INFO : Beginning work on AHR... {November 5, 2007 9:16:24 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 5, 2007 9:16:38 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Aryl hydrocarbon receptor
| HGNCid = 348
| Symbol = AHR
| AltSymbols =;
| OMIM = 600253
| ECnumber =
| Homologene = 1224
| MGIid = 105043
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0004879 |text = ligand-dependent nuclear receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006950 |text = response to stress}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0009410 |text = response to xenobiotic stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 196
| Hs_Ensembl = ENSG00000106546
| Hs_RefseqProtein = NP_001612
| Hs_RefseqmRNA = NM_001621
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 17304832
| Hs_GenLoc_end = 17349400
| Hs_Uniprot = P35869
| Mm_EntrezGene = 11622
| Mm_Ensembl = ENSMUSG00000019256
| Mm_RefseqmRNA = NM_013464
| Mm_RefseqProtein = NP_038492
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 12
| Mm_GenLoc_start = 36088776
| Mm_GenLoc_end = 36119695
| Mm_Uniprot = Q3U2B1
}}
}}
'''Aryl hydrocarbon receptor''', also known as '''AHR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of aromatic hydrocarbons.<ref>{{cite web | title = Entrez Gene: AHR aryl hydrocarbon receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=196| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hahn ME |title=The aryl hydrocarbon receptor: a comparative perspective. |journal=Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. |volume=121 |issue= 1-3 |pages= 23-53 |year= 1999 |pmid= 9972449 |doi= }}
*{{cite journal | author=Puga A, Xia Y, Elferink C |title=Role of the aryl hydrocarbon receptor in cell cycle regulation. |journal=Chem. Biol. Interact. |volume=141 |issue= 1-2 |pages= 117-30 |year= 2002 |pmid= 12213388 |doi= }}
*{{cite journal | author=Harper PA, Wong JY, Lam MS, Okey AB |title=Polymorphisms in the human AH receptor. |journal=Chem. Biol. Interact. |volume=141 |issue= 1-2 |pages= 161-87 |year= 2002 |pmid= 12213390 |doi= }}
*{{cite journal | author=Safe S, Wormke M, Samudio I |title=Mechanisms of inhibitory aryl hydrocarbon receptor-estrogen receptor crosstalk in human breast cancer cells. |journal=Journal of mammary gland biology and neoplasia |volume=5 |issue= 3 |pages= 295-306 |year= 2004 |pmid= 14973392 |doi= }}
*{{cite journal | author=Fujii-Kuriyama Y, Mimura J |title=Molecular mechanisms of AhR functions in the regulation of cytochrome P450 genes. |journal=Biochem. Biophys. Res. Commun. |volume=338 |issue= 1 |pages= 311-7 |year= 2005 |pmid= 16153594 |doi= 10.1016/j.bbrc.2005.08.162 }}
*{{cite journal | author=Ramadoss P, Marcus C, Perdew GH |title=Role of the aryl hydrocarbon receptor in drug metabolism. |journal=Expert opinion on drug metabolism & toxicology |volume=1 |issue= 1 |pages= 9-21 |year= 2006 |pmid= 16922649 |doi= 10.1517/17425255.1.1.9 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on B2M... {November 5, 2007 9:17:31 AM PST} UPLOAD : Added new Image to wiki: {November 5, 2007 9:18:32 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 5, 2007 9:18:45 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_B2M_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a1m.
| PDB = {{PDB2|1a1m}}, {{PDB2|1a1n}}, {{PDB2|1a1o}}, {{PDB2|1a6z}}, {{PDB2|1a9b}}, {{PDB2|1a9e}}, {{PDB2|1agb}}, {{PDB2|1agc}}, {{PDB2|1agd}}, {{PDB2|1age}}, {{PDB2|1agf}}, {{PDB2|1akj}}, {{PDB2|1ao7}}, {{PDB2|1b0g}}, {{PDB2|1b0r}}, {{PDB2|1bd2}}, {{PDB2|1c16}}, {{PDB2|1ce6}}, {{PDB2|1cg9}}, {{PDB2|1de4}}, {{PDB2|1duy}}, {{PDB2|1duz}}, {{PDB2|1e27}}, {{PDB2|1e28}}, {{PDB2|1eey}}, {{PDB2|1eez}}, {{PDB2|1efx}}, {{PDB2|1exu}}, {{PDB2|1gzp}}, {{PDB2|1gzq}}, {{PDB2|1hhg}}, {{PDB2|1hhh}}, {{PDB2|1hhi}}, {{PDB2|1hhj}}, {{PDB2|1hhk}}, {{PDB2|1hla}}, {{PDB2|1hsa}}, {{PDB2|1hsb}}, {{PDB2|1i1f}}, {{PDB2|1i1y}}, {{PDB2|1i4f}}, {{PDB2|1i7r}}, {{PDB2|1i7t}}, {{PDB2|1i7u}}, {{PDB2|1im3}}, {{PDB2|1im9}}, {{PDB2|1jf1}}, {{PDB2|1jgd}}, {{PDB2|1jge}}, {{PDB2|1jht}}, {{PDB2|1jnj}}, {{PDB2|1k5n}}, {{PDB2|1kpr}}, {{PDB2|1ktl}}, {{PDB2|1lds}}, {{PDB2|1lp9}}, {{PDB2|1m05}}, {{PDB2|1m6o}}, {{PDB2|1mhe}}, {{PDB2|1mi5}}, {{PDB2|1n2r}}, {{PDB2|1of2}}, {{PDB2|1oga}}, {{PDB2|1ogt}}, {{PDB2|1onq}}, {{PDB2|1p7q}}, {{PDB2|1py4}}, {{PDB2|1q94}}, {{PDB2|1qew}}, {{PDB2|1qlf}}, {{PDB2|1qqd}}, {{PDB2|1qr1}}, {{PDB2|1qrn}}, {{PDB2|1qse}}, {{PDB2|1qsf}}, {{PDB2|1qvo}}, {{PDB2|1r3h}}, {{PDB2|1s8d}}, {{PDB2|1s9w}}, {{PDB2|1s9x}}, {{PDB2|1s9y}}, {{PDB2|1sys}}, {{PDB2|1syv}}, {{PDB2|1t1w}}, {{PDB2|1t1x}}, {{PDB2|1t1y}}, {{PDB2|1t1z}}, {{PDB2|1t20}}, {{PDB2|1t21}}, {{PDB2|1t22}}, {{PDB2|1tmc}}, {{PDB2|1tvb}}, {{PDB2|1tvh}}, {{PDB2|1uqs}}, {{PDB2|1uxs}}, {{PDB2|1uxw}}, {{PDB2|1vgk}}, {{PDB2|1w0v}}, {{PDB2|1w0w}}, {{PDB2|1w72}}, {{PDB2|1x7q}}, {{PDB2|1xh3}}, {{PDB2|1xr8}}, {{PDB2|1xr9}}, {{PDB2|1xz0}}, {{PDB2|1ydp}}, {{PDB2|1ypz}}, {{PDB2|1zhk}}, {{PDB2|1zhl}}, {{PDB2|1zs8}}, {{PDB2|1zsd}}, {{PDB2|1zt4}}, {{PDB2|1zvs}}, {{PDB2|2a83}}, {{PDB2|2ak4}}, {{PDB2|2av1}}, {{PDB2|2av7}}, {{PDB2|2axf}}, {{PDB2|2axg}}, {{PDB2|2bck}}, {{PDB2|2bnq}}, {{PDB2|2bnr}}, {{PDB2|2bsr}}, {{PDB2|2bss}}, {{PDB2|2bst}}, {{PDB2|2bsu}}, {{PDB2|2bsv}}, {{PDB2|2bvo}}, {{PDB2|2bvp}}, {{PDB2|2bvq}}, {{PDB2|2c7u}}, {{PDB2|2cii}}, {{PDB2|2cik}}, {{PDB2|2clr}}, {{PDB2|2d31}}, {{PDB2|2d4d}}, {{PDB2|2d4f}}, {{PDB2|2dyp}}, {{PDB2|2esv}}, {{PDB2|2f53}}, {{PDB2|2f54}}, {{PDB2|2f74}}, {{PDB2|2f8o}}, {{PDB2|2fyy}}, {{PDB2|2fz3}}, {{PDB2|2git}}, {{PDB2|2gj6}}, {{PDB2|2h26}}, {{PDB2|2h6p}}, {{PDB2|2hjk}}, {{PDB2|2hjl}}, {{PDB2|2hla}}, {{PDB2|2hn7}}, {{PDB2|2nw3}}, {{PDB2|2nx5}}, {{PDB2|3hla}}
| Name = Beta-2-microglobulin
| HGNCid = 914
| Symbol = B2M
| AltSymbols =;
| OMIM = 109700
| ECnumber =
| Homologene = 2987
| MGIid = 88127
| GeneAtlas_image1 = PBB_GE_B2M_201891_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_B2M_216231_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0042612 |text = MHC class I protein complex}}
| Process = {{GNF_GO|id=GO:0002474 |text = antigen processing and presentation of peptide antigen via MHC class I}} {{GNF_GO|id=GO:0006955 |text = immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 567
| Hs_Ensembl = ENSG00000166710
| Hs_RefseqProtein = NP_004039
| Hs_RefseqmRNA = NM_004048
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 42790977
| Hs_GenLoc_end = 42797649
| Hs_Uniprot = P61769
| Mm_EntrezGene = 12010
| Mm_Ensembl = ENSMUSG00000060802
| Mm_RefseqmRNA = NM_009735
| Mm_RefseqProtein = NP_033865
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 121839127
| Mm_GenLoc_end = 121844524
| Mm_Uniprot = Q3U679
}}
}}
