Other Pages: CD1a molecule (No Data); CD1A (No Data); CD1 (Unknown Data); Cd1 (No Data); FCB6 (No Data); Fcb6 (No Data); HTA1 (No Data); Hta1 (No Data); R4 (DisAmbig); T6 (DisAmbig);
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:30:16 PM PST}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CD1A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1onq.
| PDB = {{PDB2|1onq}}, {{PDB2|1xz0}}
| Name = CD1a molecule
| HGNCid = 1634
| Symbol = CD1A
| AltSymbols =; CD1; FCB6; HTA1; R4; T6
| OMIM = 188370
| ECnumber =
| Homologene = 74408
| MGIid =
| GeneAtlas_image1 = PBB_GE_CD1A_210325_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0042612 |text = MHC class I protein complex}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0019882 |text = antigen processing and presentation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 909
| Hs_Ensembl = ENSG00000158477
| Hs_RefseqProtein = NP_001754
| Hs_RefseqmRNA = NM_001763
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 156490551
| Hs_GenLoc_end = 156494683
| Hs_Uniprot = P06126
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''CD1a molecule''', also known as '''CD1A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined.<ref>{{cite web | title = Entrez Gene: CD1A CD1a molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=909| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Melián A, Beckman EM, Porcelli SA, Brenner MB |title=Antigen presentation by CD1 and MHC-encoded class I-like molecules. |journal=Curr. Opin. Immunol. |volume=8 |issue= 1 |pages= 82-8 |year= 1996 |pmid= 8729450 |doi= }}
*{{cite journal | author=Park SH, Bendelac A |title=CD1-restricted T-cell responses and microbial infection. |journal=Nature |volume=406 |issue= 6797 |pages= 788-92 |year= 2000 |pmid= 10963609 |doi= 10.1038/35021233 }}
*{{cite journal | author=Brigl M, Brenner MB |title=CD1: antigen presentation and T cell function. |journal=Annu. Rev. Immunol. |volume=22 |issue= |pages= 817-90 |year= 2004 |pmid= 15032598 |doi= 10.1146/annurev.immunol.22.012703.104608 }}
*{{cite journal | author=Coventry B, Heinzel S |title=CD1a in human cancers: a new role for an old molecule. |journal=Trends Immunol. |volume=25 |issue= 5 |pages= 242-8 |year= 2004 |pmid= 15099564 |doi= 10.1016/j.it.2004.03.002 }}
*{{cite journal | author=Moody DB, Zajonc DM, Wilson IA |title=Anatomy of CD1-lipid antigen complexes. |journal=Nat. Rev. Immunol. |volume=5 |issue= 5 |pages= 387-99 |year= 2005 |pmid= 15864273 |doi= 10.1038/nri1605 }}
*{{cite journal | author=Stove V, Verhasselt B |title=Modelling thymic HIV-1 Nef effects. |journal=Curr. HIV Res. |volume=4 |issue= 1 |pages= 57-64 |year= 2006 |pmid= 16454711 |doi= }}
*{{cite journal | author=Quaranta MG, Mattioli B, Giordani L, Viora M |title=The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS. |journal=FASEB J. |volume=20 |issue= 13 |pages= 2198-208 |year= 2006 |pmid= 17077296 |doi= 10.1096/fj.06-6260rev }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on COL6A1... {November 9, 2007 1:32:27 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:34:26 PM PST}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Collagen, type VI, alpha 1
| HGNCid = 2211
| Symbol = COL6A1
| AltSymbols =; OPLL
| OMIM = 120220
| ECnumber =
| Homologene = 1391
| MGIid = 88459
| GeneAtlas_image1 = PBB_GE_COL6A1_212091_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_COL6A1_212937_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_COL6A1_212938_at_tn.png
| Function = {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005581 |text = collagen}} {{GNF_GO|id=GO:0005589 |text = collagen type VI}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006817 |text = phosphate transport}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1291
| Hs_Ensembl = ENSG00000142156
| Hs_RefseqProtein = NP_001839
| Hs_RefseqmRNA = NM_001848
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 21
| Hs_GenLoc_start = 46226111
| Hs_GenLoc_end = 46248443
| Hs_Uniprot = P12109
| Mm_EntrezGene = 12833
| Mm_Ensembl = ENSMUSG00000001119
| Mm_RefseqmRNA = NM_009933
| Mm_RefseqProtein = NP_034063
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 76152508
| Mm_GenLoc_end = 76169760
| Mm_Uniprot = Q8C6Y0
}}
}}
'''Collagen, type VI, alpha 1''', also known as '''COL6A1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The collagens are a superfamily of proteins that play a role in maintaining the integrity of various tissues. Collagens are extracellular matrix proteins and have a triple-helical domain as their common structural element. Collagen VI is a major structural component of microfibrils. The basic structural unit of collagen VI is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI) chains. The alpha2(VI) and alpha3(VI) chains are encoded by the COL6A2 and COL6A3 genes, respectively. The protein encoded by this gene is the alpha 1 subunit of type VI collagen (alpha1(VI) chain). Mutations in the genes that code for the collagen VI subunits result in the autosomal dominant disorder, Bethlem myopathy.<ref>{{cite web | title = Entrez Gene: COL6A1 collagen, type VI, alpha 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1291| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bertini E, Pepe G |title=Collagen type VI and related disorders: Bethlem myopathy and Ullrich scleroatonic muscular dystrophy. |journal=Eur. J. Paediatr. Neurol. |volume=6 |issue= 4 |pages= 193-8 |year= 2002 |pmid= 12374585 |doi= }}
*{{cite journal | author=Lampe AK, Bushby KM |title=Collagen VI related muscle disorders. |journal=J. Med. Genet. |volume=42 |issue= 9 |pages= 673-85 |year= 2006 |pmid= 16141002 |doi= 10.1136/jmg.2002.002311 }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:36:19 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CSTB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1stf.
