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AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:10:21 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ALDH2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a4z.
| PDB = {{PDB2|1a4z}}, {{PDB2|1ag8}}, {{PDB2|1cw3}}, {{PDB2|1nzw}}, {{PDB2|1nzx}}, {{PDB2|1nzz}}, {{PDB2|1o00}}, {{PDB2|1o01}}, {{PDB2|1o02}}, {{PDB2|1o04}}, {{PDB2|1o05}}, {{PDB2|1of7}}, {{PDB2|1zum}}, {{PDB2|2onm}}, {{PDB2|2onn}}, {{PDB2|2ono}}, {{PDB2|2onp}}
| Name = Aldehyde dehydrogenase 2 family (mitochondrial)
| HGNCid = 404
| Symbol = ALDH2
| AltSymbols =; ALDH-E2; ALDHI; ALDM; MGC1806
| OMIM = 100650
| ECnumber =
| Homologene = 55480
| MGIid = 99600
| GeneAtlas_image1 = PBB_GE_ALDH2_201425_at_tn.png
| Function = {{GNF_GO|id=GO:0004029 |text = aldehyde dehydrogenase (NAD) activity}} {{GNF_GO|id=GO:0004030 |text = aldehyde dehydrogenase [NAD(P)+] activity}} {{GNF_GO|id=GO:0009055 |text = electron carrier activity}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}}
| Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006066 |text = alcohol metabolic process}} {{GNF_GO|id=GO:0008152 |text = metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 217
| Hs_Ensembl = ENSG00000111275
| Hs_RefseqProtein = NP_000681
| Hs_RefseqmRNA = NM_000690
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 110688729
| Hs_GenLoc_end = 110732165
| Hs_Uniprot = P05091
| Mm_EntrezGene = 11669
| Mm_Ensembl = ENSMUSG00000029455
| Mm_RefseqmRNA = NM_009656
| Mm_RefseqProtein = NP_033786
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 121828319
| Mm_GenLoc_end = 121854203
| Mm_Uniprot = Q3TVM2
}}
}}
'''Aldehyde dehydrogenase 2 family (mitochondrial)''', also known as '''ALDH2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix.<ref>{{cite web | title = Entrez Gene: ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=217| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Yoshida A |title=Molecular genetics of human aldehyde dehydrogenase. |journal=Pharmacogenetics |volume=2 |issue= 4 |pages= 139-47 |year= 1993 |pmid= 1306115 |doi= }}
*{{cite journal | author=Chao YC, Liou SR, Tsai SF, Yin SJ |title=Dominance of the mutant ALDH2(2) allele in the expression of human stomach aldehyde dehydrogenase-2 activity. |journal=Proc. Natl. Sci. Counc. Repub. China B |volume=17 |issue= 3 |pages= 98-102 |year= 1994 |pmid= 8290656 |doi= }}
*{{cite journal | author=Seitz HK, Meier P |title=The role of acetaldehyde in upper digestive tract cancer in alcoholics. |journal=Translational research : the journal of laboratory and clinical medicine |volume=149 |issue= 6 |pages= 293-7 |year= 2007 |pmid= 17543846 |doi= 10.1016/j.trsl.2006.12.002 }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on ATF2... {November 7, 2007 1:18:30 AM PST}
UPLOAD: Added new Image to wiki: {November 7, 2007 1:19:21 AM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:19:39 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ATF2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bhi.
| PDB = {{PDB2|1bhi}}, {{PDB2|1t2k}}
| Name = Activating transcription factor 2
| HGNCid = 784
| Symbol = ATF2
| AltSymbols =; CREB2; CRE-BP1; HB16; MGC111558; TREB7
| OMIM = 123811
| ECnumber =
| Homologene = 31061
| MGIid = 109349
| GeneAtlas_image1 = PBB_GE_ATF2_205446_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ATF2_212984_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1386
| Hs_Ensembl = ENSG00000115966
| Hs_RefseqProtein = NP_001871
| Hs_RefseqmRNA = NM_001880
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 175645228
| Hs_GenLoc_end = 175741161
| Hs_Uniprot = P15336
| Mm_EntrezGene = 11909
| Mm_Ensembl = ENSMUSG00000027104
| Mm_RefseqmRNA = NM_001025093
| Mm_RefseqProtein = NP_001020264
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 73617360
| Mm_GenLoc_end = 73664083
| Mm_Uniprot = P70299
}}
}}
'''Activating transcription factor 2''', also known as '''ATF2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. The protein forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. The protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Additional transcript variants have been identified but their biological validity has not been determined.<ref>{{cite web | title = Entrez Gene: ATF2 activating transcription factor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1386| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:12:29 AM PST}
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{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_AVP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1jk4.
