Gambit21

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Nathan2055^{talk - contribs} 00:21, 22 December 2020 (UTC)

December 2020

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Deletion discussion about HIF strengthening factor

Hello, Gambit21, and welcome to Wikipedia. I edit here too, under the username Graeme Bartlett, and I thank you for your contributions.

I wanted to let you know, however, that I've started a discussion about whether an article that you created, HIF strengthening factor, should be deleted, as I am not sure that it is suitable for inclusion in Wikipedia in its current form. Your comments are welcome at Wikipedia:Articles for deletion/HIF strengthening factor .

You might like to note that such discussions usually run for seven days and are not ballot-polls. And, our guide about effectively contributing to such discussions is worth a read. Last but not least, you are highly encouraged to continue improving the article; just be sure not to remove the tag about the deletion nomination from the top.

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(Message delivered via the Page Curation tool, on behalf of the reviewer.)

Graeme Bartlett (talk) 23:32, 25 December 2020 (UTC)

Dear (talk),

I have commented on the deletion discussion illustrating wh I think a lone standing article on HIF strengthening molecules has merit. I am looking forward to your reply.

Best

Gambit21 (talk) 09:03, 26 December 2020 (UTC)

Actually I failed to nominate this for deletion properly, so I changed my mind about the AFD and just changed it to a redirect. As the content would be better merged. However I see that you created the Wikipedia:Articles for deletion/HIF strengthening factor. I don't think it will result in anything happening as I did not end up with my reason for deletion being added. Graeme Bartlett (talk) 12:12, 26 December 2020 (UTC)

Dear @Graeme Bartlett:.

Ah, thank you, I am unfamiliar with this protocol. However I think the redirect or any merger with existing articles (I looked at Deferoxamine, Deferiprone, Minoxidil, Chelation therapy and some more) would be misleading and loose important information (see my reasons below) and a lone standing article is best. Can you please cancel your redirect?

I think redirect is not correct because:

1. HIF strengthening factor is a molecule not limited to the example of Deferoxamine. In fact it is at least also Deferiprone used and called HSF in the scientific literature. See this paper for example where this is the case (HSF as a term is mentioned in the manuscript 3 times): https://pubmed.ncbi.nlm.nih.gov/32479616/ also Sodium Gluconate, Minoxidil and DMOG have been used in this context (meaning HIF strengthening/stabilisation for regeneration). I can't see how this could fit all under Deferoxamine. It would be short of important aspects. I also checked out the other molecule articles and the chelation therapy article for a potential merger. However, the HIF strengthening effect is via inhomogenious mechanistics (one time via pro chelation, another time via PHD inhibition) and therefore does't fit in either of the other articles as a subheading or so. This further confirmed my belief that this should be kept as a stand alone article.

2. The article gives insights on the very important regenerative aspects of HIF stimulation. HIF stimulation as an aspect of Deferoxamine is not covered in the Deferoxamine article let alone the implications of it for regneration.

In conclusion I think my article on the new molecule type HSF that stimulates HIF signaling for regenerative purposes (wound healing, scar mitigation, skin and hair regeneration) has merit, adds important information and should be kept as a lone standing article.

Best greetings

Gambit21 (talk) 11:10, 26 December 2020 (UTC)

I have now properly nominated the page, so we should get input from other people. Graeme Bartlett (talk) 01:34, 28 December 2020 (UTC)