'''Beta-2-microglobulin''', also known as '''B2M''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Winchester JF, Salsberg JA, Levin NW |title=Beta-2 microglobulin in ESRD: an in-depth review. |journal=Advances in renal replacement therapy |volume=10 |issue= 4 |pages= 279-309 |year= 2004 |pmid= 14681859 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on CCNB1... {November 5, 2007 9:18:45 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein CCNB1 image.jpg {November 5, 2007 9:19:26 AM PST} CREATE : Found no pages, creating new page. {November 5, 2007 9:19:36 AM PST} CREATED : Created new protein page: CCNB1 {November 5, 2007 9:19:44 AM PST} INFO : Beginning work on CDK4... {November 5, 2007 9:19:44 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 5, 2007 9:20:25 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cyclin-dependent kinase 4
| HGNCid = 1773
| Symbol = CDK4
| AltSymbols =; CMM3; MGC14458; PSK-J3
| OMIM = 123829
| ECnumber =
| Homologene = 55429
| MGIid = 88357
| GeneAtlas_image1 = PBB_GE_CDK4_202246_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004672 |text = protein kinase activity}} {{GNF_GO|id=GO:0004693 |text = cyclin-dependent protein kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0000307 |text = cyclin-dependent protein kinase holoenzyme complex}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005667 |text = transcription factor complex}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0000082 |text = G1/S transition of mitotic cell cycle}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0042127 |text = regulation of cell proliferation}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1019
| Hs_Ensembl = ENSG00000135446
| Hs_RefseqProtein = NP_000066
| Hs_RefseqmRNA = NM_000075
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 56428272
| Hs_GenLoc_end = 56432431
| Hs_Uniprot = P11802
| Mm_EntrezGene = 12567
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_009870
| Mm_RefseqProtein = NP_034000
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Cyclin-dependent kinase 4''', also known as '''CDK4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.<ref>{{cite web | title = Entrez Gene: CDK4 cyclin-dependent kinase 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1019| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on CRK... {November 5, 2007 9:20:25 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein CRK image.jpg {November 5, 2007 9:21:47 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 5, 2007 9:21:57 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CRK_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1b07.
| PDB = {{PDB2|1b07}}, {{PDB2|1cka}}, {{PDB2|1ckb}}, {{PDB2|1ju5}}, {{PDB2|1m30}}, {{PDB2|1m3a}}, {{PDB2|1m3b}}, {{PDB2|1m3c}}, {{PDB2|2dvj}}, {{PDB2|2eyv}}, {{PDB2|2eyw}}, {{PDB2|2eyx}}, {{PDB2|2eyy}}, {{PDB2|2eyz}}, {{PDB2|2ggr}}
| Name = V-crk sarcoma virus CT10 oncogene homolog (avian)
| HGNCid = 2362
| Symbol = CRK
| AltSymbols =; CRKII
| OMIM = 164762
| ECnumber =
| Homologene = 81850
| MGIid = 88508
| GeneAtlas_image1 = PBB_GE_CRK_202224_at_tn.png
| GeneAtlas_image2 = PBB_GE_CRK_202225_at_tn.png
| GeneAtlas_image3 = PBB_GE_CRK_202226_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005070 |text = SH3/SH2 adaptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0042169 |text = SH2 domain binding}} {{GNF_GO|id=GO:0045309 |text = protein phosphorylated amino acid binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0030036 |text = actin cytoskeleton organization and biogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1398
| Hs_Ensembl = ENSG00000167193
| Hs_RefseqProtein = NP_005197
| Hs_RefseqmRNA = NM_005206
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 1270733
| Hs_GenLoc_end = 1306302
| Hs_Uniprot = P46108
| Mm_EntrezGene = 12928
| Mm_Ensembl = ENSMUSG00000017776
| Mm_RefseqmRNA = NM_133656
| Mm_RefseqProtein = NP_598417
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 75495505
| Mm_GenLoc_end = 75522289
| Mm_Uniprot = Q3TQV3
}}
}}
'''V-crk sarcoma virus CT10 oncogene homolog (avian)''', also known as '''CRK''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.<ref>{{cite web | title = Entrez Gene: CRK v-crk sarcoma virus CT10 oncogene homolog (avian)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1398| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Feller SM, Ren R, Hanafusa H, Baltimore D |title=SH2 and SH3 domains as molecular adhesives: the interactions of Crk and Abl. |journal=Trends Biochem. Sci. |volume=19 |issue= 11 |pages= 453-8 |year= 1995 |pmid= 7855886 |doi= }}
*{{cite journal | author=Feller SM, Posern G, Voss J, ''et al.'' |title=Physiological signals and oncogenesis mediated through Crk family adapter proteins. |journal=J. Cell. Physiol. |volume=177 |issue= 4 |pages= 535-52 |year= 1999 |pmid= 10092207 |doi= 10.1002/(SICI)1097-4652(199812)177:4<535::AID-JCP5>3.0.CO;2-E }}
*{{cite journal | author=Pessin JE, Okada S |title=Insulin and EGF receptors integrate the Ras and Rap signaling pathways. |journal=Endocr. J. |volume=46 Suppl |issue= |pages= S11-6 |year= 2002 |pmid= 12054111 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on CSNK2B... {November 5, 2007 9:21:57 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein CSNK2B image.jpg {November 5, 2007 9:22:35 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 5, 2007 9:23:02 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CSNK2B_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1jwh.
| PDB = {{PDB2|1jwh}}, {{PDB2|1qf8}}, {{PDB2|1rqf}}
| Name = Casein kinase 2, beta polypeptide
| HGNCid = 2460
| Symbol = CSNK2B
| AltSymbols =; CK2B; CK2N; CSK2B; G5A; MGC138222; MGC138224
| OMIM = 115441
| ECnumber =
| Homologene = 55572
| MGIid = 88548
| GeneAtlas_image1 = PBB_GE_CSNK2B_201390_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004682 |text = protein kinase CK2 activity}} {{GNF_GO|id=GO:0008605 |text = protein kinase CK2 regulator activity}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005956 |text = protein kinase CK2 complex}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0016055 |text = Wnt receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1460
| Hs_Ensembl = ENSG00000206300
| Hs_RefseqProtein = NP_001311
| Hs_RefseqmRNA = NM_001320
| Hs_GenLoc_db =
| Hs_GenLoc_chr = c6_COX
| Hs_GenLoc_start = 31768327
| Hs_GenLoc_end = 31775955
| Hs_Uniprot = P67870
| Mm_EntrezGene = 13001
| Mm_Ensembl = ENSMUSG00000024387
| Mm_RefseqmRNA = NM_009975
| Mm_RefseqProtein = NP_034105
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 34724251
| Mm_GenLoc_end = 34729503
| Mm_Uniprot = P67871
}}
}}
'''Casein kinase 2, beta polypeptide''', also known as '''CSNK2B''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus.<ref>{{cite web | title = Entrez Gene: CSNK2B casein kinase 2, beta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1460| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on CYP3A4... {November 5, 2007 9:23:02 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein CYP3A4 image.jpg {November 5, 2007 9:24:25 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 5, 2007 9:24:55 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CYP3A4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1tqn.