| PDB = {{PDB2|1stf}}, {{PDB2|2oct}}
| Name = Cystatin B (stefin B)
| HGNCid = 2482
| Symbol = CSTB
| AltSymbols =; CST6; EPM1; PME; STFB
| OMIM = 601145
| ECnumber =
| Homologene = 79
| MGIid = 109514
| GeneAtlas_image1 = PBB_GE_CSTB_201201_at_tn.png
| Function = {{GNF_GO|id=GO:0004869 |text = cysteine protease inhibitor activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0008344 |text = adult locomotory behavior}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1476
| Hs_Ensembl = ENSG00000160213
| Hs_RefseqProtein = NP_000091
| Hs_RefseqmRNA = NM_000100
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 21
| Hs_GenLoc_start = 44016826
| Hs_GenLoc_end = 44020585
| Hs_Uniprot = P04080
| Mm_EntrezGene = 13014
| Mm_Ensembl = ENSMUSG00000005054
| Mm_RefseqmRNA = NM_007793
| Mm_RefseqProtein = NP_031819
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 77828799
| Mm_GenLoc_end = 77830755
| Mm_Uniprot = Q62426
}}
}}
'''Cystatin B (stefin B)''', also known as '''CSTB''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1).<ref>{{cite web | title = Entrez Gene: CSTB cystatin B (stefin B)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1476| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Turk V, Bode W |title=The cystatins: protein inhibitors of cysteine proteinases. |journal=FEBS Lett. |volume=285 |issue= 2 |pages= 213-9 |year= 1991 |pmid= 1855589 |doi= }}
*{{cite journal | author=Järvinen M, Rinne A, Hopsu-Havu VK |title=Human cystatins in normal and diseased tissues--a review. |journal=Acta Histochem. |volume=82 |issue= 1 |pages= 5-18 |year= 1988 |pmid= 3122506 |doi= }}
*{{cite journal | author=Brown WM, Dziegielewska KM |title=Friends and relations of the cystatin superfamily--new members and their evolution. |journal=Protein Sci. |volume=6 |issue= 1 |pages= 5-12 |year= 1997 |pmid= 9007972 |doi= }}
*{{cite journal | author=Kos J, Lah TT |title=Cysteine proteinases and their endogenous inhibitors: target proteins for prognosis, diagnosis and therapy in cancer (review). |journal=Oncol. Rep. |volume=5 |issue= 6 |pages= 1349-61 |year= 1998 |pmid= 9769367 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on DKC1... {November 9, 2007 1:37:08 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:38:34 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Dyskeratosis congenita 1, dyskerin
| HGNCid = 2890
| Symbol = DKC1
| AltSymbols =; DKC; NAP57; NOLA4; XAP101; dyskerin
| OMIM = 300126
| ECnumber =
| Homologene = 1045
| MGIid =
| GeneAtlas_image1 = PBB_GE_DKC1_201479_at_tn.png
| GeneAtlas_image2 = PBB_GE_DKC1_201478_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_DKC1_216212_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003720 |text = telomerase activity}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0016439 |text = tRNA-pseudouridine synthase activity}} {{GNF_GO|id=GO:0016853 |text = isomerase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}} {{GNF_GO|id=GO:0005697 |text = telomerase holoenzyme complex}} {{GNF_GO|id=GO:0005730 |text = nucleolus}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006364 |text = rRNA processing}} {{GNF_GO|id=GO:0007004 |text = telomere maintenance via telomerase}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1736
| Hs_Ensembl = ENSG00000130826
| Hs_RefseqProtein = NP_001354
| Hs_RefseqmRNA = NM_001363
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 153644229
| Hs_GenLoc_end = 153659158
| Hs_Uniprot = O60832
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Dyskeratosis congenita 1, dyskerin''', also known as '''DKC1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the NOLA1, 2 and 3 proteins. The protein encoded by this gene and the three NOLA proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The protein encoded by this gene is related to the Saccharomyces cerevisiae Cbf5p and Drosophila melanogaster Nop60B proteins. The gene lies in a tail-to-tail orientation with the palmitoylated erythrocyte membrane protein (MPP1) gene and is transcribed in a telomere to centromere direction. Both nucleotide substitutions and single trinucleotide repeat polymorphisms have been found in this gene. Mutations in this gene cause X-linked dyskeratosis congenita disease.<ref>{{cite web | title = Entrez Gene: DKC1 dyskeratosis congenita 1, dyskerin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1736| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Marrone A, Dokal I |title=Dyskeratosis congenita: molecular insights into telomerase function, ageing and cancer. |journal=Expert reviews in molecular medicine |volume=6 |issue= 26 |pages= 1-23 |year= 2007 |pmid= 15613268 |doi= 10.1017/S1462399404008671 }}
