INFO : Beginning work on ABL2... {November 9, 2007 8:55:06 PM PST} UPLOAD : Added new Image to wiki: {November 9, 2007 8:55:48 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 9, 2007 8:55:59 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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| update_page = yes
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| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ABL2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ab2.
| PDB = {{PDB2|1ab2}}, {{PDB2|1abo}}, {{PDB2|1abq}}, {{PDB2|1bbz}}, {{PDB2|1fpu}}, {{PDB2|1iep}}, {{PDB2|1ju5}}, {{PDB2|1m52}}, {{PDB2|1opj}}, {{PDB2|2e2b}}, {{PDB2|2f4j}}, {{PDB2|2g1t}}, {{PDB2|2g2f}}, {{PDB2|2g2h}}, {{PDB2|2g2i}}, {{PDB2|2gqg}}, {{PDB2|2hiw}}, {{PDB2|2hyy}}, {{PDB2|2hz0}}, {{PDB2|2hz4}}, {{PDB2|2hzi}}, {{PDB2|2hzn}}
| Name = V-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)
| HGNCid = 77
| Symbol = ABL2
| AltSymbols =; ABLL; ARG
| OMIM = 164690
| ECnumber =
| Homologene = 5278
| MGIid = 87860
| GeneAtlas_image1 = PBB_GE_ABL2_206411_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0030145 |text = manganese ion binding}} {{GNF_GO|id=GO:0035014 |text = phosphoinositide 3-kinase regulator activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005942 |text = phosphoinositide 3-kinase complex}} {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0018108 |text = peptidyl-tyrosine phosphorylation}} {{GNF_GO|id=GO:0051017 |text = actin filament bundle formation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 27
| Hs_Ensembl = ENSG00000143322
| Hs_RefseqProtein = NP_005149
| Hs_RefseqmRNA = NM_005158
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 177339806
| Hs_GenLoc_end = 177465359
| Hs_Uniprot = P42684
| Mm_EntrezGene = 11352
| Mm_Ensembl = ENSMUSG00000026596
| Mm_RefseqmRNA = NM_009595
| Mm_RefseqProtein = NP_033725
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 158395726
| Mm_GenLoc_end = 158479393
| Mm_Uniprot = Q61055
}}
}}
'''V-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)''', also known as '''ABL2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. The ABL2 gene product is expressed as two variants bearing different amino termini, both approximately 12-kb in length.<ref>{{cite web | title = Entrez Gene: ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Pendergast AM |title=The Abl family kinases: mechanisms of regulation and signaling. |journal=Adv. Cancer Res. |volume=85 |issue= |pages= 51-100 |year= 2003 |pmid= 12374288 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on ANXA6... {November 9, 2007 8:55:59 PM PST} UPLOAD : Added new Image to wiki: File:PBB Protein ANXA6 image.jpg {November 9, 2007 8:56:37 PM PST} CREATE : Found no pages, creating new page. {November 9, 2007 8:56:50 PM PST} CREATED : Created new protein page: ANXA6 {November 9, 2007 8:56:57 PM PST} INFO : Beginning work on ARAF... {November 9, 2007 8:56:57 PM PST} UPLOAD : Added new Image to wiki: File:PBB Protein ARAF image.jpg {November 9, 2007 8:57:35 PM PST} CREATE : Found no pages, creating new page. {November 9, 2007 8:57:53 PM PST} CREATED : Created new protein page: ARAF {November 9, 2007 8:58:00 PM PST} INFO : Beginning work on BLNK... {November 9, 2007 9:16:21 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 9, 2007 9:17:06 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = B-cell linker
| HGNCid = 14211
| Symbol = BLNK
| AltSymbols =; BASH; BLNK-s; Ly57; MGC111051; SLP-65; SLP65
| OMIM = 604515
| ECnumber =
| Homologene = 32038
| MGIid = 96878
| GeneAtlas_image1 = PBB_GE_BLNK_207655_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005068 |text = transmembrane receptor protein tyrosine kinase adaptor protein activity}} {{GNF_GO|id=GO:0005070 |text = SH3/SH2 adaptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006959 |text = humoral immune response}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007516 |text = hemocyte development}} {{GNF_GO|id=GO:0030183 |text = B cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 29760
| Hs_Ensembl = ENSG00000095585
| Hs_RefseqProtein = NP_037446
| Hs_RefseqmRNA = NM_013314
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 97941453
| Hs_GenLoc_end = 98021316
| Hs_Uniprot = Q8WV28
| Mm_EntrezGene = 17060
| Mm_Ensembl = ENSMUSG00000061132
