INFO: Beginning work on ABCD1... {November 7, 2007 3:05:28 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:05:48 PM PST}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = ATP-binding cassette, sub-family D (ALD), member 1
| HGNCid = 61
| Symbol = ABCD1
| AltSymbols =; ABC42; ALD; ALDP; AMN
| OMIM = 300371
| ECnumber =
| Homologene = 55426
| MGIid = 1349215
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016887 |text = ATPase activity}} {{GNF_GO|id=GO:0042626 |text = ATPase activity, coupled to transmembrane movement of substances}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005777 |text = peroxisome}} {{GNF_GO|id=GO:0005779 |text = integral to peroxisomal membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0007031 |text = peroxisome organization and biogenesis}} {{GNF_GO|id=GO:0015919 |text = peroxisomal membrane transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 215
| Hs_Ensembl =
| Hs_RefseqProtein = NP_000024
| Hs_RefseqmRNA = NM_000033
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 11666
| Mm_Ensembl = ENSMUSG00000031378
| Mm_RefseqmRNA = XM_973209
| Mm_RefseqProtein = XP_978303
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 69969429
| Mm_GenLoc_end = 69991252
| Mm_Uniprot = P48410
}}
}}
'''ATP-binding cassette, sub-family D (ALD), member 1''', also known as '''ABCD1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in this gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system.<ref>{{cite web | title = Entrez Gene: ABCD1 ATP-binding cassette, sub-family D (ALD), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=215| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Aubourg P, Mosser J, Douar AM, ''et al.'' |title=Adrenoleukodystrophy gene: unexpected homology to a protein involved in peroxisome biogenesis. |journal=Biochimie |volume=75 |issue= 3-4 |pages= 293-302 |year= 1993 |pmid= 8507690 |doi= }}
*{{cite journal | author=Moser HW, Powers JM, Smith KD |title=Adrenoleukodystrophy: molecular genetics, pathology, and Lorenzo's oil. |journal=Brain Pathol. |volume=5 |issue= 3 |pages= 259-66 |year= 1996 |pmid= 8520725 |doi= }}
*{{cite journal | author=Dodd A, Rowland SA, Hawkes SL, ''et al.'' |title=Mutations in the adrenoleukodystrophy gene. |journal=Hum. Mutat. |volume=9 |issue= 6 |pages= 500-11 |year= 1997 |pmid= 9195223 |doi= 10.1002/(SICI)1098-1004(1997)9:6<500::AID-HUMU2>3.0.CO;2-5 }}
*{{cite journal | author=Kemp S, Pujol A, Waterham HR, ''et al.'' |title=ABCD1 mutations and the X-linked adrenoleukodystrophy mutation database: role in diagnosis and clinical correlations. |journal=Hum. Mutat. |volume=18 |issue= 6 |pages= 499-515 |year= 2002 |pmid= 11748843 |doi= 10.1002/humu.1227 }}
*{{cite journal | author=Lan F |title=Molecular diagnostics in China. |journal=Clin. Chem. Lab. Med. |volume=39 |issue= 12 |pages= 1190-4 |year= 2002 |pmid= 11798073 |doi= }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:08:10 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CDK6_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bi7.
| PDB = {{PDB2|1bi7}}, {{PDB2|1bi8}}, {{PDB2|1blx}}, {{PDB2|1g3n}}, {{PDB2|1jow}}, {{PDB2|1xo2}}, {{PDB2|2euf}}, {{PDB2|2f2c}}
| Name = Cyclin-dependent kinase 6
| HGNCid = 1777
| Symbol = CDK6
| AltSymbols =; MGC59692; PLSTIRE
| OMIM = 603368
| ECnumber =
| Homologene = 963
| MGIid = 1277162
| GeneAtlas_image1 = PBB_GE_CDK6_207143_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0000080 |text = G1 phase of mitotic cell cycle}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1021
| Hs_Ensembl = ENSG00000105810
| Hs_RefseqProtein = NP_001250
| Hs_RefseqmRNA = NM_001259
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 92072175
| Hs_GenLoc_end = 92301148
| Hs_Uniprot = Q00534
| Mm_EntrezGene = 12571
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_009873
| Mm_RefseqProtein = NP_034003
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Cyclin-dependent kinase 6''', also known as '''CDK6''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.<ref>{{cite web | title = Entrez Gene: CDK6 cyclin-dependent kinase 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1021| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:09:48 PM PST}
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{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CTSK_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1atk.
