Ken Gillman

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Hello. Please do not sign your edits to articles. Signatures are meant to be used on talk pages only. See Ownership of articles for more information. Thanks. Khatru2 01:23, 24 September 2006 (UTC)

MAOIs

hi ken-- first the standard welcome message, with good links you should check out. maybe you've gotten this already, but, here it is again, just in case . . .

Welcome!

Hello, Ken Gillman, and welcome to Wikipedia! Thank you for your contributions. I hope you like the place and decide to stay. Here are some pages that you might find helpful:

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i'd highly recomend reading through that stuff before making substantive edits to pages, such as you did with monoamine oxidase inhibitor. ie, there are ways we cite stuff, ways we use headers to seperate sections, ways we link to other articles, which you don't seem aware of. also, much of the information you added was redundant; at the very least, it needs to be integrated with the already existent article.

cheers --heah 19:12, 24 September 2006 (UTC)

Thank you. I appreciate the points made above and that there are formatting issues I have no understanding of. Because I was unable to deal with those procedures I thought it was better to contribute some material and let someone else edit it if they chose to. I simply do not have the time or ability to do that at present.

However it is important for it to be known that some of the material in this current version is significantly at odds with evidence-based science. As far as I am able to see the current version has no scientific citations and makes some important and contentious statements that absolutely require quality citations, if they are supportable. e.g. ' so increasing the available stores.' I do not believe a citation can be produced to support that statement, neither do think it is correct. I have read a substantial proportion of all scientific papers produced about MAOIs and do not recall data that would support that.

'In addition to reversibility, MAOIs differ by their selectivity of the MAO receptor. Older MAOIs inhibit both MAO-A and MAO-B equally, but newer MAOIs have been developed that target one over the other.'

Again, this is unreferenced as far as I can see, and significantly at odds with history. The original selective irreversible MAOIs, clorgyline and pargyline-, were synthesised decades prior to moclobemide and used clinically.

Dangers could be improved 'hyperserotonemia if foods containing tryptophan are consumed'- again, I don't see a citation to support this and am confident that no such evidence exists.

'The exact mechanism by which tyramine causes a hypertensive reaction is not well understood' Not many Neuropharmacologists would agree with this: it is understood, and if you wish to read about it you will find quite detailed information on my website which cites the relevant scholarly articles and summarises them.

As far as a diet is concerned it might be useful for someone to look carefully at the material I contributed: it is the most comprehensively referenced list currently in existence, either on the internet, or in any scholarly scientific article.

The current contribution has much anecdotal and unreferenced material.

It is unlikely that I shall have the time, or ability, to return to this issue for some months. Perhaps it is for someone else to decide if a link to my website giving information about diet is appropriate on wiki Note my website is being reconstructed and that process is likely to be complete within a month from now. Good luck to someone; I will try to return to this issue in while.Ken Gillman 00:00, 25 September 2006 (UTC)

Thank you for your contribution to Mirtazapine

Thank you for your contribution to the Mirtazapine article. You have raised a very interesting point. You are certainly a very well qualified person to be contributing to articles on wikipedia concerning your field of work. I hope you continue to contribute to articles on wikipedia. I have changed the format of the reference you gave in your entry on Mirtazapine to the correct format. But I realise that this could be due to your speech to text software. --Benjaminevans82 23:43, 12 October 2006 (UTC)

Thank you for edit, much appreciated. Ken Gillman 08:12, 26 November 2006 (UTC)

WikiProject Pharmacology Collaboration of the Week

WikiProject Pharmacology is currently organizing a new Collaboration of the Week program, designed to bring drug and medication related articles up to featured status. We're currently soliciting nominations and/or voting on nominations for the first WP:RxCOTW, to begin on September 5, 2007. Please stop by the Pharmacology Collaboration of the Week page to participate! Thanks! Dr. Cash 17:50, 1 September 2007 (UTC)

Pharmacology Collaboration of the Week

Aspirin has been selected as this week's Pharmacology Collaboration of the Week! Please help us bring this article up to featured standards during the week. The goal is to nominate this at WP:FAC on September 10, 2007.

Also, please visitWP:RxCOTW to support other articles for the next COTW. Articles that have been nominated thus far include Doxorubicin, Paracetamol (in the lead with 4 support votes so far), Muscle relaxant, Ethanol, and Bufotenin.

In other news:

• Bupropion has been promoted to featured status on August 31, 2007.

• The Wikipedia:WikiProject Pharmacology main page has been updated and overhauled, to make it easier to find things, as well as to highlight other goals and announcements for the project.

• Garrondo is asking for individuals to help review Therapies for multiple sclerosis, as he is considering nominating this article for GA status.