| PDB = {{PDB2|1tqn}}, {{PDB2|1w0e}}, {{PDB2|1w0f}}, {{PDB2|1w0g}}, {{PDB2|2j0c}}, {{PDB2|2j0d}}
| Name = Cytochrome P450, family 3, subfamily A, polypeptide 4
| HGNCid = 2637
| Symbol = CYP3A4
| AltSymbols =; CYP3A; CP33; CP34; CYP3A3; HLP; MGC126680; NF-25; P450C3; P450PCN1
| OMIM = 124010
| ECnumber =
| Homologene = 88816
| MGIid =
| GeneAtlas_image1 = PBB_GE_CYP3A4_205999_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_CYP3A4_205998_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_CYP3A4_208367_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004497 |text = monooxygenase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0016712 |text = oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen}} {{GNF_GO|id=GO:0019825 |text = oxygen binding}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0050381 |text = unspecific monooxygenase activity}} {{GNF_GO|id=GO:0050591 |text = quinine 3-monooxygenase activity}} {{GNF_GO|id=GO:0050649 |text = testosterone 6-beta-hydroxylase activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006805 |text = xenobiotic metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1576
| Hs_Ensembl = ENSG00000160868
| Hs_RefseqProtein = NP_059488
| Hs_RefseqmRNA = NM_017460
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 99083437
| Hs_GenLoc_end = 99219744
| Hs_Uniprot = P05184
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Cytochrome P450, family 3, subfamily A, polypeptide 4''', also known as '''CYP3A4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene, CYP3A4, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4.<ref>{{cite web | title = Entrez Gene: CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1576| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Smith G, Stubbins MJ, Harries LW, Wolf CR |title=Molecular genetics of the human cytochrome P450 monooxygenase superfamily. |journal=Xenobiotica |volume=28 |issue= 12 |pages= 1129-65 |year= 1999 |pmid= 9890157 |doi= }}
*{{cite journal | author=Guengerich FP |title=Cytochrome P-450 3A4: regulation and role in drug metabolism. |journal=Annu. Rev. Pharmacol. Toxicol. |volume=39 |issue= |pages= 1-17 |year= 1999 |pmid= 10331074 |doi= 10.1146/annurev.pharmtox.39.1.1 }}
*{{cite journal | author=Zhou S, Chan E, Pan SQ, ''et al.'' |title=Pharmacokinetic interactions of drugs with St John's wort. |journal=J. Psychopharmacol. (Oxford) |volume=18 |issue= 2 |pages= 262-76 |year= 2004 |pmid= 15260917 |doi= 10.1177/0269881104042632 }}
*{{cite journal | author=Lee SJ, Goldstein JA |title=Functionally defective or altered CYP3A4 and CYP3A5 single nucleotide polymorphisms and their detection with genotyping tests. |journal=Pharmacogenomics |volume=6 |issue= 4 |pages= 357-71 |year= 2006 |pmid= 16004554 |doi= 10.1517/14622416.6.4.357 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on EIF2AK2... {November 5, 2007 9:37:12 AM PST} UPLOAD : Added new Image to wiki: {November 5, 2007 9:38:23 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 5, 2007 9:38:41 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_EIF2AK2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1qu6.
| PDB = {{PDB2|1qu6}}, {{PDB2|2a19}}, {{PDB2|2a1a}}
| Name = Eukaryotic translation initiation factor 2-alpha kinase 2
| HGNCid = 9437
| Symbol = EIF2AK2
| AltSymbols =; EIF2AK1; MGC126524; PKR; PRKR
| OMIM = 176871
| ECnumber =
| Homologene = 48134
| MGIid = 1353449
| GeneAtlas_image1 = PBB_GE_EIF2AK2_204211_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_EIF2AK2_213294_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003725 |text = double-stranded RNA binding}} {{GNF_GO|id=GO:0004672 |text = protein kinase activity}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004694 |text = eukaryotic translation initiation factor 2alpha kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008601 |text = protein phosphatase type 2A regulator activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006412 |text = translation}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006926 |text = virus-infected cell apoptosis}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0009615 |text = response to virus}} {{GNF_GO|id=GO:0030968 |text = unfolded protein response}} {{GNF_GO|id=GO:0046777 |text = protein amino acid autophosphorylation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5610
| Hs_Ensembl = ENSG00000055332
| Hs_RefseqProtein = NP_002750
| Hs_RefseqmRNA = NM_002759
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 37179857
| Hs_GenLoc_end = 37405184
| Hs_Uniprot = P19525
| Mm_EntrezGene = 19106
| Mm_Ensembl = ENSMUSG00000024079
| Mm_RefseqmRNA = NM_011163
| Mm_RefseqProtein = NP_035293
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 78757622
| Mm_GenLoc_end = 78787630
| Mm_Uniprot = Q78E06
}}
}}
'''Eukaryotic translation initiation factor 2-alpha kinase 2''', also known as '''EIF2AK2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Williams BR |title=PKR; a sentinel kinase for cellular stress. |journal=Oncogene |volume=18 |issue= 45 |pages= 6112-20 |year= 1999 |pmid= 10557102 |doi= 10.1038/sj.onc.1203127 }}
*{{cite journal | author=García MA, Meurs EF, Esteban M |title=The dsRNA protein kinase PKR: virus and cell control. |journal=Biochimie |volume=89 |issue= 6-7 |pages= 799-811 |year= 2007 |pmid= 17451862 |doi= 10.1016/j.biochi.2007.03.001 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on F2R... {November 5, 2007 9:24:55 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 5, 2007 9:25:48 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Coagulation factor II (thrombin) receptor
| HGNCid = 3537
| Symbol = F2R
| AltSymbols =; CF2R; HTR; PAR1; TR
| OMIM = 187930
| ECnumber =
| Homologene = 1510
| MGIid = 101802
| GeneAtlas_image1 = PBB_GE_F2R_203989_x_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0015057 |text = thrombin receptor activity}}
| Component = {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006919 |text = caspase activation}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007260 |text = tyrosine phosphorylation of STAT protein}} {{GNF_GO|id=GO:0007262 |text = STAT protein nuclear translocation}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}} {{GNF_GO|id=GO:0009611 |text = response to wounding}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}} {{GNF_GO|id=GO:0043123 |text = positive regulation of I-kappaB kinase/NF-kappaB cascade}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2149
| Hs_Ensembl = ENSG00000181104
| Hs_RefseqProtein = NP_001983
| Hs_RefseqmRNA = NM_001992
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 76047542
| Hs_GenLoc_end = 76067054
| Hs_Uniprot = P25116
| Mm_EntrezGene = 14062
| Mm_Ensembl = ENSMUSG00000048376
| Mm_RefseqmRNA = NM_010169
| Mm_RefseqProtein = NP_034299
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 96702488
| Mm_GenLoc_end = 96719173
| Mm_Uniprot = Q3UK34
}}
}}
'''Coagulation factor II (thrombin) receptor''', also known as '''F2R''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member.<ref>{{cite web | title = Entrez Gene: F2R coagulation factor II (thrombin) receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2149| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Coughlin SR, Vu TK, Hung DT, Wheaton VI |title=Characterization of a functional thrombin receptor. Issues and opportunities. |journal=J. Clin. Invest. |volume=89 |issue= 2 |pages= 351-5 |year= 1992 |pmid= 1310691 |doi= }}
*{{cite journal | author=Howell DC, Laurent GJ, Chambers RC |title=Role of thrombin and its major cellular receptor, protease-activated receptor-1, in pulmonary fibrosis. |journal=Biochem. Soc. Trans. |volume=30 |issue= 2 |pages= 211-6 |year= 2002 |pmid= 12023853 |doi= 10.1042/ }}
*{{cite journal | author=Tellez C, Bar-Eli M |title=Role and regulation of the thrombin receptor (PAR-1) in human melanoma. |journal=Oncogene |volume=22 |issue= 20 |pages= 3130-7 |year= 2003 |pmid= 12789289 |doi= 10.1038/sj.onc.1206453 }}
*{{cite journal | author=Remillard CV, Yuan JX |title=PGE2 and PAR-1 in pulmonary fibrosis: a case of biting the hand that feeds you? |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=288 |issue= 5 |pages= L789-92 |year= 2005 |pmid= 15821019 |doi= 10.1152/ajplung.00016.2005 }}
*{{cite journal | author=Leger AJ, Covic L, Kuliopulos A |title=Protease-activated receptors in cardiovascular diseases. |journal=Circulation |volume=114 |issue= 10 |pages= 1070-7 |year= 2006 |pmid= 16952995 |doi= 10.1161/CIRCULATIONAHA.105.574830 }}
*{{cite journal | author=Traynelis SF, Trejo J |title=Protease-activated receptor signaling: new roles and regulatory mechanisms. |journal=Curr. Opin. Hematol. |volume=14 |issue= 3 |pages= 230-5 |year= 2007 |pmid= 17414212 |doi= 10.1097/MOH.0b013e3280dce568 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on FGA... {November 5, 2007 9:25:48 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein FGA image.jpg {November 5, 2007 9:26:44 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 5, 2007 9:29:12 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FGA_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1fza.
