- INFO: Beginning work on CROP... {December 20, 2007 1:21:39 PM PST}
- REDIRECT: Protein Redirected to: CROP (gene) {December 20, 2007 1:23:00 PM PST}
- CREATED: Created new protein page: CROP (gene) {December 20, 2007 1:23:12 PM PST}
- INFO: Beginning work on EXOSC9... {December 20, 2007 1:16:05 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein EXOSC9 image.jpg {December 20, 2007 1:16:43 PM PST}
- REDIRECT: Protein Redirected to: EXOSC9 {December 20, 2007 1:16:51 PM PST}
- CREATED: Created new protein page: EXOSC9 {December 20, 2007 1:16:59 PM PST}
- INFO: Beginning work on LSM7... {December 20, 2007 1:20:53 PM PST}
- REDIRECT: Protein Redirected to: LSM7 {December 20, 2007 1:21:28 PM PST}
- CREATED: Created new protein page: LSM7 {December 20, 2007 1:21:39 PM PST}
- INFO: Beginning work on MPP6... {December 20, 2007 1:19:53 PM PST}
- REDIRECT: Protein Redirected to: MPP6 {December 20, 2007 1:20:44 PM PST}
- CREATED: Created new protein page: MPP6 {December 20, 2007 1:20:53 PM PST}
- INFO: Beginning work on NOP5/NOP58... {December 20, 2007 1:19:27 PM PST}
- REDIRECT: Protein Redirected to: NOP5/NOP58 {December 20, 2007 1:19:44 PM PST}
- CREATED: Created new protein page: NOP5/NOP58 {December 20, 2007 1:19:53 PM PST}
- INFO: Beginning work on PFN1... {December 20, 2007 1:13:00 PM PST}
- REDIRECT: Protein Redirected to: PFN1 {December 20, 2007 1:13:19 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 1:13:20 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 1:13:20 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 1:13:20 PM PST}
- UPDATED: Updated protein page: PFN1 {December 20, 2007 1:13:26 PM PST}
- INFO: Beginning work on PHB... {December 20, 2007 1:13:26 PM PST}
- REDIRECT: Protein Redirected to: PHB (gene) {December 20, 2007 1:14:17 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 1:14:20 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 1:14:20 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 1:14:20 PM PST}
- UPDATED: Updated protein page: PHB (gene) {December 20, 2007 1:14:27 PM PST}
- INFO: Beginning work on PLSCR1... {December 20, 2007 1:14:27 PM PST}
- REDIRECT: Protein Redirected to: PLSCR1 {December 20, 2007 1:14:46 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 1:14:51 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 1:14:51 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 1:14:51 PM PST}
- UPDATED: Updated protein page: PLSCR1 {December 20, 2007 1:14:56 PM PST}
- INFO: Beginning work on PMAIP1... {December 20, 2007 1:14:56 PM PST}
- REDIRECT: Page directory gave bad page (Noxa). Continuing with search.. Please correct entry: <5366,Noxa>. {December 20, 2007 1:15:57 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {December 20, 2007 1:16:05 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Phorbol-12-myristate-13-acetate-induced protein 1
| HGNCid = 9108
| Symbol = PMAIP1
| AltSymbols =; APR; NOXA
| OMIM = 604959
| ECnumber =
| Homologene = 88883
| MGIid =
| GeneAtlas_image1 = PBB_GE_PMAIP1_204286_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PMAIP1_204285_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5366
| Hs_Ensembl = ENSG00000141682
| Hs_RefseqProtein = NP_066950
| Hs_RefseqmRNA = NM_021127
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 18
| Hs_GenLoc_start = 55718217
| Hs_GenLoc_end = 55722517
| Hs_Uniprot = Q13794
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Phorbol-12-myristate-13-acetate-induced protein 1''', also known as '''PMAIP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5366| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hijikata M, Kato N, Sato T, ''et al.'' |title=Molecular cloning and characterization of a cDNA for a novel phorbol-12-myristate-13-acetate-responsive gene that is highly expressed in an adult T-cell leukemia cell line. |journal=J. Virol. |volume=64 |issue= 10 |pages= 4632-9 |year= 1990 |pmid= 2398525 |doi= }}
*{{cite journal | author=Oda E, Ohki R, Murasawa H, ''et al.'' |title=Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. |journal=Science |volume=288 |issue= 5468 |pages= 1053-8 |year= 2000 |pmid= 10807576 |doi= }}
*{{cite journal | author=Venter JC, Adams MD, Myers EW, ''et al.'' |title=The sequence of the human genome. |journal=Science |volume=291 |issue= 5507 |pages= 1304-51 |year= 2001 |pmid= 11181995 |doi= 10.1126/science.1058040 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Jansson AK, Emterling AM, Arbman G, Sun XF |title=Noxa in colorectal cancer: a study on DNA, mRNA and protein expression. |journal=Oncogene |volume=22 |issue= 30 |pages= 4675-8 |year= 2003 |pmid= 12879012 |doi= 10.1038/sj.onc.1206655 }}
*{{cite journal | author=Seo YW, Shin JN, Ko KH, ''et al.'' |title=The molecular mechanism of Noxa-induced mitochondrial dysfunction in p53-mediated cell death. |journal=J. Biol. Chem. |volume=278 |issue= 48 |pages= 48292-9 |year= 2004 |pmid= 14500711 |doi= 10.1074/jbc.M308785200 }}
