SubhadraArjuna

Naitik Singhania

Karan Mehra / Vishal Singh as Naitik "Munna" Singhania: Gayatri and Rajshekhar's son; Devyani's step son; Rashmi's brother; Naman and Muskaan's step-brother; Akshara's widower; Naksh and Naira's father (2009–2018)
Vaishali Takkar as Sanjana "Sanju" Thakkar: Naksh's best friend (2015–2016)
Umang Jain as Nayantara "Tara" Singh Shekhawat: Chandrabhan's granddaughter; Sangram, Vikram and Aditya's sister; Naksh's ex-fiancée; Aarohi's mother (2015–2016)
Siya Makwana / Karishma Sawant as Dr. Aarohi "Aaru" Goenka: Nayantara and Kartik's daughter; Abhimanyu's ex fiancée; Neil's widow (2021–2023)
Ashnoor Kaur / Shivangi Joshi as Naira "Tina" Singhania: Queen of Naughtiness, Beauty, Attitude and Innocence; Antara and Naitik's daughter; Naksh's sister; Yash and Anmol's step sister; Nishant's cousin; Kartik's lover; Mihir's secretary; Kairav and Samaira's mother (2023–present)
Mohsin Khan as Kartik "Kittu": Gayu's crush; Naira's lover; Mishti's BFF; Vedika's fiancee; Aarohi's father (2016–2021)
Khushwant Walia as Mihir Kapoor: Naira's boss; Kairav and Samaira's father (2019)
Krishiv Mutha / Kairav Waghela / Shaurya Shah / Tanmay Shah / Aarambh Trehan / Shreyansh Kaurav / Yash Pandey / Mayank Arora / Abeer Singh Godhwani / Suraj Sonik / Sumedh Mudgalkar / Ankit Arora as Kairav Kapoor: King of Naughtiness, Handsome, Attitude and Innocence; Naira and Mihir's son; Samaira's brother; Anisha's ex-fiancée (2019-2023)
Anaya Gupta / Pranali Rathod as Boxer Samaira "Sirat Singh Shekhawat" Kapoor Sharma: Queen of Naughtiness and Beauty; Naira and Mihir's daughter; Kairav's sister; Abhimanyu's ex fiancee; Abhinav's widow; Abhira and Maira's mother (2021–2024)
Prachi Thakur / Samridhii Shukla as Advocate Abhira Sharma (née Poddar): Queen of Naughtiness and Attitude; Samaira and Abhinav's first daughter; Maira's elder sister; Armaan's ex wife (2024)
Mishka Jain / Shagun Sharma as Mahira Sharma (née Poddar): Queen of Naughtiness and Innocence; Samaira and Abhinav's second daughter; Abhira's younger sister; Rohit's ex wife (2024)
Zarina Roshan Khan as Muskaan Agrawal Awasthi: Devyani and Suresh's daughter; Rajshekhar's step-daughter; Naman's sister; Naitik and Rashmi's step-sister; Alok's wife (2014–2015)
Amit Dolawat as Alok Awasthi: Akshara's college-mate and former admirer; Muskaan's husband (2009, 2014–2015)

Manish Goenka

Sachin Tyagi as Manish Goenka: Patriarch of Goenkas; Akhilesh's brother; Soumya's widower; Swarna's husband; Keerti, Kartik and Shubham's father; Vansh and Aarohi's grandfather (2016–present)
Vedant Pandya / Mohsin Khan as Kartik "Kittu" Goenka: Soumya and Manish's son; Swarna's step-son; Keerti's brother; Shubham's half brother; Gayu's crush; Naira's lover; Mishti's BFF; Vedika's fiancée (2016–2021)
Aarna Sharma / Rhea Sharma as Mishti Agrawal: Naman and Karishma's estranged daughter; Kartik's BFF; Aarohi's mother; Rajshri and Vishambharnath's foster daughter
Payal Bhojwani / Kanchi Singh as Gayu Maheshwari: Lavanya and Shaurya's daughter; Kartik's lover; Ruhi's mother (2014–2017)
Hera Mishra / Pratiksha Honmukhe / Garvita Sadhwani as Ruhi "Rooh" Birla Poddar: Gayu and Kartik's daughter; Armaan's ex-fiancée and former fixated lover; Rohit's wife (2023–present)
Mishka Jain / Ashnoor Kaur / Shivangi Joshi as Naira "Tina" Singhania: Antara and Naitik's daughter; Naksh's sister; Akshara's step daughter; Kartik's ex wife; Mihir's secretary; Kairav's mother (2015–present)
Pankhuri Awasthy Rode as Vedika Maheshwari: Sneha and Shaurya's daughter; Dr. Pallavi's friend; Akshat's ex fiancée; Kartik's fiancée (2019–2020)

