AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 8:12:50 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PRDX2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1qmv.
| PDB = {{PDB2|1qmv}}
| Name = Peroxiredoxin 2
| HGNCid = 9353
| Symbol = PRDX2
| AltSymbols =; PRP; MGC4104; NKEFB; PRXII; TDPX1; TSA
| OMIM = 600538
| ECnumber =
| Homologene = 21182
| MGIid = 109486
| GeneAtlas_image1 = PBB_GE_PRDX2_39729_at_tn.png
| Function = {{GNF_GO|id=GO:0008379 |text = thioredoxin peroxidase activity}} {{GNF_GO|id=GO:0016209 |text = antioxidant activity}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0051920 |text = peroxiredoxin activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0006979 |text = response to oxidative stress}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7001
| Hs_Ensembl = ENSG00000167815
| Hs_RefseqProtein = NP_859427
| Hs_RefseqmRNA = NM_181737
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 12768635
| Hs_GenLoc_end = 12773694
| Hs_Uniprot = P32119
| Mm_EntrezGene = 21672
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_011563
| Mm_RefseqProtein = NP_035693
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Peroxiredoxin 2''', also known as '''PRDX2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. The crystal structure of this protein has been resolved to 2.7 angstroms. Transcript variants encoding distinct isoforms have been identified for this gene.<ref>{{cite web | title = Entrez Gene: PRDX2 peroxiredoxin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7001| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on RRM1... {November 9, 2007 8:02:47 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 8:03:48 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Ribonucleotide reductase M1 polypeptide
| HGNCid = 10451
| Symbol = RRM1
| AltSymbols =; R1; RIR1; RR1
| OMIM = 180410
| ECnumber =
| Homologene = 806
| MGIid = 98180
| GeneAtlas_image1 = PBB_GE_RRM1_201477_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_RRM1_201476_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004748 |text = ribonucleoside-diphosphate reductase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}}
| Component = {{GNF_GO|id=GO:0005971 |text = ribonucleoside-diphosphate reductase complex}}
| Process = {{GNF_GO|id=GO:0006260 |text = DNA replication}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6240
| Hs_Ensembl = ENSG00000167325
| Hs_RefseqProtein = NP_001024
| Hs_RefseqmRNA = NM_001033
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 4072587
| Hs_GenLoc_end = 4116681
| Hs_Uniprot = P23921
| Mm_EntrezGene = 20133
| Mm_Ensembl = ENSMUSG00000030978
| Mm_RefseqmRNA = NM_009103
| Mm_RefseqProtein = NP_033129
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 102315638
| Mm_GenLoc_end = 102342746
| Mm_Uniprot = Q05DU8
}}
}}
'''Ribonucleotide reductase M1 polypeptide''', also known as '''RRM1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes one of two non-identical subunits which constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. This gene is oriented in a head-to-tail configuration with the stromal interaction molecule 1 gene (STIM1), with the 3' end of STIM1 situated 1.6 kb from the 5' end of this gene.<ref>{{cite web | title = Entrez Gene: RRM1 ribonucleotide reductase M1 polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6240| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on SEMG1... {November 9, 2007 8:06:09 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 8:06:45 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Semenogelin I
| HGNCid = 10742
| Symbol = SEMG1
| AltSymbols =; MGC14719; SEMG; SGI
| OMIM = 182140
| ECnumber =
| Homologene =
| MGIid =
| GeneAtlas_image1 = PBB_GE_SEMG1_206442_at_tn.png
| Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0030141 |text = secretory granule}}
| Process = {{GNF_GO|id=GO:0007320 |text = insemination}} {{GNF_GO|id=GO:0019953 |text = sexual reproduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6406
| Hs_Ensembl = ENSG00000124233
| Hs_RefseqProtein = NP_002998
| Hs_RefseqmRNA = NM_003007
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 43269052
| Hs_GenLoc_end = 43271827
| Hs_Uniprot = P04279