*{{cite journal | author=Yamaguchi H |title=Mutations of telomerase complex genes linked to bone marrow failures. |journal=Journal of Nippon Medical School = Nihon Ika Daigaku zasshi |volume=74 |issue= 3 |pages= 202-9 |year= 2007 |pmid= 17625368 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on NR1I3... {November 9, 2007 1:48:31 PM PST}
UPLOAD: Added new Image to wiki: {November 9, 2007 1:49:04 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:49:27 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NR1I3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1xv9.
| PDB = {{PDB2|1xv9}}, {{PDB2|1xvp}}
| Name = Nuclear receptor subfamily 1, group I, member 3
| HGNCid = 7969
| Symbol = NR1I3
| AltSymbols =; CAR; CAR1; MB67; MGC150433; MGC97144; MGC97209
| OMIM = 603881
| ECnumber =
| Homologene = 3759
| MGIid = 1346307
| GeneAtlas_image1 = PBB_GE_NR1I3_207007_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004879 |text = ligand-dependent nuclear receptor activity}} {{GNF_GO|id=GO:0004882 |text = androgen receptor activity}} {{GNF_GO|id=GO:0004887 |text = thyroid hormone receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9970
| Hs_Ensembl = ENSG00000143257
| Hs_RefseqProtein = NP_001070937
| Hs_RefseqmRNA = NM_001077469
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 159466079
| Hs_GenLoc_end = 159474590
| Hs_Uniprot = Q14994
| Mm_EntrezGene = 12355
| Mm_Ensembl = ENSMUSG00000005677
| Mm_RefseqmRNA = NM_009803
| Mm_RefseqProtein = NP_033933
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 173050645
| Mm_GenLoc_end = 173055519
| Mm_Uniprot = Q3UEP1
}}
}}
'''Nuclear receptor subfamily 1, group I, member 3''', also known as '''NR1I3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: NR1I3 nuclear receptor subfamily 1, group I, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9970| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:43:07 PM PST}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TEC_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gl5.
| PDB = {{PDB2|1gl5}}
| Name = Tec protein tyrosine kinase
| HGNCid = 11719
| Symbol = TEC
| AltSymbols =; MGC126760; MGC126762; PSCTK4
| OMIM = 600583
| ECnumber =
| Homologene = 1302
| MGIid = 98662
| GeneAtlas_image1 = PBB_GE_TEC_206301_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004715 |text = non-membrane spanning protein tyrosine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007243 |text = protein kinase cascade}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7006
| Hs_Ensembl = ENSG00000135605
| Hs_RefseqProtein = NP_003206
| Hs_RefseqmRNA = NM_003215
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 47832557
| Hs_GenLoc_end = 47966638
| Hs_Uniprot = P42680
| Mm_EntrezGene = 21682
| Mm_Ensembl = ENSMUSG00000029217
| Mm_RefseqmRNA = NM_013689
| Mm_RefseqProtein = NP_038717
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 73034869
| Mm_GenLoc_end = 73147618
| Mm_Uniprot = Q3U436
}}
}}
'''Tec protein tyrosine kinase''', also known as '''TEC''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.<ref>{{cite web | title = Entrez Gene: TEC tec protein tyrosine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7006| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Mano H |title=Tec family of protein-tyrosine kinases: an overview of their structure and function. |journal=Cytokine Growth Factor Rev. |volume=10 |issue= 3-4 |pages= 267-80 |year= 2000 |pmid= 10647781 |doi= }}
*{{cite journal | author=Yang WC, Collette Y, Nunès JA, Olive D |title=Tec kinases: a family with multiple roles in immunity. |journal=Immunity |volume=12 |issue= 4 |pages= 373-82 |year= 2000 |pmid= 10795735 |doi= }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:43:58 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TFF3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1e9t.
