User talk:Persiamariah/sandbox

Hi I just finished reading your article outline, here are some additions/changes you could make. A couple of minor points to start off: you mention some neurotoxic effects in animals and people under the "Physiology" section, if you wanted to you could take these points out and put them into a new subheading like "Signs and symptoms" for example. This is a very minor point that is more focused on the structural layout of the article. As well I found two articles that could be added to this section as well. One article I found discusses many characteristics you have already discussed but also mentions a few symptoms caused by the neurotoxin not mentioned (i.e. trembling). It also acts as a good summary of many of the points you have previously outlined. Here is the link (http://www.fao.org/docrep/x5036e/x5036e08.htm). The second paper briefly discusses how people who are immunocompromised due to HIV/AIDS are more susceptible to Penicillium crustosum infection, similar to what was covered in lecture previously. As well, it mentions some indoor aspects of the fungus as well. Here is the link to that article if you want to use it (http://www.moldbacteriaconsulting.com/fungi/penicillium-species-as-indoor-air.html). Furthermore I found a paper that gives historical context to your fungus. The paper describes the first report of P. crustosum causing mold on apple fruit in Serbia. The facts from this paper would be relevant to your "History and taxonomy" heading. Here is the link for that paper (https://apsjournals.apsnet.org/doi/abs/10.1094/PDIS-02-14-0179-PDN). You could also use the following paper to provide an example of a spoilage incident caused by the fungus in order to demonstrate the relevance of P. crustosum on the food industry to the reader. Lastly, if you wanted to include a genetic aspect of the fungus in your article I found a paper that discusses a minor allergen found within P. crustosum. As a result, your article would provide the reader with a deeper understanding of the fungus. Here is the link to that paper (https://www.ncbi.nlm.nih.gov/pubmed/23902156). I hope this helps! --T.henderson (talk) 15:31, 24 October 2017 (UTC)

Hello!

I just finished reading your outline and here are my suggestions and questions:

First, you mentioned who discovered your fungi and when it was discovered but is there an article that says how? (i.e. a clinical case discovery, etc.)

Second, why was it thought to be originally uncommon? What is the mechanism by which this fungi became more common now?

Perhaps state the temperatures at which the fungi lives and dies if you can.

Under Physiology, maybe you might want to add the metabolites your fungi produces. I found an article that discusses metabolites from your species and their implications, done by Kyriakidis et al. (1981): http://pubmedcentralcanada.ca/pmcc/articles/PMC243961/. Moreover, can you provide a clinical case regarding the point about how some people experienced dizziness and vomiting due to ingesting drinks that contained a mould of your fungi? I think it'll help strengthen your point better.

Under Habitat - just a grammar detail - maybe put your first two points together in a sentence.

Great job so far! I hope this helps! || Rachelleisidro (talk) 03:18, 27 October 2017 (UTC)

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Hello Persiamariah, I've reading over your article and listed some suggestsions that you may want to make for the final draft:

1. History and Taxonomy: You have a good start point, but I feel like you're missing some details. For example, you've mentioned that your species has been characterized as variation of Penicillium expansum, but how is this information relevant and important to your article? In what ways are they different and similar? why is it important that it is a variation, particularly, of Penicillium expansum? / The fourth bullet point should go under habitat and ecology.

2. Growth and Morphology: What do you mean that it's the most complex penicillium? complex it terms of structure? lifecycle? / maybe define penicilli? / I suggest you add hyperlinks to conidiophore and Phialide to make it easier for your readers to follow your article.

3. Phyiology Hyperlink to : Penitrem A. / I really like how you've listed the stimulants for the production of penitrem A. / I really enjoyed reading this section of your outline. Well done! The information under each bullet points flowed very well in an organized matter, You've done a great job connecting between its the production of penitrem A and brain damage due to P crutosum. / However, I suggest most of informations should go under a separate section (Epidemiology or Clinical implications) It has a lot of detailed information in terms of neurotoxicity of Penitrem A and their potential clinical implications, rather than the phyioslogy of the fungus.

