User:ProteinBoxBot/PBB Log Wiki 12-20-2007-DECS-9

Log file for Protein Box Bot

Log page index: User:ProteinBoxBot/PBB_Log_Index

Protein Status Quick Log - Date: 20:53, 20 December 2007 (UTC)

Proteins with a High Potential Match (1)

Redirected Proteins (11)

MTHFD1	MT1G	MUTYH	MRE11A	MLLT7
MCM5	NUDT1	MSH3	MNAT1	MSH2
MYB

Created (1)

MT1G

Manual Inspection (Page not found) (1)

MCM6

Updated (10)

MTHFD1	MUTYH	MRE11A	MLLT7	MCM5
NUDT1	MSH3	MNAT1	MSH2	MYB

Protein Status Grid - Date: 20:53, 20 December 2007 (UTC)

HUGO Symbol	Action Summary	Target page(s)	WP Symbol Search
MTHFD1	Updated	Location: MTHFD1;	[1]
MT1G	Created	Location: MT1G;	[2]
MUTYH	Updated	Location: MUTYH (gene);	[3]
MCM6	Manual Inspection (Page not found)	Other Pages: Minichromosome maintenance deficient 6 homolog (No Data); MCM6 (Protein Template); MCG40308 (No Data); Mcg40308 (No Data); Mis5 (No Data); P105MCM (No Data); P105mcm (No Data);	[4]
MRE11A	Updated	Location: MRE11A;	[5]
MLLT7	Updated	Location: FOXO4;	[6]
MCM5	Updated	Location: MCM5;	[7]
NUDT1	Updated	Location: NUDT1;	[8]
MSH3	Updated	Location: MSH3;	[9]
MNAT1	Updated	Location: MNAT1;	[10]
MSH2	Updated	Location: MSH2;	[11]
MYB	Updated	Location: MYB;	[12]

Vebose Log - Date: 20:53, 20 December 2007 (UTC)

MCM5

INFO: Beginning work on MCM5... {December 20, 2007 12:46:23 PM PST}
REDIRECT: Protein Redirected to: MCM5 {December 20, 2007 12:46:50 PM PST}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 12:46:53 PM PST}
UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 12:46:53 PM PST}
UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 12:46:53 PM PST}
UPDATED: Updated protein page: MCM5 {December 20, 2007 12:47:00 PM PST}

MCM6

INFO: Beginning work on MCM6... {December 20, 2007 12:47:00 PM PST}
REDIRECT: Page directory gave bad page (MCM6). Continuing with search.. Please correct entry: <4175,MCM6>. {December 20, 2007 12:47:43 PM PST}
AMBIGUITY: Did not locate an acceptable page to update. {December 20, 2007 12:47:53 PM PST}

 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Minichromosome maintenance deficient 6 homolog (S. cerevisiae)
 | HGNCid = 6949
 | Symbol = MCM6
 | AltSymbols =; MCG40308; Mis5; P105MCM
 | OMIM = 601806
 | ECnumber =  
 | Homologene = 4322
 | MGIid = 1298227
 | GeneAtlas_image1 = PBB_GE_MCM6_201930_at_tn.png
 | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003678 |text = DNA helicase activity}} {{GNF_GO|id=GO:0003697 |text = single-stranded DNA binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008094 |text = DNA-dependent ATPase activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}} 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} 
 | Process = {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0006268 |text = DNA unwinding during replication}} {{GNF_GO|id=GO:0006270 |text = DNA replication initiation}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4175
    | Hs_Ensembl = ENSG00000076003
    | Hs_RefseqProtein = NP_005906
    | Hs_RefseqmRNA = NM_005915
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 136313674
    | Hs_GenLoc_end = 136350481
    | Hs_Uniprot = Q14566
    | Mm_EntrezGene = 17219
    | Mm_Ensembl = ENSMUSG00000026355
    | Mm_RefseqmRNA = NM_008567
    | Mm_RefseqProtein = NP_032593
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 130159137
    | Mm_GenLoc_end = 130187210
    | Mm_Uniprot = Q3UC10
  }}
}}
'''Minichromosome maintenance deficient 6 homolog (S. cerevisiae)''', also known as '''MCM6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MCM6 minichromosome maintenance deficient 6 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4175| accessdate = }}</ref>