| Mm_RefseqmRNA = NM_008528
| Mm_RefseqProtein = NP_032554
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 40982484
| Mm_GenLoc_end = 41025964
| Mm_Uniprot = Q9QUN3
}}
}}
'''B-cell linker''', also known as '''BLNK''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Linker or adaptor proteins provide mechanisms by which receptors can amplify and regulate downstream effector proteins. The B-cell linker protein is essential for normal B-cell development.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: BLNK B-cell linker| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29760| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on CEACAM6... {November 9, 2007 9:14:50 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 9, 2007 9:15:46 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
| HGNCid = 1818
| Symbol = CEACAM6
| AltSymbols =; NCA; CD66c; CEAL
| OMIM = 163980
| ECnumber =
| Homologene =
| MGIid =
| GeneAtlas_image1 = PBB_GE_CEACAM6_203757_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CEACAM6_211657_at_tn.png
| Function = {{GNF_GO|id=GO:0048503 |text = GPI anchor binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4680
| Hs_Ensembl = ENSG00000086548
| Hs_RefseqProtein = NP_002474
| Hs_RefseqmRNA = NM_002483
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 46951337
| Hs_GenLoc_end = 46967953
| Hs_Uniprot = P40199
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)''', also known as '''CEACAM6''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on DARC... {November 9, 2007 8:59:52 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 9, 2007 9:00:12 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Duffy blood group, chemokine receptor
| HGNCid = 4035
| Symbol = DARC
| AltSymbols =; CCBP1; CD234; Dfy; FY; GPD
| OMIM = 110700
| ECnumber =
| Homologene = 48067
| MGIid = 1097689
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004950 |text = chemokine receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2532
| Hs_Ensembl =
| Hs_RefseqProtein = NP_002027
| Hs_RefseqmRNA = NM_002036
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 13349
| Mm_Ensembl = ENSMUSG00000037872
| Mm_RefseqmRNA = NM_010045
| Mm_RefseqProtein = NP_034175
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 175168621
| Mm_GenLoc_end = 175170348
| Mm_Uniprot = Q53ZP8
}}
}}
'''Duffy blood group, chemokine receptor''', also known as '''DARC''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Pogo AO, Chaudhuri A |title=Duffy and receptors for P. vivax and chemotactic peptides. |journal=Transfusion clinique et biologique : journal de la Société française de transfusion sanguine |volume=2 |issue= 4 |pages= 269-76 |year= 1996 |pmid= 8542025 |doi= }}
*{{cite journal | author=Pruenster M, Rot A |title=Throwing light on DARC. |journal=Biochem. Soc. Trans. |volume=34 |issue= Pt 6 |pages= 1005-8 |year= 2007 |pmid= 17073738 |doi= 10.1042/BST0341005 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on FOLR1... {November 9, 2007 8:58:00 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 9, 2007 8:58:46 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_summary = yes
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}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Folate receptor 1 (adult)
| HGNCid = 3791
| Symbol = FOLR1
| AltSymbols =; FBP; FOLR; FR-alpha; MOv18
| OMIM = 136430
| ECnumber =
| Homologene = 7322
| MGIid = 95568
| GeneAtlas_image1 = PBB_GE_FOLR1_204437_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005542 |text = folic acid binding}} {{GNF_GO|id=GO:0048503 |text = GPI anchor binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006898 |text = receptor-mediated endocytosis}} {{GNF_GO|id=GO:0015884 |text = folic acid transport}} {{GNF_GO|id=GO:0046655 |text = folic acid metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2348
| Hs_Ensembl = ENSG00000110195
| Hs_RefseqProtein = NP_000793
| Hs_RefseqmRNA = NM_000802
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 71578250
| Hs_GenLoc_end = 71584992
| Hs_Uniprot = P15328
| Mm_EntrezGene = 14275
| Mm_Ensembl = ENSMUSG00000001827
| Mm_RefseqmRNA = NM_008034
| Mm_RefseqProtein = NP_032060
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 101732171
| Mm_GenLoc_end = 101744602
| Mm_Uniprot = A1A4B2
