- INFO: Beginning work on AGRP... {November 19, 2007 11:06:22 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 11:06:52 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_AGRP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1hyk.
| PDB = {{PDB2|1hyk}}, {{PDB2|1mr0}}
| Name = Agouti related protein homolog (mouse)
| HGNCid = 330
| Symbol = AGRP
| AltSymbols =; AGRT; ART; ASIP2; MGC118963
| OMIM = 602311
| ECnumber =
| Homologene = 7184
| MGIid = 892013
| GeneAtlas_image1 = PBB_GE_AGRP_207193_at_tn.png
| Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0005184 |text = neuropeptide hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}} {{GNF_GO|id=GO:0007631 |text = feeding behavior}} {{GNF_GO|id=GO:0009755 |text = hormone-mediated signaling}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 181
| Hs_Ensembl = ENSG00000159723
| Hs_RefseqProtein = NP_001129
| Hs_RefseqmRNA = NM_001138
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 66073978
| Hs_GenLoc_end = 66075217
| Hs_Uniprot = O00253
| Mm_EntrezGene = 11604
| Mm_Ensembl = ENSMUSG00000005705
| Mm_RefseqmRNA = NM_007427
| Mm_RefseqProtein = NP_031453
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 108455827
| Mm_GenLoc_end = 108457427
| Mm_Uniprot = Q3UU47
}}
}}
'''Agouti related protein homolog (mouse)''', also known as '''AGRP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AGRP agouti related protein homolog (mouse)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=181| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Agouti-related protein is an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation. Agouti-related protein is alternatively spliced into 2 variants which differ in 5' untranslated sequence length.<ref name="entrez">{{cite web | title = Entrez Gene: AGRP agouti related protein homolog (mouse)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=181| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Wilson BD, Ollmann MM, Barsh GS |title=The role of agouti-related protein in regulating body weight. |journal=Molecular medicine today |volume=5 |issue= 6 |pages= 250-6 |year= 1999 |pmid= 10366820 |doi= }}
*{{cite journal | author=Shutter JR, Graham M, Kinsey AC, ''et al.'' |title=Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. |journal=Genes Dev. |volume=11 |issue= 5 |pages= 593-602 |year= 1997 |pmid= 9119224 |doi= }}
*{{cite journal | author=Ollmann MM, Wilson BD, Yang YK, ''et al.'' |title=Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. |journal=Science |volume=278 |issue= 5335 |pages= 135-8 |year= 1997 |pmid= 9311920 |doi= }}
*{{cite journal | author=Graham M, Shutter JR, Sarmiento U, ''et al.'' |title=Overexpression of Agrt leads to obesity in transgenic mice. |journal=Nat. Genet. |volume=17 |issue= 3 |pages= 273-4 |year= 1997 |pmid= 9354787 |doi= 10.1038/ng1197-273 }}
*{{cite journal | author=Bures EJ, Hui JO, Young Y, ''et al.'' |title=Determination of disulfide structure in agouti-related protein (AGRP) by stepwise reduction and alkylation. |journal=Biochemistry |volume=37 |issue= 35 |pages= 12172-7 |year= 1998 |pmid= 9724530 |doi= 10.1021/bi981082v }}
*{{cite journal | author=Rossi M, Kim MS, Morgan DG, ''et al.'' |title=A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo. |journal=Endocrinology |volume=139 |issue= 10 |pages= 4428-31 |year= 1998 |pmid= 9751529 |doi= }}
*{{cite journal | author=Yang YK, Thompson DA, Dickinson CJ, ''et al.'' |title=Characterization of Agouti-related protein binding to melanocortin receptors. |journal=Mol. Endocrinol. |volume=13 |issue= 1 |pages= 148-55 |year= 1999 |pmid= 9892020 |doi= }}
*{{cite journal | author=Tota MR, Smith TS, Mao C, ''et al.'' |title=Molecular interaction of Agouti protein and Agouti-related protein with human melanocortin receptors. |journal=Biochemistry |volume=38 |issue= 3 |pages= 897-904 |year= 1999 |pmid= 9893984 |doi= 10.1021/bi9815602 }}
*{{cite journal | author=Yang YK, Dickinson CJ, Zeng Q, ''et al.'' |title=Contribution of melanocortin receptor exoloops to Agouti-related protein binding. |journal=J. Biol. Chem. |volume=274 |issue= 20 |pages= 14100-6 |year= 1999 |pmid= 10318826 |doi= }}
*{{cite journal | author=Bolin KA, Anderson DJ, Trulson JA, ''et al.'' |title=NMR structure of a minimized human agouti related protein prepared by total chemical synthesis. |journal=FEBS Lett. |volume=451 |issue= 2 |pages= 125-31 |year= 1999 |pmid= 10371151 |doi= }}
*{{cite journal | author=Nakazato M, Murakami N, Date Y, ''et al.'' |title=A role for ghrelin in the central regulation of feeding. |journal=Nature |volume=409 |issue= 6817 |pages= 194-8 |year= 2001 |pmid= 11196643 |doi= 10.1038/35051587 }}
*{{cite journal | author=Vink T, Hinney A, van Elburg AA, ''et al.'' |title=Association between an agouti-related protein gene polymorphism and anorexia nervosa. |journal=Mol. Psychiatry |volume=6 |issue= 3 |pages= 325-8 |year= 2001 |pmid= 11326303 |doi= 10.1038/sj.mp.4000854 }}
*{{cite journal | author=Katsuki A, Sumida Y, Gabazza EC, ''et al.'' |title=Plasma levels of agouti-related protein are increased in obese men. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 5 |pages= 1921-4 |year= 2001 |pmid= 11344185 |doi= }}
*{{cite journal | author=Mayfield DK, Brown AM, Page GP, ''et al.'' |title=A role for the Agouti-Related Protein promoter in obesity and type 2 diabetes. |journal=Biochem. Biophys. Res. Commun. |volume=287 |issue= 2 |pages= 568-73 |year= 2001 |pmid= 11554767 |doi= 10.1006/bbrc.2001.5600 }}
*{{cite journal | author=Brown AM, Mayfield DK, Volaufova J, Argyropoulos G |title=The gene structure and minimal promoter of the human agouti related protein. |journal=Gene |volume=277 |issue= 1-2 |pages= 231-8 |year= 2001 |pmid= 11602360 |doi= }}
*{{cite journal | author=McNulty JC, Thompson DA, Bolin KA, ''et al.'' |title=High-resolution NMR structure of the chemically-synthesized melanocortin receptor binding domain AGRP(87-132) of the agouti-related protein. |journal=Biochemistry |volume=40 |issue= 51 |pages= 15520-7 |year= 2002 |pmid= 11747427 |doi= }}
*{{cite journal | author=Jackson PJ, McNulty JC, Yang YK, ''et al.'' |title=Design, pharmacology, and NMR structure of a minimized cystine knot with agouti-related protein activity. |journal=Biochemistry |volume=41 |issue= 24 |pages= 7565-72 |year= 2002 |pmid= 12056887 |doi= }}
*{{cite journal | author=Shen CP, Wu KK, Shearman LP, ''et al.'' |title=Plasma agouti-related protein level: a possible correlation with fasted and fed states in humans and rats. |journal=J. Neuroendocrinol. |volume=14 |issue= 8 |pages= 607-10 |year= 2002 |pmid= 12153462 |doi= }}
*{{cite journal | author=Argyropoulos G, Rankinen T, Neufeld DR, ''et al.'' |title=A polymorphism in the human agouti-related protein is associated with late-onset obesity. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 9 |pages= 4198-202 |year= 2002 |pmid= 12213871 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on AKAP13... {November 19, 2007 11:22:54 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 11:23:38 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = A kinase (PRKA) anchor protein 13
| HGNCid = 371
| Symbol = AKAP13
| AltSymbols =; AKAP-Lbc; BRX; FLJ11952; FLJ43341; HA-3; Ht31; LBC; PROTO-LB; PROTO-LBC; c-lbc
| OMIM = 604686
| ECnumber =
| Homologene = 4903
| MGIid = 2676556
| Function = {{GNF_GO|id=GO:0004691 |text = cAMP-dependent protein kinase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005085 |text = guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005089 |text = Rho guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0016301 |text = kinase activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005624 |text = membrane fraction}}
| Process = {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0035023 |text = regulation of Rho protein signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 11214
| Hs_Ensembl = ENSG00000170776
| Hs_RefseqProtein = NP_006729
| Hs_RefseqmRNA = NM_006738
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 83578821
| Hs_GenLoc_end = 84093590
| Hs_Uniprot = Q12802
| Mm_EntrezGene = 75547
| Mm_Ensembl = ENSMUSG00000066406
| Mm_RefseqmRNA = XM_133543
| Mm_RefseqProtein = XP_133543
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 75329069
| Mm_GenLoc_end = 75610217
| Mm_Uniprot =
}}
}}
'''A kinase (PRKA) anchor protein 13''', also known as '''AKAP13''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AKAP13 A kinase (PRKA) anchor protein 13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11214| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in at least 3 transcript variants encoding different isoforms containing a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway and, in addition, function as protein kinase A-anchoring proteins.<ref name="entrez">{{cite web | title = Entrez Gene: AKAP13 A kinase (PRKA) anchor protein 13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11214| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Carr DW, Hausken ZE, Fraser ID, ''et al.'' |title=Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain. |journal=J. Biol. Chem. |volume=267 |issue= 19 |pages= 13376-82 |year= 1992 |pmid= 1618839 |doi= }}
*{{cite journal | author=Carr DW, Stofko-Hahn RE, Fraser ID, ''et al.'' |title=Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif. |journal=J. Biol. Chem. |volume=266 |issue= 22 |pages= 14188-92 |year= 1991 |pmid= 1860836 |doi= }}
*{{cite journal | author=Hausken ZE, Coghlan VM, Hastings CA, ''et al.'' |title=Type II regulatory subunit (RII) of the cAMP-dependent protein kinase interaction with A-kinase anchor proteins requires isoleucines 3 and 5. |journal=J. Biol. Chem. |volume=269 |issue= 39 |pages= 24245-51 |year= 1994 |pmid= 7929081 |doi= }}
*{{cite journal | author=Toksoz D, Williams DA |title=Novel human oncogene lbc detected by transfection with distinct homology regions to signal transduction products. |journal=Oncogene |volume=9 |issue= 2 |pages= 621-8 |year= 1994 |pmid= 8290273 |doi= }}
*{{cite journal | author=Rubino D, Driggers P, Arbit D, ''et al.'' |title=Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action. |journal=Oncogene |volume=16 |issue= 19 |pages= 2513-26 |year= 1998 |pmid= 9627117 |doi= 10.1038/sj.onc.1201783 }}
*{{cite journal | author=Sterpetti P, Hack AA, Bashar MP, ''et al.'' |title=Activation of the Lbc Rho exchange factor proto-oncogene by truncation of an extended C terminus that regulates transformation and targeting. |journal=Mol. Cell. Biol. |volume=19 |issue= 2 |pages= 1334-45 |year= 1999 |pmid= 9891067 |doi= }}
*{{cite journal | author=Sagi SA, Seasholtz TM, Kobiashvili M, ''et al.'' |title=Physical and functional interactions of Galphaq with Rho and its exchange factors. |journal=J. Biol. Chem. |volume=276 |issue= 18 |pages= 15445-52 |year= 2001 |pmid= 11278452 |doi= 10.1074/jbc.M008961200 }}
*{{cite journal | author=Newlon MG, Roy M, Morikis D, ''et al.'' |title=A novel mechanism of PKA anchoring revealed by solution structures of anchoring complexes. |journal=EMBO J. |volume=20 |issue= 7 |pages= 1651-62 |year= 2001 |pmid= 11285229 |doi= 10.1093/emboj/20.7.1651 }}
