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editLog page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 02:55, 13 November 2007 (UTC)
editProteins with a High Potential Match (2)
edit| CSNK2B | CDK4 |
Manual Inspection (Page not found) (2)
edit| CSNK2B | CDK4 |
Protein Status Grid - Date: 02:55, 13 November 2007 (UTC)
edit| HUGO Symbol | Action Summary | Target page(s) | WP Symbol Search |
|---|---|---|---|
| CSNK2B | Manual Inspection (Page not found) | Other Pages: Casein kinase 2 (Protein Template); CSNK2B (No Data); CK2B (No Data); Ck2b (No Data); CK2N (No Data); Ck2n (No Data); CSK2B (No Data); Csk2b (No Data); G5A (No Data); G5a (No Data); MGC138222 (No Data); Mgc138222 (No Data); MGC138224 (No Data); Mgc138224 (No Data); | [1] |
| CDK4 | Manual Inspection (Page not found) | Other Pages: Cyclin-dependent kinase 4 (Protein Template); CDK4 (Redirect -> Cyclin-dependent kinase 4); CMM3 (No Data); Cmm3 (No Data); MGC14458 (No Data); Mgc14458 (No Data); PSK-J3 (No Data); Psk-j3 (No Data); | [2] |
Vebose Log - Date: 02:55, 13 November 2007 (UTC)
edit- INFO: Beginning work on CDK4... {November 12, 2007 6:43:58 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 12, 2007 6:45:52 PM PST}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cyclin-dependent kinase 4
| HGNCid = 1773
| Symbol = CDK4
| AltSymbols =; CMM3; MGC14458; PSK-J3
| OMIM = 123829
| ECnumber =
| Homologene = 55429
| MGIid = 88357
| GeneAtlas_image1 = PBB_GE_CDK4_202246_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004672 |text = protein kinase activity}} {{GNF_GO|id=GO:0004693 |text = cyclin-dependent protein kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0000307 |text = cyclin-dependent protein kinase holoenzyme complex}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005667 |text = transcription factor complex}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0000082 |text = G1/S transition of mitotic cell cycle}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0042127 |text = regulation of cell proliferation}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1019
| Hs_Ensembl = ENSG00000135446
| Hs_RefseqProtein = NP_000066
| Hs_RefseqmRNA = NM_000075
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 56428272
| Hs_GenLoc_end = 56432431
| Hs_Uniprot = P11802
| Mm_EntrezGene = 12567
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_009870
| Mm_RefseqProtein = NP_034000
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Cyclin-dependent kinase 4''', also known as '''CDK4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.<ref>{{cite web | title = Entrez Gene: CDK4 cyclin-dependent kinase 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1019| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hanks SK |title=Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 2 |pages= 388-92 |year= 1987 |pmid= 2948189 |doi= }}
*{{cite journal | author=Hall M, Bates S, Peters G |title=Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins. |journal=Oncogene |volume=11 |issue= 8 |pages= 1581-8 |year= 1995 |pmid= 7478582 |doi= }}
*{{cite journal | author=Tassan JP, Jaquenoud M, Léopold P, ''et al.'' |title=Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 19 |pages= 8871-5 |year= 1995 |pmid= 7568034 |doi= }}
*{{cite journal | author=Mitchell EL, White GR, Santibanez-Koref MF, ''et al.'' |title=Mapping of gene loci in the Q13-Q15 region of chromosome 12. |journal=Chromosome Res. |volume=3 |issue= 4 |pages= 261-2 |year= 1995 |pmid= 7606365 |doi= }}