}}
}}
'''Folate receptor 1 (adult)''', also known as '''FOLR1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This gene is composed of 7 exons; exons 1 through 4 encode the 5' UTR and exons 4 through 7 encode the open reading frame. Due to the presence of 2 promoters, multiple transcription start sites, and alternative splicing of exons, several transcript variants are derived from this gene. These variants differ in the lengths of 5' and 3' UTR, but they encode an identical amino acid sequence.<ref>{{cite web | title = Entrez Gene: FOLR1 folate receptor 1 (adult)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2348| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Henderson GB |title=Folate-binding proteins. |journal=Annu. Rev. Nutr. |volume=10 |issue= |pages= 319-35 |year= 1990 |pmid= 2166548 |doi= 10.1146/annurev.nu.10.070190.001535 }}
*{{cite journal | author=Kelemen LE |title=The role of folate receptor alpha in cancer development, progression and treatment: cause, consequence or innocent bystander? |journal=Int. J. Cancer |volume=119 |issue= 2 |pages= 243-50 |year= 2006 |pmid= 16453285 |doi= 10.1002/ijc.21712 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on FUS... {November 9, 2007 8:58:46 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 9, 2007 8:59:52 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Fusion (involved in t(12;16) in malignant liposarcoma)
| HGNCid = 4010
| Symbol = FUS
| AltSymbols =; CHOP; FUS-CHOP; FUS1; TLS; TLS/CHOP
| OMIM = 137070
| ECnumber =
| Homologene = 3639
| MGIid = 1353633
| GeneAtlas_image1 = PBB_GE_FUS_200959_at_tn.png
| GeneAtlas_image2 = PBB_GE_FUS_217370_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2521
| Hs_Ensembl = ENSG00000089280
| Hs_RefseqProtein = NP_001010850
| Hs_RefseqmRNA = NM_001010850
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 31098954
| Hs_GenLoc_end = 31110598
| Hs_Uniprot = P35637
| Mm_EntrezGene = 233908
| Mm_Ensembl = ENSMUSG00000030795
| Mm_RefseqmRNA = XM_986259
| Mm_RefseqProtein = XP_991353
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 127758702
| Mm_GenLoc_end = 127773179
| Mm_Uniprot = Q0VDX4
}}
}}
'''Fusion (involved in t(12;16) in malignant liposarcoma)''', also known as '''FUS''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kaplowitz N, Ji C |title=Unfolding new mechanisms of alcoholic liver disease in the endoplasmic reticulum. |journal=J. Gastroenterol. Hepatol. |volume=21 Suppl 3 |issue= |pages= S7-9 |year= 2007 |pmid= 16958678 |doi= 10.1111/j.1440-1746.2006.04581.x }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on GHRHR... {November 9, 2007 9:01:36 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 9, 2007 9:02:48 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Growth hormone releasing hormone receptor
| HGNCid = 4266
| Symbol = GHRHR
| AltSymbols =; GHRFR; GHRHRpsv; GRFR
| OMIM = 139191
| ECnumber =
| Homologene = 640
| MGIid = 95710
| GeneAtlas_image1 = PBB_GE_GHRHR_207825_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_GHRHR_211544_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_GHRHR_211545_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0004999 |text = vasoactive intestinal polypeptide receptor activity}} {{GNF_GO|id=GO:0016520 |text = growth hormone-releasing hormone receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007190 |text = adenylate cyclase activation}} {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2692
| Hs_Ensembl = ENSG00000106128
| Hs_RefseqProtein = NP_000814
| Hs_RefseqmRNA = NM_000823
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 30970161
| Hs_GenLoc_end = 30990114
| Hs_Uniprot = Q02643
| Mm_EntrezGene = 14602
| Mm_Ensembl = ENSMUSG00000004654
| Mm_RefseqmRNA = NM_001003685
| Mm_RefseqProtein = NP_001003685
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 55305921
| Mm_GenLoc_end = 55318108
| Mm_Uniprot = Q0VB62
}}
}}
'''Growth hormone releasing hormone receptor''', also known as '''GHRHR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene, expressed in the pituitary, encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. Many alternate transcriptional splice variants encoding different isoforms have been described, but only two have been characterized to date.<ref>{{cite web | title = Entrez Gene: GHRHR growth hormone releasing hormone receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2692| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Gaylinn BD |title=Molecular and cell biology of the growth hormone-releasing hormone receptor. |journal=Growth Horm. IGF Res. |volume=9 Suppl A |issue= |pages= 37-44 |year= 1999 |pmid= 10429879 |doi= }}