Vanraj Shah

Sudhanshu Pandey as Vanraj "V" Shah: Leela and Hasmukh's son; Dolly's brother; Ritika's lover; Anupamaa's ex-husband; Kavya's husband; Paritosh and Pakhi's father; Mahi's stepfather; Aarya's grandfather; Anshuman and Ishaani's adoptive grandfather (2020–2024)
Dheer Bhanushali / Aashish Mehrotra / Gaurav Sharma / Manish Naggdev as Paritosh "Toshu" Shah: Ritika and Vanraj's son; Kavya's step-son; Pakhi's brother; Aadhya and Mahi's step-brother; Kinjal's husband; Aarya's father; Dimple's boyfriend (2020–present)
Harbandana Kaur / Nidhi Shah / Pankhuri Awasthy Rode as Kinjal "Kinju" Dave Shah: Rakhi and Pramod's daughter; Paritosh's wife; Aarya's mother (2020–2024)
Noorain Khan / Princy Prajapati as Aarya "Pari / Angel" Shah: Kinjal and Paritosh's daughter; Ansh's step brother; Ishani's adopted cousin (2024–present)
Yamini Makwana / Anagha Bhosale / Deblina Chatterjee as Nandini "Nandu" Iyer: A dancer and former teacher of Anupamaa Dance Academy; Kavya's niece; Aadhya and Mahi's cousin; Samar's former fiancé (2020–2022)
Aarna Sharma / Nishi Saxena / Rhea Sharma as Dimple aka Dimpy: Pammi's daughter; Nirmit's ex-wife; Paritosh's girlfriend; Ansh's mother; Tapish's wife (2022–2024)
Trishaan Shah as Ansh Shah: Paritosh and Dimple's son; Tapish's step-son; Aarya's step brother; Ishaani's adopted cousin (2023–present)
Muskan Bamne / Chandni Bhagwanani / Kreetika Sharma / Tanya Sharma as Pakhi "Sweety" Shah: Ritika and Vanraj's daughter; Kavya's step-daughter; Paritosh and Samar's sister; Mahi's step-sister; Aadhya's adopted sister; Adhik's ex-wife; Tapish's former obsessive lover; Ishaani's adoptive mother (2020–2023) / (2024–present)
Aadhya Barot / Yukti Kapoor as Ishani "Ishu" Mehta: Pakhi and Adhik's adopted daughter; Sara, Aarya and Ansh's adopted cousin (2024–present
Madalsa Sharma as Kavya Shah: Aniruddh's ex-wife; Vanraj's wife; Aadhya and Mahi's mother; Nandini's aunt; Paritosh and Pakhi's step-mother; Aarya's step-grandmother; Anshuman and Ishaani's adoptive step-grandmother (2020–2024)
Asmi Deo / Aurra Bhatnagar Badoni / Kaveri Priyam as Aadhya "Chhoti Anu" "Priya" Kapadia: Kavya and Aniruddh's first daughter; Anuj and Anupamaa's adopted daughter; Viren and Megha's foster daughter; Paritosh and Pakhi's step sister (2022–present)
Nirbhay Thakur / Ankur Nayyar as Kiaan "Vansh" Kapadia: Aadhya's son; Saisha's brother (2024–present)
Amayra Khurana / Bhavika Sharma / Alisha Parveen as Saisha "Sai" Kapadia: Aadhya's daughter; Savi's step-daughter; Kiaan's sister; Nia's cousin (2024–present)

Harshvardhan Birla

Vinay Jain as Dr. Harshvardhan "Harsh" Birla: Anandvardhan's brother; Manjari's husband; Sukanya's father; Anisha and Abhimanyu's grandfather (2021–2023)
Ami Trivedi as Manjari Birla: Mahima's sister; Harshvardhan's wife; Sukanya's mother; Anisha and Abhimanyu's grandmother (2021–2023)
Sheetal Tiwari as Sukanya Birla: Naira's friend; Anisha and Abhimanyu's mother (2016)
Kashish Rai as Anisha Birla: Mahima and Anandvardhan's elder daughter; Parth and Nishtha's sister; Kairav's ex-fiancée (2022)
Het Makwana / Harshad Chopda as Dr. Abhimanyu "Abhi" Birla: Manjari and Harshvardhan's grandson; Sukanya's son; Aarohi's ex-fiancé; Abhira's ex-husband (2021–2023)