| PDB = {{PDB2|1jk4}}, {{PDB2|1jk6}}, {{PDB2|1npo}}, {{PDB2|2bn2}}
| Name = Arginine vasopressin (neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal)
| HGNCid = 894
| Symbol = AVP
| AltSymbols =; ADH; ARVP; AVP-NPII; AVRP; VP
| OMIM = 192340
| ECnumber =
| Homologene = 417
| MGIid = 88121
| GeneAtlas_image1 = PBB_GE_AVP_207848_at_tn.png
| Function = {{GNF_GO|id=GO:0005185 |text = neurohypophyseal hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
| Process = {{GNF_GO|id=GO:0006091 |text = generation of precursor metabolites and energy}} {{GNF_GO|id=GO:0006833 |text = water transport}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0030146 |text = diuresis}} {{GNF_GO|id=GO:0030819 |text = positive regulation of cAMP biosynthetic process}} {{GNF_GO|id=GO:0042310 |text = vasoconstriction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 551
| Hs_Ensembl = ENSG00000101200
| Hs_RefseqProtein = NP_000481
| Hs_RefseqmRNA = NM_000490
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 3011203
| Hs_GenLoc_end = 3014058
| Hs_Uniprot = P01185
| Mm_EntrezGene = 11998
| Mm_Ensembl = ENSMUSG00000037727
| Mm_RefseqmRNA = NM_009732
| Mm_RefseqProtein = NP_033862
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 130272062
| Mm_GenLoc_end = 130273995
| Mm_Uniprot = Q3UUQ5
}}
}}
'''Arginine vasopressin (neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal)''', also known as '''AVP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin II and a glycopeptide, copeptin. Arginine vasopressin is a posterior pituitary hormone which is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin II, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. Mutations in this gene cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI).<ref>{{cite web | title = Entrez Gene: AVP arginine vasopressin (neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=551| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Riphagen CL, Pittman QJ |title=Arginine vasopressin as a central neurotransmitter. |journal=Fed. Proc. |volume=45 |issue= 9 |pages= 2318-22 |year= 1986 |pmid= 2874053 |doi= }}
*{{cite journal | author=Ishikawa SE |title=[Nephrogenic diabetes insipidus associated with mutations of vasopressin V2 receptors and aquaporin-2] |journal=Nippon Rinsho |volume=60 |issue= 2 |pages= 350-5 |year= 2002 |pmid= 11857925 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on CCR3... {November 7, 2007 1:15:48 AM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:16:27 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Chemokine (C-C motif) receptor 3
| HGNCid = 1604
| Symbol = CCR3
| AltSymbols =; CC-CKR-3; CD193; CKR3; CMKBR3; MGC102841
| OMIM = 601268
| ECnumber =
| Homologene = 20436
| MGIid = 104616
| GeneAtlas_image1 = PBB_GE_CCR3_208304_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016493 |text = C-C chemokine receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006968 |text = cellular defense response}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007188 |text = G-protein signaling, coupled to cAMP nucleotide second messenger}} {{GNF_GO|id=GO:0007204 |text = elevation of cytosolic calcium ion concentration}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1232
| Hs_Ensembl = ENSG00000183625
| Hs_RefseqProtein = NP_001828
| Hs_RefseqmRNA = NM_001837
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 46227186
| Hs_GenLoc_end = 46283103
| Hs_Uniprot = P51677
| Mm_EntrezGene = 12771
| Mm_Ensembl = ENSMUSG00000035448
| Mm_RefseqmRNA = NM_009914
| Mm_RefseqProtein = NP_034044
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 123870898
| Mm_GenLoc_end = 123879738
| Mm_Uniprot = Q3U5L7
}}
}}
'''Chemokine (C-C motif) receptor 3''', also known as '''CCR3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants encoding the same protein have been described.<ref>{{cite web | title = Entrez Gene: CCR3 chemokine (C-C motif) receptor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1232| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Marone G, Florio G, Petraroli A, de Paulis A |title=Dysregulation of the IgE/Fc epsilon RI network in HIV-1 infection. |journal=J. Allergy Clin. Immunol. |volume=107 |issue= 1 |pages= 22-30 |year= 2001 |pmid= 11149986 |doi= }}
*{{cite journal | author=Marone G, Florio G, Triggiani M, ''et al.'' |title=Mechanisms of IgE elevation in HIV-1 infection. |journal=Crit. Rev. Immunol. |volume=20 |issue= 6 |pages= 477-96 |year= 2001 |pmid= 11396683 |doi= }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:14:10 AM PST}
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| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CEACAM1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2gk2.