*{{cite journal | author=Lin-Su K, Wajnrajch MP |title=Growth Hormone Releasing Hormone (GHRH) and the GHRH Receptor. |journal=Reviews in endocrine & metabolic disorders |volume=3 |issue= 4 |pages= 313-23 |year= 2003 |pmid= 12424433 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on GPC3... {November 9, 2007 9:02:48 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 9, 2007 9:03:30 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Glypican 3
| HGNCid = 4451
| Symbol = GPC3
| AltSymbols =; DGSX; OCI-5; SDYS; SGB; SGBS; SGBS1
| OMIM = 300037
| ECnumber =
| Homologene = 20944
| MGIid = 104903
| GeneAtlas_image1 = PBB_GE_GPC3_209220_at_tn.png
| Function = {{GNF_GO|id=GO:0048503 |text = GPI anchor binding}}
| Component = {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0001658 |text = ureteric bud branching}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0030513 |text = positive regulation of BMP signaling pathway}} {{GNF_GO|id=GO:0045926 |text = negative regulation of growth}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2719
| Hs_Ensembl = ENSG00000147257
| Hs_RefseqProtein = NP_004475
| Hs_RefseqmRNA = NM_004484
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 132497439
| Hs_GenLoc_end = 132947588
| Hs_Uniprot = P51654
| Mm_EntrezGene = 14734
| Mm_Ensembl = ENSMUSG00000055653
| Mm_RefseqmRNA = NM_016697
| Mm_RefseqProtein = NP_057906
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 48517053
| Mm_GenLoc_end = 48858548
| Mm_Uniprot = Q3TWB2
}}
}}
'''Glypican 3''', also known as '''GPC3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome.<ref>{{cite web | title = Entrez Gene: GPC3 glypican 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2719| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Li M, Squire JA, Weksberg R |title=Overgrowth syndromes and genomic imprinting: from mouse to man. |journal=Clin. Genet. |volume=53 |issue= 3 |pages= 165-70 |year= 1998 |pmid= 9630066 |doi= }}
*{{cite journal | author=Filmus J |title=Glypicans in growth control and cancer. |journal=Glycobiology |volume=11 |issue= 3 |pages= 19R-23R |year= 2001 |pmid= 11320054 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on GPX4... {November 9, 2007 9:03:30 PM PST} UPLOAD : Added new Image to wiki: File:PBB Protein GPX4 image.jpg {November 9, 2007 9:03:46 PM PST} CREATE : Found no pages, creating new page. {November 9, 2007 9:04:03 PM PST} CREATED : Created new protein page: GPX4 {November 9, 2007 9:04:10 PM PST} INFO : Beginning work on IL9... {November 9, 2007 9:04:10 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 9, 2007 9:04:49 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Interleukin 9
| HGNCid = 6029
| Symbol = IL9
| AltSymbols =; HP40; IL-9; P40
| OMIM = 146931
| ECnumber =
| Homologene = 492
| MGIid = 96563
| GeneAtlas_image1 = PBB_GE_IL9_208193_at_tn.png
| Function = {{GNF_GO|id=GO:0005140 |text = interleukin-9 receptor binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0045407 |text = positive regulation of interleukin-5 biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3578
| Hs_Ensembl = ENSG00000145839
| Hs_RefseqProtein = NP_000581
| Hs_RefseqmRNA = NM_000590
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 135255834
| Hs_GenLoc_end = 135259415
| Hs_Uniprot = P15248
| Mm_EntrezGene = 16198
| Mm_Ensembl = ENSMUSG00000021538
| Mm_RefseqmRNA = NM_008373
| Mm_RefseqProtein = NP_032399
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 56488899
| Mm_GenLoc_end = 56491868
| Mm_Uniprot = P15247
}}
}}
'''Interleukin 9''', also known as '''IL9''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness.<ref>{{cite web | title = Entrez Gene: IL9 interleukin 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3578| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Renauld JC, Houssiau F, Louahed J, ''et al.'' |title=Interleukin-9. |journal=Adv. Immunol. |volume=54 |issue= |pages= 79-97 |year= 1993 |pmid= 8379467 |doi= }}
