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Linda Hsieh-Wilson Article
Things To Do:
- Find a picture of Linda I can use without breaking copyright
- Include more information about her work on the importance of carbohydrates in brain chemistry
Maybe try and find more information on her background- Update her notable papers section
- Update the references for the page b/c they are unideal
Linda Hsieh-Wilson Article
editThis article is acting as a sort of love letter to Dr. Hsieh-Wilson. I think she's absolutely wonderful and I think the work she's doing is pioneering into new terrain that many have yet to even think about. She is truely inspirational... (this is not going into the article, I just thought this space looked weird and needed something in it).
Biography
editCurrent
editHsieh-Wilson received her Bachelor's degree in chemistry at Yale University. After graduating, she completed her Ph.D. in 1996 at the University of California, Berkeley, where she worked with Peter G. Schultz on antibody-based catalysis.[1] She studied the neuronal targeting protein spinophilin at the Rockefeller University with Nobel Laureate Paul Greengard until 2000.[2] She then obtained an appointment at the Department of Chemistry at the California Institute of Technology in 2000 as an assistant professor and became an associate professor of chemistry and an investigator at the Howard Hughes Medical Institute in 2005.[3][4] She was appointed a full professor of chemistry at the California Institute of Technology in 2010.
New
editHsieh-Wilson was born in New York City, NY and received her Bachelor's degree in chemistry at Yale University, where she graduated magna cum laude. She then completed her Ph.D. in 1996 at the University of California, Berkeley. There she was a Natonal Science Foundation Fellow in the laboratory of Peter G. Schultz and studied antibody-based catalysis [2] [3]. She then joined the lab of Professor and Nobel Prize Laureate Paul Greengard at Rockefeller University until 2000. There she characterized the protein phosphatase and actin-binding protein spinophilin[4] and investigated its role in dendritic spines[5] [6]. Hsieh-Wilson then obtained an appointment at the Department of Chemistry at the California Institute of Technology in 2000 as an assistant professor and became an investigator at the Howard Hughes Medical Institute in 2005. She then became an associate professor of chemistry in 2006 and was appointed a full professor of chemistry at the California Institute of Technology in 2010 [7].
Changes
edit- Born in New York City. Graduated Magna cum laude from Yale.
- Was a national Science foundation fellow at UC Berkeley in Peter's lab.
- Was a Damon Runyon-Walter Winchell postdoctoral fellow under Paul.
- Became faculty at CalTech in 2000 and didn't become a accociate professor until 2006 (check that)
- In 2005 she became a investigator of HHMI.
- Has pioneered the application of OChem to probe the roles of carbohydrates and protein glycosylation in neurobiology and cancer.
Research Intrests
editCurrent
editHsieh-Wilson's research is at the interface between organic chemistry and neuroscience.[5] She investigates how the post-translational addition of glycans affect the structure and function of proteins in the nervous system. Her laboratory has developed a chemoenzymatic method to tag proteins that have been appended with a dynamic form of glycosylation called O-GlcNAc.[6] Her work with glycosaminoglycan microarrays has significantly advanced an understanding of specific sulfated glycosaminoglycans in neuronal communication, learning, and memory as well as advanced the field of chemical biology.[7] She has demonstrated how fucosylation can modulate neurite growth and neuronal morphology.[8]
New
editOverview
editHsieh-Wilson's research is at the interface between organic chemistry and neuroscience.[8] She investigates how the post-translational addition of glycans affect the structure and function of proteins in the nervous system. Her laboratory has developed a chemoenzymatic method to tag proteins that have been appended with a dynamic form of glycosylation called O-GlcNAc.[9] Her work with glycosaminoglycan microarrays has significantly advanced an understanding of specific sulfated glycosaminoglycans in neuronal communication, learning, and memory as well as advanced the field of chemical biology.[10] She has demonstrated how fucosylation can modulate neurite growth and neuronal morphology.[11]
O-GlcNAc Glycosylation
editHsieh-Wilson and her collegues have found that the covalent-modifications of intercellular proteins by O-linked-N-acetylglucosamine (O-GlcNAc) within the mammalian nervous system have a large role in the regulation of gene expression, neuronal signaling, and synaptic plasticity [12]. This post-translational modification, has been analysed in the rat brain using a novel chemoenzymatic strategy wherein O-GlcNAc modified proteins are slectively labeled with flourecent or biotin tags. This technique developed by Hsieh-Wilson and her lab has revealed over 200 O-GlcNAc modified proteins within the mammilian brain and such modifications have been shown to activate transcriptional function of proteins [13], regulate cancer metabolism [14], regulate gene expression and memory formation [15], and carry out many other tasks in the brain and beyond.
