 | This is the sandbox page where you will draft your initial Wikipedia contribution.
If you're starting a new article, you can develop it here until it's ready to go live. If you're working on improvements to an existing article, copy only one section at a time of the article to this sandbox to work on, and be sure to use an edit summary linking to the article you copied from. Do not copy over the entire article. You can find additional instructions here. Remember to save your work regularly using the "Publish page" button. (It just means 'save'; it will still be in the sandbox.) You can add bold formatting to your additions to differentiate them from existing content. |
Oocyte Selection
editLead
editNot all women can conceive naturally, leaving them with a need for technologies and research that can help them have children. Women who might not be able to have their kids naturally may have the option of in vitro fertilization. In vitro fertilization can be a series of treatments that involves the fertilization of a mature egg with a sperm in a laboratory.[1] Oocyte selection is a part the process for in vitro fertilization.
An Oocyte is an egg/ovum that is not fully mature or developed and has not been fertilized; Therefore an oocyte is an undeveloped ovum.[2] In vitro fertilization can be defined as Oocyte selection is a procedure that is performed prior to in vitro fertilization, in order to use oocytes with maximal chances of resulting in pregnancy. In contrast, embryo selection takes place after fertilization.
Article body
editThe process of oocyte selection
editSelecting an oocyte for in vitro fertilization involves assessing the quality of the oocyte which is usually done by accessing the morphological features of the oocyte. The major parts of the oocyte that are accessed for quality in terms of morphological characteristics are the cumulus cells, zona pellucida, polar body, perivitelline space, and cytoplasm; These are the main parts of the oocyte and are usually assessed by conventional microscopy.[3] The size of an oocyte is another factor of the quality of the oocyte; Larger oocyte are usually more quality than smaller ones. [4]
Morphological features of the oocyte can be obtained by standard light or polarized light microscopy. However, there is no clear tendency in recent publications to a general increase in the predictive value of morphological features. Suggested techniques include zona pellucida imaging, which can detect differences in birefringence between eggs, which is a predictor of compaction, blastulation and pregnancy.
Potentially, polar body biopsy may be used for molecular analysis, and can be used for preimplantation genetic screening.
Chromosomal evaluation may be performed. Embryos from rescued in vitro-matured metaphase II (IVM-MII) oocytes show significantly higher fertilization rates and more blastomeres per embryo compared with those from arrested metaphase I (MI) oocytes (58.5% vs. 43.9% and 5.7 vs. 5.0, respectively).
References
edit"Definition of OOCYTE". www.merriam-webster.com. 2024-03-14. Retrieved 2024-03-25.
"In vitro fertilization (IVF) - Mayo Clinic". www.mayoclinic.org. Retrieved 2024-03-26.
Lemseffer, Yassir; Terret, Marie-Emilie; Campillo, Clément; Labrune, Elsa (2022-09-04). "Methods for Assessing Oocyte Quality: A Review of Literature". Biomedicines. 10 (9): 2184. doi:10.3390/biomedicines10092184.
- ^ "In vitro fertilization (IVF) - Mayo Clinic". www.mayoclinic.org. Retrieved 2024-03-26.
- ^ "Definition of OOCYTE". www.merriam-webster.com. 2024-03-14. Retrieved 2024-03-25.
- ^ Lemseffer, Yassir; Terret, Marie-Emilie; Campillo, Clément; Labrune, Elsa (2022-09-04). "Methods for Assessing Oocyte Quality: A Review of Literature". Biomedicines. 10 (9): 2184. doi:10.3390/biomedicines10092184. ISSN 2227-9059. PMC 9495944. PMID 36140285.
{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link) - ^ Wiegel, Rosalieke E.; Rubini, Eleonora; Rousian, Melek; Schoenmakers, Sam; Laven, Joop S. E.; Willemsen, Sten P.; Baart, Esther B.; Steegers-Theunissen, Régine P. M. (2023-06). "Human oocyte area is associated with preimplantation embryo usage and early embryo development: the Rotterdam Periconception Cohort". Journal of Assisted Reproduction and Genetics. 40 (6): 1495–1506. doi:10.1007/s10815-023-02803-1. ISSN 1058-0468. PMC 10310608. PMID 37129725 – via PubMed Central.
{{cite journal}}: Check date values in:|date=(help)CS1 maint: PMC format (link)