*{{cite journal | author=Knoops L, Renauld JC |title=IL-9 and its receptor: from signal transduction to tumorigenesis. |journal=Growth Factors |volume=22 |issue= 4 |pages= 207-15 |year= 2005 |pmid= 15621723 |doi= 10.1080/08977190410001720879 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on IRF2... {November 9, 2007 9:04:49 PM PST} UPLOAD : Added new Image to wiki: File:PBB Protein IRF2 image.jpg {November 9, 2007 9:05:27 PM PST} CREATE : Found no pages, creating new page. {November 9, 2007 9:05:40 PM PST} CREATED : Created new protein page: IRF2 {November 9, 2007 9:05:49 PM PST} INFO : Beginning work on IRF7... {November 9, 2007 9:05:49 PM PST} CREATE : Found no pages, creating new page. {November 9, 2007 9:06:27 PM PST} CREATED : Created new protein page: IRF7 {November 9, 2007 9:06:34 PM PST} INFO : Beginning work on KCNIP3... {November 9, 2007 9:17:06 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 9, 2007 9:17:38 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Kv channel interacting protein 3, calsenilin
| HGNCid = 15523
| Symbol = KCNIP3
| AltSymbols =; CSEN; DREAM; KCHIP3; MGC18289
| OMIM = 604662
| ECnumber =
| Homologene = 8382
| MGIid = 1929258
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005244 |text = voltage-gated ion channel activity}} {{GNF_GO|id=GO:0005267 |text = potassium channel activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 30818
| Hs_Ensembl = ENSG00000115041
| Hs_RefseqProtein = NP_001030086
| Hs_RefseqmRNA = NM_001034914
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 95326799
| Hs_GenLoc_end = 95415551
| Hs_Uniprot = Q9Y2W7
| Mm_EntrezGene = 56461
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_019789
| Mm_RefseqProtein = NP_062763
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Kv channel interacting protein 3, calsenilin''', also known as '''KCNIP3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described.<ref>{{cite web | title = Entrez Gene: KCNIP3 Kv channel interacting protein 3, calsenilin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30818| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on KCNQ3... {November 9, 2007 9:06:34 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 9, 2007 9:07:12 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Potassium voltage-gated channel, KQT-like subfamily, member 3
| HGNCid = 6297
| Symbol = KCNQ3
| AltSymbols =; BFNC2; EBN2; KV7.3
| OMIM = 602232
| ECnumber =
| Homologene = 20949
| MGIid = 1336181
| GeneAtlas_image1 = PBB_GE_KCNQ3_206573_at_tn.png
| Function = {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005249 |text = voltage-gated potassium channel activity}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0008076 |text = voltage-gated potassium channel complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3786
| Hs_Ensembl = ENSG00000184156
| Hs_RefseqProtein = NP_004510
| Hs_RefseqmRNA = NM_004519
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 133210691
| Hs_GenLoc_end = 133561961
| Hs_Uniprot = O43525
| Mm_EntrezGene = 110862
| Mm_Ensembl = ENSMUSG00000056258
| Mm_RefseqmRNA = NM_152923
| Mm_RefseqProtein = NP_690887
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 65824844
| Mm_GenLoc_end = 66115893
| Mm_Uniprot = Q14B66
}}
}}
'''Potassium voltage-gated channel, KQT-like subfamily, member 3''', also known as '''KCNQ3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2).<ref>{{cite web | title = Entrez Gene: KCNQ3 potassium voltage-gated channel, KQT-like subfamily, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3786| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Gutman GA, Chandy KG, Grissmer S, ''et al.'' |title=International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 473-508 |year= 2006 |pmid= 16382104 |doi= 10.1124/pr.57.4.10 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on KLRD1... {November 9, 2007 9:07:12 PM PST} UPLOAD : Added new Image to wiki: File:PBB Protein KLRD1 image.jpg {November 9, 2007 9:08:20 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 9, 2007 9:08:30 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
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| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_KLRD1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1b6e.