| PDB = {{PDB2|1e9t}}, {{PDB2|1pe3}}
| Name = Trefoil factor 3 (intestinal)
| HGNCid = 11757
| Symbol = TFF3
| AltSymbols =; HITF; ITF; TFI; hP1.B
| OMIM = 600633
| ECnumber =
| Homologene = 2427
| MGIid = 104638
| GeneAtlas_image1 = PBB_GE_TFF3_204623_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0030141 |text = secretory granule}}
| Process = {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0007586 |text = digestion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7033
| Hs_Ensembl = ENSG00000160180
| Hs_RefseqProtein = NP_003217
| Hs_RefseqmRNA = NM_003226
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 21
| Hs_GenLoc_start = 42599751
| Hs_GenLoc_end = 42608775
| Hs_Uniprot = Q07654
| Mm_EntrezGene = 21786
| Mm_Ensembl = ENSMUSG00000024029
| Mm_RefseqmRNA = NM_011575
| Mm_RefseqProtein = NP_035705
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 30852327
| Mm_GenLoc_end = 30856623
| Mm_Uniprot = Q62395
}}
}}
'''Trefoil factor 3 (intestinal)''', also known as '''TFF3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.<ref>{{cite web | title = Entrez Gene: TFF3 trefoil factor 3 (intestinal)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7033| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hoffmann W, Jagla W, Wiede A |title=Molecular medicine of TFF-peptides: from gut to brain. |journal=Histol. Histopathol. |volume=16 |issue= 1 |pages= 319-34 |year= 2001 |pmid= 11193208 |doi= }}
*{{cite journal | author=Hoffmann W, Jagla W |title=Cell type specific expression of secretory TFF peptides: colocalization with mucins and synthesis in the brain. |journal=Int. Rev. Cytol. |volume=213 |issue= |pages= 147-81 |year= 2002 |pmid= 11837892 |doi= }}
*{{cite journal | author=Langer G, Jagla W, Behrens-Baumann W, ''et al.'' |title=Ocular TFF-peptides: new mucus-associated secretory products of conjunctival goblet cells. |journal=Adv. Exp. Med. Biol. |volume=506 |issue= Pt A |pages= 313-6 |year= 2003 |pmid= 12613926 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on TRIM5... {November 9, 2007 1:51:39 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:52:34 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Tripartite motif-containing 5
| HGNCid = 16276
| Symbol = TRIM5
| AltSymbols =; RNF88; TRIM5alpha
| OMIM = 608487
| ECnumber =
| Homologene = 75345
| MGIid = 2441735
| GeneAtlas_image1 = PBB_GE_TRIM5_210705_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016874 |text = ligase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0009615 |text = response to virus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 85363
| Hs_Ensembl = ENSG00000132256
| Hs_RefseqProtein = NP_149023
| Hs_RefseqmRNA = NM_033034
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 5641363
| Hs_GenLoc_end = 5850164
| Hs_Uniprot = Q9C035
| Mm_EntrezGene = 319236
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_175677
| Mm_RefseqProtein = NP_783608
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Tripartite motif-containing 5''', also known as '''TRIM5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Five alternatively spliced transcript variants for this gene have been described. However, the full length nature of two of the variants has not been determined.<ref>{{cite web | title = Entrez Gene: TRIM5 tripartite motif-containing 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=85363| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Luban J |title=Cyclophilin A, TRIM5, and resistance to human immunodeficiency virus type 1 infection. |journal=J. Virol. |volume=81 |issue= 3 |pages= 1054-61 |year= 2007 |pmid= 16956947 |doi= 10.1128/JVI.01519-06 }}
*{{cite journal | author=Freed EO, Mouland AJ |title=The cell biology of HIV-1 and other retroviruses. |journal=Retrovirology |volume=3 |issue= |pages= 77 |year= 2006 |pmid= 17083721 |doi= 10.1186/1742-4690-3-77 }}
}}
{{refend}}
{{protein-stub}}