| PDB = {{PDB2|1fza}}, {{PDB2|1fzb}}, {{PDB2|1fzc}}, {{PDB2|1fzd}}, {{PDB2|1fze}}, {{PDB2|1fzf}}, {{PDB2|1fzg}}, {{PDB2|1lt9}}, {{PDB2|1ltj}}, {{PDB2|1n86}}, {{PDB2|1n8e}}, {{PDB2|1re3}}, {{PDB2|1re4}}, {{PDB2|1rf0}}, {{PDB2|1rf1}}, {{PDB2|2a45}}, {{PDB2|2ffd}}, {{PDB2|2h43}}, {{PDB2|2hod}}, {{PDB2|2hpc}}, {{PDB2|2oyh}}, {{PDB2|2oyi}}
| Name = Fibrinogen alpha chain
| HGNCid = 3661
| Symbol = FGA
| AltSymbols =; Fib2; MGC119422; MGC119423; MGC119425
| OMIM = 134820
| ECnumber =
| Homologene = 428
| MGIid = 1316726
| GeneAtlas_image1 = PBB_GE_FGA_205650_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_FGA_205649_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0030674 |text = protein binding, bridging}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005577 |text = fibrinogen complex}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008217 |text = blood pressure regulation}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0030168 |text = platelet activation}} {{GNF_GO|id=GO:0051258 |text = protein polymerization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2243
| Hs_Ensembl = ENSG00000171560
| Hs_RefseqProtein = NP_000499
| Hs_RefseqmRNA = NM_000508
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 155723730
| Hs_GenLoc_end = 155731347
| Hs_Uniprot = P02671
| Mm_EntrezGene = 14161
| Mm_Ensembl = ENSMUSG00000028001
| Mm_RefseqmRNA = NM_010196
| Mm_RefseqProtein = NP_034326
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 83112081
| Mm_GenLoc_end = 83118197
| Mm_Uniprot =
}}
}}
'''Fibrinogen alpha chain''', also known as '''FGA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus.<ref>{{cite web | title = Entrez Gene: FGA fibrinogen alpha chain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2243| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Doolittle RF |title=Fibrinogen and fibrin. |journal=Annu. Rev. Biochem. |volume=53 |issue= |pages= 195-229 |year= 1984 |pmid= 6383194 |doi= 10.1146/annurev.bi.53.070184.001211 }}
*{{cite journal | author=Galanakis DK |title=Inherited dysfibrinogenemia: emerging abnormal structure associations with pathologic and nonpathologic dysfunctions. |journal=Semin. Thromb. Hemost. |volume=19 |issue= 4 |pages= 386-95 |year= 1994 |pmid= 8140431 |doi= }}
*{{cite journal | author=Herrick S, Blanc-Brude O, Gray A, Laurent G |title=Fibrinogen. |journal=Int. J. Biochem. Cell Biol. |volume=31 |issue= 7 |pages= 741-6 |year= 1999 |pmid= 10467729 |doi= }}
*{{cite journal | author=Bennett JS |title=Platelet-fibrinogen interactions. |journal=Ann. N. Y. Acad. Sci. |volume=936 |issue= |pages= 340-54 |year= 2001 |pmid= 11460491 |doi= }}
*{{cite journal | author=Redman CM, Xia H |title=Fibrinogen biosynthesis. Assembly, intracellular degradation, and association with lipid synthesis and secretion. |journal=Ann. N. Y. Acad. Sci. |volume=936 |issue= |pages= 480-95 |year= 2001 |pmid= 11460506 |doi= }}
*{{cite journal | author=Matsuda M, Sugo T |title=Structure and function of human fibrinogen inferred from dysfibrinogens. |journal=Int. J. Hematol. |volume=76 Suppl 1 |issue= |pages= 352-60 |year= 2003 |pmid= 12430881 |doi= }}
*{{cite journal | author=Everse SJ |title=New insights into fibrin (ogen) structure and function. |journal=Vox Sang. |volume=83 Suppl 1 |issue= |pages= 375-82 |year= 2003 |pmid= 12617173 |doi= }}
*{{cite journal | author=Scott EM, Ariëns RA, Grant PJ |title=Genetic and environmental determinants of fibrin structure and function: relevance to clinical disease. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=24 |issue= 9 |pages= 1558-66 |year= 2005 |pmid= 15217804 |doi= 10.1161/01.ATV.0000136649.83297.bf }}
*{{cite journal | author=Lord ST |title=Fibrinogen and fibrin: scaffold proteins in hemostasis. |journal=Curr. Opin. Hematol. |volume=14 |issue= 3 |pages= 236-41 |year= 2007 |pmid= 17414213 |doi= 10.1097/MOH.0b013e3280dce58c }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on GP1BA... {November 5, 2007 9:29:12 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein GP1BA image.jpg {November 5, 2007 9:29:47 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 5, 2007 9:30:07 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GP1BA_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gwb.
| PDB = {{PDB2|1gwb}}, {{PDB2|1m0z}}, {{PDB2|1m10}}, {{PDB2|1ook}}, {{PDB2|1p8v}}, {{PDB2|1p9a}}, {{PDB2|1qyy}}, {{PDB2|1sq0}}, {{PDB2|1u0n}}
| Name = Glycoprotein Ib (platelet), alpha polypeptide
| HGNCid = 4439
| Symbol = GP1BA
| AltSymbols =; BSS; CD42B; CD42b-alpha; GP1B; MGC34595
| OMIM = 606672
| ECnumber =
| Homologene = 143
| MGIid = 1333744
| GeneAtlas_image1 = PBB_GE_GP1BA_207389_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0015057 |text = thrombin receptor activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0000902 |text = cell morphogenesis}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0030168 |text = platelet activation}} {{GNF_GO|id=GO:0030193 |text = regulation of blood coagulation}} {{GNF_GO|id=GO:0042730 |text = fibrinolysis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2811
| Hs_Ensembl = ENSG00000185245
| Hs_RefseqProtein = NP_000164
| Hs_RefseqmRNA = NM_000173
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 4776680
| Hs_GenLoc_end = 4778599
| Hs_Uniprot = P07359
| Mm_EntrezGene = 14723
| Mm_Ensembl = ENSMUSG00000050675
| Mm_RefseqmRNA = NM_010326
| Mm_RefseqProtein = NP_034456
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 70455317
| Mm_GenLoc_end = 70458253
| Mm_Uniprot = O35930
}}
}}
'''Glycoprotein Ib (platelet), alpha polypeptide''', also known as '''GP1BA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that are linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.<ref>{{cite web | title = Entrez Gene: GP1BA glycoprotein Ib (platelet), alpha polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2811| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kunishima S, Kamiya T, Saito H |title=Genetic abnormalities of Bernard-Soulier syndrome. |journal=Int. J. Hematol. |volume=76 |issue= 4 |pages= 319-27 |year= 2003 |pmid= 12463594 |doi= }}
*{{cite journal | author=Du X |title=Signaling and regulation of the platelet glycoprotein Ib-IX-V complex. |journal=Curr. Opin. Hematol. |volume=14 |issue= 3 |pages= 262-9 |year= 2007 |pmid= 17414217 |doi= 10.1097/MOH.0b013e3280dce51a }}
*{{cite journal | author=Clemetson KJ |title=A short history of platelet glycoprotein Ib complex. |journal=Thromb. Haemost. |volume=98 |issue= 1 |pages= 63-8 |year= 2007 |pmid= 17597992 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on HBG1... {November 5, 2007 9:30:07 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein HBG1 image.jpg {November 5, 2007 9:30:27 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 5, 2007 9:30:45 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_HBG1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1fdh.