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Semenogelin I''', also known as '''SEMG1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. The prostate-specific antigen (PSA) protease processes this protein into smaller peptides, with each possibly having a separate function. The proteolysis process breaks down the gel matrix and allows the spermatozoa to move more freely. Two transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: SEMG1 semenogelin I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6406| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Robert M, Gagnon C |title=Semenogelin I: a coagulum forming, multifunctional seminal vesicle protein. |journal=Cell. Mol. Life Sci. |volume=55 |issue= 6-7 |pages= 944-60 |year= 1999 |pmid= 10412373 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on SMC1A... {November 9, 2007 8:15:58 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 8:17:16 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Structural maintenance of chromosomes 1A
| HGNCid = 11111
| Symbol = SMC1A
| AltSymbols =; DKFZp686L19178; DXS423E; KIAA0178; MGC138332; SB1.8; SMC1; SMC1L1; SMC1alpha; SMCB
| OMIM = 300040
| ECnumber =
| Homologene = 4597
| MGIid = 1344345
| GeneAtlas_image1 = PBB_GE_SMC1A_201589_at_tn.png
| GeneAtlas_image2 = PBB_GE_SMC1A_217555_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0003777 |text = microtubule motor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016887 |text = ATPase activity}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0000776 |text = kinetochore}} {{GNF_GO|id=GO:0000794 |text = condensed nuclear chromosome}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}} {{GNF_GO|id=GO:0008280 |text = cohesin core heterodimer}}
| Process = {{GNF_GO|id=GO:0000075 |text = cell cycle checkpoint}} {{GNF_GO|id=GO:0006259 |text = DNA metabolic process}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007052 |text = mitotic spindle organization and biogenesis}} {{GNF_GO|id=GO:0007059 |text = chromosome segregation}} {{GNF_GO|id=GO:0007064 |text = mitotic sister chromatid cohesion}} {{GNF_GO|id=GO:0007126 |text = meiosis}} {{GNF_GO|id=GO:0009314 |text = response to radiation}} {{GNF_GO|id=GO:0042770 |text = DNA damage response, signal transduction}} {{GNF_GO|id=GO:0051276 |text = chromosome organization and biogenesis}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8243
| Hs_Ensembl = ENSG00000072501
| Hs_RefseqProtein = NP_006297
| Hs_RefseqmRNA = NM_006306
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 53417795
| Hs_GenLoc_end = 53466343
| Hs_Uniprot = Q14683
| Mm_EntrezGene = 24061
| Mm_Ensembl = ENSMUSG00000041133
| Mm_RefseqmRNA = NM_019710
| Mm_RefseqProtein = NP_062684
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 147357144
| Mm_GenLoc_end = 147402683
| Mm_Uniprot = A0JLM6
}}
}}
'''Structural maintenance of chromosomes 1A''', also known as '''SMC1A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation.<ref>{{cite web | title = Entrez Gene: SMC1A structural maintenance of chromosomes 1A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8243| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO: Beginning work on SSRP1... {November 9, 2007 8:10:46 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 8:11:52 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Structure specific recognition protein 1
| HGNCid = 11327
| Symbol = SSRP1
| AltSymbols =; FACT; FACT80; T160
| OMIM = 604328
| ECnumber =
| Homologene = 2370
| MGIid = 107912
| GeneAtlas_image1 = PBB_GE_SSRP1_200957_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SSRP1_200956_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0000785 |text = chromatin}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}}
| Process = {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6749
| Hs_Ensembl = ENSG00000149136
| Hs_RefseqProtein = NP_003137
| Hs_RefseqmRNA = NM_003146
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 56850036
| Hs_GenLoc_end = 56859927
| Hs_Uniprot = Q08945
| Mm_EntrezGene = 20833
| Mm_Ensembl = ENSMUSG00000027067
| Mm_RefseqmRNA = NM_182990
| Mm_RefseqProtein = NP_892035
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 84838111
| Mm_GenLoc_end = 84847948
| Mm_Uniprot = Q05DR5
}}
}}
'''Structure specific recognition protein 1''', also known as '''SSRP1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63.<ref>{{cite web | title = Entrez Gene: SSRP1 structure specific recognition protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6749| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
{November 9, 2007 8:20:44 PM PST} 