*{{cite journal | author=Wölfel T, Hauer M, Schneider J, ''et al.'' |title=A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. |journal=Science |volume=269 |issue= 5228 |pages= 1281-4 |year= 1995 |pmid= 7652577 |doi= }}
*{{cite journal | author=Hirai H, Roussel MF, Kato JY, ''et al.'' |title=Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. |journal=Mol. Cell. Biol. |volume=15 |issue= 5 |pages= 2672-81 |year= 1995 |pmid= 7739547 |doi= }}
*{{cite journal | author=Chan FK, Zhang J, Cheng L, ''et al.'' |title=Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4. |journal=Mol. Cell. Biol. |volume=15 |issue= 5 |pages= 2682-8 |year= 1995 |pmid= 7739548 |doi= }}
*{{cite journal | author=Guan KL, Jenkins CW, Li Y, ''et al.'' |title=Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. |journal=Genes Dev. |volume=8 |issue= 24 |pages= 2939-52 |year= 1995 |pmid= 8001816 |doi= }}
*{{cite journal | author=Kato JY, Matsuoka M, Strom DK, Sherr CJ |title=Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase. |journal=Mol. Cell. Biol. |volume=14 |issue= 4 |pages= 2713-21 |year= 1994 |pmid= 8139570 |doi= }}
*{{cite journal | author=Khatib ZA, Matsushime H, Valentine M, ''et al.'' |title=Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas. |journal=Cancer Res. |volume=53 |issue= 22 |pages= 5535-41 |year= 1993 |pmid= 8221695 |doi= }}
*{{cite journal | author=Serrano M, Hannon GJ, Beach D |title=A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. |journal=Nature |volume=366 |issue= 6456 |pages= 704-7 |year= 1994 |pmid= 8259215 |doi= 10.1038/366704a0 }}
*{{cite journal | author=Demetrick DJ, Zhang H, Beach DH |title=Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes. |journal=Cytogenet. Cell Genet. |volume=66 |issue= 1 |pages= 72-4 |year= 1994 |pmid= 8275715 |doi= }}
*{{cite journal | author=Kato J, Matsushime H, Hiebert SW, ''et al.'' |title=Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. |journal=Genes Dev. |volume=7 |issue= 3 |pages= 331-42 |year= 1993 |pmid= 8449399 |doi= }}
*{{cite journal | author=Zuo L, Weger J, Yang Q, ''et al.'' |title=Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma. |journal=Nat. Genet. |volume=12 |issue= 1 |pages= 97-9 |year= 1996 |pmid= 8528263 |doi= 10.1038/ng0196-97 }}
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal | author=Knudsen ES, Wang JY |title=Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites. |journal=J. Biol. Chem. |volume=271 |issue= 14 |pages= 8313-20 |year= 1996 |pmid= 8626527 |doi= }}
*{{cite journal | author=Poon RY, Jiang W, Toyoshima H, Hunter T |title=Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage. |journal=J. Biol. Chem. |volume=271 |issue= 22 |pages= 13283-91 |year= 1996 |pmid= 8662825 |doi= }}
*{{cite journal | author=Stepanova L, Leng X, Parker SB, Harper JW |title=Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4. |journal=Genes Dev. |volume=10 |issue= 12 |pages= 1491-502 |year= 1996 |pmid= 8666233 |doi= }}
*{{cite journal | author=Dai K, Kobayashi R, Beach D |title=Physical interaction of mammalian CDC37 with CDK4. |journal=J. Biol. Chem. |volume=271 |issue= 36 |pages= 22030-4 |year= 1996 |pmid= 8703009 |doi= }}
*{{cite journal | author=Fåhraeus R, Paramio JM, Ball KL, ''et al.'' |title=Inhibition of pRb phosphorylation and cell-cycle progression by a 20-residue peptide derived from p16CDKN2/INK4A. |journal=Curr. Biol. |volume=6 |issue= 1 |pages= 84-91 |year= 1996 |pmid= 8805225 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CSNK2B... {November 12, 2007 6:45:52 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 12, 2007 6:47:08 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CSNK2B_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1jwh.
