- INFO: Beginning work on MCM5... {December 20, 2007 12:46:23 PM PST}
- REDIRECT: Protein Redirected to: MCM5 {December 20, 2007 12:46:50 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 12:46:53 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 12:46:53 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 12:46:53 PM PST}
- UPDATED: Updated protein page: MCM5 {December 20, 2007 12:47:00 PM PST}
- INFO: Beginning work on MCM6... {December 20, 2007 12:47:00 PM PST}
- REDIRECT: Page directory gave bad page (MCM6). Continuing with search.. Please correct entry: <4175,MCM6>. {December 20, 2007 12:47:43 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {December 20, 2007 12:47:53 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Minichromosome maintenance deficient 6 homolog (S. cerevisiae)
| HGNCid = 6949
| Symbol = MCM6
| AltSymbols =; MCG40308; Mis5; P105MCM
| OMIM = 601806
| ECnumber =
| Homologene = 4322
| MGIid = 1298227
| GeneAtlas_image1 = PBB_GE_MCM6_201930_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003678 |text = DNA helicase activity}} {{GNF_GO|id=GO:0003697 |text = single-stranded DNA binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008094 |text = DNA-dependent ATPase activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0006268 |text = DNA unwinding during replication}} {{GNF_GO|id=GO:0006270 |text = DNA replication initiation}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007049 |text = cell cycle}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4175
| Hs_Ensembl = ENSG00000076003
| Hs_RefseqProtein = NP_005906
| Hs_RefseqmRNA = NM_005915
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 136313674
| Hs_GenLoc_end = 136350481
| Hs_Uniprot = Q14566
| Mm_EntrezGene = 17219
| Mm_Ensembl = ENSMUSG00000026355
| Mm_RefseqmRNA = NM_008567
| Mm_RefseqProtein = NP_032593
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 130159137
| Mm_GenLoc_end = 130187210
| Mm_Uniprot = Q3UC10
}}
}}
'''Minichromosome maintenance deficient 6 homolog (S. cerevisiae)''', also known as '''MCM6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MCM6 minichromosome maintenance deficient 6 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4175| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication.<ref name="entrez">{{cite web | title = Entrez Gene: MCM6 minichromosome maintenance deficient 6 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4175| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ishimi Y, Ichinose S, Omori A, ''et al.'' |title=Binding of human minichromosome maintenance proteins with histone H3. |journal=J. Biol. Chem. |volume=271 |issue= 39 |pages= 24115-22 |year= 1996 |pmid= 8798650 |doi= }}
*{{cite journal | author=Holthoff HP, Hameister H, Knippers R |title=A novel human Mcm protein: homology to the yeast replication protein Mis5 and chromosomal location. |journal=Genomics |volume=37 |issue= 1 |pages= 131-4 |year= 1997 |pmid= 8921380 |doi= 10.1006/geno.1996.0530 }}
*{{cite journal | author=Harvey CB, Wang Y, Darmoul D, ''et al.'' |title=Characterisation of a human homologue of a yeast cell division cycle gene, MCM6, located adjacent to the 5' end of the lactase gene on chromosome 2q21. |journal=FEBS Lett. |volume=398 |issue= 2-3 |pages= 135-40 |year= 1997 |pmid= 8977093 |doi= }}
*{{cite journal | author=Tsuruga H, Yabuta N, Hosoya S, ''et al.'' |title=HsMCM6: a new member of the human MCM/P1 family encodes a protein homologous to fission yeast Mis5. |journal=Genes Cells |volume=2 |issue= 6 |pages= 381-99 |year= 1997 |pmid= 9286856 |doi= }}
*{{cite journal | author=Ishimi Y |title=A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex. |journal=J. Biol. Chem. |volume=272 |issue= 39 |pages= 24508-13 |year= 1997 |pmid= 9305914 |doi= }}
*{{cite journal | author=Holthoff HP, Baack M, Richter A, ''et al.'' |title=Human protein MCM6 on HeLa cell chromatin. |journal=J. Biol. Chem. |volume=273 |issue= 13 |pages= 7320-5 |year= 1998 |pmid= 9516426 |doi= }}
*{{cite journal | author=Ohtani K, Iwanaga R, Nakamura M, ''et al.'' |title=Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F. |journal=Oncogene |volume=18 |issue= 14 |pages= 2299-309 |year= 1999 |pmid= 10327050 |doi= 10.1038/sj.onc.1202544 }}
*{{cite journal | author=You Z, Komamura Y, Ishimi Y |title=Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity. |journal=Mol. Cell. Biol. |volume=19 |issue= 12 |pages= 8003-15 |year= 2000 |pmid= 10567526 |doi= }}
*{{cite journal | author=Ishimi Y, Komamura-Kohno Y, You Z, ''et al.'' |title=Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2. |journal=J. Biol. Chem. |volume=275 |issue= 21 |pages= 16235-41 |year= 2000 |pmid= 10748114 |doi= 10.1074/jbc.M909040199 }}
*{{cite journal | author=Izumi M, Yanagi K, Mizuno T, ''et al.'' |title=The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase. |journal=Nucleic Acids Res. |volume=28 |issue= 23 |pages= 4769-77 |year= 2001 |pmid= 11095689 |doi= }}
*{{cite journal | author=Lee JK, Hurwitz J |title=Processive DNA helicase activity of the minichromosome maintenance proteins 4, 6, and 7 complex requires forked DNA structures. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 1 |pages= 54-9 |year= 2001 |pmid= 11136247 |doi= 10.1073/pnas.98.1.54 }}
*{{cite journal | author=Enattah NS, Sahi T, Savilahti E, ''et al.'' |title=Identification of a variant associated with adult-type hypolactasia. |journal=Nat. Genet. |volume=30 |issue= 2 |pages= 233-7 |year= 2002 |pmid= 11788828 |doi= 10.1038/ng826 }}
*{{cite journal | author=Yanagi K, Mizuno T, You Z, Hanaoka F |title=Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40871-80 |year= 2002 |pmid= 12192004 |doi= 10.1074/jbc.M206202200 }}
