INFO: Beginning work on BMPR1B... {November 9, 2007 1:01:27 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:02:11 PM PST}
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| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Bone morphogenetic protein receptor, type IB
| HGNCid = 1077
| Symbol = BMPR1B
| AltSymbols =; ALK-6; ALK6; CDw293
| OMIM = 603248
| ECnumber =
| Homologene = 20322
| MGIid = 107191
| GeneAtlas_image1 = PBB_GE_BMPR1B_210523_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005025 |text = transforming growth factor beta receptor activity, type I}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0030145 |text = manganese ion binding}} {{GNF_GO|id=GO:0046332 |text = SMAD binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0043235 |text = receptor complex}}
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0001502 |text = cartilage condensation}} {{GNF_GO|id=GO:0001550 |text = ovarian cumulus expansion}} {{GNF_GO|id=GO:0001654 |text = eye development}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006703 |text = estrogen biosynthetic process}} {{GNF_GO|id=GO:0009953 |text = dorsal/ventral pattern formation}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0030509 |text = BMP signaling pathway}} {{GNF_GO|id=GO:0035108 |text = limb morphogenesis}} {{GNF_GO|id=GO:0042698 |text = menstrual cycle}} {{GNF_GO|id=GO:0045597 |text = positive regulation of cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 658
| Hs_Ensembl = ENSG00000138696
| Hs_RefseqProtein = NP_001194
| Hs_RefseqmRNA = NM_001203
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 95898151
| Hs_GenLoc_end = 96295099
| Hs_Uniprot = O00238
| Mm_EntrezGene = 12167
| Mm_Ensembl = ENSMUSG00000052430
| Mm_RefseqmRNA = NM_007560
| Mm_RefseqProtein = NP_031586
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 141774523
| Mm_GenLoc_end = 142106600
| Mm_Uniprot = Q3USS1
}}
}}
'''Bone morphogenetic protein receptor, type IB''', also known as '''BMPR1B''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. This gene expresses two transcript variants.<ref>{{cite web | title = Entrez Gene: BMPR1B bone morphogenetic protein receptor, type IB| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=658| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Josso N, di Clemente N, Gouédard L |title=Anti-Müllerian hormone and its receptors. |journal=Mol. Cell. Endocrinol. |volume=179 |issue= 1-2 |pages= 25-32 |year= 2001 |pmid= 11420127 |doi= }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:18:24 PM PST}
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{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_REG1A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1lit.
| PDB = {{PDB2|1lit}}, {{PDB2|1qdd}}
| Name = Regenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein)
| HGNCid = 9951
| Symbol = REG1A
| AltSymbols =; REG; PSP; ICRF; MGC12447; P19; PSPS; PSPS1; PTP
| OMIM = 167770
| ECnumber =
| Homologene = 68282
| MGIid = 97895
| GeneAtlas_image1 = PBB_GE_REG1A_209752_at_tn.png
| Function = {{GNF_GO|id=GO:0005529 |text = sugar binding}}
| Component =
| Process = {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5967
| Hs_Ensembl = ENSG00000115386
| Hs_RefseqProtein = NP_002900
| Hs_RefseqmRNA = NM_002909
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 79201092
| Hs_GenLoc_end = 79204053
| Hs_Uniprot = P05451
| Mm_EntrezGene = 19692
| Mm_Ensembl = ENSMUSG00000059654
| Mm_RefseqmRNA = NM_009042
| Mm_RefseqProtein = NP_033068
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 78355492
| Mm_GenLoc_end = 78358175
| Mm_Uniprot = Q3TV26
}}
}}
'''Regenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein)''', also known as '''REG1A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandomly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication.<ref>{{cite web | title = Entrez Gene: REG1A regenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5967| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=De Reggi M, Gharib B |title=Protein-X, Pancreatic Stone-, Pancreatic thread-, reg-protein, P19, lithostathine, and now what? Characterization, structural analysis and putative function(s) of the major non-enzymatic protein of pancreatic secretions. |journal=Curr. Protein Pept. Sci. |volume=2 |issue= 1 |pages= 19-42 |year= 2002 |pmid= 12369899 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on SHOX... {November 9, 2007 1:18:47 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:19:16 PM PST}
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{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Short stature homeobox
| HGNCid = 10853
| Symbol = SHOX
| AltSymbols =; SS; GCFX; PHOG; SHOXY
| OMIM = 312865
| ECnumber =
| Homologene = 55463
| MGIid =
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6473
| Hs_Ensembl = ENSG00000185960
| Hs_RefseqProtein = NP_000442
| Hs_RefseqmRNA = NM_000451