• Fvasconcellos notes that discussion is ongoing regarding the current wording of MEDMOS on including dosage information in drug articles and ugly people. All input is welcome.

Dr. Cash 00:48, 5 September 2007 (UTC)

WikiProject Pharmacology Update

Here's a brief update in some of the recent developments of WikiProject Pharmacology!

• Aspirin has just completed its two week run as the first Collaboration of the Week! Many thanks to those editors that contributed; the article got a lot of good work accomplished, and in particular, much work was done in fixing up the history section. It's still not quite "done" yet (is a wikipedia article really ever done?), but after two weeks I think it's more important to push onwards with the development of the new collaboration of the week program. I will be fixing up Aspirin in the next few days and possibly nominating it for either GA or FA status.

• Muscle relaxant has been selected as the new Collaboration of the week until October 2, 2007! This article is currently rated as a "stub", so it's got quite a bit of work cut out for collaborators! Admittedly, featured status could be a long way off,... but still attainable! At the least, maybe we could at least get it up to meeting the Good article criteria? Please stop by the article and help improve it.

• Resveratrol, having recently achieved GA status on August 16, 2007, is now making a run for featured status. This is quite a fascinating compound. If you can, please stop by its discussion page and leave comments in support of it.

• Please remember that Wikipedia is not a forum for discussing or dispensing medical advice amongst users. Specifically, talk pages of articles should only be used to discuss improving the actual article in question. To help alleviate this situation, the template {{talkheader}} may be added to the top of talk pages, reminding users of the purpose of such pages. Additionally, unsigned comments and comments by anonymous users that are inappropriate may be removed from talk pages without being considered vandalism.

• There was an interesting article on ZDNet last week about Hewlett Packard licensing its patented microneedle technology used in common inkjet printers to be used in transdermal patches to deliver a time-controlled release of drugs to patients. This information could be added to articles such as route of administration or drug delivery.

You are receiving this message because you are listed as one of the participants of WikiProject Pharmacology.

Dr. Cash 04:58, 19 September 2007 (UTC)

WikiProject Pharmacology Update

Here are a few updates in the realm of WikiProject Pharmacology:

• The Pharmacology Collaboration of the Week has been changed to Collaboration of the Month, based on current participation levels. It is also more likely that articles collaborated on for one month are more likely to achieve featured quality than articles worked on for only a week or two.

• The current Collaboration of the Month for November is Receptor antagonist. Please take a look at that article and contribute to it if you get a chance. Ideally, the article should adhere to the featured article criteria.

• Therapies for multiple sclerosis is currently a featured article candidate. If you are familiar with the featured article criteria, please visit WP:FAC and review the article.

• Anabolic steroid is the wikiproject's newest Featured Article, having been promoted on October 8, 2007.

• Theobromine was delisted as a Good Article. The Peer review and GA reassessment discussions provide suggestions on improvement. Muscle relaxant was recently reviewed for Good Article status, but not promoted. Please see the full review full review here for details.

Dr. Cash 22:13, 31 October 2007 (UTC)

Dr Gillman please can you help me?