| PDB = {{PDB2|1atk}}, {{PDB2|1au0}}, {{PDB2|1au2}}, {{PDB2|1au3}}, {{PDB2|1au4}}, {{PDB2|1ayu}}, {{PDB2|1ayv}}, {{PDB2|1ayw}}, {{PDB2|1bgo}}, {{PDB2|1by8}}, {{PDB2|1mem}}, {{PDB2|1nl6}}, {{PDB2|1nlj}}, {{PDB2|1q6k}}, {{PDB2|1snk}}, {{PDB2|1tu6}}, {{PDB2|1u9v}}, {{PDB2|1u9w}}, {{PDB2|1u9x}}, {{PDB2|1vsn}}, {{PDB2|1yk7}}, {{PDB2|1yk8}}, {{PDB2|1yt7}}, {{PDB2|2ato}}, {{PDB2|2aux}}, {{PDB2|2auz}}, {{PDB2|2bdl}}, {{PDB2|2f7d}}, {{PDB2|2ftd}}, {{PDB2|7pck}}
| Name = Cathepsin K
| HGNCid = 2536
| Symbol = CTSK
| AltSymbols =; CTS02; CTSO; CTSO1; CTSO2; MGC23107; PKND; PYCD
| OMIM = 601105
| ECnumber =
| Homologene = 68053
| MGIid = 107823
| GeneAtlas_image1 = PBB_GE_CTSK_202450_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004216 |text = cathepsin K activity}}
| Component = {{GNF_GO|id=GO:0005764 |text = lysosome}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1513
| Hs_Ensembl = ENSG00000143387
| Hs_RefseqProtein = NP_000387
| Hs_RefseqmRNA = NM_000396
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 149035311
| Hs_GenLoc_end = 149047436
| Hs_Uniprot = P43235
| Mm_EntrezGene = 13038
| Mm_Ensembl = ENSMUSG00000028111
| Mm_RefseqmRNA = NM_007802
| Mm_RefseqProtein = NP_031828
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 95584660
| Mm_GenLoc_end = 95594766
| Mm_Uniprot = Q545T0
}}
}}
'''Cathepsin K''', also known as '''CTSK''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may be subject to RNA editing.<ref>{{cite web | title = Entrez Gene: CTSK cathepsin K| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1513| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Motyckova G, Fisher DE |title=Pycnodysostosis: role and regulation of cathepsin K in osteoclast function and human disease. |journal=Curr. Mol. Med. |volume=2 |issue= 5 |pages= 407-21 |year= 2003 |pmid= 12125807 |doi= }}
*{{cite journal | author=Troen BR |title=The regulation of cathepsin K gene expression. |journal=Ann. N. Y. Acad. Sci. |volume=1068 |issue= |pages= 165-72 |year= 2006 |pmid= 16831915 |doi= 10.1196/annals.1346.018 }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on PSMC5... {November 7, 2007 3:14:35 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:15:14 PM PST}
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{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Proteasome (prosome, macropain) 26S subunit, ATPase, 5
| HGNCid = 9552
| Symbol = PSMC5
| AltSymbols =; p45; S8; SUG1; TBP10; TRIP1; p45/SUG
| OMIM = 601681
| ECnumber =
| Homologene = 2098
| MGIid = 105047
| GeneAtlas_image1 = PBB_GE_PSMC5_209503_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003712 |text = transcription cofactor activity}} {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0016887 |text = ATPase activity}} {{GNF_GO|id=GO:0031531 |text = thyrotropin-releasing hormone receptor binding}}
| Component = {{GNF_GO|id=GO:0000502 |text = proteasome complex (sensu Eukaryota)}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}} {{GNF_GO|id=GO:0030163 |text = protein catabolic process}} {{GNF_GO|id=GO:0043069 |text = negative regulation of programmed cell death}} {{GNF_GO|id=GO:0043161 |text = proteasomal ubiquitin-dependent protein catabolic process}} {{GNF_GO|id=GO:0043193 |text = positive regulation of gene-specific transcription}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5705
| Hs_Ensembl = ENSG00000087191
| Hs_RefseqProtein = NP_002796
| Hs_RefseqmRNA = NM_002805
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 59258519
| Hs_GenLoc_end = 59263098
| Hs_Uniprot = P62195
| Mm_EntrezGene = 19184
| Mm_Ensembl = ENSMUSG00000020708
| Mm_RefseqmRNA = NM_008950
| Mm_RefseqProtein = NP_032976
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 106072244
| Mm_GenLoc_end = 106079207
| Mm_Uniprot = Q99KR1
}}
}}
'''Proteasome (prosome, macropain) 26S subunit, ATPase, 5''', also known as '''PSMC5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha.<ref>{{cite web | title = Entrez Gene: PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5705| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Coux O, Tanaka K, Goldberg AL |title=Structure and functions of the 20S and 26S proteasomes. |journal=Annu. Rev. Biochem. |volume=65 |issue= |pages= 801-47 |year= 1996 |pmid= 8811196 |doi= 10.1146/annurev.bi.65.070196.004101 }}
*{{cite journal | author=Goff SP |title=Death by deamination: a novel host restriction system for HIV-1. |journal=Cell |volume=114 |issue= 3 |pages= 281-3 |year= 2003 |pmid= 12914693 |doi= }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:22:11 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TFF1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1hi7.
| PDB = {{PDB2|1hi7}}, {{PDB2|1ps2}}
| Name = Trefoil factor 1
| HGNCid = 11755
| Symbol = TFF1
| AltSymbols =; BCEI; D21S21; HP1.A; HPS2; pNR-2; pS2
| OMIM = 113710
| ECnumber =
| Homologene = 2426
| MGIid = 88135
| GeneAtlas_image1 = PBB_GE_TFF1_205009_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component =
| Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0007586 |text = digestion}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7031
| Hs_Ensembl = ENSG00000160182
| Hs_RefseqProtein = NP_003216
| Hs_RefseqmRNA = NM_003225
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 21
| Hs_GenLoc_start = 42655462
| Hs_GenLoc_end = 42659713
| Hs_Uniprot = P04155
| Mm_EntrezGene = 21784
| Mm_Ensembl = ENSMUSG00000024032
| Mm_RefseqmRNA = NM_009362
| Mm_RefseqProtein = NP_033388
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 30872609
| Mm_GenLoc_end = 30892065
| Mm_Uniprot = Q149Y8
}}
}}
'''Trefoil factor 1''', also known as '''TFF1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.<ref>{{cite web | title = Entrez Gene: TFF1 trefoil factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7031| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Langer G, Jagla W, Behrens-Baumann W, ''et al.'' |title=Ocular TFF-peptides: new mucus-associated secretory products of conjunctival goblet cells. |journal=Adv. Exp. Med. Biol. |volume=506 |issue= Pt A |pages= 313-6 |year= 2003 |pmid= 12613926 |doi= }}
}}
{{refend}}
{{protein-stub}}
{November 7, 2007 3:20:54 PM PST} 