*{{cite journal | author=Diviani D, Soderling J, Scott JD |title=AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation. |journal=J. Biol. Chem. |volume=276 |issue= 47 |pages= 44247-57 |year= 2001 |pmid= 11546812 |doi= 10.1074/jbc.M106629200 }}
*{{cite journal | author=Driggers PH, Segars JH, Rubino DM |title=The proto-oncoprotein Brx activates estrogen receptor beta by a p38 mitogen-activated protein kinase pathway. |journal=J. Biol. Chem. |volume=276 |issue= 50 |pages= 46792-7 |year= 2002 |pmid= 11579095 |doi= 10.1074/jbc.M106927200 }}
*{{cite journal | author=Klussmann E, Edemir B, Pepperle B, ''et al.'' |title=Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling. |journal=FEBS Lett. |volume=507 |issue= 3 |pages= 264-8 |year= 2001 |pmid= 11696353 |doi= }}
*{{cite journal | author=Park B, Nguyen NT, Dutt P, ''et al.'' |title=Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation. |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 45361-70 |year= 2003 |pmid= 12270917 |doi= 10.1074/jbc.M202447200 }}
*{{cite journal | author=Tan YC, Wu H, Wang WN, ''et al.'' |title=Characterization of the interactions between the small GTPase RhoA and its guanine nucleotide exchange factors. |journal=Anal. Biochem. |volume=310 |issue= 2 |pages= 156-62 |year= 2003 |pmid= 12423633 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Spierings E, Brickner AG, Caldwell JA, ''et al.'' |title=The minor histocompatibility antigen HA-3 arises from differential proteasome-mediated cleavage of the lymphoid blast crisis (Lbc) oncoprotein. |journal=Blood |volume=102 |issue= 2 |pages= 621-9 |year= 2003 |pmid= 12663445 |doi= 10.1182/blood-2003-01-0260 }}
*{{cite journal | author=Alto NM, Soderling SH, Hoshi N, ''et al.'' |title=Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 8 |pages= 4445-50 |year= 2003 |pmid= 12672969 |doi= 10.1073/pnas.0330734100 }}
*{{cite journal | author=Hornemann T, Kempa S, Himmel M, ''et al.'' |title=Muscle-type creatine kinase interacts with central domains of the M-band proteins myomesin and M-protein. |journal=J. Mol. Biol. |volume=332 |issue= 4 |pages= 877-87 |year= 2003 |pmid= 12972258 |doi= }}
*{{cite journal | author=Dutt P, Nguyen N, Toksoz D |title=Role of Lbc RhoGEF in Galpha12/13-induced signals to Rho GTPase. |journal=Cell. Signal. |volume=16 |issue= 2 |pages= 201-9 |year= 2004 |pmid= 14636890 |doi= }}
*{{cite journal | author=Chen LY, Zuraw BL, Ye RD, Pan ZK |title=A Rho exchange factor mediates fMet-Leu-Phe-induced NF-kappaB activation in human peripheral blood monocytes. |journal=J. Biol. Chem. |volume=279 |issue= 8 |pages= 7208-12 |year= 2004 |pmid= 14660653 |doi= 10.1074/jbc.M309542200 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ATF6... {November 19, 2007 11:23:38 AM PST}
- SEARCH REDIRECT: Control Box Found: ATF6 {November 19, 2007 11:24:07 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 19, 2007 11:24:10 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 19, 2007 11:24:10 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 19, 2007 11:24:10 AM PST}
- UPDATED: Updated protein page: ATF6 {November 19, 2007 11:24:15 AM PST}
- INFO: Beginning work on BCAP31... {November 19, 2007 11:19:01 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 11:19:52 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = B-cell receptor-associated protein 31
| HGNCid = 16695
| Symbol = BCAP31
| AltSymbols =; CDM; 6C6-AG; BAP31; DXS1357E
| OMIM = 300398
| ECnumber =
| Homologene = 38095
| MGIid = 1350933
| GeneAtlas_image1 = PBB_GE_BCAP31_200837_at_tn.png
| Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}}
| Component = {{GNF_GO|id=GO:0000139 |text = Golgi membrane}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0006888 |text = ER to Golgi vesicle-mediated transport}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006955 |text = immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 10134
| Hs_Ensembl = ENSG00000185825
| Hs_RefseqProtein = NP_005736
| Hs_RefseqmRNA = NM_005745
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 152619148
| Hs_GenLoc_end = 152643364
| Hs_Uniprot = P51572
| Mm_EntrezGene = 27061
| Mm_Ensembl = ENSMUSG00000002015
| Mm_RefseqmRNA = NM_012060
| Mm_RefseqProtein = NP_036190
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 69938903
| Mm_GenLoc_end = 69968895
| Mm_Uniprot = Q3U9U5
}}
}}
'''B-cell receptor-associated protein 31''', also known as '''BCAP31''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BCAP31 B-cell receptor-associated protein 31| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10134| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Mosser J, Sarde CO, Vicaire S, ''et al.'' |title=A new human gene (DXS1357E) with ubiquitous expression, located in Xq28 adjacent to the adrenoleukodystrophy gene. |journal=Genomics |volume=22 |issue= 2 |pages= 469-71 |year= 1995 |pmid= 7806238 |doi= 10.1006/geno.1994.1413 }}
*{{cite journal | author=Sora I, Richman J, Santoro G, ''et al.'' |title=The cloning and expression of a human creatine transporter. |journal=Biochem. Biophys. Res. Commun. |volume=204 |issue= 1 |pages= 419-27 |year= 1994 |pmid= 7945388 |doi= }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal | author=Adachi T, Schamel WW, Kim KM, ''et al.'' |title=The specificity of association of the IgD molecule with the accessory proteins BAP31/BAP29 lies in the IgD transmembrane sequence. |journal=EMBO J. |volume=15 |issue= 7 |pages= 1534-41 |year= 1996 |pmid= 8612576 |doi= }}
*{{cite journal | author=Li E, Bestagno M, Burrone O |title=Molecular cloning and characterization of a transmembrane surface antigen in human cells. |journal=Eur. J. Biochem. |volume=238 |issue= 3 |pages= 631-8 |year= 1996 |pmid= 8706661 |doi= }}
*{{cite journal | author=Brenner V, Nyakatura G, Rosenthal A, Platzer M |title=Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse. |journal=Genomics |volume=44 |issue= 1 |pages= 8-14 |year= 1997 |pmid= 9286695 |doi= 10.1006/geno.1997.4822 }}
*{{cite journal | author=Ng FW, Nguyen M, Kwan T, ''et al.'' |title=p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum. |journal=J. Cell Biol. |volume=139 |issue= 2 |pages= 327-38 |year= 1997 |pmid= 9334338 |doi= }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal | author=Annaert WG, Becker B, Kistner U, ''et al.'' |title=Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31. |journal=J. Cell Biol. |volume=139 |issue= 6 |pages= 1397-410 |year= 1998 |pmid= 9396746 |doi= }}
*{{cite journal | author=Nguyen M, Breckenridge DG, Ducret A, Shore GC |title=Caspase-resistant BAP31 inhibits fas-mediated apoptotic membrane fragmentation and release of cytochrome c from mitochondria. |journal=Mol. Cell. Biol. |volume=20 |issue= 18 |pages= 6731-40 |year= 2000 |pmid= 10958671 |doi= }}
*{{cite journal | author=Bell AW, Ward MA, Blackstock WP, ''et al.'' |title=Proteomics characterization of abundant Golgi membrane proteins. |journal=J. Biol. Chem. |volume=276 |issue= 7 |pages= 5152-65 |year= 2001 |pmid= 11042173 |doi= 10.1074/jbc.M006143200 }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
*{{cite journal | author=Spiliotis ET, Manley H, Osorio M, ''et al.'' |title=Selective export of MHC class I molecules from the ER after their dissociation from TAP. |journal=Immunity |volume=13 |issue= 6 |pages= 841-51 |year= 2001 |pmid= 11163199 |doi= }}
*{{cite journal | author=Manley HA, Lennon VA |title=Endoplasmic reticulum membrane-sorting protein of lymphocytes (BAP31) is highly expressed in neurons and discrete endocrine cells. |journal=J. Histochem. Cytochem. |volume=49 |issue= 10 |pages= 1235-43 |year= 2001 |pmid= 11561007 |doi= }}
*{{cite journal | author=Zuppini A, Groenendyk J, Cormack LA, ''et al.'' |title=Calnexin deficiency and endoplasmic reticulum stress-induced apoptosis. |journal=Biochemistry |volume=41 |issue= 8 |pages= 2850-8 |year= 2002 |pmid= 11851433 |doi= }}
*{{cite journal | author=Breckenridge DG, Nguyen M, Kuppig S, ''et al.'' |title=The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 7 |pages= 4331-6 |year= 2002 |pmid= 11917123 |doi= 10.1073/pnas.072088099 }}
*{{cite journal | author=Corzo D, Gibson W, Johnson K, ''et al.'' |title=Contiguous deletion of the X-linked adrenoleukodystrophy gene (ABCD1) and DXS1357E: a novel neonatal phenotype similar to peroxisomal biogenesis disorders. |journal=Am. J. Hum. Genet. |volume=70 |issue= 6 |pages= 1520-31 |year= 2002 |pmid= 11992258 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Wang B, Nguyen M, Breckenridge DG, ''et al.'' |title=Uncleaved BAP31 in association with A4 protein at the endoplasmic reticulum is an inhibitor of Fas-initiated release of cytochrome c from mitochondria. |journal=J. Biol. Chem. |volume=278 |issue= 16 |pages= 14461-8 |year= 2003 |pmid= 12529377 |doi= 10.1074/jbc.M209684200 }}
*{{cite journal | author=Mund T, Gewies A, Schoenfeld N, ''et al.'' |title=Spike, a novel BH3-only protein, regulates apoptosis at the endoplasmic reticulum. |journal=FASEB J. |volume=17 |issue= 6 |pages= 696-8 |year= 2003 |pmid= 12594175 |doi= 10.1096/fj.02-0657fje }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CA3... {November 19, 2007 11:06:52 AM PST}
- SEARCH REDIRECT: Control Box Found: CA3 {November 19, 2007 11:07:53 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 19, 2007 11:07:54 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 19, 2007 11:07:54 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 19, 2007 11:07:54 AM PST}
- UPDATED: Updated protein page: CA3 {November 19, 2007 11:08:00 AM PST}
- INFO: Beginning work on CCNB2... {November 19, 2007 11:17:57 AM PST}
- SEARCH REDIRECT: Control Box Found: CCNB2 {November 19, 2007 11:18:21 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 19, 2007 11:18:24 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 19, 2007 11:18:24 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 19, 2007 11:18:24 AM PST}
- UPDATED: Updated protein page: CCNB2 {November 19, 2007 11:18:32 AM PST}
- INFO: Beginning work on CEBPD... {November 19, 2007 11:08:00 AM PST}
- SEARCH REDIRECT: Control Box Found: CEBPD {November 19, 2007 11:08:25 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 19, 2007 11:08:27 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 19, 2007 11:08:27 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 19, 2007 11:08:27 AM PST}
- UPDATED: Updated protein page: CEBPD {November 19, 2007 11:08:34 AM PST}
- INFO: Beginning work on CHRNA3... {November 19, 2007 11:08:35 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 11:09:03 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cholinergic receptor, nicotinic, alpha 3
| HGNCid = 1957
| Symbol = CHRNA3
| AltSymbols =; MGC104879
| OMIM = 118503
| ECnumber =
| Homologene = 591
| MGIid = 87887
| GeneAtlas_image1 = PBB_GE_CHRNA3_210221_at_tn.png
| GeneAtlas_image2 = PBB_GE_CHRNA3_211587_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_CHRNA3_211772_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004889 |text = nicotinic acetylcholine-activated cation-selective channel activity}} {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005230 |text = extracellular ligand-gated ion channel activity}} {{GNF_GO|id=GO:0015464 |text = acetylcholine receptor activity}} {{GNF_GO|id=GO:0030594 |text = neurotransmitter receptor activity}}
