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Linda Hsieh-Wilson Article

Things To Do:

• Find a picture of Linda I can use without breaking copyright
• Include more information about her work on the importance of carbohydrates in brain chemistry
• Maybe try and find more information on her background
• Update her notable papers section
• Update the references for the page b/c they are unideal

Linda Hsieh-Wilson Article

This article is acting as a sort of love letter to Dr. Hsieh-Wilson. I think she's absolutely wonderful and I think the work she's doing is pioneering into new terrain that many have yet to even think about. She is truely inspirational... (this is not going into the article, I just thought this space looked weird and needed something in it).

Biography

Current

Hsieh-Wilson received her Bachelor's degree in chemistry at Yale University. After graduating, she completed her Ph.D. in 1996 at the University of California, Berkeley, where she worked with Peter G. Schultz on antibody-based catalysis.[1] She studied the neuronal targeting protein spinophilin at the Rockefeller University with Nobel Laureate Paul Greengard until 2000.[2] She then obtained an appointment at the Department of Chemistry at the California Institute of Technology in 2000 as an assistant professor and became an associate professor of chemistry and an investigator at the Howard Hughes Medical Institute in 2005.[3][4] She was appointed a full professor of chemistry at the California Institute of Technology in 2010.

New

Hsieh-Wilson was born in New York City, NY and received her Bachelor's degree in chemistry at Yale University, where she graduated magna cum laude. She then completed her Ph.D. in 1996 at the University of California, Berkeley. There she was a Natonal Science Foundation Fellow in the laboratory of Peter G. Schultz and studied antibody-based catalysis . She then joined the lab of Professor and Nobel Prize Laureate Paul Greengard at Rockefeller University until 2000. There she characterized the protein phosphatase and actin-binding protein spinophilin and investigated its role in dendritic spines . Hsieh-Wilson then obtained an appointment at the Department of Chemistry at the California Institute of Technology in 2000 as an assistant professor and became an investigator at the Howard Hughes Medical Institute in 2005. She then became an associate professor of chemistry in 2006 and was appointed a full professor of chemistry at the California Institute of Technology in 2010 .

Changes

• Born in New York City. Graduated Magna cum laude from Yale.
• Was a national Science foundation fellow at UC Berkeley in Peter's lab.
• Was a Damon Runyon-Walter Winchell postdoctoral fellow under Paul.
• Became faculty at CalTech in 2000 and didn't become a accociate professor until 2006 (check that)
• In 2005 she became a investigator of HHMI.
• Has pioneered the application of OChem to probe the roles of carbohydrates and protein glycosylation in neurobiology and cancer.

Research Intrests

Current

Hsieh-Wilson's research is at the interface between organic chemistry and neuroscience.[5] She investigates how the post-translational addition of glycans affect the structure and function of proteins in the nervous system. Her laboratory has developed a chemoenzymatic method to tag proteins that have been appended with a dynamic form of glycosylation called O-GlcNAc.[6] Her work with glycosaminoglycan microarrays has significantly advanced an understanding of specific sulfated glycosaminoglycans in neuronal communication, learning, and memory as well as advanced the field of chemical biology.[7] She has demonstrated how fucosylation can modulate neurite growth and neuronal morphology.[8]

New

Overview

Hsieh-Wilson's research is at the interface between organic chemistry and neuroscience. She investigates how the post-translational addition of glycans affect the structure and function of proteins in the nervous system. Her laboratory has developed a chemoenzymatic method to tag proteins that have been appended with a dynamic form of glycosylation called O-GlcNAc. Her work with glycosaminoglycan microarrays has significantly advanced an understanding of specific sulfated glycosaminoglycans in neuronal communication, learning, and memory as well as advanced the field of chemical biology. She has demonstrated how fucosylation can modulate neurite growth and neuronal morphology.

O-GlcNAc Glycosylation

Hsieh-Wilson and her collegues have found that the covalent-modifications of intercellular proteins by O-linked-N-acetylglucosamine (O-GlcNAc) within the mammalian nervous system have a large role in the regulation of gene expression, neuronal signaling, and synaptic plasticity . This post-translational modification, has been analysed in the rat brain using a novel chemoenzymatic strategy wherein O-GlcNAc modified proteins are slectively labeled with flourecent or biotin tags. This technique developed by Hsieh-Wilson and her lab has revealed over 200 O-GlcNAc modified proteins within the mammilian brain and such modifications have been shown to activate transcriptional function of proteins , regulate cancer metabolism , regulate gene expression and memory formation , and carry out many other tasks in the brain and beyond.

Glycosaminoglycans

Glycosaminoglycans are heterogeneously sulfated oligosaccharides that are very important in nervous system development, spinal cord injury, inflamation and cancer metastasis. Hsieh-Wilson's research on this subject implicates the specific sulfation sequence of glycosaminoglycans as a way to modulate biological function. Specifically, her work with chondroitin sulfate (CS) and heparan sulfate (HS), the two most common glycosaminoglycans in the nervous system, has shown that this "sulfation code" functions as a molecular recognition element for growth factors and modulates neuronal growth , indicating that these specific sulfated glycosaminoglycans play a major role in neuronal communication, learning, and memory. Additionally, Hsieh-Wilson has ellucidated the role of this sulfation in glycosaminoglycan-protein interaction using a carbohydrate microarray-based approach developed in her lab.

Changes

• As it is right now it is very technical, need to dumb it down a bit
• Thinking about adding multiple sections (eg. overview, antibody catalysis, spinophilin, carbohydrates in neurochem, etc..)
• Possibly rename whole section to just say "Research"
• Beef it up!!!!! while still making it accessible

What makes a good article

• A lead section that is easy to understand
• A clear structure
• Balanced coverage
• Neutral content
• Reliable sources

Courtesy of wikied training

Bioenergetics Review

• Definitely need more citations
• Heterotrophs and autotrophs are mentioned twice in the overview, once in the second paragraph then again in the forth. It makes the whole thing sound kind of repetatitve and incohesive. Maybe clean that up a bit.
• I really like a lot of what you're saying in your sandbox! I also think you're totally right in saying that there needs to be a larger disscusion of the three laws of thermodynamics
• I also totally agree with what you were saying about cotransport, it seems odd that it's just kind of thrown in there ( maybe Crane just popped it in themselves when feeling insecure), but, it would be cool to give a shout out to more specific processes in bioenergetics (maybe like ketosis or gluconeogenesis)
• It might even be a good idea to to give the larger topics in bioenergetics (like cellular respiration and photosynthesis) their own little sections that provide really general overviews
• Also, this may be excessive but it might be good to mention the page Bioenergetic Analysis in an attempt to acheive "Balenced coverage" (although it totally makes sense if you don't b/c it's described as "body psychotherapy" and sounds a bit ridiculous)
• Also in terms of organization maybe give this video a watch (this guy got me though AP biology)