BrettLomman

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Hello, BrettLomman, and welcome to Wikipedia! My name is Ian and I work with the Wiki Education Foundation; I help support students who are editing as part of a class assignment.

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If you have any questions, please don't hesitate to contact me on my talk page. Ian (Wiki Ed) (talk) 01:08, 5 September 2016 (UTC)

Here is my information to add to the Turmeric page:

Since they say that there is some research ongoing about the effects it has on Alzheimer's but goes into no detail, pretty much everything from my paper can be added. But I will add the main points here:

One in vitro study by Yoshida et al., (2011,630) looked at curcumin's effects on the expression of the genes which code for the proteins which make up the enzyme presenilin1 which is the enzyme which cleaves precursor proteins to form the ß-amyloid plaques which cause Alzheimer's. What they found was that by exposing the cells to curcumin at various concentrations over a time period up to 72 hours there was upwards of a 95% decrease in expression of the proteins for the presenilin1 enzyme.

In a study conducted by Ahmed and Gilani (2009, 555) they were looking to see if curcumin as well as other forms of curcumin (under the umbrella group name curcuminoids) could be used to inhibit acetylcholinesterase activity. This is the current type of drugs prescribed for Alzheimer's Disease. What they found was that in vitro the curcuminoids caused acetylcholinesterase inhibition in a dose-dependent manner. In an ex-vivo study on rats they found that at concentrations of 3 and 10 mg/kg the rat hippocampuses were able to have significantly decrease acetylcholinesterase activity which showed that it could be used in place of acetylcholinesterase inhibitors. What they also found was that curcumin or a combination of curcuminoids were able to reverse the effects of a drug that caused spatial amnesia in these same species of rats by use of the Morris Water maze test.

Lastly a study by He et al., (2016, 218) examined whether or not curcumin was as effective at improving cognitive function as an antidiabetic drug RSG (rosiglitazone maleate) which has been shown to have effects on improving rat memory. The found that when exposed to curcumin, the mice synapses showed a significant increase in the production of the protein PSD95 which is believed to protect the synapses and increase cognition which is lost due to Alzheimer's. There is still some to be learned as to how the synapses are improved because they only speculate that the increase in protein production caused a protective effect, but they are unsure as to how.

BrettLomman (talk) 03:49, 26 October 2016 (UTC)