| Component = {{GNF_GO|id=GO:0005892 |text = nicotinic acetylcholine-gated receptor-channel complex}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1136
| Hs_Ensembl = ENSG00000080644
| Hs_RefseqProtein = NP_000734
| Hs_RefseqmRNA = NM_000743
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 76672452
| Hs_GenLoc_end = 76700692
| Hs_Uniprot = P32297
| Mm_EntrezGene = 110834
| Mm_Ensembl = ENSMUSG00000032303
| Mm_RefseqmRNA = NM_145129
| Mm_RefseqProtein = NP_660111
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 54809480
| Mm_GenLoc_end = 54824696
| Mm_Uniprot = Q0VBK4
}}
}}
'''Cholinergic receptor, nicotinic, alpha 3''', also known as '''CHRNA3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CHRNA3 cholinergic receptor, nicotinic, alpha 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1136| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Raimondi E, Rubboli F, Moralli D, ''et al.'' |title=Chromosomal localization and physical linkage of the genes encoding the human alpha 3, alpha 5, and beta 4 neuronal nicotinic receptor subunits. |journal=Genomics |volume=12 |issue= 4 |pages= 849-50 |year= 1992 |pmid= 1572664 |doi= }}
*{{cite journal | author=Boulter J, O'Shea-Greenfield A, Duvoisin RM, ''et al.'' |title=Alpha 3, alpha 5, and beta 4: three members of the rat neuronal nicotinic acetylcholine receptor-related gene family form a gene cluster. |journal=J. Biol. Chem. |volume=265 |issue= 8 |pages= 4472-82 |year= 1990 |pmid= 1689727 |doi= }}
*{{cite journal | author=Papke RL, Heinemann SF |title=The role of the beta 4-subunit in determining the kinetic properties of rat neuronal nicotinic acetylcholine alpha 3-receptors. |journal=J. Physiol. (Lond.) |volume=440 |issue= |pages= 95-112 |year= 1992 |pmid= 1725184 |doi= }}
*{{cite journal | author=Mihovilovic M, Roses AD |title=Expression of mRNAs in human thymus coding for the alpha 3 subunit of a neuronal acetylcholine receptor. |journal=Exp. Neurol. |volume=111 |issue= 2 |pages= 175-80 |year= 1991 |pmid= 1989896 |doi= }}
*{{cite journal | author=Eng CM, Kozak CA, Beaudet AL, Zoghbi HY |title=Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse. |journal=Genomics |volume=9 |issue= 2 |pages= 278-82 |year= 1991 |pmid= 2004777 |doi= }}
*{{cite journal | author=Fornasari D, Chini B, Tarroni P, Clementi F |title=Molecular cloning of human neuronal nicotinic receptor alpha 3-subunit. |journal=Neurosci. Lett. |volume=111 |issue= 3 |pages= 351-6 |year= 1990 |pmid= 2336208 |doi= }}
*{{cite journal | author=Grando SA, Horton RM, Pereira EF, ''et al.'' |title=A nicotinic acetylcholine receptor regulating cell adhesion and motility is expressed in human keratinocytes. |journal=J. Invest. Dermatol. |volume=105 |issue= 6 |pages= 774-81 |year= 1996 |pmid= 7490471 |doi= }}
*{{cite journal | author=Rubboli F, Court JA, Sala C, ''et al.'' |title=Distribution of nicotinic receptors in the human hippocampus and thalamus. |journal=Eur. J. Neurosci. |volume=6 |issue= 10 |pages= 1596-604 |year= 1995 |pmid= 7850023 |doi= }}
*{{cite journal | author=Hiemke C, Stolp M, Reuss S, ''et al.'' |title=Expression of alpha subunit genes of nicotinic acetylcholine receptors in human lymphocytes. |journal=Neurosci. Lett. |volume=214 |issue= 2-3 |pages= 171-4 |year= 1997 |pmid= 8878111 |doi= }}
*{{cite journal | author=Elliott KJ, Ellis SB, Berckhan KJ, ''et al.'' |title=Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits. |journal=J. Mol. Neurosci. |volume=7 |issue= 3 |pages= 217-28 |year= 1997 |pmid= 8906617 |doi= }}
*{{cite journal | author=Groot Kormelink PJ, Luyten WH |title=Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32. |journal=FEBS Lett. |volume=400 |issue= 3 |pages= 309-14 |year= 1997 |pmid= 9009220 |doi= }}
*{{cite journal | author=Zia S, Ndoye A, Nguyen VT, Grando SA |title=Nicotine enhances expression of the alpha 3, alpha 4, alpha 5, and alpha 7 nicotinic receptors modulating calcium metabolism and regulating adhesion and motility of respiratory epithelial cells. |journal=Res. Commun. Mol. Pathol. Pharmacol. |volume=97 |issue= 3 |pages= 243-62 |year= 1998 |pmid= 9387186 |doi= }}
*{{cite journal | author=Groot-Kormelink PJ, Luyten WH, Colquhoun D, Sivilotti LG |title=A reporter mutation approach shows incorporation of the "orphan" subunit beta3 into a functional nicotinic receptor. |journal=J. Biol. Chem. |volume=273 |issue= 25 |pages= 15317-20 |year= 1998 |pmid= 9624109 |doi= }}
*{{cite journal | author=Maus AD, Pereira EF, Karachunski PI, ''et al.'' |title=Human and rodent bronchial epithelial cells express functional nicotinic acetylcholine receptors. |journal=Mol. Pharmacol. |volume=54 |issue= 5 |pages= 779-88 |year= 1998 |pmid= 9804613 |doi= }}
*{{cite journal | author=Rempel N, Heyers S, Engels H, ''et al.'' |title=The structures of the human neuronal nicotinic acetylcholine receptor beta2- and alpha3-subunit genes (CHRNB2 and CHRNA3). |journal=Hum. Genet. |volume=103 |issue= 6 |pages= 645-53 |year= 1999 |pmid= 9921897 |doi= }}
*{{cite journal | author=Hellström-Lindahl E, Mousavi M, Zhang X, ''et al.'' |title=Regional distribution of nicotinic receptor subunit mRNAs in human brain: comparison between Alzheimer and normal brain. |journal=Brain Res. Mol. Brain Res. |volume=66 |issue= 1-2 |pages= 94-103 |year= 1999 |pmid= 10095081 |doi= }}
*{{cite journal | author=Sato KZ, Fujii T, Watanabe Y, ''et al.'' |title=Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines. |journal=Neurosci. Lett. |volume=266 |issue= 1 |pages= 17-20 |year= 1999 |pmid= 10336173 |doi= }}
*{{cite journal | author=Flora A, Schulz R, Benfante R, ''et al.'' |title=Transcriptional regulation of the human alpha5 nicotinic receptor subunit gene in neuronal and non-neuronal tissues. |journal=Eur. J. Pharmacol. |volume=393 |issue= 1-3 |pages= 85-95 |year= 2000 |pmid= 10771001 |doi= }}
*{{cite journal | author=Boorman JP, Groot-Kormelink PJ, Sivilotti LG |title=Stoichiometry of human recombinant neuronal nicotinic receptors containing the b3 subunit expressed in Xenopus oocytes. |journal=J. Physiol. (Lond.) |volume=529 Pt 3 |issue= |pages= 565-77 |year= 2001 |pmid= 11118490 |doi= }}
*{{cite journal | author=Lev-Lehman E, Bercovich D, Xu W, ''et al.'' |title=Characterization of the human beta4 nAChR gene and polymorphisms in CHRNA3 and CHRNB4. |journal=J. Hum. Genet. |volume=46 |issue= 7 |pages= 362-6 |year= 2001 |pmid= 11450844 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CLEC4M... {November 19, 2007 11:20:39 AM PST}
- SEARCH REDIRECT: Control Box Found: CLEC4M {November 19, 2007 11:21:30 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 19, 2007 11:21:31 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 19, 2007 11:21:31 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 19, 2007 11:21:31 AM PST}
- UPDATED: Updated protein page: CLEC4M {November 19, 2007 11:21:39 AM PST}
- INFO: Beginning work on CYP24A1... {November 19, 2007 11:09:03 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 11:09:41 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cytochrome P450, family 24, subfamily A, polypeptide 1
| HGNCid = 2602
| Symbol = CYP24A1
| AltSymbols =; CP24; CYP24; MGC126273; MGC126274; P450-CC24
| OMIM = 126065
| ECnumber =
| Homologene = 68094
| MGIid = 88593
| GeneAtlas_image1 = PBB_GE_CYP24A1_206504_at_tn.png
| Function = {{GNF_GO|id=GO:0004497 |text = monooxygenase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0008403 |text = 25-hydroxycholecalciferol-24-hydroxylase activity}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0030342 |text = 1-alpha,25-dihydroxyvitamin D3 (1,25-(OH)2D3) 24-hydroxylase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0042359 |text = vitamin D metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1591
| Hs_Ensembl = ENSG00000019186
| Hs_RefseqProtein = NP_000773
| Hs_RefseqmRNA = NM_000782
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 52203395
| Hs_GenLoc_end = 52223931
| Hs_Uniprot = Q07973
| Mm_EntrezGene = 13081
| Mm_Ensembl = ENSMUSG00000038567
| Mm_RefseqmRNA = NM_009996
| Mm_RefseqProtein = NP_034126
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 170174170
| Mm_GenLoc_end = 170188343
| Mm_Uniprot = Q3TP55
}}
}}
'''Cytochrome P450, family 24, subfamily A, polypeptide 1''', also known as '''CYP24A1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1591| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system.<ref name="entrez">{{cite web | title = Entrez Gene: CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1591| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Okuda K, Usui E, Ohyama Y |title=Recent progress in enzymology and molecular biology of enzymes involved in vitamin D metabolism. |journal=J. Lipid Res. |volume=36 |issue= 8 |pages= 1641-52 |year= 1995 |pmid= 7595086 |doi= }}
*{{cite journal | author=Chen KS, DeLuca HF |title=Cloning of the human 1 alpha,25-dihydroxyvitamin D-3 24-hydroxylase gene promoter and identification of two vitamin D-responsive elements. |journal=Biochim. Biophys. Acta |volume=1263 |issue= 1 |pages= 1-9 |year= 1995 |pmid= 7632726 |doi= }}
*{{cite journal | author=Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, ''et al.'' |title=Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. |journal=Genomics |volume=23 |issue= 1 |pages= 42-50 |year= 1995 |pmid= 7829101 |doi= 10.1006/geno.1994.1457 }}
*{{cite journal | author=Chen ML, Heinrich G, Ohyama YI, ''et al.'' |title=Expression of 25-hydroxyvitamin D3-24-hydroxylase mRNA in cultured human keratinocytes. |journal=Proc. Soc. Exp. Biol. Med. |volume=207 |issue= 1 |pages= 57-61 |year= 1994 |pmid= 7938037 |doi= }}
*{{cite journal | author=Labuda M, Lemieux N, Tihy F, ''et al.'' |title=Human 25-hydroxyvitamin D 24-hydroxylase cytochrome P450 subunit maps to a different chromosomal location than that of pseudovitamin D-deficient rickets. |journal=J. Bone Miner. Res. |volume=8 |issue= 11 |pages= 1397-406 |year= 1994 |pmid= 8266831 |doi= }}
*{{cite journal | author=Hahn CN, Baker E, Laslo P, ''et al.'' |title=Localization of the human vitamin D 24-hydroxylase gene (CYP24) to chromosome 20q13.2-->q13.3. |journal=Cytogenet. Cell Genet. |volume=62 |issue= 4 |pages= 192-3 |year= 1993 |pmid= 8440135 |doi= }}
*{{cite journal | author=Chen KS, Prahl JM, DeLuca HF |title=Isolation and expression of human 1,25-dihydroxyvitamin D3 24-hydroxylase cDNA. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 10 |pages= 4543-7 |year= 1993 |pmid= 8506296 |doi= }}
*{{cite journal | author=Bland R, Walker EA, Hughes SV, ''et al.'' |title=Constitutive expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in a transformed human proximal tubule cell line: evidence for direct regulation of vitamin D metabolism by calcium. |journal=Endocrinology |volume=140 |issue= 5 |pages= 2027-34 |year= 1999 |pmid= 10218951 |doi= }}
*{{cite journal | author=Taniguchi T, Eto TA, Shiotsuki H, ''et al.'' |title=Newly established assay method for 25-hydroxyvitamin D3 24-hydroxylase revealed much lower Km for 25-hydroxyvitamin D3 than for 1alpha,25-dihydroxyvitamin D3. |journal=J. Bone Miner. Res. |volume=16 |issue= 1 |pages= 57-62 |year= 2001 |pmid= 11149490 |doi= }}