| PDB = {{PDB2|1jwh}}, {{PDB2|1qf8}}, {{PDB2|1rqf}}
| Name = Casein kinase 2, beta polypeptide
| HGNCid = 2460
| Symbol = CSNK2B
| AltSymbols =; CK2B; CK2N; CSK2B; G5A; MGC138222; MGC138224
| OMIM = 115441
| ECnumber =
| Homologene = 55572
| MGIid = 88548
| GeneAtlas_image1 = PBB_GE_CSNK2B_201390_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004682 |text = protein kinase CK2 activity}} {{GNF_GO|id=GO:0008605 |text = protein kinase CK2 regulator activity}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005956 |text = protein kinase CK2 complex}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0016055 |text = Wnt receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1460
| Hs_Ensembl = ENSG00000206300
| Hs_RefseqProtein = NP_001311
| Hs_RefseqmRNA = NM_001320
| Hs_GenLoc_db =
| Hs_GenLoc_chr = c6_COX
| Hs_GenLoc_start = 31768327
| Hs_GenLoc_end = 31775955
| Hs_Uniprot = P67870
| Mm_EntrezGene = 13001
| Mm_Ensembl = ENSMUSG00000024387
| Mm_RefseqmRNA = NM_009975
| Mm_RefseqProtein = NP_034105
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 34724251
| Mm_GenLoc_end = 34729503
| Mm_Uniprot = P67871
}}
}}
'''Casein kinase 2, beta polypeptide''', also known as '''CSNK2B''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus.<ref>{{cite web | title = Entrez Gene: CSNK2B casein kinase 2, beta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1460| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Schubert U, Schneider T, Henklein P, ''et al.'' |title=Human-immunodeficiency-virus-type-1-encoded Vpu protein is phosphorylated by casein kinase II. |journal=Eur. J. Biochem. |volume=204 |issue= 2 |pages= 875-83 |year= 1992 |pmid= 1541298 |doi= }}
*{{cite journal | author=Teitz T, Eli D, Penner M, ''et al.'' |title=Expression of the cDNA for the beta subunit of human casein kinase II confers partial UV resistance on xeroderma pigmentosum cells. |journal=Mutat. Res. |volume=236 |issue= 1 |pages= 85-97 |year= 1990 |pmid= 1694965 |doi= }}
*{{cite journal | author=Voss H, Wirkner U, Jakobi R, ''et al.'' |title=Structure of the gene encoding human casein kinase II subunit beta. |journal=J. Biol. Chem. |volume=266 |issue= 21 |pages= 13706-11 |year= 1991 |pmid= 1856204 |doi= }}
*{{cite journal | author=Litchfield DW, Lozeman FJ, Cicirelli MF, ''et al.'' |title=Phosphorylation of the beta subunit of casein kinase II in human A431 cells. Identification of the autophosphorylation site and a site phosphorylated by p34cdc2. |journal=J. Biol. Chem. |volume=266 |issue= 30 |pages= 20380-9 |year= 1991 |pmid= 1939094 |doi= }}
*{{cite journal | author=Yang-Feng TL, Teitz T, Cheung MC, ''et al.'' |title=Assignment of the human casein kinase II beta-subunit gene to 6p12----p21. |journal=Genomics |volume=8 |issue= 4 |pages= 741-2 |year= 1991 |pmid= 2276748 |doi= }}
*{{cite journal | author=Ackerman P, Glover CV, Osheroff N |title=Stimulation of casein kinase II by epidermal growth factor: relationship between the physiological activity of the kinase and the phosphorylation state of its beta subunit. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 2 |pages= 821-5 |year= 1990 |pmid= 2300566 |doi= }}
*{{cite journal | author=Heller-Harrison RA, Meisner H, Czech MP |title=Cloning and characterization of a cDNA encoding the beta subunit of human casein kinase II. |journal=Biochemistry |volume=28 |issue= 23 |pages= 9053-8 |year= 1990 |pmid= 2513884 |doi= }}