| PDB = {{PDB2|1b6e}}
| Name = Killer cell lectin-like receptor subfamily D, member 1
| HGNCid = 6378
| Symbol = KLRD1
| AltSymbols =; CD94
| OMIM = 602894
| ECnumber =
| Homologene = 1705
| MGIid = 1196275
| GeneAtlas_image1 = PBB_GE_KLRD1_207795_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_KLRD1_207796_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_KLRD1_210606_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0005529 |text = sugar binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3824
| Hs_Ensembl = ENSG00000134539
| Hs_RefseqProtein = NP_002253
| Hs_RefseqmRNA = NM_002262
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 10351816
| Hs_GenLoc_end = 10359983
| Hs_Uniprot = Q13241
| Mm_EntrezGene = 16643
| Mm_Ensembl = ENSMUSG00000030165
| Mm_RefseqmRNA = NM_010654
| Mm_RefseqProtein = NP_034784
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 129559176
| Mm_GenLoc_end = 129564465
| Mm_Uniprot =
}}
}}
'''Killer cell lectin-like receptor subfamily D, member 1''', also known as '''KLRD1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. KLRD1 has two alternatively spliced variants that differ in the presence or absence of exon 2 sequence.<ref>{{cite web | title = Entrez Gene: KLRD1 killer cell lectin-like receptor subfamily D, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3824| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on LAMA2... {November 9, 2007 9:08:30 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 9, 2007 9:09:45 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Laminin, alpha 2 (merosin, congenital muscular dystrophy)
| HGNCid = 6482
| Symbol = LAMA2
| AltSymbols =; LAMM
| OMIM = 156225
| ECnumber =
| Homologene = 37306
| MGIid = 99912
| GeneAtlas_image1 = PBB_GE_LAMA2_205116_at_tn.png
| GeneAtlas_image2 = PBB_GE_LAMA2_213519_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_LAMA2_216840_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}}
| Component = {{GNF_GO|id=GO:0005604 |text = basement membrane}} {{GNF_GO|id=GO:0005606 |text = laminin-1 complex}} {{GNF_GO|id=GO:0031012 |text = extracellular matrix}}
| Process = {{GNF_GO|id=GO:0007517 |text = muscle development}} {{GNF_GO|id=GO:0030155 |text = regulation of cell adhesion}} {{GNF_GO|id=GO:0030334 |text = regulation of cell migration}} {{GNF_GO|id=GO:0045995 |text = regulation of embryonic development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3908
| Hs_Ensembl = ENSG00000196569
| Hs_RefseqProtein = NP_000417
| Hs_RefseqmRNA = NM_000426
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 129246035
| Hs_GenLoc_end = 129879407
| Hs_Uniprot = P24043
| Mm_EntrezGene = 16773
| Mm_Ensembl = ENSMUSG00000019899
| Mm_RefseqmRNA = NM_008481
| Mm_RefseqProtein = NP_032507
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 26670815
| Mm_GenLoc_end = 27306267
| Mm_Uniprot = Q8C9J2
}}
}}
'''Laminin, alpha 2 (merosin, congenital muscular dystrophy)''', also known as '''LAMA2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene.<ref>{{cite web | title = Entrez Gene: LAMA2 laminin, alpha 2 (merosin, congenital muscular dystrophy)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3908| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Timpl R |title=Macromolecular organization of basement membranes. |journal=Curr. Opin. Cell Biol. |volume=8 |issue= 5 |pages= 618-24 |year= 1997 |pmid= 8939648 |doi= }}
*{{cite journal | author=Belkin AM, Stepp MA |title=Integrins as receptors for laminins. |journal=Microsc. Res. Tech. |volume=51 |issue= 3 |pages= 280-301 |year= 2000 |pmid= 11054877 |doi= 10.1002/1097-0029(20001101)51:3<280::AID-JEMT7>3.0.CO;2-O }}
*{{cite journal | author=Jones KJ, Morgan G, Johnston H, ''et al.'' |title=The expanding phenotype of laminin alpha2 chain (merosin) abnormalities: case series and review. |journal=J. Med. Genet. |volume=38 |issue= 10 |pages= 649-57 |year= 2002 |pmid= 11584042 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on LMAN1... {November 9, 2007 9:09:45 PM PST} UPLOAD : Added new Image to wiki: File:PBB Protein LMAN1 image.jpg {November 9, 2007 9:10:58 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 9, 2007 9:11:21 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_LMAN1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1r1z.