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 505079
| Hs_GenLoc_end = 540146
| Hs_Uniprot = O15266
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Short stature homeobox''', also known as '''SHOX''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The pseudoautosomal region (PAR1) contains an interval of 170 kb that tends to be deleted in individuals with short stature and different rearrangements on Xp22 or Yp11.3. SHOX (Short stature HOmeoboX-containing gene) a homeo box-containing gene located in the PAR1, has at least 2 alternatively spliced forms encoding proteins with different patterns of expression. SHOX is involved in idiopathic growth retardation and in the short stature phenotype of Turner syndrome patients. The 2 mRNAs, SHOXa and SHOXb, code for proteins of 292 and 225 amino acids, respectively. Both transcripts have a common 5' end, diverging after exon IV. The SHOX gene is composed of 6 exons ranging in size from 58 bp to 1,146 bp. SHOX is highly conserved across species. The absence of the SHOX gene may be responsible for the growth failure in Turner syndrome females.<ref>{{cite web | title = Entrez Gene: SHOX short stature homeobox| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6473| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bernasconi S, Mariani S, Falcinelli C, ''et al.'' |title=SHOX gene in Leri-Weill syndrome and in idiopathic short stature. |journal=J. Endocrinol. Invest. |volume=24 |issue= 9 |pages= 737-41 |year= 2002 |pmid= 11716161 |doi= }}
*{{cite journal | author=Leka SK, Kitsiou-Tzeli S, Kalpini-Mavrou A, Kanavakis E |title=Short stature and dysmorphology associated with defects in the SHOX gene. |journal=Hormones (Athens, Greece) |volume=5 |issue= 2 |pages= 107-18 |year= 2006 |pmid= 16807223 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on SST... {November 9, 2007 1:20:54 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:21:28 PM PST}
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{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Somatostatin
| HGNCid = 11329
| Symbol = SST
| AltSymbols =; SMST
| OMIM = 182450
| ECnumber =
| Homologene = 819
| MGIid = 98326
| GeneAtlas_image1 = PBB_GE_SST_213921_at_tn.png
| Function = {{GNF_GO|id=GO:0005179 |text = hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007584 |text = response to nutrient}} {{GNF_GO|id=GO:0007586 |text = digestion}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0008628 |text = induction of apoptosis by hormones}} {{GNF_GO|id=GO:0030334 |text = regulation of cell migration}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6750
| Hs_Ensembl = ENSG00000157005
| Hs_RefseqProtein = NP_001039
| Hs_RefseqmRNA = NM_001048
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 188869399
| Hs_GenLoc_end = 188870895
| Hs_Uniprot = P61278
| Mm_EntrezGene = 20604
| Mm_Ensembl = ENSMUSG00000004366
| Mm_RefseqmRNA = NM_009215
| Mm_RefseqProtein = NP_033241
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 23804930
| Mm_GenLoc_end = 23806193
| Mm_Uniprot = Q545V6
}}
}}
'''Somatostatin''', also known as '''SST''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells.<ref>{{cite web | title = Entrez Gene: SST somatostatin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6750| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Florio T, Schettini G |title=[Somatostatin and its receptors. Role in the control of cell proliferation] |journal=Minerva Endocrinol. |volume=26 |issue= 3 |pages= 91-102 |year= 2002 |pmid= 11753230 |doi= }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:20:54 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TRIM21_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2iwg.
| PDB = {{PDB2|2iwg}}
| Name = Tripartite motif-containing 21
| HGNCid = 11312
| Symbol = TRIM21
| AltSymbols =; SSA; RNF81; RO52; SSA1
| OMIM = 109092
| ECnumber =
| Homologene = 2365
| MGIid = 106657
| GeneAtlas_image1 = PBB_GE_TRIM21_204804_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0030529 |text = ribonucleoprotein complex}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6737
| Hs_Ensembl = ENSG00000132109
| Hs_RefseqProtein = NP_003132
| Hs_RefseqmRNA = NM_003141
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 4362734
| Hs_GenLoc_end = 4371502
| Hs_Uniprot = P19474
| Mm_EntrezGene = 20821
| Mm_Ensembl = ENSMUSG00000030966
| Mm_RefseqmRNA = XM_991802
| Mm_RefseqProtein = XP_996896
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 102432657
| Mm_GenLoc_end = 102439262
| Mm_Uniprot = Q3U7K7
}}
}}
'''Tripartite motif-containing 21''', also known as '''TRIM21''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.<ref>{{cite web | title = Entrez Gene: TRIM21 tripartite motif-containing 21| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6737| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
{November 9, 2007 12:59:39 PM PST} 