| PDB = {{PDB2|1fdh}}, {{PDB2|1i3d}}, {{PDB2|1i3e}}
| Name = Hemoglobin, gamma A
| HGNCid = 4831
| Symbol = HBG1
| AltSymbols =; HBGA; HBGR; HSGGL1; PRO2979
| OMIM = 142200
| ECnumber =
| Homologene = 73883
| MGIid = 96024
| Function = {{GNF_GO|id=GO:0005344 |text = oxygen transporter activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0019825 |text = oxygen binding}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005833 |text = hemoglobin complex}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0015671 |text = oxygen transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3047
| Hs_Ensembl =
| Hs_RefseqProtein = NP_000550
| Hs_RefseqmRNA = NM_000559
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 15132
| Mm_Ensembl = ENSMUSG00000052217
| Mm_RefseqmRNA = XM_993220
| Mm_RefseqProtein = XP_998314
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 103715459
| Mm_GenLoc_end = 103716983
| Mm_Uniprot = Q3TUN7
}}
}}
'''Hemoglobin, gamma A''', also known as '''HBG1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.<ref>{{cite web | title = Entrez Gene: HBG1 hemoglobin, gamma A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3047| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Huisman TH, Kutlar F, Gu LH |title=Gamma chain abnormalities and gamma-globin gene rearrangements in newborn babies of various populations. |journal=Hemoglobin |volume=15 |issue= 5 |pages= 349-79 |year= 1992 |pmid= 1802881 |doi= }}
*{{cite journal | author=Gelinas R, Yagi M, Endlich B, ''et al.'' |title=Sequences of G gamma, A gamma, and beta genes of the Greek (A gamma) HPFH mutant: evidence for a distal CCAAT box mutation in the A gamma gene. |journal=Prog. Clin. Biol. Res. |volume=191 |issue= |pages= 125-39 |year= 1985 |pmid= 2413469 |doi= }}
*{{cite journal | author=Higgs DR, Vickers MA, Wilkie AO, ''et al.'' |title=A review of the molecular genetics of the human alpha-globin gene cluster. |journal=Blood |volume=73 |issue= 5 |pages= 1081-104 |year= 1989 |pmid= 2649166 |doi= }}
*{{cite journal | author=Giardina B, Messana I, Scatena R, Castagnola M |title=The multiple functions of hemoglobin. |journal=Crit. Rev. Biochem. Mol. Biol. |volume=30 |issue= 3 |pages= 165-96 |year= 1995 |pmid= 7555018 |doi= }}
*{{cite journal | author=Anderson NL, Anderson NG |title=The human plasma proteome: history, character, and diagnostic prospects. |journal=Mol. Cell Proteomics |volume=1 |issue= 11 |pages= 845-67 |year= 2003 |pmid= 12488461 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on HCK... {November 5, 2007 9:30:45 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein HCK image.jpg {November 5, 2007 9:31:19 AM PST} CREATE : Found no pages, creating new page. {November 5, 2007 9:32:04 AM PST} CREATED : Created new protein page: HCK {November 5, 2007 9:32:13 AM PST} INFO : Beginning work on HSPD1... {November 5, 2007 9:32:13 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 5, 2007 9:33:27 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Heat shock 60kDa protein 1 (chaperonin)
| HGNCid = 5261
| Symbol = HSPD1
| AltSymbols =; CPN60; GROEL; HSP60; HSP65; HuCHA60; SPG13
| OMIM = 118190
| ECnumber =
| Homologene = 86105
| MGIid = 96242
| GeneAtlas_image1 = PBB_GE_HSPD1_200807_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_HSPD1_200806_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0051082 |text = unfolded protein binding}} {{GNF_GO|id=GO:0051087 |text = chaperone binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}}
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0006986 |text = response to unfolded protein}} {{GNF_GO|id=GO:0030150 |text = protein import into mitochondrial matrix}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}} {{GNF_GO|id=GO:0044267 |text = cellular protein metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3329
| Hs_Ensembl = ENSG00000144381
| Hs_RefseqProtein = NP_002147
| Hs_RefseqmRNA = NM_002156
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 198059555
| Hs_GenLoc_end = 198073243
| Hs_Uniprot = P10809
| Mm_EntrezGene = 15510
| Mm_Ensembl = ENSMUSG00000025980
| Mm_RefseqmRNA = NM_010477
| Mm_RefseqProtein = NP_034607
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 55022380
| Mm_GenLoc_end = 55032390
| Mm_Uniprot = Q3KQP2
}}
}}
'''Heat shock 60kDa protein 1 (chaperonin)''', also known as '''HSPD1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Two pseudogenes, both located on chromosome 8, have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13.<ref>{{cite web | title = Entrez Gene: HSPD1 heat shock 60kDa protein 1 (chaperonin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3329| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Tabibzadeh S, Broome J |title=Heat shock proteins in human endometrium throughout the menstrual cycle. |journal=Infectious diseases in obstetrics and gynecology |volume=7 |issue= 1-2 |pages= 5-9 |year= 1999 |pmid= 10231001 |doi= }}
*{{cite journal | author=Schäfer C, Williams JA |title=Stress kinases and heat shock proteins in the pancreas: possible roles in normal function and disease. |journal=J. Gastroenterol. |volume=35 |issue= 1 |pages= 1-9 |year= 2000 |pmid= 10632533 |doi= }}
*{{cite journal | author=Moseley P |title=Stress proteins and the immune response. |journal=Immunopharmacology |volume=48 |issue= 3 |pages= 299-302 |year= 2000 |pmid= 10960671 |doi= }}
*{{cite journal | author=Liu Y, Steinacker JM |title=Changes in skeletal muscle heat shock proteins: pathological significance. |journal=Front. Biosci. |volume=6 |issue= |pages= D12-25 |year= 2001 |pmid= 11145923 |doi= }}
*{{cite journal | author=Van Maele B, Debyser Z |title=HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins. |journal=AIDS reviews |volume=7 |issue= 1 |pages= 26-43 |year= 2005 |pmid= 15875659 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on LEPR... {November 5, 2007 9:33:27 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 5, 2007 9:33:51 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Leptin receptor
| HGNCid = 6554
| Symbol = LEPR
| AltSymbols =; CD295; OBR
| OMIM = 601007
| ECnumber =
| Homologene = 1731
| MGIid = 104993
| Function = {{GNF_GO|id=GO:0004896 |text = hematopoietin/interferon-class (D200-domain) cytokine receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006112 |text = energy reserve metabolic process}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3953
| Hs_Ensembl =
| Hs_RefseqProtein = NP_001003679
| Hs_RefseqmRNA = NM_001003679
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 16847
| Mm_Ensembl = ENSMUSG00000057722
| Mm_RefseqmRNA = NM_010704
| Mm_RefseqProtein = NP_034834
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 101215336
| Mm_GenLoc_end = 101313489
| Mm_Uniprot = P48356
}}
}}
'''Leptin receptor''', also known as '''LEPR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Leptin (LEP; MIM 164160), an adipocyte-specific hormone that regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure, acts through the leptin receptor (LEPR), a single-transmembrane-domain receptor of the cytokine receptor family.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: LEPR leptin receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3953| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Heshka JT, Jones PJ |title=A role for dietary fat in leptin receptor, OB-Rb, function. |journal=Life Sci. |volume=69 |issue= 9 |pages= 987-1003 |year= 2001 |pmid= 11508653 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on MPO... {November 5, 2007 9:33:51 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein MPO image.jpg {November 5, 2007 9:34:43 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 5, 2007 9:34:59 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MPO_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cxp.