*{{cite journal | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Farhan H, Cross HS |title=Transcriptional inhibition of CYP24 by genistein. |journal=Ann. N. Y. Acad. Sci. |volume=973 |issue= |pages= 459-62 |year= 2003 |pmid= 12485911 |doi= }}
*{{cite journal | author=Theodoropoulos C, Demers C, Delvin E, ''et al.'' |title=Calcitriol regulates the expression of the genes encoding the three key vitamin D3 hydroxylases and the drug-metabolizing enzyme CYP3A4 in the human fetal intestine. |journal=Clin. Endocrinol. (Oxf) |volume=58 |issue= 4 |pages= 489-99 |year= 2003 |pmid= 12641633 |doi= }}
*{{cite journal | author=Fritsche J, Mondal K, Ehrnsperger A, ''et al.'' |title=Regulation of 25-hydroxyvitamin D3-1 alpha-hydroxylase and production of 1 alpha,25-dihydroxyvitamin D3 by human dendritic cells. |journal=Blood |volume=102 |issue= 9 |pages= 3314-6 |year= 2004 |pmid= 12855575 |doi= 10.1182/blood-2002-11-3521 }}
*{{cite journal | author=Nguyen TM, Lieberherr M, Fritsch J, ''et al.'' |title=The rapid effects of 1,25-dihydroxyvitamin D3 require the vitamin D receptor and influence 24-hydroxylase activity: studies in human skin fibroblasts bearing vitamin D receptor mutations. |journal=J. Biol. Chem. |volume=279 |issue= 9 |pages= 7591-7 |year= 2004 |pmid= 14665637 |doi= 10.1074/jbc.M309517200 }}
*{{cite journal | author=Mimori K, Tanaka Y, Yoshinaga K, ''et al.'' |title=Clinical significance of the overexpression of the candidate oncogene CYP24 in esophageal cancer. |journal=Ann. Oncol. |volume=15 |issue= 2 |pages= 236-41 |year= 2004 |pmid= 14760115 |doi= }}
*{{cite journal | author=Sawada N, Kusudo T, Sakaki T, ''et al.'' |title=Novel metabolism of 1 alpha,25-dihydroxyvitamin D3 with C24-C25 bond cleavage catalyzed by human CYP24A1. |journal=Biochemistry |volume=43 |issue= 15 |pages= 4530-7 |year= 2004 |pmid= 15078099 |doi= 10.1021/bi030207f }}
*{{cite journal | author=Kusudo T, Sakaki T, Abe D, ''et al.'' |title=Metabolism of A-ring diastereomers of 1alpha,25-dihydroxyvitamin D3 by CYP24A1. |journal=Biochem. Biophys. Res. Commun. |volume=321 |issue= 4 |pages= 774-82 |year= 2004 |pmid= 15358094 |doi= 10.1016/j.bbrc.2004.07.040 }}
*{{cite journal | author=Pascussi JM, Robert A, Nguyen M, ''et al.'' |title=Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia. |journal=J. Clin. Invest. |volume=115 |issue= 1 |pages= 177-86 |year= 2005 |pmid= 15630458 |doi= 10.1172/JCI200521867 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on EDN3... {November 19, 2007 11:09:41 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 11:10:16 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Endothelin 3
| HGNCid = 3178
| Symbol = EDN3
| AltSymbols =; ET3; MGC15067; MGC61498
| OMIM = 131242
| ECnumber =
| Homologene = 88
| MGIid = 95285
| GeneAtlas_image1 = PBB_GE_EDN3_208399_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_EDN3_217154_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0009405 |text = pathogenesis}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}} {{GNF_GO|id=GO:0019229 |text = regulation of vasoconstriction}} {{GNF_GO|id=GO:0030318 |text = melanocyte differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1908
| Hs_Ensembl = ENSG00000124205
| Hs_RefseqProtein = NP_000105
| Hs_RefseqmRNA = NM_000114
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 57308877
| Hs_GenLoc_end = 57334442
| Hs_Uniprot = P14138
| Mm_EntrezGene = 13616
| Mm_Ensembl = ENSMUSG00000027524
| Mm_RefseqmRNA = NM_007903
| Mm_RefseqProtein = NP_031929
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 174403712
| Mm_GenLoc_end = 174426981
| Mm_Uniprot = P48299
}}
}}
'''Endothelin 3''', also known as '''EDN3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EDN3 endothelin 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1908| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.<ref name="entrez">{{cite web | title = Entrez Gene: EDN3 endothelin 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1908| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Calderone RA |title=Molecular interactions at the interface of Candida albicans and host cells. |journal=Arch. Med. Res. |volume=24 |issue= 3 |pages= 275-9 |year= 1994 |pmid= 8298278 |doi= }}
*{{cite journal | author=Hofstra RM, Osinga J, Buys CH |title=Mutations in Hirschsprung disease: when does a mutation contribute to the phenotype. |journal=Eur. J. Hum. Genet. |volume=5 |issue= 4 |pages= 180-5 |year= 1998 |pmid= 9359036 |doi= }}
*{{cite journal | author=Parisi MA, Kapur RP |title=Genetics of Hirschsprung disease. |journal=Curr. Opin. Pediatr. |volume=12 |issue= 6 |pages= 610-7 |year= 2001 |pmid= 11106284 |doi= }}
*{{cite journal | author=O'Reilly G, Charnock-Jones DS, Davenport AP, ''et al.'' |title=Presence of messenger ribonucleic acid for endothelin-1, endothelin-2, and endothelin-3 in human endometrium and a change in the ratio of ETA and ETB receptor subtype across the menstrual cycle. |journal=J. Clin. Endocrinol. Metab. |volume=75 |issue= 6 |pages= 1545-9 |year= 1993 |pmid= 1464662 |doi= }}
*{{cite journal | author=Mills RG, O'Donoghue SI, Smith R, King GF |title=Solution structure of endothelin-3 determined using NMR spectroscopy. |journal=Biochemistry |volume=31 |issue= 24 |pages= 5640-5 |year= 1992 |pmid= 1610811 |doi= }}
*{{cite journal | author=Rao VV, Löffler C, Hansmann I |title=The gene for the novel vasoactive peptide endothelin 3 (EDN3) is localized to human chromosome 20q13.2-qter. |journal=Genomics |volume=10 |issue= 3 |pages= 840-1 |year= 1991 |pmid= 1889823 |doi= }}
*{{cite journal | author=Arinami T, Ishikawa M, Inoue A, ''et al.'' |title=Chromosomal assignments of the human endothelin family genes: the endothelin-1 gene (EDN1) to 6p23-p24, the endothelin-2 gene (EDN2) to 1p34, and the endothelin-3 gene (EDN3) to 20q13.2-q13.3. |journal=Am. J. Hum. Genet. |volume=48 |issue= 5 |pages= 990-6 |year= 1991 |pmid= 2018043 |doi= }}
*{{cite journal | author=Onda H, Ohkubo S, Ogi K, ''et al.'' |title=One of the endothelin gene family, endothelin 3 gene, is expressed in the placenta. |journal=FEBS Lett. |volume=261 |issue= 2 |pages= 327-30 |year= 1990 |pmid= 2178974 |doi= }}
*{{cite journal | author=Lees WE, Kalinka S, Meech J, ''et al.'' |title=Generation of human endothelin by cathepsin E. |journal=FEBS Lett. |volume=273 |issue= 1-2 |pages= 99-102 |year= 1990 |pmid= 2226872 |doi= }}
*{{cite journal | author=Bloch KD, Eddy RL, Shows TB, Quertermous T |title=cDNA cloning and chromosomal assignment of the gene encoding endothelin 3. |journal=J. Biol. Chem. |volume=264 |issue= 30 |pages= 18156-61 |year= 1989 |pmid= 2509452 |doi= }}
*{{cite journal | author=Inoue A, Yanagisawa M, Kimura S, ''et al.'' |title=The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 8 |pages= 2863-7 |year= 1989 |pmid= 2649896 |doi= }}
*{{cite journal | author=Yu JC, Davenport AP |title=Secretion of endothelin-1 and endothelin-3 by human cultured vascular smooth muscle cells. |journal=Br. J. Pharmacol. |volume=114 |issue= 2 |pages= 551-7 |year= 1995 |pmid= 7881755 |doi= }}
*{{cite journal | author=Baynash AG, Hosoda K, Giaid A, ''et al.'' |title=Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons. |journal=Cell |volume=79 |issue= 7 |pages= 1277-85 |year= 1995 |pmid= 8001160 |doi= }}
*{{cite journal | author=Edery P, Attié T, Amiel J, ''et al.'' |title=Mutation of the endothelin-3 gene in the Waardenburg-Hirschsprung disease (Shah-Waardenburg syndrome). |journal=Nat. Genet. |volume=12 |issue= 4 |pages= 442-4 |year= 1996 |pmid= 8630502 |doi= 10.1038/ng0496-442 }}
*{{cite journal | author=Hofstra RM, Osinga J, Tan-Sindhunata G, ''et al.'' |title=A homozygous mutation in the endothelin-3 gene associated with a combined Waardenburg type 2 and Hirschsprung phenotype (Shah-Waardenburg syndrome). |journal=Nat. Genet. |volume=12 |issue= 4 |pages= 445-7 |year= 1996 |pmid= 8630503 |doi= 10.1038/ng0496-445 }}
*{{cite journal | author=Lahav R, Ziller C, Dupin E, Le Douarin NM |title=Endothelin 3 promotes neural crest cell proliferation and mediates a vast increase in melanocyte number in culture. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 9 |pages= 3892-7 |year= 1996 |pmid= 8632985 |doi= }}
*{{cite journal | author=Bolk S, Angrist M, Xie J, ''et al.'' |title=Endothelin-3 frameshift mutation in congenital central hypoventilation syndrome. |journal=Nat. Genet. |volume=13 |issue= 4 |pages= 395-6 |year= 1996 |pmid= 8696331 |doi= 10.1038/ng0896-395 }}
*{{cite journal | author=Nakano A, Kishi F, Minami K, ''et al.'' |title=Selective conversion of big endothelins to tracheal smooth muscle-constricting 31-amino acid-length endothelins by chymase from human mast cells. |journal=J. Immunol. |volume=159 |issue= 4 |pages= 1987-92 |year= 1997 |pmid= 9257865 |doi= }}
*{{cite journal | author=Bourgeois C, Robert B, Rebourcet R, ''et al.'' |title=Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3. |journal=J. Clin. Endocrinol. Metab. |volume=82 |issue= 9 |pages= 3116-23 |year= 1997 |pmid= 9284755 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on EGR2... {November 19, 2007 11:10:16 AM PST}
- SEARCH REDIRECT: Control Box Found: EGR2 {November 19, 2007 11:10:49 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 19, 2007 11:10:50 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 19, 2007 11:10:50 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 19, 2007 11:10:50 AM PST}
- UPDATED: Updated protein page: EGR2 {November 19, 2007 11:10:56 AM PST}
- INFO: Beginning work on EIF2B5... {November 19, 2007 11:16:30 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 11:17:10 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
| HGNCid = 3261
| Symbol = EIF2B5
| AltSymbols =; EIF-2B; CACH; CLE; EIF2Bepsilon; LVWM
| OMIM = 603945
| ECnumber =
| Homologene = 2903
| MGIid = 2446176
| GeneAtlas_image1 = PBB_GE_EIF2B5_212351_at_tn.png
| Function = {{GNF_GO|id=GO:0003743 |text = translation initiation factor activity}} {{GNF_GO|id=GO:0005085 |text = guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008415 |text = acyltransferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005851 |text = eukaryotic translation initiation factor 2B complex}}
| Process = {{GNF_GO|id=GO:0001541 |text = ovarian follicle development}} {{GNF_GO|id=GO:0009408 |text = response to heat}} {{GNF_GO|id=GO:0009749 |text = response to glucose stimulus}} {{GNF_GO|id=GO:0014002 |text = astrocyte development}} {{GNF_GO|id=GO:0014003 |text = oligodendrocyte development}} {{GNF_GO|id=GO:0042552 |text = myelination}} {{GNF_GO|id=GO:0043434 |text = response to peptide hormone stimulus}} {{GNF_GO|id=GO:0045948 |text = positive regulation of translational initiation}} {{GNF_GO|id=GO:0051716 |text = cellular response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8893
| Hs_Ensembl = ENSG00000145191
| Hs_RefseqProtein = NP_003898
| Hs_RefseqmRNA = NM_003907
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 185335520
| Hs_GenLoc_end = 185345792
| Hs_Uniprot = Q13144
| Mm_EntrezGene = 224045
| Mm_Ensembl = ENSMUSG00000003235
| Mm_RefseqmRNA = NM_172265
| Mm_RefseqProtein = NP_758469
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 20412360
| Mm_GenLoc_end = 20422866
