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User:Wikiedit116/C13orf42

< User:Wikiedit116

(C13orf42) is a protein which, in humans, is encoded by the gene chromosome 13 open reading frame 42 (C13orf42). C13orf42 is also known by its aliases LINC00371 and LINC00372.[1] Transcript variant 3 is the longest mRNA transcript at 3075 nucleotides.[2] The gene encodes a 325 amino acid protein. This gene has orthologs in mammals, birds, reptiles, amphibians, bony fish, and cartilaginous fish.[3]


Gene

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Location

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C13orf42 is located at 13q14.3 on the minus strand. C13orf42 spans 118,134 base pairs.[1][4]

Aliases

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C13orf42 is also known by its aliases LINC00371 and LINC00372.[1]

Exons

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C13orf42 transcript variant 3 (Accession number: NM_001351589.3) contains 4 exons.[2]

Protein

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Isoforms

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There are two known proteins encoded by the isoforms of C13orf42.[5]

Variant 3

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Transcript variant 3 encodes the longest protein at 325 amino acids long.[5]

Variant X1

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Transcript variant X1 encodes a 189 amino acid long protein.[5]

Homology

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Figure 1: Corrected Divergence vs. Date of Divergence (MYA) of C13orf42 compared to Cytochrome C and Fibrinogen alpha.

Orthologs

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C13orf42 has orthologs in mammals, birds, reptiles, amphibians, bony fish, and cartilaginous fish as shown in the table below. No orthologs were found in jawless fish, invertebrates, plants, fungi, viruses, or bacteria.[6] All mammals contain the same 4 exons as the human C13orf42 protein, and nonmammals are missing exon 4.

Ortholog Table

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Table depicting genus and species, common name, taxonomic class, date of divergence, accession number, length, percent identity, and percent similarity of C13orf42 and its orthologs. Default sorted by date of divergence then percent sequence identity.[5] [7]
Genus and Species Common Name Taxonomic Class Date of Divergence (MYA) Accession Number Length (amino acids) Percent Identity to Homo sapiens Percent Similarity to Homo sapiens
Homo sapiens Human Primates 0 NP_001338518.1 325 100 100
Mus musculus Mouse Dasyuromorphia 87 XP_030104110.1 318 76.9 84
Tursiops truncatus Common bottlenose dolphin Cetacea 94 XP_033699576.1 319 82.8 87.7
Equus caballus Horse Perissodactyla 94 XP_023477317.1 326 82.6 90.2
Mustela putorius European polecat Carnivora 94 XP_004775284.1 326 79.4 85
Pipistrellus kuhlii Kuhl's pipistrelle (bat) Chiroptera 94 XP_036312978.1 325 79.1 86.8
Ursus maritimus Polar bear Ursidae 94 XP_040478472.1 328 77.2 82.7
Elephas maximus indicus Indian elephant Proboscidea 99 XP_049709344.1 326 79.4 86.2
Dasypus novemcinctus Nine-banded armadillo Cingulata 99 XP_023446856.1 328 72.8 81.4
Dromiciops gliroides Monito del monte Microbiotheria 160 XP_043849658.1 326 67.9 79.5
Trichosurus vulpecula Common brushtail possum Diprotodontia 160 XP_036599801.1 326 66.7 79.5
Sarcophilus harrisii Tasmanian devil Dasyuromorphia 160 XP_023355407.1 326 66.4 80.1
Ornithorhynchus anatinus Playtpus Monotremes 180 XP_028904285.1 330 62.3 73
Alligator sinensis Chinese alligator Crocodilian 319 XP_025062978.1 266 48.6 61.7
Dromaius novaehollandiae Emu Casuariiformes 319 XP_025964173.1 268 48.2 59.8
Gallus gallus Chicken Galliformes 319 XP_004938779.1 268 47.6 61.3
Camarhynchus parvulus Small tree finch Thraupidae 319 XP_030802909.1 264 47.1 60.9
Pelodiscus sinensis Chinese softshell turtle Testudines 319 XP_014429996.1 267 47 60.6
Phasianus colchicus Common pheasant Galliformes 319 XP_031471701.1 272 46.4 59.9
Varanus komodoensis Komodo dragon Squamata 319 XP_044300138.1 269 45.9 60.1
Python bivittatus Burmese python Squamata 319 XP_025026122.1 269 44.1 58
Pantherophis guttatus Corn snake Squamata 319 XP_034287884.1 267 42.7 56.4
Rhinatrema bivittatum Two-lined caecilian Rhinatrematidae 353 XP_029459031.1 273 45.4 59.5
Xenopus tropicalis Western clawed frog Anura 353 XP_031752228.1 260 43.5 57.4
Bufo gargarizans Asiatic toad Anura 353 XP_044141363.1 262 40.7 56.8
Bufo bufo Common toad Anura 353 XP_040278366.1 391 30.9 42
Protopterus annectens West african lungfish Lepidosireniformes 408 XP_043927617.1 269 37.8 53.5
Polyodon spathula Paddlefish Acipenseriformes 431 XP_041127510.1 275 33.8 52.4
Danio rerio Zebrafish Cypriniformes 431 XP_021329868.1 287 30.2 44.7
Clupea harengus Atlantic herring Clupeiformes 431 XP_042559186.1 306 29 41.7
Callorhinchus milii Australian ghostshark Chimaeriformes 464 XP_042189981.1 267 35.5 53.3
Amblyraja radiata Thorny skate Rajiformes 464 XP_032889397.1 267 33 47.5
Scyliorhinus canicula Small-spotted catshark Carcharhiniformes 464 XP_038658253.1 264 32.5 50.4

Research

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References

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  1. ^ a b c "C13orf42 chromosome 13 open reading frame 42 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov.
  2. ^ a b "Homo sapiens chromosome 13 open reading frame 42 (C13orf42), transcript variant 3, mRNA". NCBI nucleotide. 11 June 2022.
  3. ^ "C13orf42 BLAST: Basic Local Alignment Search Tool". blast.ncbi.nlm.nih.gov.
  4. ^ "C13orf42 Gene - GeneCards | CM042 Protein | CM042 Antibody". www.genecards.org.
  5. ^ a b c d "Home - Protein - NCBI". www.ncbi.nlm.nih.gov.
  6. ^ "Protein BLAST: search protein databases using a protein query". blast.ncbi.nlm.nih.gov.
  7. ^ "EMBOSS Needle < Pairwise Sequence Alignment < EMBL-EBI". www.ebi.ac.uk.
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