*{{cite journal | author=Kim JY, Ahn HJ, Ryu JH, ''et al.'' |title=BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha. |journal=J. Exp. Med. |volume=199 |issue= 1 |pages= 113-24 |year= 2004 |pmid= 14699081 |doi= 10.1084/jem.20030613 }}
*{{cite journal | author=Yakovlev AG, Di Giovanni S, Wang G, ''et al.'' |title=BOK and NOXA are essential mediators of p53-dependent apoptosis. |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28367-74 |year= 2004 |pmid= 15102863 |doi= 10.1074/jbc.M313526200 }}
*{{cite journal | author=Qin JZ, Stennett L, Bacon P, ''et al.'' |title=p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas. |journal=Mol. Cancer Ther. |volume=3 |issue= 8 |pages= 895-902 |year= 2005 |pmid= 15299072 |doi= }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Flinterman M, Guelen L, Ezzati-Nik S, ''et al.'' |title=E1A activates transcription of p73 and Noxa to induce apoptosis. |journal=J. Biol. Chem. |volume=280 |issue= 7 |pages= 5945-59 |year= 2005 |pmid= 15572378 |doi= 10.1074/jbc.M406661200 }}
*{{cite journal | author=Chen L, Willis SN, Wei A, ''et al.'' |title=Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. |journal=Mol. Cell |volume=17 |issue= 3 |pages= 393-403 |year= 2005 |pmid= 15694340 |doi= 10.1016/j.molcel.2004.12.030 }}
*{{cite journal | author=Sun Y, Leaman DW |title=Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection. |journal=J. Biol. Chem. |volume=280 |issue= 16 |pages= 15561-8 |year= 2005 |pmid= 15705586 |doi= 10.1074/jbc.M412630200 }}
*{{cite journal | author=Ceballos E, Muñoz-Alonso MJ, Berwanger B, ''et al.'' |title=Inhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells. Microarray analysis reveals defective induction of p53 target genes and upregulation of chaperone genes. |journal=Oncogene |volume=24 |issue= 28 |pages= 4559-71 |year= 2005 |pmid= 15856024 |doi= 10.1038/sj.onc.1208652 }}
*{{cite journal | author=Willis SN, Chen L, Dewson G, ''et al.'' |title=Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. |journal=Genes Dev. |volume=19 |issue= 11 |pages= 1294-305 |year= 2005 |pmid= 15901672 |doi= 10.1101/gad.1304105 }}
*{{cite journal | author=Alves NL, Derks IA, Berk E, ''et al.'' |title=The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells. |journal=Immunity |volume=24 |issue= 6 |pages= 703-16 |year= 2006 |pmid= 16782027 |doi= 10.1016/j.immuni.2006.03.018 }}
*{{cite journal | author=Obexer P, Geiger K, Ambros PF, ''et al.'' |title=FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells. |journal=Cell Death Differ. |volume=14 |issue= 3 |pages= 534-47 |year= 2007 |pmid= 16888645 |doi= 10.1038/sj.cdd.4402017 }}
*{{cite journal | author=Fribley AM, Evenchik B, Zeng Q, ''et al.'' |title=Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa. |journal=J. Biol. Chem. |volume=281 |issue= 42 |pages= 31440-7 |year= 2006 |pmid= 16928686 |doi= 10.1074/jbc.M604356200 }}
*{{cite journal | author=Smit LA, Hallaert DY, Spijker R, ''et al.'' |title=Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity. |journal=Blood |volume=109 |issue= 4 |pages= 1660-8 |year= 2007 |pmid= 17038534 |doi= 10.1182/blood-2006-05-021683 }}
*{{cite journal | author=Armstrong JL, Veal GJ, Redfern CP, Lovat PE |title=Role of Noxa in p53-independent fenretinide-induced apoptosis of neuroectodermal tumours. |journal=Apoptosis |volume=12 |issue= 3 |pages= 613-22 |year= 2007 |pmid= 17216584 |doi= 10.1007/s10495-006-0020-1 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PNN... {December 20, 2007 1:16:59 PM PST}
- REDIRECT: Protein Redirected to: PNN (gene) {December 20, 2007 1:17:21 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 1:17:24 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 1:17:24 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 1:17:24 PM PST}
- UPDATED: Updated protein page: PNN (gene) {December 20, 2007 1:17:31 PM PST}
- INFO: Beginning work on POLD1... {December 20, 2007 1:17:31 PM PST}
- REDIRECT: Protein Redirected to: POLD1 {December 20, 2007 1:17:47 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 1:17:50 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 1:17:50 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 1:17:50 PM PST}
- UPDATED: Updated protein page: POLD1 {December 20, 2007 1:17:57 PM PST}
- INFO: Beginning work on POLD2... {December 20, 2007 1:17:57 PM PST}
- REDIRECT: Protein Redirected to: POLD2 {December 20, 2007 1:18:32 PM PST}
- CREATED: Created new protein page: POLD2 {December 20, 2007 1:18:41 PM PST}
- INFO: Beginning work on TTRAP... {December 20, 2007 1:18:41 PM PST}
- REDIRECT: Protein Redirected to: TTRAP {December 20, 2007 1:19:17 PM PST}
- CREATED: Created new protein page: TTRAP {December 20, 2007 1:19:27 PM PST}
end log.