| Mm_Uniprot = Q8CHW4
}}
}}
'''Eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa''', also known as '''EIF2B5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8893| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Leegwater PA, Pronk JC, van der Knaap MS |title=Leukoencephalopathy with vanishing white matter: from magnetic resonance imaging pattern to five genes. |journal=J. Child Neurol. |volume=18 |issue= 9 |pages= 639-45 |year= 2003 |pmid= 14572143 |doi= }}
*{{cite journal | author=Chaudhri MA, Crawford AC |title=Carbon determination in human teeth by activation with He-3 ions. |journal=Biological trace element research |volume=26-27 |issue= |pages= 521-7 |year= 1991 |pmid= 1704758 |doi= }}
*{{cite journal | author=Welsh GI, Miyamoto S, Price NT, ''et al.'' |title=T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3. |journal=J. Biol. Chem. |volume=271 |issue= 19 |pages= 11410-3 |year= 1996 |pmid= 8626696 |doi= }}
*{{cite journal | author=Asuru AI, Mellor H, Thomas NS, ''et al.'' |title=Cloning and characterization of cDNAs encoding the epsilon-subunit of eukaryotic initiation factor-2B from rabbit and human. |journal=Biochim. Biophys. Acta |volume=1307 |issue= 3 |pages= 309-17 |year= 1996 |pmid= 8688466 |doi= }}
*{{cite journal | author=Kimball SR, Heinzinger NK, Horetsky RL, Jefferson LS |title=Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B. |journal=J. Biol. Chem. |volume=273 |issue= 5 |pages= 3039-44 |year= 1998 |pmid= 9446619 |doi= }}
*{{cite journal | author=Welsh GI, Miller CM, Loughlin AJ, ''et al.'' |title=Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin. |journal=FEBS Lett. |volume=421 |issue= 2 |pages= 125-30 |year= 1998 |pmid= 9468292 |doi= }}
*{{cite journal | author=Leegwater PA, Könst AA, Kuyt B, ''et al.'' |title=The gene for leukoencephalopathy with vanishing white matter is located on chromosome 3q27. |journal=Am. J. Hum. Genet. |volume=65 |issue= 3 |pages= 728-34 |year= 1999 |pmid= 10441579 |doi= }}
*{{cite journal | author=Gomez E, Pavitt GD |title=Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation. |journal=Mol. Cell. Biol. |volume=20 |issue= 11 |pages= 3965-76 |year= 2000 |pmid= 10805739 |doi= }}
*{{cite journal | author=Anthony TG, Fabian JR, Kimball SR, Jefferson LS |title=Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation. |journal=Biochim. Biophys. Acta |volume=1492 |issue= 1 |pages= 56-62 |year= 2000 |pmid= 10858531 |doi= }}
*{{cite journal | author=Williams DD, Price NT, Loughlin AJ, Proud CG |title=Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein. |journal=J. Biol. Chem. |volume=276 |issue= 27 |pages= 24697-703 |year= 2001 |pmid= 11323413 |doi= 10.1074/jbc.M011788200 }}
*{{cite journal | author=Wang X, Paulin FE, Campbell LE, ''et al.'' |title=Eukaryotic initiation factor 2B: identification of multiple phosphorylation sites in the epsilon-subunit and their functions in vivo. |journal=EMBO J. |volume=20 |issue= 16 |pages= 4349-59 |year= 2001 |pmid= 11500362 |doi= 10.1093/emboj/20.16.4349 }}
*{{cite journal | author=Leegwater PA, Vermeulen G, Könst AA, ''et al.'' |title=Subunits of the translation initiation factor eIF2B are mutant in leukoencephalopathy with vanishing white matter. |journal=Nat. Genet. |volume=29 |issue= 4 |pages= 383-8 |year= 2001 |pmid= 11704758 |doi= 10.1038/ng764 }}
*{{cite journal | author=Wang X, Janmaat M, Beugnet A, ''et al.'' |title=Evidence that the dephosphorylation of Ser(535) in the epsilon-subunit of eukaryotic initiation factor (eIF) 2B is insufficient for the activation of eIF2B by insulin. |journal=Biochem. J. |volume=367 |issue= Pt 2 |pages= 475-81 |year= 2002 |pmid= 12133000 |doi= 10.1042/BJ20020677 }}
*{{cite journal | author=Fogli A, Wong K, Eymard-Pierre E, ''et al.'' |title=Cree leukoencephalopathy and CACH/VWM disease are allelic at the EIF2B5 locus. |journal=Ann. Neurol. |volume=52 |issue= 4 |pages= 506-10 |year= 2002 |pmid= 12325082 |doi= 10.1002/ana.10339 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Fogli A, Dionisi-Vici C, Deodato F, ''et al.'' |title=A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation. |journal=Neurology |volume=59 |issue= 12 |pages= 1966-8 |year= 2003 |pmid= 12499492 |doi= }}
*{{cite journal | author=Fogli A, Rodriguez D, Eymard-Pierre E, ''et al.'' |title=Ovarian failure related to eukaryotic initiation factor 2B mutations. |journal=Am. J. Hum. Genet. |volume=72 |issue= 6 |pages= 1544-50 |year= 2003 |pmid= 12707859 |doi= }}
*{{cite journal | author=van der Knaap MS, van Berkel CG, Herms J, ''et al.'' |title=eIF2B-related disorders: antenatal onset and involvement of multiple organs. |journal=Am. J. Hum. Genet. |volume=73 |issue= 5 |pages= 1199-207 |year= 2004 |pmid= 14566705 |doi= }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on EPHB1... {November 19, 2007 11:10:56 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 11:11:32 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_EPHB1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2djs.
| PDB = {{PDB2|2djs}}
| Name = EPH receptor B1
| HGNCid = 3392
| Symbol = EPHB1
| AltSymbols =; NET; ELK; EPHT2; FLJ37986; Hek6
| OMIM = 600600
| ECnumber =
| Homologene = 20936
| MGIid = 1096337
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005003 |text = ephrin receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}} {{GNF_GO|id=GO:0007399 |text = nervous system development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2047
| Hs_Ensembl =
| Hs_RefseqProtein = NP_004432
| Hs_RefseqmRNA = NM_004441
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 270190
| Mm_Ensembl = ENSMUSG00000032537
| Mm_RefseqmRNA = NM_173447
| Mm_RefseqProtein = NP_775623
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 101779749
| Mm_GenLoc_end = 102079716
| Mm_Uniprot = Q8CA63
}}
}}
'''EPH receptor B1''', also known as '''EPHB1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EPHB1 EPH receptor B1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2047| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.<ref name="entrez">{{cite web | title = Entrez Gene: EPHB1 EPH receptor B1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2047| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Flanagan JG, Vanderhaeghen P |title=The ephrins and Eph receptors in neural development. |journal=Annu. Rev. Neurosci. |volume=21 |issue= |pages= 309-45 |year= 1998 |pmid= 9530499 |doi= 10.1146/annurev.neuro.21.1.309 }}
*{{cite journal | author=Zhou R |title=The Eph family receptors and ligands. |journal=Pharmacol. Ther. |volume=77 |issue= 3 |pages= 151-81 |year= 1998 |pmid= 9576626 |doi= }}
*{{cite journal | author=Abrahamson DR, Robert B, Hyink DP, ''et al.'' |title=Origins and formation of microvasculature in the developing kidney. |journal=Kidney Int. Suppl. |volume=67 |issue= |pages= S7-11 |year= 1998 |pmid= 9736245 |doi= }}
*{{cite journal | author=Holder N, Klein R |title=Eph receptors and ephrins: effectors of morphogenesis. |journal=Development |volume=126 |issue= 10 |pages= 2033-44 |year= 1999 |pmid= 10207129 |doi= }}
*{{cite journal | author=Wilkinson DG |title=Eph receptors and ephrins: regulators of guidance and assembly. |journal=Int. Rev. Cytol. |volume=196 |issue= |pages= 177-244 |year= 2000 |pmid= 10730216 |doi= }}
*{{cite journal | author=Xu Q, Mellitzer G, Wilkinson DG |title=Roles of Eph receptors and ephrins in segmental patterning. |journal=Philos. Trans. R. Soc. Lond., B, Biol. Sci. |volume=355 |issue= 1399 |pages= 993-1002 |year= 2001 |pmid= 11128993 |doi= 10.1098/rstb.2000.0635 }}
*{{cite journal | author=Wilkinson DG |title=Multiple roles of EPH receptors and ephrins in neural development. |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 155-64 |year= 2001 |pmid= 11256076 |doi= }}
*{{cite journal | author=Larose L, Gish G, Shoelson S, Pawson T |title=Identification of residues in the beta platelet-derived growth factor receptor that confer specificity for binding to phospholipase C-gamma 1. |journal=Oncogene |volume=8 |issue= 9 |pages= 2493-9 |year= 1993 |pmid= 7689724 |doi= }}
*{{cite journal | author=Davis S, Gale NW, Aldrich TH, ''et al.'' |title=Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. |journal=Science |volume=266 |issue= 5186 |pages= 816-9 |year= 1994 |pmid= 7973638 |doi= }}
*{{cite journal | author=Beckmann MP, Cerretti DP, Baum P, ''et al.'' |title=Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors. |journal=EMBO J. |volume=13 |issue= 16 |pages= 3757-62 |year= 1994 |pmid= 8070404 |doi= }}
*{{cite journal | author=Cerretti DP, Vanden Bos T, Nelson N, ''et al.'' |title=Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases. |journal=Mol. Immunol. |volume=32 |issue= 16 |pages= 1197-205 |year= 1996 |pmid= 8559144 |doi= }}
*{{cite journal | author=Tang XX, Biegel JA, Nycum LM, ''et al.'' |title=cDNA cloning, molecular characterization, and chromosomal localization of NET(EPHT2), a human EPH-related receptor protein-tyrosine kinase gene preferentially expressed in brain. |journal=Genomics |volume=29 |issue= 2 |pages= 426-37 |year= 1996 |pmid= 8666391 |doi= 10.1006/geno.1995.9985 }}
*{{cite journal | author=Gale NW, Holland SJ, Valenzuela DM, ''et al.'' |title=Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. |journal=Neuron |volume=17 |issue= 1 |pages= 9-19 |year= 1996 |pmid= 8755474 |doi= }}
*{{cite journal | author=Stein E, Cerretti DP, Daniel TO |title=Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells. |journal=J. Biol. Chem. |volume=271 |issue= 38 |pages= 23588-93 |year= 1996 |pmid= 8798570 |doi= }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
*{{cite journal | author=Kozlosky CJ, VandenBos T, Park L, ''et al.'' |title=LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain. |journal=Cytokine |volume=9 |issue= 8 |pages= 540-9 |year= 1997 |pmid= 9245480 |doi= 10.1006/cyto.1997.0199 }}
*{{cite journal | author= |title=Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. |journal=Cell |volume=90 |issue= 3 |pages= 403-4 |year= 1997 |pmid= 9267020 |doi= }}
*{{cite journal | author=Stein E, Huynh-Do U, Lane AA, ''et al.'' |title=Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase. |journal=J. Biol. Chem. |volume=273 |issue= 3 |pages= 1303-8 |year= 1998 |pmid= 9430661 |doi= }}
*{{cite journal | author=Stein E, Lane AA, Cerretti DP, ''et al.'' |title=Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses. |journal=Genes Dev. |volume=12 |issue= 5 |pages= 667-78 |year= 1998 |pmid= 9499402 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on F2RL2... {November 19, 2007 11:12:00 AM PST}
- SEARCH REDIRECT: Control Box Found: F2RL2 {November 19, 2007 11:12:32 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 19, 2007 11:12:35 AM PST}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {November 19, 2007 11:12:35 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 19, 2007 11:12:35 AM PST}
- UPDATED: Updated protein page: F2RL2 {November 19, 2007 11:12:41 AM PST}
- INFO: Beginning work on FBL... {November 19, 2007 11:11:32 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 11:11:59 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FBL_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ipx.