Glycosaminoglycans
editGlycosaminoglycans are heterogeneously sulfated oligosaccharides that are very important in nervous system development, spinal cord injury, inflamation and cancer metastasis. Hsieh-Wilson's research on this subject implicates the specific sulfation sequence of glycosaminoglycans as a way to modulate biological function. Specifically, her work with chondroitin sulfate (CS) and heparan sulfate (HS), the two most common glycosaminoglycans in the nervous system, has shown that this "sulfation code" functions as a molecular recognition element for growth factors and modulates neuronal growth [16][17] , indicating that these specific sulfated glycosaminoglycans play a major role in neuronal communication, learning, and memory. Additionally, Hsieh-Wilson has ellucidated the role of this sulfation in glycosaminoglycan-protein interaction using a carbohydrate microarray-based approach developed in her lab[18].
Fucose-Galactose Saccharides
editGlycan Engineering
editChanges
edit- As it is right now it is very technical, need to dumb it down a bit
- Thinking about adding multiple sections (eg. overview, antibody catalysis, spinophilin, carbohydrates in neurochem, etc..)
- Possibly rename whole section to just say "Research"
- Beef it up!!!!! while still making it accessible
What makes a good article
edit- A lead section that is easy to understand
- A clear structure
- Balanced coverage
- Neutral content
- Reliable sources
Courtesy of wikied training
Bioenergetics Review
edit- Definitely need more citations
- Heterotrophs and autotrophs are mentioned twice in the overview, once in the second paragraph then again in the forth. It makes the whole thing sound kind of repetatitve and incohesive. Maybe clean that up a bit.
- I really like a lot of what you're saying in your sandbox! I also think you're totally right in saying that there needs to be a larger disscusion of the three laws of thermodynamics
- I also totally agree with what you were saying about cotransport, it seems odd that it's just kind of thrown in there ( maybe Crane just popped it in themselves when feeling insecure), but, it would be cool to give a shout out to more specific processes in bioenergetics (maybe like ketosis or gluconeogenesis)
- It might even be a good idea to to give the larger topics in bioenergetics (like cellular respiration and photosynthesis) their own little sections that provide really general overviews
- Also, this may be excessive but it might be good to mention the page Bioenergetic Analysis in an attempt to acheive "Balenced coverage" (although it totally makes sense if you don't b/c it's described as "body psychotherapy" and sounds a bit ridiculous)
- Also in terms of organization maybe give this video a watch (this guy got me though AP biology)
Notes
edit- ^ Wikipedia:Be Bold
- ^ Finder, Expertise. "Linda Carol Hsieh-Wilson, California Institute of Technology: Learning and memory, Memory and motor control, Neurobiology • Expertise Finder Network". network.expertisefinder.com. Retrieved 2017-05-02.
- ^ Hsieh-Wilson, L. C.; Schultz, P. G.; Stevens, R. C. (1996-05-28). "Insights into antibody catalysis: structure of an oxygenation catalyst at 1.9-angstrom resolution". Proceedings of the National Academy of Sciences of the United States of America. 93 (11): 5363–5367. ISSN 0027-8424. PMC 39251. PMID 8643580.
{{cite journal}}
: CS1 maint: PMC format (link) - ^ Hsieh-Wilson, L. C.; Allen, P. B.; Watanabe, T.; Nairn, A. C.; Greengard, P. (1999-04-06). "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1". Biochemistry. 38 (14): 4365–4373. doi:10.1021/bi982900m. ISSN 0006-2960. PMID 10194355.