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication.<ref name="entrez">{{cite web | title = Entrez Gene: MCM6 minichromosome maintenance deficient 6 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4175| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Ishimi Y, Ichinose S, Omori A, ''et al.'' |title=Binding of human minichromosome maintenance proteins with histone H3. |journal=J. Biol. Chem. |volume=271 |issue= 39 |pages= 24115-22 |year= 1996 |pmid= 8798650 |doi=  }}
*{{cite journal  | author=Holthoff HP, Hameister H, Knippers R |title=A novel human Mcm protein: homology to the yeast replication protein Mis5 and chromosomal location. |journal=Genomics |volume=37 |issue= 1 |pages= 131-4 |year= 1997 |pmid= 8921380 |doi= 10.1006/geno.1996.0530 }}
*{{cite journal  | author=Harvey CB, Wang Y, Darmoul D, ''et al.'' |title=Characterisation of a human homologue of a yeast cell division cycle gene, MCM6, located adjacent to the 5' end of the lactase gene on chromosome 2q21. |journal=FEBS Lett. |volume=398 |issue= 2-3 |pages= 135-40 |year= 1997 |pmid= 8977093 |doi=  }}
*{{cite journal  | author=Tsuruga H, Yabuta N, Hosoya S, ''et al.'' |title=HsMCM6: a new member of the human MCM/P1 family encodes a protein homologous to fission yeast Mis5. |journal=Genes Cells |volume=2 |issue= 6 |pages= 381-99 |year= 1997 |pmid= 9286856 |doi=  }}
*{{cite journal  | author=Ishimi Y |title=A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex. |journal=J. Biol. Chem. |volume=272 |issue= 39 |pages= 24508-13 |year= 1997 |pmid= 9305914 |doi=  }}
*{{cite journal  | author=Holthoff HP, Baack M, Richter A, ''et al.'' |title=Human protein MCM6 on HeLa cell chromatin. |journal=J. Biol. Chem. |volume=273 |issue= 13 |pages= 7320-5 |year= 1998 |pmid= 9516426 |doi=  }}
*{{cite journal  | author=Ohtani K, Iwanaga R, Nakamura M, ''et al.'' |title=Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F. |journal=Oncogene |volume=18 |issue= 14 |pages= 2299-309 |year= 1999 |pmid= 10327050 |doi= 10.1038/sj.onc.1202544 }}
*{{cite journal  | author=You Z, Komamura Y, Ishimi Y |title=Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity. |journal=Mol. Cell. Biol. |volume=19 |issue= 12 |pages= 8003-15 |year= 2000 |pmid= 10567526 |doi=  }}
*{{cite journal  | author=Ishimi Y, Komamura-Kohno Y, You Z, ''et al.'' |title=Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2. |journal=J. Biol. Chem. |volume=275 |issue= 21 |pages= 16235-41 |year= 2000 |pmid= 10748114 |doi= 10.1074/jbc.M909040199 }}
*{{cite journal  | author=Izumi M, Yanagi K, Mizuno T, ''et al.'' |title=The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase. |journal=Nucleic Acids Res. |volume=28 |issue= 23 |pages= 4769-77 |year= 2001 |pmid= 11095689 |doi=  }}
*{{cite journal  | author=Lee JK, Hurwitz J |title=Processive DNA helicase activity of the minichromosome maintenance proteins 4, 6, and 7 complex requires forked DNA structures. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 1 |pages= 54-9 |year= 2001 |pmid= 11136247 |doi= 10.1073/pnas.98.1.54 }}
*{{cite journal  | author=Enattah NS, Sahi T, Savilahti E, ''et al.'' |title=Identification of a variant associated with adult-type hypolactasia. |journal=Nat. Genet. |volume=30 |issue= 2 |pages= 233-7 |year= 2002 |pmid= 11788828 |doi= 10.1038/ng826 }}
*{{cite journal  | author=Yanagi K, Mizuno T, You Z, Hanaoka F |title=Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40871-80 |year= 2002 |pmid= 12192004 |doi= 10.1074/jbc.M206202200 }}
*{{cite journal  | author=You Z, Ishimi Y, Masai H, Hanaoka F |title=Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 42471-9 |year= 2003 |pmid= 12207017 |doi= 10.1074/jbc.M205769200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Kneissl M, Pütter V, Szalay AA, Grummt F |title=Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells. |journal=J. Mol. Biol. |volume=327 |issue= 1 |pages= 111-28 |year= 2003 |pmid= 12614612 |doi=  }}
*{{cite journal  | author=Yabuta N, Kajimura N, Mayanagi K, ''et al.'' |title=Mammalian Mcm2/4/6/7 complex forms a toroidal structure. |journal=Genes Cells |volume=8 |issue= 5 |pages= 413-21 |year= 2004 |pmid= 12694531 |doi=  }}
*{{cite journal  | author=Johnson EM, Kinoshita Y, Daniel DC |title=A new member of the MCM protein family encoded by the human MCM8 gene, located contrapodal to GCD10 at chromosome band 20p12.3-13. |journal=Nucleic Acids Res. |volume=31 |issue= 11 |pages= 2915-25 |year= 2003 |pmid= 12771218 |doi=  }}
*{{cite journal  | author=Ramachandran N, Hainsworth E, Bhullar B, ''et al.'' |title=Self-assembling protein microarrays. |journal=Science |volume=305 |issue= 5680 |pages= 86-90 |year= 2004 |pmid= 15232106 |doi= 10.1126/science.1097639 }}
*{{cite journal  | author=Yu Z, Feng D, Liang C |title=Pairwise interactions of the six human MCM protein subunits. |journal=J. Mol. Biol. |volume=340 |issue= 5 |pages= 1197-206 |year= 2004 |pmid= 15236977 |doi= 10.1016/j.jmb.2004.05.024 }}
}}
{{refend}}

