year= 2005 |pmid= 15668251 |doi= 10.1074/jbc.M414287200 }}
*{{cite journal | author=Galindo-Cuspinera V, Winnig M, Bufe B, ''et al.'' |title=A TAS1R receptor-based explanation of sweet 'water-taste'. |journal=Nature |volume=441 |issue= 7091 |pages= 354-7 |year= 2006 |pmid= 16633339 |doi= 10.1038/nature04765 }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal | author=Behrens M, Bartelt J, Reichling C, ''et al.'' |title=Members of RTP and REEP gene families influence functional bitter taste receptor expression. |journal=J. Biol. Chem. |volume=281 |issue= 29 |pages= 20650-9 |year= 2006 |pmid= 16720576 |doi= 10.1074/jbc.M513637200 }}
*{{cite journal | author=Koizumi A, Nakajima K, Asakura T, ''et al.'' |title=Taste-modifying sweet protein, neoculin, is received at human T1R3 amino terminal domain. |journal=Biochem. Biophys. Res. Commun. |volume=358 |issue= 2 |pages= 585-9 |year= 2007 |pmid= 17499612 |doi= 10.1016/j.bbrc.2007.04.171 }}
}}
{{refend}}
{{protein-stub}}
end log.
