AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:05:52 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CAMK2G_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ux0.
| PDB = {{PDB2|2ux0}}
| Name = Calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
| HGNCid = 1463
| Symbol = CAMK2G
| AltSymbols =; CAMK; CAMK-II; CAMKG; FLJ16043; MGC26678
| OMIM = 602123
| ECnumber =
| Homologene = 15596
| MGIid = 88259
| GeneAtlas_image1 = PBB_GE_CAMK2G_212669_at_tn.png
| GeneAtlas_image2 = PBB_GE_CAMK2G_212757_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004685 |text = calmodulin-dependent protein kinase activity}} {{GNF_GO|id=GO:0004723 |text = calcium-dependent protein serine/threonine phosphatase activity}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005954 |text = calcium- and calmodulin-dependent protein kinase complex}}
| Process = {{GNF_GO|id=GO:0000082 |text = G1/S transition of mitotic cell cycle}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006816 |text = calcium ion transport}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0030073 |text = insulin secretion}} {{GNF_GO|id=GO:0046777 |text = protein amino acid autophosphorylation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 818
| Hs_Ensembl = ENSG00000148660
| Hs_RefseqProtein = NP_001213
| Hs_RefseqmRNA = NM_001222
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 75242265
| Hs_GenLoc_end = 75304349
| Hs_Uniprot = Q13555
| Mm_EntrezGene = 12325
| Mm_Ensembl = ENSMUSG00000021820
| Mm_RefseqmRNA = XM_980738
| Mm_RefseqProtein = XP_985832
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 19523427
| Mm_GenLoc_end = 19582640
| Mm_Uniprot = Q923T9
}}
}}
'''Calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma''', also known as '''CAMK2G''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Six alternatively spliced variants that encode six different isoforms have been characterized to date. Additional alternative splice variants that encode different isoforms have been described, but their full-length nature has not been determined.<ref>{{cite web | title = Entrez Gene: CAMK2G calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=818| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hook SS, Means AR |title=Ca(2+)/CaM-dependent kinases: from activation to function. |journal=Annu. Rev. Pharmacol. Toxicol. |volume=41 |issue= |pages= 471-505 |year= 2001 |pmid= 11264466 |doi= 10.1146/annurev.pharmtox.41.1.471 }}
*{{cite journal | author=Yamamoto H |title=[Molecular mechanisms of the intracellular localizations of Ca2+/calmodulin-dependent protein kinase II isoforms, and their physiological functions] |journal=Tanpakushitsu Kakusan Koso |volume=47 |issue= 3 |pages= 241-7 |year= 2002 |pmid= 11889801 |doi= }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:28:05 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_COL18A1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bnl.
| PDB = {{PDB2|1bnl}}
| Name = Collagen, type XVIII, alpha 1
| HGNCid = 2195
| Symbol = COL18A1
| AltSymbols =; FLJ27325; KNO; MGC74745
| OMIM = 120328
| ECnumber =
| Homologene = 7673
| MGIid = 88451
| GeneAtlas_image1 = PBB_GE_COL18A1_209082_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_COL18A1_209081_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005581 |text = collagen}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006817 |text = phosphate transport}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 80781
| Hs_Ensembl = ENSG00000182871
| Hs_RefseqProtein = NP_085059
| Hs_RefseqmRNA = NM_030582
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 21
| Hs_GenLoc_start = 45649516
| Hs_GenLoc_end = 45758061
| Hs_Uniprot = P39060
| Mm_EntrezGene = 12822
| Mm_Ensembl = ENSMUSG00000001435
| Mm_RefseqmRNA = NM_009929
| Mm_RefseqProtein = NP_034059
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 76495895
| Mm_GenLoc_end = 76610217
| Mm_Uniprot = Q61434
}}
}}
'''Collagen, type XVIII, alpha 1''', also known as '''COL18A1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Two transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: COL18A1 collagen, type XVIII, alpha 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80781| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Pufe T, Kurz B, Petersen W, ''et al.'' |title=The influence of biomechanical parameters on the expression of VEGF and endostatin in the bone and joint system. |journal=Ann. Anat. |volume=187 |issue= 5-6 |pages= 461-72 |year= 2006 |pmid= 16320826 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on MUC2... {November 7, 2007 2:15:50 AM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:16:10 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Mucin 2, oligomeric mucus/gel-forming
| HGNCid = 7512
| Symbol = MUC2
| AltSymbols =; MLP; SMUC
| OMIM = 158370
| ECnumber =
| Homologene = 80094
| MGIid =
| Function = {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0030197 |text = extracellular matrix constituent, lubricant activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0030277 |text = maintenance of gastrointestinal epithelium}} {{GNF_GO|id=GO:0030336 |text = negative regulation of cell migration}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4583
| Hs_Ensembl =
| Hs_RefseqProtein = NP_002448
| Hs_RefseqmRNA = NM_002457
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Mucin 2, oligomeric mucus/gel-forming''', also known as '''MUC2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.<ref>{{cite web | title = Entrez Gene: MUC2 mucin 2, oligomeric mucus/gel-forming| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4583| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Allen A, Hutton DA, Pearson JP |title=The MUC2 gene product: a human intestinal mucin. |journal=Int. J. Biochem. Cell Biol. |volume=30 |issue= 7 |pages= 797-801 |year= 1998 |pmid= 9722984 |doi= }}
*{{cite journal | author=Byrd JC, Bresalier RS |title=Mucins and mucin binding proteins in colorectal cancer. |journal=Cancer Metastasis Rev. |volume=23 |issue= 1-2 |pages= 77-99 |year= 2004 |pmid= 15000151 |doi= }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:20:03 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SOS1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1awe.