{{protein-stub}}

MLLT7

INFO: Beginning work on MLLT7... {December 20, 2007 12:47:53 PM PST}
REDIRECT: Protein Redirected to: FOXO4 {December 20, 2007 12:48:21 PM PST}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 12:48:22 PM PST}
UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 12:48:22 PM PST}
UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 12:48:22 PM PST}
UPDATED: Updated protein page: FOXO4 {December 20, 2007 12:48:31 PM PST}

MNAT1

INFO: Beginning work on MNAT1... {December 20, 2007 12:48:31 PM PST}
REDIRECT: Protein Redirected to: MNAT1 {December 20, 2007 12:49:01 PM PST}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 12:49:02 PM PST}
UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 12:49:02 PM PST}
UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 12:49:02 PM PST}
UPDATED: Updated protein page: MNAT1 {December 20, 2007 12:49:09 PM PST}

MRE11A

INFO: Beginning work on MRE11A... {December 20, 2007 12:49:09 PM PST}
REDIRECT: Protein Redirected to: MRE11A {December 20, 2007 12:49:44 PM PST}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 12:49:47 PM PST}
UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 12:49:47 PM PST}
UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 12:49:47 PM PST}
UPDATED: Updated protein page: MRE11A {December 20, 2007 12:49:53 PM PST}

MSH2

INFO: Beginning work on MSH2... {December 20, 2007 12:49:53 PM PST}
REDIRECT: Protein Redirected to: MSH2 {December 20, 2007 12:50:16 PM PST}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 12:50:18 PM PST}
UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 12:50:18 PM PST}
UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 12:50:18 PM PST}
UPDATED: Updated protein page: MSH2 {December 20, 2007 12:50:24 PM PST}

MSH3

INFO: Beginning work on MSH3... {December 20, 2007 12:50:24 PM PST}
REDIRECT: Protein Redirected to: MSH3 {December 20, 2007 12:50:59 PM PST}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 12:51:02 PM PST}
UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 12:51:02 PM PST}
UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 12:51:02 PM PST}
UPDATED: Updated protein page: MSH3 {December 20, 2007 12:51:08 PM PST}

MT1G

INFO: Beginning work on MT1G... {December 20, 2007 12:51:08 PM PST}
UPLOAD: Added new Image to wiki: File:PBB Protein MT1G image.jpg {December 20, 2007 12:51:55 PM PST}
REDIRECT: Protein Redirected to: MT1G {December 20, 2007 12:52:02 PM PST}
CREATED: Created new protein page: MT1G {December 20, 2007 12:52:13 PM PST}

MTHFD1

INFO: Beginning work on MTHFD1... {December 20, 2007 12:52:42 PM PST}
REDIRECT: Protein Redirected to: MTHFD1 {December 20, 2007 12:53:09 PM PST}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 12:53:10 PM PST}
UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 12:53:10 PM PST}
UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 12:53:10 PM PST}
UPDATED: Updated protein page: MTHFD1 {December 20, 2007 12:53:19 PM PST}

MUTYH

INFO: Beginning work on MUTYH... {December 20, 2007 12:53:19 PM PST}
REDIRECT: Protein Redirected to: MUTYH (gene) {December 20, 2007 12:53:57 PM PST}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 12:53:58 PM PST}
UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 12:53:58 PM PST}
UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 12:53:58 PM PST}
UPDATED: Updated protein page: MUTYH (gene) {December 20, 2007 12:54:10 PM PST}

MYB

INFO: Beginning work on MYB... {December 20, 2007 12:54:10 PM PST}
REDIRECT: Protein Redirected to: MYB {December 20, 2007 12:54:49 PM PST}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 12:54:50 PM PST}
UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 12:54:50 PM PST}
UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 12:54:50 PM PST}
UPDATED: Updated protein page: MYB {December 20, 2007 12:54:57 PM PST}

NUDT1

INFO: Beginning work on NUDT1... {December 20, 2007 12:52:13 PM PST}
REDIRECT: Protein Redirected to: NUDT1 {December 20, 2007 12:52:34 PM PST}
UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 12:52:36 PM PST}
UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 12:52:36 PM PST}
UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 12:52:36 PM PST}
UPDATED: Updated protein page: NUDT1 {December 20, 2007 12:52:42 PM PST}

end log.