| PDB = {{PDB2|2ipx}}
| Name = Fibrillarin
| HGNCid = 3599
| Symbol = FBL
| AltSymbols =; FIB; FLRN; RNU3IP1
| OMIM = 134795
| ECnumber =
| Homologene = 1099
| MGIid = 95486
| GeneAtlas_image1 = PBB_GE_FBL_211623_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0008168 |text = methyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0030529 |text = ribonucleoprotein complex}}
| Process = {{GNF_GO|id=GO:0006364 |text = rRNA processing}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2091
| Hs_Ensembl = ENSG00000105202
| Hs_RefseqProtein = NP_001427
| Hs_RefseqmRNA = NM_001436
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 45016938
| Hs_GenLoc_end = 45028848
| Hs_Uniprot = P22087
| Mm_EntrezGene = 14113
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_007991
| Mm_RefseqProtein = NP_032017
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Fibrillarin''', also known as '''FBL''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FBL fibrillarin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2091| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin.<ref name="entrez">{{cite web | title = Entrez Gene: FBL fibrillarin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2091| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Baserga SJ, Yang XD, Steitz JA |title=An intact Box C sequence in the U3 snRNA is required for binding of fibrillarin, the protein common to the major family of nucleolar snRNPs. |journal=EMBO J. |volume=10 |issue= 9 |pages= 2645-51 |year= 1991 |pmid= 1714385 |doi= }}
*{{cite journal | author=Okano Y, Steen VD, Medsger TA |title=Autoantibody to U3 nucleolar ribonucleoprotein (fibrillarin) in patients with systemic sclerosis. |journal=Arthritis Rheum. |volume=35 |issue= 1 |pages= 95-100 |year= 1992 |pmid= 1731817 |doi= }}
*{{cite journal | author=Aris JP, Blobel G |title=cDNA cloning and sequencing of human fibrillarin, a conserved nucleolar protein recognized by autoimmune antisera. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 3 |pages= 931-5 |year= 1991 |pmid= 1846968 |doi= }}
*{{cite journal | author=Jansen RP, Hurt EC, Kern H, ''et al.'' |title=Evolutionary conservation of the human nucleolar protein fibrillarin and its functional expression in yeast. |journal=J. Cell Biol. |volume=113 |issue= 4 |pages= 715-29 |year= 1991 |pmid= 2026646 |doi= }}
*{{cite journal | author=Lischwe MA, Ochs RL, Reddy R, ''et al.'' |title=Purification and partial characterization of a nucleolar scleroderma antigen (Mr = 34,000; pI, 8.5) rich in NG,NG-dimethylarginine. |journal=J. Biol. Chem. |volume=260 |issue= 26 |pages= 14304-10 |year= 1985 |pmid= 2414294 |doi= }}
*{{cite journal | author=Méhes G, Pajor L |title=Nucleolin and fibrillarin expression in stimulated lymphocytes and differentiating HL-60 cells. A flow cytometric assay. |journal=Cell Prolif. |volume=28 |issue= 6 |pages= 329-36 |year= 1995 |pmid= 7626687 |doi= }}
*{{cite journal | author=Liu Q, Dreyfuss G |title=A novel nuclear structure containing the survival of motor neurons protein. |journal=EMBO J. |volume=15 |issue= 14 |pages= 3555-65 |year= 1996 |pmid= 8670859 |doi= }}
*{{cite journal | author=Magoulas C, Zatsepina OV, Jordan PW, ''et al.'' |title=The SURF-6 protein is a component of the nucleolar matrix and has a high binding capacity for nucleic acids in vitro. |journal=Eur. J. Cell Biol. |volume=75 |issue= 2 |pages= 174-83 |year= 1998 |pmid= 9548374 |doi= }}
*{{cite journal | author=Ai LS, Lin CH, Hsieh M, Li C |title=Arginine methylation of a glycine and arginine rich peptide derived from sequences of human FMRP and fibrillarin. |journal=Proc. Natl. Sci. Counc. Repub. China B |volume=23 |issue= 4 |pages= 175-80 |year= 1999 |pmid= 10518318 |doi= }}
*{{cite journal | author=Pintard L, Kressler D, Lapeyre B |title=Spb1p is a yeast nucleolar protein associated with Nop1p and Nop58p that is able to bind S-adenosyl-L-methionine in vitro. |journal=Mol. Cell. Biol. |volume=20 |issue= 4 |pages= 1370-81 |year= 2000 |pmid= 10648622 |doi= }}
*{{cite journal | author=Nicol SM, Causevic M, Prescott AR, Fuller-Pace FV |title=The nuclear DEAD box RNA helicase p68 interacts with the nucleolar protein fibrillarin and colocalizes specifically in nascent nucleoli during telophase. |journal=Exp. Cell Res. |volume=257 |issue= 2 |pages= 272-80 |year= 2000 |pmid= 10837141 |doi= 10.1006/excr.2000.4886 }}
*{{cite journal | author=Pellizzoni L, Baccon J, Charroux B, Dreyfuss G |title=The survival of motor neurons (SMN) protein interacts with the snoRNP proteins fibrillarin and GAR1. |journal=Curr. Biol. |volume=11 |issue= 14 |pages= 1079-88 |year= 2001 |pmid= 11509230 |doi= }}
*{{cite journal | author=Zhou X, Tan FK, Xiong M, ''et al.'' |title=Systemic sclerosis (scleroderma): specific autoantigen genes are selectively overexpressed in scleroderma fibroblasts. |journal=J. Immunol. |volume=167 |issue= 12 |pages= 7126-33 |year= 2001 |pmid= 11739535 |doi= }}
*{{cite journal | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi= }}
*{{cite journal | author=Cimato TR, Tang J, Xu Y, ''et al.'' |title=Nerve growth factor-mediated increases in protein methylation occur predominantly at type I arginine methylation sites and involve protein arginine methyltransferase 1. |journal=J. Neurosci. Res. |volume=67 |issue= 4 |pages= 435-42 |year= 2002 |pmid= 11835310 |doi= }}
*{{cite journal | author=Fujiyama S, Yanagida M, Hayano T, ''et al.'' |title=Isolation and proteomic characterization of human Parvulin-associating preribosomal ribonucleoprotein complexes. |journal=J. Biol. Chem. |volume=277 |issue= 26 |pages= 23773-80 |year= 2002 |pmid= 11960984 |doi= 10.1074/jbc.M201181200 }}
*{{cite journal | author=Whitehead SE, Jones KW, Zhang X, ''et al.'' |title=Determinants of the interaction of the spinal muscular atrophy disease protein SMN with the dimethylarginine-modified box H/ACA small nucleolar ribonucleoprotein GAR1. |journal=J. Biol. Chem. |volume=277 |issue= 50 |pages= 48087-93 |year= 2003 |pmid= 12244096 |doi= 10.1074/jbc.M204551200 }}
*{{cite journal | author=Herrera-Esparza R, Kruse L, von Essen M, ''et al.'' |title=U3 snoRNP associates with fibrillarin a component of the scleroderma clumpy nucleolar domain. |journal=Arch. Dermatol. Res. |volume=294 |issue= 7 |pages= 310-7 |year= 2003 |pmid= 12373336 |doi= 10.1007/s00403-002-0338-7 }}
*{{cite journal | author=Chen M, Rockel T, Steinweger G, ''et al.'' |title=Subcellular recruitment of fibrillarin to nucleoplasmic proteasomes: implications for processing of a nucleolar autoantigen. |journal=Mol. Biol. Cell |volume=13 |issue= 10 |pages= 3576-87 |year= 2003 |pmid= 12388758 |doi= 10.1091/mbc.02-05-0083 }}
*{{cite journal | author=Watkins NJ, Dickmanns A, Lührmann R |title=Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP. |journal=Mol. Cell. Biol. |volume=22 |issue= 23 |pages= 8342-52 |year= 2003 |pmid= 12417735 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on METAP2... {November 19, 2007 11:22:10 AM PST}
- SEARCH REDIRECT: Control Box Found: METAP2 {November 19, 2007 11:22:46 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 19, 2007 11:22:47 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 19, 2007 11:22:47 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 19, 2007 11:22:47 AM PST}
- UPDATED: Updated protein page: METAP2 {November 19, 2007 11:22:54 AM PST}
- INFO: Beginning work on NUP153... {November 19, 2007 11:18:32 AM PST}
- SEARCH REDIRECT: Control Box Found: NUP153 {November 19, 2007 11:18:54 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 19, 2007 11:18:55 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 19, 2007 11:18:55 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 19, 2007 11:18:55 AM PST}
- UPDATED: Updated protein page: NUP153 {November 19, 2007 11:19:01 AM PST}
- INFO: Beginning work on PTGES3... {November 19, 2007 11:21:39 AM PST}
- SEARCH REDIRECT: Control Box Found: PTGES3 {November 19, 2007 11:22:02 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 19, 2007 11:22:03 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 19, 2007 11:22:03 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 19, 2007 11:22:03 AM PST}
- UPDATED: Updated protein page: PTGES3 {November 19, 2007 11:22:09 AM PST}
- INFO: Beginning work on SERPINA7... {November 19, 2007 11:13:18 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 11:13:43 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SERPINA7_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ceo.