| PDB = {{PDB2|1awe}}, {{PDB2|1bkd}}, {{PDB2|1dbh}}, {{PDB2|1nvu}}, {{PDB2|1nvv}}, {{PDB2|1nvw}}, {{PDB2|1nvx}}, {{PDB2|1pms}}, {{PDB2|1q9c}}, {{PDB2|1xd2}}, {{PDB2|1xd4}}, {{PDB2|1xdv}}, {{PDB2|2ii0}}
| Name = Son of sevenless homolog 1 (Drosophila)
| HGNCid = 11187
| Symbol = SOS1
| AltSymbols =; GF1; HGF; GGF1; GINGF; NS4
| OMIM = 182530
| ECnumber =
| Homologene = 4117
| MGIid = 98354
| GeneAtlas_image1 = PBB_GE_SOS1_212777_at_tn.png
| GeneAtlas_image2 = PBB_GE_SOS1_212780_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005085 |text = guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005089 |text = Rho guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005100 |text = Rho GTPase activator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0000786 |text = nucleosome}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007265 |text = Ras protein signal transduction}} {{GNF_GO|id=GO:0035023 |text = regulation of Rho protein signal transduction}} {{GNF_GO|id=GO:0051056 |text = regulation of small GTPase mediated signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6654
| Hs_Ensembl = ENSG00000115904
| Hs_RefseqProtein = NP_005624
| Hs_RefseqmRNA = NM_005633
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 39066469
| Hs_GenLoc_end = 39201067
| Hs_Uniprot = Q07889
| Mm_EntrezGene = 20662
| Mm_Ensembl = ENSMUSG00000024241
| Mm_RefseqmRNA = NM_009231
| Mm_RefseqProtein = NP_033257
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 80306507
| Mm_GenLoc_end = 80388261
| Mm_Uniprot = Q2M4G6
}}
}}
'''Son of sevenless homolog 1 (Drosophila)''', also known as '''SOS1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = RAS genes (e.g., MIM 190020) encode membrane-bound guanine nucleotide-binding proteins that function in the transduction of signals that control cell growth and differentiation. Binding of GTP activates RAS proteins, and subsequent hydrolysis of the bound GTP to GDP and phosphate inactivates signaling by these proteins. GTP binding can be catalyzed by guanine nucleotide exchange factors for RAS, and GTP hydrolysis can be accelerated by GTPase-activating proteins (GAPs). The first exchange factor to be identified for RAS was the S. cerevisiae CDC25 gene product. Genetic analysis indicated that CDC25 is essential for activation of RAS proteins. In Drosophila, the protein encoded by the 'son of sevenless' gene (Sos) contains a domain that shows sequence similarity with the catalytic domain of CDC25. Sos may act as a positive regulator of RAS by promoting guanine nucleotide exchange.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: SOS1 son of sevenless homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6654| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 2:27:01 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_YWHAQ_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2btp.
| PDB = {{PDB2|2btp}}
| Name = Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
| HGNCid = 12854
| Symbol = YWHAQ
| AltSymbols =; HS1; 14-3-3; 1C5
| OMIM = 609009
| ECnumber =
| Homologene = 48407
| MGIid = 891963
| GeneAtlas_image1 = PBB_GE_YWHAQ_212426_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_YWHAQ_200693_at_tn.png
| GeneAtlas_image3 = PBB_GE_YWHAQ_213699_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008426 |text = protein kinase C inhibitor activity}} {{GNF_GO|id=GO:0019904 |text = protein domain specific binding}}
| Component =
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006605 |text = protein targeting}} {{GNF_GO|id=GO:0006887 |text = exocytosis}} {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 10971
| Hs_Ensembl = ENSG00000134308
| Hs_RefseqProtein = NP_006817
| Hs_RefseqmRNA = NM_006826
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 9641552
| Hs_GenLoc_end = 9688629
| Hs_Uniprot = P27348
| Mm_EntrezGene = 22630
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_011739
| Mm_RefseqProtein = NP_035869
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide''', also known as '''YWHAQ''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease.<ref>{{cite web | title = Entrez Gene: YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10971| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kino T, Chrousos GP |title=Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? |journal=Ann. N. Y. Acad. Sci. |volume=1024 |issue= |pages= 153-67 |year= 2004 |pmid= 15265780 |doi= 10.1196/annals.1321.013 }}
*{{cite journal | author=Calinisan V, Gravem D, Chen RP, ''et al.'' |title=New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium. |journal=Front. Biosci. |volume=11 |issue= |pages= 1646-66 |year= 2006 |pmid= 16368544 |doi= }}
}}
{{refend}}
{{protein-stub}}
{November 7, 2007 2:16:45 AM PST} 