- ^ Grossman, Stacie D.; Hsieh-Wilson, Linda C.; Allen, Patrick B.; Nairn, Angus C.; Greengard, Paul (2002-01-01). "The actin-binding domain of spinophilin is necessary and sufficient for targeting to dendritic spines". Neuromolecular Medicine. 2 (1): 61–69. doi:10.1385/NMM:2:1:61. ISSN 1535-1084. PMID 12230305.
- ^ Hsieh-Wilson, Linda C.; Benfenati, Fabio; Snyder, Gretchen L.; Allen, Patrick B.; Nairn, Angus C.; Greengard, Paul (2003-01-10). "Phosphorylation of spinophilin modulates its interaction with actin filaments". The Journal of Biological Chemistry. 278 (2): 1186–1194. doi:10.1074/jbc.M205754200. ISSN 0021-9258. PMID 12417592.
{{cite journal}}
: CS1 maint: unflagged free DOI (link) - ^ "Linda C. Hsieh-Wilson | www.cce.caltech.edu". www.cce.caltech.edu. Retrieved 2017-05-02.
- ^ "HHMI Scientist Abstract: Linda C. Hsieh-Wilson, Ph.D." Howard Hughes Medical Institute. Retrieved 2011-07-16.
- ^ Khidekel, Nelly; Ficarro, Scott B; Clark, Peter M; Bryan, Marian C; Swaney, Danielle L; Rexach, Jessica E; Sun, Yi E; Coon, Joshua J; Peters, Eric C (2007). "Probing the dynamics of O-GlcNAc glycosylation in the brain using quantitative proteomics". Nature Chemical Biology. 3 (6): 339–348. doi:10.1038/nchembio881. PMID 17496889.
{{cite journal}}
: Unknown parameter|displayauthors=
ignored (|display-authors=
suggested) (help) - ^ Gama, Cristal I; Tully, Sarah E; Sotogaku, Naoki; Clark, Peter M; Rawat, Manish; Vaidehi, Nagarajan; Goddard, William A; Nishi, Akinori; Hsieh-Wilson, Linda C (2006). "Sulfation patterns of glycosaminoglycans encode molecular recognition and activity". Nature Chemical Biology. 2 (9): 467–473. doi:10.1038/nchembio810. PMID 16878128.
{{cite journal}}
: Unknown parameter|displayauthors=
ignored (|display-authors=
suggested) (help) - ^ "Sweet Memories of Synapsins?". Science's STKE. 2006 (317): tw472–tw472. 2006. doi:10.1126/stke.3172006tw472.
- ^ http://www.pnas.org/content/101/36/13132.full.pdf
- ^ http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=DaisyOneClickSearch&qid=11&SID=1AMO2etzAYAIFJZoUSG&page=1&doc=6&cacheurlFromRightClick=no
- ^ Hsieh-Wilson, Linda (2013-04-01). "O-GlcNAc Signaling Regulates Cancer Metabolism". The FASEB Journal. 27 (1 Supplement): 452.2–452.2. ISSN 0892-6638.
- ^ http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=DaisyOneClickSearch&qid=11&SID=1AMO2etzAYAIFJZoUSG&page=1&doc=21
- ^ https://www.nature.com/nchembio/journal/v2/n9/full/nchembio810.html
- ^ Tully, Sarah E.; Mabon, Ross; Gama, Cristal I.; Tsai, Sherry M.; Liu, Xuewei; Hsieh-Wilson, Linda C. (2004-06-01). "A Chondroitin Sulfate Small Molecule that Stimulates Neuronal Growth". Journal of the American Chemical Society. 126 (25): 7736–7737. doi:10.1021/ja0484045. ISSN 0002-7863.
- ^ Shipp, Eric L.; Hsieh-Wilson, Linda C. (2007-02-01). "Profiling the Sulfation Specificities of Glycosaminoglycan Interactions with Growth Factors and Chemotactic Proteins Using Microarrays". Chemistry & Biology. 14 (2): 195–208. doi:10.1016/j.chembiol.2006.12.009.