| PDB = {{PDB2|2ceo}}
| Name = Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
| HGNCid = 11583
| Symbol = SERPINA7
| AltSymbols =; TBG
| OMIM = 314200
| ECnumber =
| Homologene = 20113
| MGIid = 3041197
| GeneAtlas_image1 = PBB_GE_SERPINA7_206386_at_tn.png
| Function = {{GNF_GO|id=GO:0004867 |text = serine-type endopeptidase inhibitor activity}} {{GNF_GO|id=GO:0005488 |text = binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6906
| Hs_Ensembl = ENSG00000123561
| Hs_RefseqProtein = NP_000345
| Hs_RefseqmRNA = NM_000354
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 105163853
| Hs_GenLoc_end = 105169385
| Hs_Uniprot = P05543
| Mm_EntrezGene = 331535
| Mm_Ensembl = ENSMUSG00000031271
| Mm_RefseqmRNA = NM_177920
| Mm_RefseqProtein = NP_808588
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 134426145
| Mm_GenLoc_end = 134431581
| Mm_Uniprot = Q3UEL9
}}
}}
'''Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7''', also known as '''SERPINA7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6906| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Cheng SY |title=Partial amino acid sequence of human thyroxine-binding globulin. Further evidence for a single polypeptide chain. |journal=Biochem. Biophys. Res. Commun. |volume=79 |issue= 4 |pages= 1212-8 |year= 1978 |pmid= 414747 |doi= }}
*{{cite journal | author=Shirotani T, Kishikawa H, Wake N, ''et al.'' |title=Thyroxine-binding globulin variant (TBG-Kumamoto): identification of a point mutation and genotype analysis of its family. |journal=Endocrinol. Jpn. |volume=39 |issue= 6 |pages= 577-84 |year= 1993 |pmid= 1294376 |doi= }}
*{{cite journal | author=Bertenshaw R, Sarne D, Tornari J, ''et al.'' |title=Sequencing of the variant thyroxine-binding globulin (TBG)-San Diego reveals two nucleotide substitutions. |journal=Biochim. Biophys. Acta |volume=1139 |issue= 4 |pages= 307-10 |year= 1992 |pmid= 1515456 |doi= }}
*{{cite journal | author=Bertenshaw R, Takeda K, Refetoff S |title=Sequencing of the variant thyroxine-binding globulin (TBG)-Quebec reveals two nucleotide substitutions. |journal=Am. J. Hum. Genet. |volume=48 |issue= 4 |pages= 741-4 |year= 1991 |pmid= 1901689 |doi= }}
*{{cite journal | author=Imamura S, Mori Y, Murata Y, ''et al.'' |title=Molecular cloning and primary structure of rat thyroxine-binding globulin. |journal=Biochemistry |volume=30 |issue= 22 |pages= 5406-11 |year= 1991 |pmid= 1903654 |doi= }}
*{{cite journal | author=Janssen OE, Takeda K, Refetoff S |title=Sequence of the variant thyroxine-binding globulin (TBG) in a Montreal family with partial TBG deficiency. |journal=Hum. Genet. |volume=87 |issue= 2 |pages= 119-22 |year= 1991 |pmid= 1906047 |doi= }}
*{{cite journal | author=Yamamori I, Mori Y, Seo H, ''et al.'' |title=Nucleotide deletion resulting in frameshift as a possible cause of complete thyroxine-binding globulin deficiency in six Japanese families. |journal=J. Clin. Endocrinol. Metab. |volume=73 |issue= 2 |pages= 262-7 |year= 1991 |pmid= 1906892 |doi= }}
*{{cite journal | author=Li P, Janssen OE, Takeda K, ''et al.'' |title=Complete thyroxine-binding globulin (TBG) deficiency caused by a single nucleotide deletion in the TBG gene. |journal=Metab. Clin. Exp. |volume=40 |issue= 11 |pages= 1231-4 |year= 1991 |pmid= 1943753 |doi= }}
*{{cite journal | author=Waltz MR, Pullman TN, Takeda K, ''et al.'' |title=Molecular basis for the properties of the thyroxine-binding globulin-slow variant in American blacks. |journal=J. Endocrinol. Invest. |volume=13 |issue= 4 |pages= 343-9 |year= 1990 |pmid= 2115061 |doi= }}
*{{cite journal | author=Mori Y, Takeda K, Charbonneau M, Refetoff S |title=Replacement of Leu227 by Pro in thyroxine-binding globulin (TBG) is associated with complete TBG deficiency in three of eight families with this inherited defect. |journal=J. Clin. Endocrinol. Metab. |volume=70 |issue= 3 |pages= 804-9 |year= 1990 |pmid= 2155256 |doi= }}
*{{cite journal | author=Takeda K, Mori Y, Sobieszczyk S, ''et al.'' |title=Sequence of the variant thyroxine-binding globulin of Australian aborigines. Only one of two amino acid replacements is responsible for its altered properties. |journal=J. Clin. Invest. |volume=83 |issue= 4 |pages= 1344-8 |year= 1989 |pmid= 2495303 |doi= }}
*{{cite journal | author=Mori Y, Seino S, Takeda K, ''et al.'' |title=A mutation causing reduced biological activity and stability of thyroxine-binding globulin probably as a result of abnormal glycosylation of the molecule. |journal=Mol. Endocrinol. |volume=3 |issue= 3 |pages= 575-9 |year= 1989 |pmid= 2501669 |doi= }}
*{{cite journal | author=Flink IL, Bailey TJ, Gustafson TA, ''et al.'' |title=Complete amino acid sequence of human thyroxine-binding globulin deduced from cloned DNA: close homology to the serine antiproteases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 20 |pages= 7708-12 |year= 1986 |pmid= 3094014 |doi= }}
*{{cite journal | author=Janssen OE, Chen B, Büttner C, ''et al.'' |title=Molecular and structural characterization of the heat-resistant thyroxine-binding globulin-Chicago. |journal=J. Biol. Chem. |volume=270 |issue= 47 |pages= 28234-8 |year= 1996 |pmid= 7499319 |doi= }}
*{{cite journal | author=Mori Y, Miura Y, Oiso Y, ''et al.'' |title=Precise localization of the human thyroxine-binding globulin gene to chromosome Xq22.2 by fluorescence in situ hybridization. |journal=Hum. Genet. |volume=96 |issue= 4 |pages= 481-2 |year= 1995 |pmid= 7557975 |doi= }}
*{{cite journal | author=Miura Y, Mori Y, Yamamori I, ''et al.'' |title=Sequence of a variant thyroxine-binding globulin (TBG) in a family with partial TBG deficiency in Japanese (TBG-PDJ). |journal=Endocr. J. |volume=40 |issue= 1 |pages= 127-32 |year= 1994 |pmid= 7951486 |doi= }}
*{{cite journal | author=Hayashi Y, Mori Y, Janssen OE, ''et al.'' |title=Human thyroxine-binding globulin gene: complete sequence and transcriptional regulation. |journal=Mol. Endocrinol. |volume=7 |issue= 8 |pages= 1049-60 |year= 1993 |pmid= 8232304 |doi= }}
*{{cite journal | author=Akbari MT, Kapadi A, Farmer MJ, ''et al.'' |title=The structure of the human thyroxine binding globulin (TBG) gene. |journal=Biochim. Biophys. Acta |volume=1216 |issue= 3 |pages= 446-54 |year= 1994 |pmid= 8268226 |doi= }}
*{{cite journal | author=Mori Y, Miura Y, Takeuchi H, ''et al.'' |title=Gene amplification as a cause of inherited thyroxine-binding globulin excess in two Japanese families. |journal=J. Clin. Endocrinol. Metab. |volume=80 |issue= 12 |pages= 3758-62 |year= 1996 |pmid= 8530630 |doi= }}
*{{cite journal | author=Carvalho GA, Weiss RE, Vladutiu AO, Refetoff S |title=Complete deficiency of thyroxine-binding globulin (TBG-CD Buffalo) caused by a new nonsense mutation in the thyroxine-binding globulin gene. |journal=Thyroid |volume=8 |issue= 2 |pages= 161-5 |year= 1998 |pmid= 9510125 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SYT1... {November 19, 2007 11:12:41 AM PST}
- SEARCH REDIRECT: Control Box Found: SYT1 {November 19, 2007 11:13:10 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 19, 2007 11:13:11 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 19, 2007 11:13:11 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 19, 2007 11:13:11 AM PST}
- UPDATED: Updated protein page: SYT1 {November 19, 2007 11:13:18 AM PST}
- INFO: Beginning work on TNFRSF4... {November 19, 2007 11:14:42 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 11:16:30 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TNFRSF4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2hev.