Hello Dr

    My name is Robert Wankel I have had problems for years I was dignosed ADD in the 3rd grade and put on ridillian. I tested with the IQ of a 12th grade in 3rd I noticed all the drug did for me was make me fat and lazy. I think my step mother being a nurse and knowing what the drug would do to me wanted me on it and managed to get me on it. I never had problems in school before I was ahead of the class I didnt have problems after I was just a skinny hipper active kid with a high metabolism. When I got in JR high and started playing football I sat infront of my step mother and my sychatrist and told them both I would no longer take them medication I knew then it was only harming me and not helping me. I started playing football and lifting weights 4 hours a day 5 days a week in our school gym and thank god for god germany blood line I was no longer fat by the time I was a senior I was huge to tell the truth I should have got my ged and when to california and trianed in gyms and competed in weight lifting I was 16 years old and bench pressing 450 pounds in high school compititions. Instead because of the loose of my daughter I was deppressed and wanted to die for my country and went to the army to become the smartest killing machine in the armed forces atleast they gave us a fancy name combat engineers its infiantry plus explosives. My pick of a job by the way. I became a sharp shooter and went to sniper trianing school from there I became a airborne sapper whitch is a special forces clasification for my job. Then if I didnt get lucky afghanistan here I come lean mean fighting machine in early 2000. well everything when according to plan mentaly I never had a problem pulling the trigger in away I injoyed it. Then the worst happened 45 pounds of C-4 turned me in to superman I was flying and when I landed on my left wrist it spidder fractured the ball cup of the raidius in over a 100 places. I was found unfit while trying to stay in the army I loved my job and they gave me something I had never gotten in my life an iferstructure that wasnt curruptable. I fit I would go back to day. The military doctor cuncluded that the risck of permanatly disabling my was to high they were considering me 35% at that time and I was still passing my pt test with a cast on my arm 65 push ups in 2 minutes with a broken wrist not only apove passing but amazing still it was enough I was being sent back tono were I had no were to go my father never wanted me as a son in the first place I had no were to live. I will never forget what my seargant first class and company comanddar siad to me the day I let I was so pissed I did not know how to deal with everything I had lost my stability and infrastructure in my life. I actualy whent to the base commanders office door of fortlenardwood MO and burnt my class A uniforms with all my ribbins and metals on them. Anyways got off the subject my seargant first class and company commander came to me the day I was going home and gave me a box and told me no good soldier should every leave here without the medials he earned. they also told me something that in retrospect I know now was true they siad for a soldier like you becoming a civilian agian can mean death . they were telling me it was going to be hard things out here are not like in the military. I beleive I developed what is called post dramatic stress syndrome I couldnt keep jobs I havent held a job for over a year since. My mental condition worsened in 2006 I was having anxiety attacks and panic attacks people would piss me of and I couldnt control my self I was an alcholic like lynard skynard sang I drink enough wisky to float a battle ship around. I didnot want to kill my self because that would have gone agianst all my code of values and every thing instilled in me in the army but I wanted to die. Well I hit a tree with my s10 I decided it was time to stop drinking and get help for my problems wel in the prosses of being in between jobs a ray of hope we want you back in the national gaurd same job same rank like you never left go to refresh trianer couse basicaly take all my trianning over agian but wouldnt have to be in the barraks withe the newbees. Things were looking up well in that time my family physition put me on paxil and god as my witness I was alwas a health man blood preasure of 120 over 60 give or take a couple digits top and bottom but perfect evryday of my life I started on 10mgs a day of paxil I went to meps for my physical had been on the meds for 3 days I pass everything with flighing colors then they go to check my blood pressure 160 0ver 85 they took it 3 time and avaradged it out. I now realize I had trouble consentrating on my asvab test any ways the medic taking my blood pressure got me in aroom and asked my what the heck your old files show you always having great blood pressure I looked at him and siad it was perfect 4 days ago when I visited my doctor. I was put on hold untill I coud get my blood pressure under control I am actualy still on hold anyways I didnt know what was wrong I was at the motel waiting to get on an airplane the next day and go home I went outside to smoke and its like it got worse. I called they love of my life she just doesnt feel the same for me actualy I think she is scared. She is a nurse and that night she siad to me while we were talking whats wrong you dont sound like your self your getting worse I didnt tell her whatmedication I was on I siad I am just upset I love you and will call you tomorrow after work. So I got back intime to go to work 4 day on pill I notice my anxiety was getting hundreds of times worse I actualy got in a arguement with my forman and picked up a coke machine and through it on the ground. I was sent home every one was looking at me like bob theres something wrong with you man. I went home and called my nurse we talk and she told me to shut up she still calls me bobby like since I was 7. She asked me do you realize what your saying I was out of it I told here no she siad your talking about killing people who dont deserve it she siad what medication are you taking I told her paxil she siad you better go to the doctor tomorrow and quiet taking the paxil. Well I didnt I got up the next morning toke the pill out of habit I guess and by 4 pm I was in the emergency room suffering from what my doctor called SS witch I here you have done some research on. Anyways needless to say the next time I talked to my nurse was from the hospital phone. My question I was hoping you can answer for me because its hard to find a doctor that knows what to do I have been suffering from the same symptoms since the day I went in to the hospital almost 2 years ago I take lysinipril 20 mgs morning and night and metatoperal 50 mgs morning and night and avapro 300 mgs every morning plus a daily dose of 3 mgs of kolonapin a day and 3 mgs of Xanax a day to keep the anxiety down and helps withe the muscle spasims my blood pressure will only come down to 169 over 98. DR. do you think it might be possible god as my witness that for those 5 days the only drug in my system was paxil and nothing else that considering the small does a short period of time a period of time that they say wasnt even long enough for it to be properly working in my system yet. That some who it has permanatly damaged the part of my brian so that I am always producing a toxic level of syritonine. I am trying to get my disability whitch I should get easly on mental condition alone but is there any hope for me getting back to normal. Thank you for any information.

Robert —Preceding unsigned comment added by 74.38.224.189 (talk) 10:18, 8 February 2008 (UTC)

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