*{{cite journal | author=Jakobi R, Voss H, Pyerin W |title=Human phosvitin/casein kinase type II. Molecular cloning and sequencing of full-length cDNA encoding subunit beta. |journal=Eur. J. Biochem. |volume=183 |issue= 1 |pages= 227-33 |year= 1989 |pmid= 2666134 |doi= }}
*{{cite journal | author=Vincent MJ, Abdul Jabbar M |title=The human immunodeficiency virus type 1 Vpu protein: a potential regulator of proteolysis and protein transport in the mammalian secretory pathway. |journal=Virology |volume=213 |issue= 2 |pages= 639-49 |year= 1996 |pmid= 7491787 |doi= }}
*{{cite journal | author=Litchfield DW, Bosc DG, Slominski E |title=The protein kinase from mitotic human cells that phosphorylates Ser-209 on the casein kinase II beta-subunit is p34cdc2. |journal=Biochim. Biophys. Acta |volume=1269 |issue= 1 |pages= 69-78 |year= 1995 |pmid= 7578274 |doi= }}
*{{cite journal | author=Jin YJ, Burakoff SJ |title=The 25-kDa FK506-binding protein is localized in the nucleus and associates with casein kinase II and nucleolin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 16 |pages= 7769-73 |year= 1993 |pmid= 7689229 |doi= }}
*{{cite journal | author=Gietz RD, Graham KC, Litchfield DW |title=Interactions between the subunits of casein kinase II. |journal=J. Biol. Chem. |volume=270 |issue= 22 |pages= 13017-21 |year= 1995 |pmid= 7768894 |doi= }}
*{{cite journal | author=Szebeni A, Herrera JE, Olson MO |title=Interaction of nucleolar protein B23 with peptides related to nuclear localization signals. |journal=Biochemistry |volume=34 |issue= 25 |pages= 8037-42 |year= 1995 |pmid= 7794916 |doi= }}
*{{cite journal | author=Arnold SF, Obourn JD, Jaffe H, Notides AC |title=Serine 167 is the major estradiol-induced phosphorylation site on the human estrogen receptor. |journal=Mol. Endocrinol. |volume=8 |issue= 9 |pages= 1208-14 |year= 1995 |pmid= 7838153 |doi= }}
*{{cite journal | author=Pyerin W |title=Human casein kinase II: structures, genes, expression and requirement in cell growth stimulation. |journal=Adv. Enzyme Regul. |volume=34 |issue= |pages= 225-46 |year= 1994 |pmid= 7942276 |doi= }}
*{{cite journal | author=el Benna J, Faust LP, Babior BM |title=The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases. |journal=J. Biol. Chem. |volume=269 |issue= 38 |pages= 23431-6 |year= 1994 |pmid= 8089108 |doi= }}
*{{cite journal | author=Schubert U, Henklein P, Boldyreff B, ''et al.'' |title=The human immunodeficiency virus type 1 encoded Vpu protein is phosphorylated by casein kinase-2 (CK-2) at positions Ser52 and Ser56 within a predicted alpha-helix-turn-alpha-helix-motif. |journal=J. Mol. Biol. |volume=236 |issue= 1 |pages= 16-25 |year= 1994 |pmid= 8107101 |doi= 10.1006/jmbi.1994.1114 }}
*{{cite journal | author=Schubert U, Strebel K |title=Differential activities of the human immunodeficiency virus type 1-encoded Vpu protein are regulated by phosphorylation and occur in different cellular compartments. |journal=J. Virol. |volume=68 |issue= 4 |pages= 2260-71 |year= 1994 |pmid= 8139011 |doi= }}
*{{cite journal | author=Tanasijevic MJ, Myers MG, Thoma RS, ''et al.'' |title=Phosphorylation of the insulin receptor substrate IRS-1 by casein kinase II. |journal=J. Biol. Chem. |volume=268 |issue= 24 |pages= 18157-66 |year= 1993 |pmid= 8349691 |doi= }}
*{{cite journal | author=Friborg J, Ladha A, Göttlinger H, ''et al.'' |title=Functional analysis of the phosphorylation sites on the human immunodeficiency virus type 1 Vpu protein. |journal=J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. |volume=8 |issue= 1 |pages= 10-22 |year= 1996 |pmid= 8548340 |doi= }}
}}
{{refend}}
{{protein-stub}}
end log.