| PDB = {{PDB2|2hev}}, {{PDB2|2hey}}
| Name = Tumor necrosis factor receptor superfamily, member 4
| HGNCid = 11918
| Symbol = TNFRSF4
| AltSymbols =; ACT35; CD134; OX40; TXGP1L
| OMIM = 600315
| ECnumber =
| Homologene = 2496
| MGIid = 104512
| GeneAtlas_image1 = PBB_GE_TNFRSF4_214228_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005031 |text = tumor necrosis factor receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7293
| Hs_Ensembl = ENSG00000186827
| Hs_RefseqProtein = NP_003318
| Hs_RefseqmRNA = NM_003327
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 1136569
| Hs_GenLoc_end = 1139375
| Hs_Uniprot = P43489
| Mm_EntrezGene = 22163
| Mm_Ensembl = ENSMUSG00000029075
| Mm_RefseqmRNA = NM_011659
| Mm_RefseqProtein = NP_035789
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 154857495
| Mm_GenLoc_end = 154860412
| Mm_Uniprot = P47741
}}
}}
'''Tumor necrosis factor receptor superfamily, member 4''', also known as '''TNFRSF4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TNFRSF4 tumor necrosis factor receptor superfamily, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7293| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.<ref name="entrez">{{cite web | title = Entrez Gene: TNFRSF4 tumor necrosis factor receptor superfamily, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7293| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Weinberg AD |title=OX40: targeted immunotherapy--implications for tempering autoimmunity and enhancing vaccines. |journal=Trends Immunol. |volume=23 |issue= 2 |pages= 102-9 |year= 2002 |pmid= 11929124 |doi= }}
*{{cite journal | author=Paterson DJ, Jefferies WA, Green JR, ''et al.'' |title=Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts. |journal=Mol. Immunol. |volume=24 |issue= 12 |pages= 1281-90 |year= 1988 |pmid= 2828930 |doi= }}
*{{cite journal | author=Latza U, Dürkop H, Schnittger S, ''et al.'' |title=The human OX40 homolog: cDNA structure, expression and chromosomal assignment of the ACT35 antigen. |journal=Eur. J. Immunol. |volume=24 |issue= 3 |pages= 677-83 |year= 1994 |pmid= 7510240 |doi= }}
*{{cite journal | author=Baum PR, Gayle RB, Ramsdell F, ''et al.'' |title=Identification of OX40 ligand and preliminary characterization of its activities on OX40 receptor. |journal=Circ. Shock |volume=44 |issue= 1 |pages= 30-4 |year= 1995 |pmid= 7704935 |doi= }}
*{{cite journal | author=Birkeland ML, Copeland NG, Gilbert DJ, ''et al.'' |title=Gene structure and chromosomal localization of the mouse homologue of rat OX40 protein. |journal=Eur. J. Immunol. |volume=25 |issue= 4 |pages= 926-30 |year= 1995 |pmid= 7737295 |doi= }}
*{{cite journal | author=Stüber E, Neurath M, Calderhead D, ''et al.'' |title=Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells. |journal=Immunity |volume=2 |issue= 5 |pages= 507-21 |year= 1995 |pmid= 7749983 |doi= }}
*{{cite journal | author=Arch RH, Thompson CB |title=4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB. |journal=Mol. Cell. Biol. |volume=18 |issue= 1 |pages= 558-65 |year= 1998 |pmid= 9418902 |doi= }}
*{{cite journal | author=Kawamata S, Hori T, Imura A, ''et al.'' |title=Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation. |journal=J. Biol. Chem. |volume=273 |issue= 10 |pages= 5808-14 |year= 1998 |pmid= 9488716 |doi= }}
*{{cite journal | author=Kopf M, Ruedl C, Schmitz N, ''et al.'' |title=OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection. |journal=Immunity |volume=11 |issue= 6 |pages= 699-708 |year= 2000 |pmid= 10626892 |doi= }}
*{{cite journal | author=Pankow R, Dürkop H, Latza U, ''et al.'' |title=The HTLV-I tax protein transcriptionally modulates OX40 antigen expression. |journal=J. Immunol. |volume=165 |issue= 1 |pages= 263-70 |year= 2000 |pmid= 10861060 |doi= }}
*{{cite journal | author=Takasawa N, Ishii N, Higashimura N, ''et al.'' |title=Expression of gp34 (OX40 ligand) and OX40 on human T cell clones. |journal=Jpn. J. Cancer Res. |volume=92 |issue= 4 |pages= 377-82 |year= 2001 |pmid= 11346458 |doi= }}
*{{cite journal | author=Taylor L, Schwarz H |title=Identification of a soluble OX40 isoform: development of a specific and quantitative immunoassay. |journal=J. Immunol. Methods |volume=255 |issue= 1-2 |pages= 67-72 |year= 2001 |pmid= 11470287 |doi= }}
*{{cite journal | author=Bansal-Pakala P, Jember AG, Croft M |title=Signaling through OX40 (CD134) breaks peripheral T-cell tolerance. |journal=Nat. Med. |volume=7 |issue= 8 |pages= 907-12 |year= 2001 |pmid= 11479622 |doi= 10.1038/90942 }}
*{{cite journal | author=Rogers PR, Song J, Gramaglia I, ''et al.'' |title=OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. |journal=Immunity |volume=15 |issue= 3 |pages= 445-55 |year= 2001 |pmid= 11567634 |doi= }}
*{{cite journal | author=Tian L, Guo W, Yuan Z, ''et al.'' |title=Association of the CD134/CD134L costimulatory pathway with acute rejection of small bowel allograft. |journal=Transplantation |volume=74 |issue= 1 |pages= 133-8 |year= 2002 |pmid= 12134113 |doi= }}
*{{cite journal | author=Kalthoff FS, Chung J, Stuetz A |title=Pimecrolimus inhibits up-regulation of OX40 and synthesis of inflammatory cytokines upon secondary T cell activation by allogeneic dendritic cells. |journal=Clin. Exp. Immunol. |volume=130 |issue= 1 |pages= 85-92 |year= 2002 |pmid= 12296857 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Spinicelli S, Nocentini G, Ronchetti S, ''et al.'' |title=GITR interacts with the pro-apoptotic protein Siva and induces apoptosis. |journal=Cell Death Differ. |volume=9 |issue= 12 |pages= 1382-4 |year= 2003 |pmid= 12478477 |doi= 10.1038/sj.cdd.4401140 }}
*{{cite journal | author=Matsumura Y, Hori T, Nishigori C, ''et al.'' |title=Expression of CD134 and CD134 ligand in lesional and nonlesional psoriatic skin. |journal=Arch. Dermatol. Res. |volume=294 |issue= 12 |pages= 563-6 |year= 2003 |pmid= 12624783 |doi= 10.1007/s00403-002-0363-6 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TSPY1... {November 19, 2007 11:13:43 AM PST}
- SEARCH REDIRECT: Control Box Found: TSPY1 {November 19, 2007 11:14:33 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 19, 2007 11:14:36 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 19, 2007 11:14:36 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 19, 2007 11:14:36 AM PST}
- UPDATED: Updated protein page: TSPY1 {November 19, 2007 11:14:42 AM PST}
- INFO: Beginning work on WASF1... {November 19, 2007 11:17:10 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 19, 2007 11:17:57 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = WAS protein family, member 1
| HGNCid = 12732
| Symbol = WASF1
| AltSymbols =; FLJ31482; KIAA0269; SCAR1; WAVE; WAVE1
| OMIM = 605035
| ECnumber =
| Homologene = 2920
| MGIid = 1890563
| GeneAtlas_image1 = PBB_GE_WASF1_204165_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005741 |text = mitochondrial outer membrane}} {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}} {{GNF_GO|id=GO:0030027 |text = lamellipodium}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0030041 |text = actin filament polymerization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8936
| Hs_Ensembl = ENSG00000112290
| Hs_RefseqProtein = NP_001020105
| Hs_RefseqmRNA = NM_001024934
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 110528382
| Hs_GenLoc_end = 110607819
| Hs_Uniprot = Q92558
| Mm_EntrezGene = 83767
| Mm_Ensembl = ENSMUSG00000019831
| Mm_RefseqmRNA = NM_031877
| Mm_RefseqProtein = NP_114083
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 40571988
| Mm_GenLoc_end = 40626982
| Mm_Uniprot = Q8R5H6
}}
}}
'''WAS protein family, member 1''', also known as '''WASF1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: WASF1 WAS protein family, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8936| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: WASF1 WAS protein family, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8936| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Whitebread S, Mele M, Kamber B, de Gasparo M |title=Preliminary biochemical characterization of two angiotensin II receptor subtypes. |journal=Biochem. Biophys. Res. Commun. |volume=163 |issue= 1 |pages= 284-91 |year= 1989 |pmid= 2775266 |doi= }}
*{{cite journal | author=Kitamura T, Kitamura Y, Yonezawa K, ''et al.'' |title=Molecular cloning of p125Nap1, a protein that associates with an SH3 domain of Nck. |journal=Biochem. Biophys. Res. Commun. |volume=219 |issue= 2 |pages= 509-14 |year= 1996 |pmid= 8605018 |doi= }}
*{{cite journal | author=Nagase T, Seki N, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. |journal=DNA Res. |volume=3 |issue= 5 |pages= 321-9, 341-54 |year= 1997 |pmid= 9039502 |doi= }}
*{{cite journal | author=She HY, Rockow S, Tang J, ''et al.'' |title=Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells. |journal=Mol. Biol. Cell |volume=8 |issue= 9 |pages= 1709-21 |year= 1997 |pmid= 9307968 |doi= }}
*{{cite journal | author=Witke W, Podtelejnikov AV, Di Nardo A, ''et al.'' |title=In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly. |journal=EMBO J. |volume=17 |issue= 4 |pages= 967-76 |year= 1998 |pmid= 9463375 |doi= 10.1093/emboj/17.4.967 }}
*{{cite journal | author=Bear JE, Rawls JF, Saxe CL |title=SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development. |journal=J. Cell Biol. |volume=142 |issue= 5 |pages= 1325-35 |year= 1998 |pmid= 9732292 |doi= }}
*{{cite journal | author=Wu Y, Dowbenko D, Lasky LA |title=PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase. |journal=J. Biol. Chem. |volume=273 |issue= 46 |pages= 30487-96 |year= 1998 |pmid= 9804817 |doi= }}
*{{cite journal | author=Miki H, Suetsugu S, Takenawa T |title=WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac. |journal=EMBO J. |volume=17 |issue= 23 |pages= 6932-41 |year= 1999 |pmid= 9843499 |doi= 10.1093/emboj/17.23.6932 }}
*{{cite journal | author=Machesky LM, Insall RH |title=Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex. |journal=Curr. Biol. |volume=8 |issue= 25 |pages= 1347-56 |year= 1999 |pmid= 9889097 |doi= }}
*{{cite journal | author=Suetsugu S, Miki H, Takenawa T |title=Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex. |journal=Biochem. Biophys. Res. Commun. |volume=260 |issue= 1 |pages= 296-302 |year= 1999 |pmid= 10381382 |doi= 10.1006/bbrc.1999.0894 }}
*{{cite journal | author=Banin S, Gout I, Brickell P |title=Interaction between Wiskott-Aldrich Syndrome protein (WASP) and the Fyn protein-tyrosine kinase. |journal=Mol. Biol. Rep. |volume=26 |issue= 3 |pages= 173-7 |year= 1999 |pmid= 10532312 |doi= }}
*{{cite journal | author=Higgs HN, Blanchoin L, Pollard TD |title=Influence of the C terminus of Wiskott-Aldrich syndrome protein (WASp) and the Arp2/3 complex on actin polymerization. |journal=Biochemistry |volume=38 |issue= 46 |pages= 15212-22 |year= 1999 |pmid= 10563804 |doi= }}
*{{cite journal | author=Westphal RS, Soderling SH, Alto NM, ''et al.'' |title=Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold. |journal=EMBO J. |volume=19 |issue= 17 |pages= 4589-600 |year= 2000 |pmid= 10970852 |doi= 10.1093/emboj/19.17.4589 }}
*{{cite journal | author=Prehoda KE, Scott JA, Mullins RD, Lim WA |title=Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex. |journal=Science |volume=290 |issue= 5492 |pages= 801-6 |year= 2000 |pmid= 11052943 |doi= }}
*{{cite journal | author=Miki H, Yamaguchi H, Suetsugu S, Takenawa T |title=IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. |journal=Nature |volume=408 |issue= 6813 |pages= 732-5 |year= 2001 |pmid= 11130076 |doi= 10.1038/35047107 }}
*{{cite journal | author=Marchand JB, Kaiser DA, Pollard TD, Higgs HN |title=Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex. |journal=Nat. Cell Biol. |volume=3 |issue= 1 |pages= 76-82 |year= 2001 |pmid= 11146629 |doi= 10.1038/35050590 }}
*{{cite journal | author=Eden S, Rohatgi R, Podtelejnikov AV, ''et al.'' |title=Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. |journal=Nature |volume=418 |issue= 6899 |pages= 790-3 |year= 2002 |pmid= 12181570 |doi= 10.1038/nature00859 }}
*{{cite journal | author=Yarar D, D'Alessio JA, Jeng RL, Welch MD |title=Motility determinants in WASP family proteins. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4045-59 |year= 2003 |pmid= 12429845 |doi= 10.1091/mbc.E02-05-0294 }}
*{{cite journal | author=Soderling SH, Binns KL, Wayman GA, ''et al.'' |title=The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling. |journal=Nat. Cell Biol. |volume=4 |issue= 12 |pages= 970-5 |year= 2003 |pmid= 12447388 |doi= 10.1038/ncb886 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on WASF2... {November 19, 2007 11:19:53 AM PST}
- SEARCH REDIRECT: Control Box Found: WASF2 {November 19, 2007 11:20:30 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 19, 2007 11:20:32 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 19, 2007 11:20:32 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 19, 2007 11:20:32 AM PST}
- UPDATED: Updated protein page: WASF2 {November 19, 2007 11:20:39 AM PST}
end log.