| PDB = {{PDB2|2gk2}}
| Name = Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
| HGNCid = 1814
| Symbol = CEACAM1
| AltSymbols =; BGP; BGP1; BGPI
| OMIM = 109770
| ECnumber =
| Homologene = 86044
| MGIid = 1347245
| GeneAtlas_image1 = PBB_GE_CEACAM1_206576_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CEACAM1_209498_at_tn.png
| GeneAtlas_image3 = PBB_GE_CEACAM1_211883_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0007156 |text = homophilic cell adhesion}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}} {{GNF_GO|id=GO:0007565 |text = female pregnancy}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0016477 |text = cell migration}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 634
| Hs_Ensembl = ENSG00000079385
| Hs_RefseqProtein = NP_001020083
| Hs_RefseqmRNA = NM_001024912
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 47703298
| Hs_GenLoc_end = 47724479
| Hs_Uniprot = P13688
| Mm_EntrezGene = 26365
| Mm_Ensembl = ENSMUSG00000074272
| Mm_RefseqmRNA = XM_989614
| Mm_RefseqProtein = XP_994708
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 24990200
| Mm_GenLoc_end = 25186385
| Mm_Uniprot = Q3LFS7
}}
}}
'''Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)''', also known as '''CEACAM1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of only two has been determined.<ref>{{cite web | title = Entrez Gene: CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=634| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Gray-Owen SD, Blumberg RS |title=CEACAM1: contact-dependent control of immunity. |journal=Nat. Rev. Immunol. |volume=6 |issue= 6 |pages= 433-46 |year= 2006 |pmid= 16724098 |doi= 10.1038/nri1864 }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on CYP3A5... {November 7, 2007 1:21:31 AM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:22:24 AM PST}
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| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cytochrome P450, family 3, subfamily A, polypeptide 5
| HGNCid = 2638
| Symbol = CYP3A5
| AltSymbols =; CP35; P450PCN3; PCN3
| OMIM = 605325
| ECnumber =
| Homologene = 88340
| MGIid = 88609
| GeneAtlas_image1 = PBB_GE_CYP3A5_205765_at_tn.png
| GeneAtlas_image2 = PBB_GE_CYP3A5_214234_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004497 |text = monooxygenase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0019825 |text = oxygen binding}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0050381 |text = unspecific monooxygenase activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0006805 |text = xenobiotic metabolic process}} {{GNF_GO|id=GO:0008202 |text = steroid metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1577
| Hs_Ensembl = ENSG00000106258
| Hs_RefseqProtein = NP_000768
| Hs_RefseqmRNA = NM_000777
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 99083759
| Hs_GenLoc_end = 99115557
| Hs_Uniprot = P20815
| Mm_EntrezGene = 13112
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_984479
| Mm_RefseqProtein = XP_989573
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Cytochrome P450, family 3, subfamily A, polypeptide 5''', also known as '''CYP3A5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene,CYP3A5, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. This cluster includes a pseudogene, CYP3A5P1, which is very similar to CYP3A5. This similarity has caused some difficulty in determining whether cloned sequences represent the gene or the pseudogene.<ref>{{cite web | title = Entrez Gene: CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1577| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Smith G, Stubbins MJ, Harries LW, Wolf CR |title=Molecular genetics of the human cytochrome P450 monooxygenase superfamily. |journal=Xenobiotica |volume=28 |issue= 12 |pages= 1129-65 |year= 1999 |pmid= 9890157 |doi= }}
*{{cite journal | author=Lee SJ, Goldstein JA |title=Functionally defective or altered CYP3A4 and CYP3A5 single nucleotide polymorphisms and their detection with genotyping tests. |journal=Pharmacogenomics |volume=6 |issue= 4 |pages= 357-71 |year= 2006 |pmid= 16004554 |doi= 10.1517/14622416.6.4.357 }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 1:28:21 AM PST}
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{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_S100A9_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1irj.
| PDB = {{PDB2|1irj}}, {{PDB2|1xk4}}
| Name = S100 calcium binding protein A9
| HGNCid = 10499
| Symbol = S100A9
| AltSymbols =; MIF; 60B8AG; CFAG; NIF; CAGB; CGLB; L1AG; LIAG; MAC387; MRP14; P14
| OMIM = 123886
| ECnumber =
| Homologene = 2227
| MGIid = 1338947
| GeneAtlas_image1 = PBB_GE_S100A9_203535_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6280
| Hs_Ensembl = ENSG00000163220
| Hs_RefseqProtein = NP_002956
| Hs_RefseqmRNA = NM_002965
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 151596954
| Hs_GenLoc_end = 151600127
| Hs_Uniprot = P06702
| Mm_EntrezGene = 20202
| Mm_Ensembl = ENSMUSG00000056071
| Mm_RefseqmRNA = NM_009114
| Mm_RefseqProtein = NP_033140
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 90778560
| Mm_GenLoc_end = 90781618
| Mm_Uniprot = Q3UP42
}}
}}
'''S100 calcium binding protein A9''', also known as '''S100A9''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis.<ref>{{cite web | title = Entrez Gene: S100A9 S100 calcium binding protein A9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6280| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Schäfer BW, Heizmann CW |title=The S100 family of EF-hand calcium-binding proteins: functions and pathology. |journal=Trends Biochem. Sci. |volume=21 |issue= 4 |pages= 134-40 |year= 1996 |pmid= 8701470 |doi= }}
*{{cite journal | author=Kerkhoff C, Klempt M, Sorg C |title=Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9). |journal=Biochim. Biophys. Acta |volume=1448 |issue= 2 |pages= 200-11 |year= 1999 |pmid= 9920411 |doi= }}
*{{cite journal | author=Nacken W, Roth J, Sorg C, Kerkhoff C |title=S100A9/S100A8: Myeloid representatives of the S100 protein family as prominent players in innate immunity. |journal=Microsc. Res. Tech. |volume=60 |issue= 6 |pages= 569-80 |year= 2003 |pmid= 12645005 |doi= 10.1002/jemt.10299 }}
}}
{{refend}}
{{protein-stub}}