| PDB = {{PDB2|1r1z}}
| Name = Lectin, mannose-binding, 1
| HGNCid = 6631
| Symbol = LMAN1
| AltSymbols =; ERGIC-53; ERGIC53; F5F8D; FMFD1; MCFD1; MR60; gp58
| OMIM = 601567
| ECnumber =
| Homologene = 4070
| MGIid = 1917611
| GeneAtlas_image1 = PBB_GE_LMAN1_203293_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_LMAN1_203294_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005529 |text = sugar binding}} {{GNF_GO|id=GO:0005537 |text = mannose binding}} {{GNF_GO|id=GO:0051082 |text = unfolded protein binding}}
| Component = {{GNF_GO|id=GO:0000139 |text = Golgi membrane}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005789 |text = endoplasmic reticulum membrane}} {{GNF_GO|id=GO:0005793 |text = ER-Golgi intermediate compartment}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0030017 |text = sarcomere}}
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0006888 |text = ER to Golgi vesicle-mediated transport}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}} {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3998
| Hs_Ensembl = ENSG00000074695
| Hs_RefseqProtein = NP_005561
| Hs_RefseqmRNA = NM_005570
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 18
| Hs_GenLoc_start = 55148088
| Hs_GenLoc_end = 55177463
| Hs_Uniprot = P49257
| Mm_EntrezGene = 70361
| Mm_Ensembl = ENSMUSG00000041891
| Mm_RefseqmRNA = NM_027400
| Mm_RefseqProtein = NP_081676
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 18
| Mm_GenLoc_start = 66106123
| Mm_GenLoc_end = 66127981
| Mm_Uniprot = Q3U944
}}
}}
'''Lectin, mannose-binding, 1''', also known as '''LMAN1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.<ref>{{cite web | title = Entrez Gene: LMAN1 lectin, mannose-binding, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3998| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Botos I, Wlodawer A |title=Proteins that bind high-mannose sugars of the HIV envelope. |journal=Prog. Biophys. Mol. Biol. |volume=88 |issue= 2 |pages= 233-82 |year= 2005 |pmid= 15572157 |doi= 10.1016/j.pbiomolbio.2004.05.001 }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on LY96... {November 9, 2007 9:15:46 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 9, 2007 9:16:21 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Lymphocyte antigen 96
| HGNCid = 17156
| Symbol = LY96
| AltSymbols =; MD-2
| OMIM = 605243
| ECnumber =
| Homologene = 9109
| MGIid = 1341909
| GeneAtlas_image1 = PBB_GE_LY96_206584_at_tn.png
| Function = {{GNF_GO|id=GO:0015026 |text = coreceptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0006968 |text = cellular defense response}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0019733 |text = antibacterial humoral response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 23643
| Hs_Ensembl = ENSG00000154589
| Hs_RefseqProtein = NP_056179
| Hs_RefseqmRNA = NM_015364
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 75066141
| Hs_GenLoc_end = 75103859
| Hs_Uniprot = Q9Y6Y9
| Mm_EntrezGene = 17087
| Mm_Ensembl = ENSMUSG00000025779
| Mm_RefseqmRNA = NM_016923
| Mm_RefseqProtein = NP_058619
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 16673647
| Mm_GenLoc_end = 16694819
| Mm_Uniprot = Q14AM4
}}
}}
'''Lymphocyte antigen 96''', also known as '''LY96''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The MD-2 protein appears to associate with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling.<ref>{{cite web | title = Entrez Gene: LY96 lymphocyte antigen 96| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23643| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on MMP10... {November 9, 2007 9:12:22 PM PST} UPLOAD : Added new Image to wiki: File:PBB Protein MMP10 image.jpg {November 9, 2007 9:13:01 PM PST} CREATE : Found no pages, creating new page. {November 9, 2007 9:13:14 PM PST} CREATED : Created new protein page: MMP10 {November 9, 2007 9:13:21 PM PST} INFO : Beginning work on MMP12... {November 9, 2007 9:13:21 PM PST} UPLOAD : Added new Image to wiki: File:PBB Protein MMP12 image.jpg {November 9, 2007 9:13:55 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 9, 2007 9:14:12 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MMP12_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1jiz.
| PDB = {{PDB2|1jiz}}, {{PDB2|1jk3}}, {{PDB2|1os2}}, {{PDB2|1os9}}, {{PDB2|1rmz}}, {{PDB2|1ros}}, {{PDB2|1utt}}, {{PDB2|1utz}}, {{PDB2|1y93}}, {{PDB2|1ycm}}, {{PDB2|1z3j}}, {{PDB2|2hu6}}, {{PDB2|2oxu}}, {{PDB2|2oxw}}, {{PDB2|2oxz}}
| Name = Matrix metallopeptidase 12 (macrophage elastase)
| HGNCid = 7158
| Symbol = MMP12
| AltSymbols =; MME; HME; MGC138506
| OMIM = 601046
| ECnumber =
| Homologene = 20547
| MGIid = 97005
| GeneAtlas_image1 = PBB_GE_MMP12_204580_at_tn.png
| Function = {{GNF_GO|id=GO:0004234 |text = macrophage elastase activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}}