| PDB = {{PDB2|1cxp}}, {{PDB2|1d2v}}, {{PDB2|1d5l}}, {{PDB2|1d7w}}, {{PDB2|1dnu}}, {{PDB2|1dnw}}, {{PDB2|1mhl}}, {{PDB2|1myp}}
| Name = Myeloperoxidase
| HGNCid = 7218
| Symbol = MPO
| AltSymbols =;
| OMIM = 606989
| ECnumber =
| Homologene = 55450
| MGIid = 97137
| GeneAtlas_image1 = PBB_GE_MPO_203948_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_MPO_203949_at_tn.png
| Function = {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0004601 |text = peroxidase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005764 |text = lysosome}}
| Process = {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0006979 |text = response to oxidative stress}} {{GNF_GO|id=GO:0042744 |text = hydrogen peroxide catabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4353
| Hs_Ensembl = ENSG00000005381
| Hs_RefseqProtein = NP_000241
| Hs_RefseqmRNA = NM_000250
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 53702201
| Hs_GenLoc_end = 53713281
| Hs_Uniprot = P05164
| Mm_EntrezGene = 17523
| Mm_Ensembl = ENSMUSG00000009350
| Mm_RefseqmRNA = NM_010824
| Mm_RefseqProtein = NP_034954
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 87609776
| Mm_GenLoc_end = 87620592
| Mm_Uniprot = Q571G0
}}
}}
'''Myeloperoxidase''', also known as '''MPO''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils.<ref>{{cite web | title = Entrez Gene: MPO myeloperoxidase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4353| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Arnhold J |title=Properties, functions, and secretion of human myeloperoxidase. |journal=Biochemistry Mosc. |volume=69 |issue= 1 |pages= 4-9 |year= 2004 |pmid= 14972011 |doi= }}
*{{cite journal | author=Suzuki K, Okazaki T |title=Contribution of myeloperoxidase in vasculitis development. |journal=Jpn. J. Infect. Dis. |volume=57 |issue= 5 |pages= S2-3 |year= 2005 |pmid= 15507759 |doi= }}
*{{cite journal | author=Nicholls SJ, Hazen SL |title=The role of myeloperoxidase in the pathogenesis of coronary artery disease. |journal=Jpn. J. Infect. Dis. |volume=57 |issue= 5 |pages= S21-2 |year= 2005 |pmid= 15507760 |doi= }}
*{{cite journal | author=Nauseef WM |title=Lessons from MPO deficiency about functionally important structural features. |journal=Jpn. J. Infect. Dis. |volume=57 |issue= 5 |pages= S4-5 |year= 2005 |pmid= 15507769 |doi= }}
*{{cite journal | author=Williams J, Hewins P, Savage C |title=The influence of autoantibodies to myeloperoxidase on neutrophil function and intracellular signaling. |journal=Jpn. J. Infect. Dis. |volume=57 |issue= 5 |pages= S5-6 |year= 2005 |pmid= 15507770 |doi= }}
*{{cite journal | author=Schmitt WH |title=Newer insights into the aetiology and pathogenesis of myeloperoxidase associated autoimmunity. |journal=Jpn. J. Infect. Dis. |volume=57 |issue= 5 |pages= S7-8 |year= 2005 |pmid= 15507771 |doi= }}
*{{cite journal | author=Taioli E, Benhamou S, Bouchardy C, ''et al.'' |title=Myeloperoxidase G-463A polymorphism and lung cancer: a HuGE genetic susceptibility to environmental carcinogens pooled analysis. |journal=Genet. Med. |volume=9 |issue= 2 |pages= 67-73 |year= 2007 |pmid= 17304047 |doi= 10.1097/GIM.0b013e31803068b1 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on PCAF... {November 5, 2007 9:44:22 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein PCAF image.jpg {November 5, 2007 9:45:06 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 5, 2007 9:45:18 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PCAF_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cm0.
| PDB = {{PDB2|1cm0}}, {{PDB2|1jm4}}, {{PDB2|1n72}}, {{PDB2|1wug}}, {{PDB2|1wum}}, {{PDB2|1zs5}}
| Name = P300/CBP-associated factor
| HGNCid = 8638
| Symbol = PCAF
| AltSymbols =; P; CAF; P/CAF
| OMIM = 602303
| ECnumber =
| Homologene = 20834
| MGIid = 1343094
| GeneAtlas_image1 = PBB_GE_PCAF_203845_at_tn.png
| Function = {{GNF_GO|id=GO:0003712 |text = transcription cofactor activity}} {{GNF_GO|id=GO:0004402 |text = histone acetyltransferase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008080 |text = N-acetyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0042826 |text = histone deacetylase binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006338 |text = chromatin remodeling}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006473 |text = protein amino acid acetylation}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8850
| Hs_Ensembl = ENSG00000114166
| Hs_RefseqProtein = XP_001130666
| Hs_RefseqmRNA = XM_001130666
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 20056528
| Hs_GenLoc_end = 20170887
| Hs_Uniprot = Q92831
| Mm_EntrezGene = 18519
| Mm_Ensembl = ENSMUSG00000000708
| Mm_RefseqmRNA = XM_001003318
| Mm_RefseqProtein = XP_001003318
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 53032244
| Mm_GenLoc_end = 53137649
| Mm_Uniprot =
}}
}}
'''P300/CBP-associated factor''', also known as '''PCAF''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.<ref>{{cite web | title = Entrez Gene: PCAF p300/CBP-associated factor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8850| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Marcello A, Zoppé M, Giacca M |title=Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator. |journal=IUBMB Life |volume=51 |issue= 3 |pages= 175-81 |year= 2002 |pmid= 11547919 |doi= }}
*{{cite journal | author=Ott M, Dorr A, Hetzer-Egger C, ''et al.'' |title=Tat acetylation: a regulatory switch between early and late phases in HIV transcription elongation. |journal=Novartis Found. Symp. |volume=259 |issue= |pages= 182-93; discussion 193-6, 223-5 |year= 2004 |pmid= 15171254 |doi= }}
*{{cite journal | author=Liou LY, Herrmann CH, Rice AP |title=HIV-1 infection and regulation of Tat function in macrophages. |journal=Int. J. Biochem. Cell Biol. |volume=36 |issue= 9 |pages= 1767-75 |year= 2005 |pmid= 15183343 |doi= 10.1016/j.biocel.2004.02.018 }}
*{{cite journal | author=Gibellini D, Vitone F, Schiavone P, Re MC |title=HIV-1 tat protein and cell proliferation and survival: a brief review. |journal=New Microbiol. |volume=28 |issue= 2 |pages= 95-109 |year= 2005 |pmid= 16035254 |doi= }}
*{{cite journal | author=Hetzer C, Dormeyer W, Schnölzer M, Ott M |title=Decoding Tat: the biology of HIV Tat posttranslational modifications. |journal=Microbes Infect. |volume=7 |issue= 13 |pages= 1364-9 |year= 2006 |pmid= 16046164 |doi= 10.1016/j.micinf.2005.06.003 }}
*{{cite journal | author=Peruzzi F |title=The multiple functions of HIV-1 Tat: proliferation versus apoptosis. |journal=Front. Biosci. |volume=11 |issue= |pages= 708-17 |year= 2006 |pmid= 16146763 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on PIK3CA... {November 5, 2007 9:36:19 AM PST} SEARCH REDIRECT : Control Box Found: PIK3R1 {November 5, 2007 9:37:04 AM PST} UPDATE PROTEIN BOX : Updating Protein Box, No errors. {November 5, 2007 9:37:06 AM PST} UPDATE SUMMARY : Updating Summary, No Errors. {November 5, 2007 9:37:06 AM PST} UPDATE CITATIONS : Updating Citations, No Errors. {November 5, 2007 9:37:06 AM PST} UPDATED : Updated protein page: PIK3R1 {November 5, 2007 9:37:12 AM PST} INFO : Beginning work on RAD51... {November 5, 2007 9:38:41 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein RAD51 image.jpg {November 5, 2007 9:39:34 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 5, 2007 9:39:59 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_RAD51_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1b22.
