Possible relations to Addison's Disease
It has been proposed by some specialists that Chronic Fatigue Syndrome is a form of Addison's disease (referred to as adrenal insufficiency or hypoadrenalism). The following evidence has been presented 'In view of the 36 features shared by Chronic Fatigue Syndrome and Addison’s disease, including hypocortisolism and a host of neuropsychological complaints[1][2][3][4][5][6][7] and investigations of the effects after supplementation with mineralocorticoids (fludrocortisone), low-dose hydrocortisone (cortisol) in the treatment of CFS’.[8][9][10][11]
Refrences
edit- ^ Cleare AJ, Heap E, Malhi GS, Wessely S, O’Keane V, Miell J. 1999 Low-dose hydrocortisone in chronic fatigue syndrome: a randomised crossover trial. Lancet. 353:455–458.
- ^ Hunt PJ, Gurnell EM, Huppert FA, Richards C, Prevost AT, Wass JA, Herbert J, Chatterjee VK. Improvement in mood and fatigue after dehydroepiandrosterone replacement in Addison’s disease in a randomized, double blind trial. J Clin Endocrinol Metab 2000; 85:4650–6.
- ^ Role of the Endocrine System in Chronic Fatigue Syndrome, Pro Health, ProHealth.com [1]
- ^ 'Similarity of symptoms in chronic fatigue syndrome and Addison's disease' European Journal of Clinical Investigation Volume 27, Issue 12, page 1062, December 1997 [2]
- ^ Chronic Fatigue Syndrome for Dummies By Susan R. Lisman, Karla Dougherty, Chapter 3, page 49
- ^ The Journal of Clinical Endocrinology & Metabolism Vol. 84, No. 6 2263-2264 1999, Investigations of Hydrocortisone and Fludrocortisone in the Treatment of Chronic Fatigue Syndrome, Riccardo Baschetti, M.D. [3]
- ^ Baschetti R. 1999 Psychological factors and chronic fatigue syndrome. NZ Med J. 112:58–59
- ^ Baschetti R. Chronic fatigue syndrome: a form of Addison’s disease. J Intern Med 2000; 247:737–9.
- ^ Naschitz JE, Rosner I, Rozenbaum M, Naschitz S, Musafia-Priselac R, Shaviv N, Fields M, Isseroff H, Zuckerman E, Yeshurun D, Sabo E. The head-up tilt test with haemodynamic instability score in diagnosing chronic fatigue syndrome. Q J Med 2003; 96:133–42.
- ^ Baschetti R. Chronic fatigue syndrome, decreased exercise capacity, and adrenal insufficiency. Arch Intern Med 2001; 161:1558–9.
- ^ Kuratsune H, Yamaguti K, Sawada M, Kodate S, Machii T, Kanakura Y, Kitani T. Dehydroepiandrosterone sulfate deficiency in chronic fatigue syndrome. Int J Mol Med 1998; 1:143–6.