| Component = {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}}
| Process = {{GNF_GO|id=GO:0000270 |text = peptidoglycan metabolic process}} {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006928 |text = cell motility}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4321
| Hs_Ensembl = ENSG00000110347
| Hs_RefseqProtein = NP_002417
| Hs_RefseqmRNA = NM_002426
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 102238686
| Hs_GenLoc_end = 102250922
| Hs_Uniprot = P39900
| Mm_EntrezGene = 17381
| Mm_Ensembl = ENSMUSG00000049723
| Mm_RefseqmRNA = NM_008605
| Mm_RefseqProtein = NP_032631
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 7347406
| Mm_GenLoc_end = 7369499
| Mm_Uniprot = Q3TB28
}}
}}
'''Matrix metallopeptidase 12 (macrophage elastase)''', also known as '''MMP12''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.<ref>{{cite web | title = Entrez Gene: MMP12 matrix metallopeptidase 12 (macrophage elastase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4321| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Nagase H, Woessner JF |title=Matrix metalloproteinases. |journal=J. Biol. Chem. |volume=274 |issue= 31 |pages= 21491-4 |year= 1999 |pmid= 10419448 |doi= }}
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on MST1R... {November 9, 2007 9:14:12 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 9, 2007 9:14:50 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
| HGNCid = 7381
| Symbol = MST1R
| AltSymbols =; CDw136; PTK8; RON
| OMIM = 600168
| ECnumber =
| Homologene = 1835
| MGIid = 99614
| GeneAtlas_image1 = PBB_GE_MST1R_205455_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005011 |text = macrophage colony stimulating factor receptor activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0001725 |text = stress fiber}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007338 |text = single fertilization}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4486
| Hs_Ensembl = ENSG00000164078
| Hs_RefseqProtein = NP_002438
| Hs_RefseqmRNA = NM_002447
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 49899444
| Hs_GenLoc_end = 49916074
| Hs_Uniprot = Q04912
| Mm_EntrezGene = 19882
| Mm_Ensembl = ENSMUSG00000032584
| Mm_RefseqmRNA = NM_009074
| Mm_RefseqProtein = NP_033100
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 107764990
| Mm_GenLoc_end = 107778488
| Mm_Uniprot = Q62190
}}
}}
'''Macrophage stimulating 1 receptor (c-met-related tyrosine kinase)''', also known as '''MST1R''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
INFO : Beginning work on SLC37A4... {November 9, 2007 9:00:12 PM PST} CREATE : Found no pages, creating new page. {November 9, 2007 9:01:27 PM PST} CREATED : Created new protein page: SLC37A4 {November 9, 2007 9:01:36 PM PST} INFO : Beginning work on SMAD6... {November 9, 2007 9:11:21 PM PST} AMBIGUITY : Did not locate an acceptable page to update. {November 9, 2007 9:12:22 PM PST} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = SMAD family member 6
| HGNCid = 6772
| Symbol = SMAD6
| AltSymbols =; HsT17432; MADH6; MADH7
| OMIM = 602931
| ECnumber =
| Homologene = 4079
| MGIid = 1336883
| GeneAtlas_image1 = PBB_GE_SMAD6_207069_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SMAD6_209886_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005076 |text = receptor signaling protein serine/threonine kinase signaling protein activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0030617 |text = transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4091
| Hs_Ensembl = ENSG00000137834
| Hs_RefseqProtein = NP_005576
| Hs_RefseqmRNA = NM_005585
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 64781722
| Hs_GenLoc_end = 64861377
| Hs_Uniprot = O43541
| Mm_EntrezGene = 17130
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_008542
| Mm_RefseqProtein = NP_032568
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''SMAD family member 6''', also known as '''SMAD6''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Massagué J |title=TGF-beta signal transduction. |journal=Annu. Rev. Biochem. |volume=67 |issue= |pages= 753-91 |year= 1998 |pmid= 9759503 |doi= 10.1146/annurev.biochem.67.1.753 }}
*{{cite journal | author=Verschueren K, Huylebroeck D |title=Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells. |journal=Cytokine Growth Factor Rev. |volume=10 |issue= 3-4 |pages= 187-99 |year= 2000 |pmid= 10647776 |doi= }}
*{{cite journal | author=Wrana JL, Attisano L |title=The Smad pathway. |journal=Cytokine Growth Factor Rev. |volume=11 |issue= 1-2 |pages= 5-13 |year= 2000 |pmid= 10708948 |doi= }}
*{{cite journal | author=Miyazono K |title=TGF-beta signaling by Smad proteins. |journal=Cytokine Growth Factor Rev. |volume=11 |issue= 1-2 |pages= 15-22 |year= 2000 |pmid= 10708949 |doi= }}
}}
{{refend}}
{{protein-stub}}
end log.
{November 9, 2007 8:55:48 PM PST} 