| PDB = {{PDB2|1b22}}, {{PDB2|1n0w}}
| Name = RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)
| HGNCid = 9817
| Symbol = RAD51
| AltSymbols =; BRCC5; HRAD51; HsRad51; HsT16930; RAD51A; RECA
| OMIM = 179617
| ECnumber =
| Homologene = 2155
| MGIid = 97890
| GeneAtlas_image1 = PBB_GE_RAD51_205024_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_RAD51_205023_at_tn.png
| Function = {{GNF_GO|id=GO:0000150 |text = recombinase activity}} {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003684 |text = damaged DNA binding}} {{GNF_GO|id=GO:0003690 |text = double-stranded DNA binding}} {{GNF_GO|id=GO:0003697 |text = single-stranded DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008094 |text = DNA-dependent ATPase activity}} {{GNF_GO|id=GO:0016887 |text = ATPase activity}} {{GNF_GO|id=GO:0017111 |text = nucleoside-triphosphatase activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}} {{GNF_GO|id=GO:0043142 |text = single-stranded DNA-dependent ATPase activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0000795 |text = synaptonemal complex}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000724 |text = double-strand break repair via homologous recombination}} {{GNF_GO|id=GO:0006268 |text = DNA unwinding during replication}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006312 |text = mitotic recombination}} {{GNF_GO|id=GO:0007126 |text = meiosis}} {{GNF_GO|id=GO:0007131 |text = meiotic recombination}} {{GNF_GO|id=GO:0051106 |text = positive regulation of DNA ligation}} {{GNF_GO|id=GO:0051260 |text = protein homooligomerization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5888
| Hs_Ensembl = ENSG00000051180
| Hs_RefseqProtein = NP_002866
| Hs_RefseqmRNA = NM_002875
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 38774661
| Hs_GenLoc_end = 38811646
| Hs_Uniprot = Q06609
| Mm_EntrezGene = 19361
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_011234
| Mm_RefseqProtein = NP_035364
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)''', also known as '''RAD51''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. Transcript variants utilizing alternative polyA signals exist.<ref>{{cite web | title = Entrez Gene: RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5888| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Daniel DC |title=Highlight: BRCA1 and BRCA2 proteins in breast cancer. |journal=Microsc. Res. Tech. |volume=59 |issue= 1 |pages= 68-83 |year= 2002 |pmid= 12242698 |doi= 10.1002/jemt.10178 }}
*{{cite journal | author=Henning W, Stürzbecher HW |title=Homologous recombination and cell cycle checkpoints: Rad51 in tumour progression and therapy resistance. |journal=Toxicology |volume=193 |issue= 1-2 |pages= 91-109 |year= 2003 |pmid= 14599770 |doi= }}
*{{cite journal | author=Hasselbach L, Haase S, Fischer D, ''et al.'' |title=Characterisation of the promoter region of the human DNA-repair gene Rad51. |journal=Eur. J. Gynaecol. Oncol. |volume=26 |issue= 6 |pages= 589-98 |year= 2006 |pmid= 16398215 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on SERPINC1... {November 5, 2007 9:16:38 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein SERPINC1 image.jpg {November 5, 2007 9:17:16 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 5, 2007 9:17:31 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SERPINC1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ant.
| PDB = {{PDB2|1ant}}, {{PDB2|1ath}}, {{PDB2|1azx}}, {{PDB2|1br8}}, {{PDB2|1dzg}}, {{PDB2|1dzh}}, {{PDB2|1e03}}, {{PDB2|1e04}}, {{PDB2|1e05}}, {{PDB2|1jvq}}, {{PDB2|1lk6}}, {{PDB2|1nq9}}, {{PDB2|1oyh}}, {{PDB2|1r1l}}, {{PDB2|1sr5}}, {{PDB2|1t1f}}, {{PDB2|1tb6}}, {{PDB2|2ant}}, {{PDB2|2b4x}}, {{PDB2|2b5t}}, {{PDB2|2beh}}, {{PDB2|2gd4}}
| Name = Serpin peptidase inhibitor, clade C (antithrombin), member 1
| HGNCid = 775
| Symbol = SERPINC1
| AltSymbols =; AT3; ATIII; MGC22579
| OMIM = 107300
| ECnumber =
| Homologene = 20139
| MGIid = 88095
| GeneAtlas_image1 = PBB_GE_SERPINC1_210049_at_tn.png
| Function = {{GNF_GO|id=GO:0004867 |text = serine-type endopeptidase inhibitor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008201 |text = heparin binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0007596 |text = blood coagulation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 462
| Hs_Ensembl = ENSG00000117601
| Hs_RefseqProtein = NP_000479
| Hs_RefseqmRNA = NM_000488
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 172139562
| Hs_GenLoc_end = 172153139
| Hs_Uniprot = P01008
| Mm_EntrezGene = 11905
| Mm_Ensembl = ENSMUSG00000026715
| Mm_RefseqmRNA = NM_080844
| Mm_RefseqProtein = NP_543120
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 162815323
| Mm_GenLoc_end = 162839687
| Mm_Uniprot = Q543J5
}}
}}
'''Serpin peptidase inhibitor, clade C (antithrombin), member 1''', also known as '''SERPINC1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Blajchman MA, Austin RC, Fernandez-Rachubinski F, Sheffield WP |title=Molecular basis of inherited human antithrombin deficiency. |journal=Blood |volume=80 |issue= 9 |pages= 2159-71 |year= 1992 |pmid= 1421387 |doi= }}
*{{cite journal | author=Mourey L, Samama JP, Delarue M, ''et al.'' |title=Antithrombin III: structural and functional aspects. |journal=Biochimie |volume=72 |issue= 8 |pages= 599-608 |year= 1991 |pmid= 2126464 |doi= }}
*{{cite journal | author=Hultin MB, McKay J, Abildgaard U |title=Antithrombin Oslo: type Ib classification of the first reported antithrombin-deficient family, with a review of hereditary antithrombin variants. |journal=Thromb. Haemost. |volume=59 |issue= 3 |pages= 468-73 |year= 1988 |pmid= 3055413 |doi= }}
*{{cite journal | author=Stein PE, Carrell RW |title=What do dysfunctional serpins tell us about molecular mobility and disease? |journal=Nat. Struct. Biol. |volume=2 |issue= 2 |pages= 96-113 |year= 1995 |pmid= 7749926 |doi= }}
*{{cite journal | author=Perry DJ, Carrell RW |title=Molecular genetics of human antithrombin deficiency. |journal=Hum. Mutat. |volume=7 |issue= 1 |pages= 7-22 |year= 1996 |pmid= 8664906 |doi= 10.1002/(SICI)1098-1004(1996)7:1<7::AID-HUMU2>3.0.CO;2-B }}
*{{cite journal | author=Lane DA, Bayston T, Olds RJ, ''et al.'' |title=Antithrombin mutation database: 2nd (1997) update. For the Plasma Coagulation Inhibitors Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. |journal=Thromb. Haemost. |volume=77 |issue= 1 |pages= 197-211 |year= 1997 |pmid= 9031473 |doi= }}
*{{cite journal | author=Kuhle S, Lane DA, Jochmanns K, ''et al.'' |title=Homozygous antithrombin deficiency type II (99 Leu to Phe mutation) and childhood thromboembolism. |journal=Thromb. Haemost. |volume=86 |issue= 4 |pages= 1007-11 |year= 2002 |pmid= 11686316 |doi= }}
*{{cite journal | author=Witt I |title=[Molecular biological basis and diagnosis of hereditary defect of antithrombin III, protein c and protein S] |journal=Hamostaseologie |volume=22 |issue= 2 |pages= 14-24 |year= 2002 |pmid= 12193972 |doi= 10.1267/Hamo02020057 }}
*{{cite journal | author=Wiedermann CJ |title=Clinical review: molecular mechanisms underlying the role of antithrombin in sepsis. |journal=Critical care (London, England) |volume=10 |issue= 1 |pages= 209 |year= 2006 |pmid= 16542481 |doi= 10.1186/cc4822 }}
*{{cite journal | author=Abildgaard U |title=Antithrombin--early prophecies and present challenges. |journal=Thromb. Haemost. |volume=98 |issue= 1 |pages= 97-104 |year= 2007 |pmid= 17597998 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on TNFRSF11B... {November 5, 2007 9:34:59 AM PST} SEARCH REDIRECT : Control Box Found: CD120 {November 5, 2007 9:36:11 AM PST} UPDATE PROTEIN BOX : Updating Protein Box, No errors. {November 5, 2007 9:36:12 AM PST} SKIP SUMMARY : SKIPPING Summary, No Errors. {November 5, 2007 9:36:12 AM PST} UPDATE CITATIONS : Updating Citations, No Errors. {November 5, 2007 9:36:12 AM PST} UPDATED : Updated protein page: CD120 {November 5, 2007 9:36:19 AM PST} INFO : Beginning work on UBE2I... {November 5, 2007 9:39:59 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein UBE2I image.jpg {November 5, 2007 9:41:18 AM PST} CREATE : Found no pages, creating new page. {November 5, 2007 9:41:33 AM PST} CREATED : Created new protein page: UBE2I {November 5, 2007 9:41:43 AM PST} INFO : Beginning work on VAV1... {November 5, 2007 9:41:43 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein VAV1 image.jpg {November 5, 2007 9:42:20 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 5, 2007 9:42:32 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_VAV1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1k1z.