*{{cite journal | author=You Z, Ishimi Y, Masai H, Hanaoka F |title=Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 42471-9 |year= 2003 |pmid= 12207017 |doi= 10.1074/jbc.M205769200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Kneissl M, PĆ¼tter V, Szalay AA, Grummt F |title=Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells. |journal=J. Mol. Biol. |volume=327 |issue= 1 |pages= 111-28 |year= 2003 |pmid= 12614612 |doi= }}
*{{cite journal | author=Yabuta N, Kajimura N, Mayanagi K, ''et al.'' |title=Mammalian Mcm2/4/6/7 complex forms a toroidal structure. |journal=Genes Cells |volume=8 |issue= 5 |pages= 413-21 |year= 2004 |pmid= 12694531 |doi= }}
*{{cite journal | author=Johnson EM, Kinoshita Y, Daniel DC |title=A new member of the MCM protein family encoded by the human MCM8 gene, located contrapodal to GCD10 at chromosome band 20p12.3-13. |journal=Nucleic Acids Res. |volume=31 |issue= 11 |pages= 2915-25 |year= 2003 |pmid= 12771218 |doi= }}
*{{cite journal | author=Ramachandran N, Hainsworth E, Bhullar B, ''et al.'' |title=Self-assembling protein microarrays. |journal=Science |volume=305 |issue= 5680 |pages= 86-90 |year= 2004 |pmid= 15232106 |doi= 10.1126/science.1097639 }}
*{{cite journal | author=Yu Z, Feng D, Liang C |title=Pairwise interactions of the six human MCM protein subunits. |journal=J. Mol. Biol. |volume=340 |issue= 5 |pages= 1197-206 |year= 2004 |pmid= 15236977 |doi= 10.1016/j.jmb.2004.05.024 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MLLT7... {December 20, 2007 12:47:53 PM PST}
- REDIRECT: Protein Redirected to: FOXO4 {December 20, 2007 12:48:21 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 12:48:22 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 12:48:22 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 12:48:22 PM PST}
- UPDATED: Updated protein page: FOXO4 {December 20, 2007 12:48:31 PM PST}
- INFO: Beginning work on MNAT1... {December 20, 2007 12:48:31 PM PST}
- REDIRECT: Protein Redirected to: MNAT1 {December 20, 2007 12:49:01 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 12:49:02 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 12:49:02 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 12:49:02 PM PST}
- UPDATED: Updated protein page: MNAT1 {December 20, 2007 12:49:09 PM PST}
- INFO: Beginning work on MRE11A... {December 20, 2007 12:49:09 PM PST}
- REDIRECT: Protein Redirected to: MRE11A {December 20, 2007 12:49:44 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 12:49:47 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 12:49:47 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 12:49:47 PM PST}
- UPDATED: Updated protein page: MRE11A {December 20, 2007 12:49:53 PM PST}
- INFO: Beginning work on MSH2... {December 20, 2007 12:49:53 PM PST}
- REDIRECT: Protein Redirected to: MSH2 {December 20, 2007 12:50:16 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 12:50:18 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 12:50:18 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 12:50:18 PM PST}
- UPDATED: Updated protein page: MSH2 {December 20, 2007 12:50:24 PM PST}
- INFO: Beginning work on MSH3... {December 20, 2007 12:50:24 PM PST}
- REDIRECT: Protein Redirected to: MSH3 {December 20, 2007 12:50:59 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 12:51:02 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 12:51:02 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 12:51:02 PM PST}
- UPDATED: Updated protein page: MSH3 {December 20, 2007 12:51:08 PM PST}
- INFO: Beginning work on MT1G... {December 20, 2007 12:51:08 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein MT1G image.jpg {December 20, 2007 12:51:55 PM PST}
- REDIRECT: Protein Redirected to: MT1G {December 20, 2007 12:52:02 PM PST}
- CREATED: Created new protein page: MT1G {December 20, 2007 12:52:13 PM PST}
- INFO: Beginning work on MTHFD1... {December 20, 2007 12:52:42 PM PST}
- REDIRECT: Protein Redirected to: MTHFD1 {December 20, 2007 12:53:09 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 12:53:10 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 12:53:10 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 12:53:10 PM PST}
- UPDATED: Updated protein page: MTHFD1 {December 20, 2007 12:53:19 PM PST}
- INFO: Beginning work on MUTYH... {December 20, 2007 12:53:19 PM PST}
- REDIRECT: Protein Redirected to: MUTYH (gene) {December 20, 2007 12:53:57 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 12:53:58 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 12:53:58 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 12:53:58 PM PST}
- UPDATED: Updated protein page: MUTYH (gene) {December 20, 2007 12:54:10 PM PST}
- INFO: Beginning work on MYB... {December 20, 2007 12:54:10 PM PST}
- REDIRECT: Protein Redirected to: MYB {December 20, 2007 12:54:49 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 12:54:50 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 12:54:50 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 12:54:50 PM PST}
- UPDATED: Updated protein page: MYB {December 20, 2007 12:54:57 PM PST}
- INFO: Beginning work on NUDT1... {December 20, 2007 12:52:13 PM PST}
- REDIRECT: Protein Redirected to: NUDT1 {December 20, 2007 12:52:34 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 12:52:36 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 12:52:36 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 12:52:36 PM PST}
- UPDATED: Updated protein page: NUDT1 {December 20, 2007 12:52:42 PM PST}
end log.