INFO: Beginning work on AKAP13... {November 10, 2007 12:00:02 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 12:00:41 PM PST}
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| update_page = yes
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = A kinase (PRKA) anchor protein 13
| HGNCid = 371
| Symbol = AKAP13
| AltSymbols =; AKAP-Lbc; BRX; FLJ11952; FLJ43341; HA-3; Ht31; LBC; PROTO-LB; PROTO-LBC; c-lbc
| OMIM = 604686
| ECnumber =
| Homologene = 4903
| MGIid = 2676556
| Function = {{GNF_GO|id=GO:0004691 |text = cAMP-dependent protein kinase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005085 |text = guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005089 |text = Rho guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0016301 |text = kinase activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005624 |text = membrane fraction}}
| Process = {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0035023 |text = regulation of Rho protein signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 11214
| Hs_Ensembl = ENSG00000170776
| Hs_RefseqProtein = NP_006729
| Hs_RefseqmRNA = NM_006738
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 83578821
| Hs_GenLoc_end = 84093590
| Hs_Uniprot = Q12802
| Mm_EntrezGene = 75547
| Mm_Ensembl = ENSMUSG00000066406
| Mm_RefseqmRNA = XM_133543
| Mm_RefseqProtein = XP_133543
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 75329069
| Mm_GenLoc_end = 75610217
| Mm_Uniprot =
}}
}}
'''A kinase (PRKA) anchor protein 13''', also known as '''AKAP13''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in at least 3 transcript variants encoding different isoforms containing a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway and, in addition, function as protein kinase A-anchoring proteins.<ref>{{cite web | title = Entrez Gene: AKAP13 A kinase (PRKA) anchor protein 13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11214| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on CYP24A1... {November 10, 2007 11:42:09 AM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 11:42:59 AM PST}
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| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cytochrome P450, family 24, subfamily A, polypeptide 1
| HGNCid = 2602
| Symbol = CYP24A1
| AltSymbols =; CP24; CYP24; MGC126273; MGC126274; P450-CC24
| OMIM = 126065
| ECnumber =
| Homologene = 68094
| MGIid = 88593
| GeneAtlas_image1 = PBB_GE_CYP24A1_206504_at_tn.png
| Function = {{GNF_GO|id=GO:0004497 |text = monooxygenase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0008403 |text = 25-hydroxycholecalciferol-24-hydroxylase activity}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0030342 |text = 1-alpha,25-dihydroxyvitamin D3 (1,25-(OH)2D3) 24-hydroxylase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0042359 |text = vitamin D metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1591
| Hs_Ensembl = ENSG00000019186
| Hs_RefseqProtein = NP_000773
| Hs_RefseqmRNA = NM_000782
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 52203395
| Hs_GenLoc_end = 52223931
| Hs_Uniprot = Q07973
| Mm_EntrezGene = 13081
| Mm_Ensembl = ENSMUSG00000038567
| Mm_RefseqmRNA = NM_009996
| Mm_RefseqProtein = NP_034126
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 170174170
| Mm_GenLoc_end = 170188343
| Mm_Uniprot = Q3TP55
}}
}}
'''Cytochrome P450, family 24, subfamily A, polypeptide 1''', also known as '''CYP24A1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system.<ref>{{cite web | title = Entrez Gene: CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1591| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Okuda K, Usui E, Ohyama Y |title=Recent progress in enzymology and molecular biology of enzymes involved in vitamin D metabolism. |journal=J. Lipid Res. |volume=36 |issue= 8 |pages= 1641-52 |year= 1995 |pmid= 7595086 |doi= }}
}}
{{refend}}
{{protein-stub}}
AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 11:46:23 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FBL_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ipx.
| PDB = {{PDB2|2ipx}}
| Name = Fibrillarin
| HGNCid = 3599
| Symbol = FBL
| AltSymbols =; FIB; FLRN; RNU3IP1
| OMIM = 134795
| ECnumber =
| Homologene = 1099
| MGIid = 95486
| GeneAtlas_image1 = PBB_GE_FBL_211623_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0008168 |text = methyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0030529 |text = ribonucleoprotein complex}}
| Process = {{GNF_GO|id=GO:0006364 |text = rRNA processing}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2091
| Hs_Ensembl = ENSG00000105202
| Hs_RefseqProtein = NP_001427
| Hs_RefseqmRNA = NM_001436
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 45016938
| Hs_GenLoc_end = 45028848
| Hs_Uniprot = P22087
| Mm_EntrezGene = 14113
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_007991
| Mm_RefseqProtein = NP_032017
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Fibrillarin''', also known as '''FBL''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin.<ref>{{cite web | title = Entrez Gene: FBL fibrillarin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2091| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on WASF1... {November 10, 2007 11:51:38 AM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 10, 2007 11:52:21 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = WAS protein family, member 1
| HGNCid = 12732
| Symbol = WASF1
| AltSymbols =; FLJ31482; KIAA0269; SCAR1; WAVE; WAVE1
| OMIM = 605035
| ECnumber =
| Homologene = 2920
| MGIid = 1890563
| GeneAtlas_image1 = PBB_GE_WASF1_204165_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005741 |text = mitochondrial outer membrane}} {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}} {{GNF_GO|id=GO:0030027 |text = lamellipodium}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0030041 |text = actin filament polymerization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8936
| Hs_Ensembl = ENSG00000112290
| Hs_RefseqProtein = NP_001020105
| Hs_RefseqmRNA = NM_001024934
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 110528382
| Hs_GenLoc_end = 110607819
| Hs_Uniprot = Q92558
| Mm_EntrezGene = 83767
| Mm_Ensembl = ENSMUSG00000019831
| Mm_RefseqmRNA = NM_031877
| Mm_RefseqProtein = NP_114083
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 40571988
| Mm_GenLoc_end = 40626982
| Mm_Uniprot = Q8R5H6
}}
}}
'''WAS protein family, member 1''', also known as '''WASF1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.<ref>{{cite web | title = Entrez Gene: WASF1 WAS protein family, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8936| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
{November 10, 2007 11:40:07 AM PST} 