| PDB = {{PDB2|1k1z}}
| Name = Vav 1 oncogene
| HGNCid = 12657
| Symbol = VAV1
| AltSymbols =; VAV
| OMIM = 164875
| ECnumber =
| Homologene = 3961
| MGIid = 98923
| GeneAtlas_image1 = PBB_GE_VAV1_206219_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005085 |text = guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0019992 |text = diacylglycerol binding}} {{GNF_GO|id=GO:0030676 |text = Rac guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006909 |text = phagocytosis}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0035023 |text = regulation of Rho protein signal transduction}} {{GNF_GO|id=GO:0042110 |text = T cell activation}} {{GNF_GO|id=GO:0043087 |text = regulation of GTPase activity}} {{GNF_GO|id=GO:0045785 |text = positive regulation of cell adhesion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7409
| Hs_Ensembl = ENSG00000141968
| Hs_RefseqProtein = NP_005419
| Hs_RefseqmRNA = NM_005428
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 6723722
| Hs_GenLoc_end = 6808371
| Hs_Uniprot = P15498
| Mm_EntrezGene = 22324
| Mm_Ensembl = ENSMUSG00000034116
| Mm_RefseqmRNA = XM_980038
| Mm_RefseqProtein = XP_985132
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 56964450
| Mm_GenLoc_end = 57013288
| Mm_Uniprot = Q3TXC4
}}
}}
'''Vav 1 oncogene''', also known as '''VAV1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.<ref>{{cite web | title = Entrez Gene: VAV1 vav 1 oncogene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7409| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Romero F, Fischer S |title=Structure and function of vav. |journal=Cell. Signal. |volume=8 |issue= 8 |pages= 545-53 |year= 1997 |pmid= 9115846 |doi= }}
*{{cite journal | author=Bustelo XR |title=Regulatory and signaling properties of the Vav family. |journal=Mol. Cell. Biol. |volume=20 |issue= 5 |pages= 1461-77 |year= 2000 |pmid= 10669724 |doi= }}
*{{cite journal | author=Geyer M, Fackler OT, Peterlin BM |title=Structure--function relationships in HIV-1 Nef. |journal=EMBO Rep. |volume=2 |issue= 7 |pages= 580-5 |year= 2001 |pmid= 11463741 |doi= 10.1093/embo-reports/kve141 }}
*{{cite journal | author=Greenway AL, Holloway G, McPhee DA, ''et al.'' |title=HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication. |journal=J. Biosci. |volume=28 |issue= 3 |pages= 323-35 |year= 2004 |pmid= 12734410 |doi= }}
*{{cite journal | author=Anderson JL, Hope TJ |title=HIV accessory proteins and surviving the host cell. |journal=Current HIV/AIDS reports |volume=1 |issue= 1 |pages= 47-53 |year= 2005 |pmid= 16091223 |doi= }}
*{{cite journal | author=Stove V, Verhasselt B |title=Modelling thymic HIV-1 Nef effects. |journal=Curr. HIV Res. |volume=4 |issue= 1 |pages= 57-64 |year= 2006 |pmid= 16454711 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on XRCC1... {November 5, 2007 9:42:32 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein XRCC1 image.jpg {November 5, 2007 9:43:06 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 5, 2007 9:43:17 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_XRCC1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cdz.
| PDB = {{PDB2|1cdz}}, {{PDB2|1xna}}, {{PDB2|1xnt}}, {{PDB2|2d8m}}
| Name = X-ray repair complementing defective repair in Chinese hamster cells 1
| HGNCid = 12828
| Symbol = XRCC1
| AltSymbols =; RCC
| OMIM = 194360
| ECnumber =
| Homologene = 31368
| MGIid = 99137
| GeneAtlas_image1 = PBB_GE_XRCC1_203655_at_tn.png
| Function = {{GNF_GO|id=GO:0003684 |text = damaged DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000012 |text = single strand break repair}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7515
| Hs_Ensembl = ENSG00000073050
| Hs_RefseqProtein = NP_006288
| Hs_RefseqmRNA = NM_006297
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 48739032
| Hs_GenLoc_end = 48771998
| Hs_Uniprot = P18887
| Mm_EntrezGene = 22594
| Mm_Ensembl = ENSMUSG00000051768
| Mm_RefseqmRNA = NM_009532
| Mm_RefseqProtein = NP_033558
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 24255049
| Mm_GenLoc_end = 24282200
| Mm_Uniprot = Q3TGI0
}}
}}
'''X-ray repair complementing defective repair in Chinese hamster cells 1''', also known as '''XRCC1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.<ref>{{cite web | title = Entrez Gene: XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7515| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hung RJ, Hall J, Brennan P, Boffetta P |title=Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review. |journal=Am. J. Epidemiol. |volume=162 |issue= 10 |pages= 925-42 |year= 2006 |pmid= 16221808 |doi= 10.1093/aje/kwi318 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on ZAP70... {November 5, 2007 9:43:17 AM PST} UPLOAD : Added new Image to wiki: File:PBB Protein ZAP70 image.jpg {November 5, 2007 9:43:53 AM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 5, 2007 9:44:22 AM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ZAP70_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1m61.
| PDB = {{PDB2|1m61}}, {{PDB2|1u59}}, {{PDB2|2oq1}}, {{PDB2|2ozo}}
| Name = Zeta-chain (TCR) associated protein kinase 70kDa
| HGNCid = 12858
| Symbol = ZAP70
| AltSymbols =; SRK; STD; TZK; ZAP-70
| OMIM = 176947
| ECnumber =
| Homologene = 839
| MGIid = 99613
| GeneAtlas_image1 = PBB_GE_ZAP70_214032_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0004715 |text = non-membrane spanning protein tyrosine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0042101 |text = T cell receptor complex}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007243 |text = protein kinase cascade}} {{GNF_GO|id=GO:0045059 |text = positive thymic T cell selection}} {{GNF_GO|id=GO:0045582 |text = positive regulation of T cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7535
| Hs_Ensembl = ENSG00000115085
| Hs_RefseqProtein = NP_001070
| Hs_RefseqmRNA = NM_001079
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 97696461
| Hs_GenLoc_end = 97722755
| Hs_Uniprot = P43403
| Mm_EntrezGene = 22637
| Mm_Ensembl = ENSMUSG00000026117
| Mm_RefseqmRNA = NM_009539
| Mm_RefseqProtein = NP_033565
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 36706371
| Mm_GenLoc_end = 36727362
| Mm_Uniprot = P97455
}}
}}
'''Zeta-chain (TCR) associated protein kinase 70kDa''', also known as '''ZAP70''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Orchard J, Ibbotson R, Best G, ''et al.'' |title=ZAP-70 in B cell malignancies. |journal=Leuk. Lymphoma |volume=46 |issue= 12 |pages= 1689-98 |year= 2006 |pmid= 16263570 |doi= 10.1080/09638280500260079 }}
*{{cite journal | author=Hamblin AD, Hamblin TJ |title=Functional and prognostic role of ZAP-70 in chronic lymphocytic leukaemia. |journal=Expert Opin. Ther. Targets |volume=9 |issue= 6 |pages= 1165-78 |year= 2006 |pmid= 16300468 |doi= 10.1517/14728222.9.6.1165 }}
}}
{{refend}}
{{protein-stub}}
end log.
{November 5, 2007 9:18:32 AM PST} 
{November 5, 2007 9:38:23 AM PST} 