4. Habitat and Ecology: Hyperlink to : Andrastin A. I think this section of your outline needs more research. It's good that you've listed where it has been found and how different environment can cause different secondary metabolism, but It'd be better if you mention their ecological impacts, sort of like what you did with Penitrem A and P. crutosum.. For example, you said that artic species produce Adastrin A, which is a Farnesyltransferase inhibitor mainly produced by other Penicillium species including Penicillium albocoremium and Penicillium roqueforti. The wikipedia page also contains some information about Farnesyltransferase inhibitor as a treatment for cancer or Alzheimer's

Your citation for 10th reference point is in a wrong-format. Here's the DOI for it: 10.1002/jobm.19810210822. Overall, your outline contains a lot of significant informations that can potentially help alot of people reading your article. However, some of the informations were poorly organized. For the final article, I suggest you look into the wikipedia page for Chrysosporium keratinophilum. In terms of formatting, I think it'll be a great guideline (ex. you could replace the Antagonistic activity section of it with the neurotoxicity of Penitrem A & Biotechnological applications section with the Use of farnesyltransferase inhibitor as potential treatment.) Watch out for grammar mistakes & formatting errors (ex. referencing should go after punctuation)

The followings are informations I've found that you may want to cnosider adding to your final draft:

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC243961/: it explains the secondary metabolites of your species as a tremorgenic mycotoxin
• https://link.springer.com/article/10.1023/B:MYCO.0000024180.99262.b1

Good luck on your final draft! --Phll (talk) 23:27, 27 October 2017 (UTC)

Hi there! You have included rich information about the fungus in your draft, and you have organized pieces of information in a logical flow, well done.

My organism also belongs to the genus Penicillium, and the flow of my draft is similar as yours. I was suggested to include a brief introduction about the organism to make it easier/ more interesting to read, please consider adding one in your article as well.

Besides that, please include more details on growth and morphology. There are sources describing morphologies under different conditions, for example, temperature. These evidence can be used to further explain the geological distribution of the organism.

I also suggest splitting your physiology section into physiology AND pathogenicity. In the pathogenicity and associated diseases section, please consider this flow: firstly, indicate toxins and metabolites produced by the fungus; then point out diseases related to/ caused by the toxins. I have found some informative links that have listed the fungus physiological aspects when growing on different growth conditions, as well as related diseases.

Please check:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC243961/

http://www.mycobank.org/BioloMICS.aspx?TableKey=14682616000000063&Rec=13482&Fields=All

http://onlinelibrary.wiley.com/doi/10.1016/j.femsec.2004.10.014/full

https://www.sciencedaily.com/releases/2011/12/111215094811.htm

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC242489/

Nannan sun (talk) 00:57, 28 October 2017 (UTC)

Hi Persiamariah! I enjoyed reading through your draft and learning about your fungus. I just have a few suggestions that you may want to consider. In your growth and morphology section, it may be interesting if you specify how your fungus is the most complex penicillium. Consider its structure, genome, secondary metabolites, and ecology. It is also good to add links to Wikipedia pages for terms such as agar (https://en.wikipedia.org/wiki/Agar), as viewers may not all have a science or mycology background. For your physiology section, I found an interesting paper discussing an allergen produced by Penicillium crustosum, which was previously not known to be allergenic, that is homologous to the allergen Pen b 26 produced by Penicillium brevicompactum; link (https://doi-org.myaccess.library.utoronto.ca/10.3109/13693786.2013.813086). In addition, the latter half of your physiology section discusses many health related issues caused by Penicillium crustosum, thus I think that creating a separate subheading named along the lines of “Disease and impact on health” would be beneficial. Perhaps adding a section called “Usage in industry” would be interesting as well since there are examples of Penicillium crustosum being used commercially. One article highlighted the effectiveness of Penicillium crustosum at removing excess boron from the environment, which can be toxic to organisms; DOI (10.2166/wst.2015.519). Another article supported Penicillium crustosum as a good mediator for the synthesis of nanoparticles; link (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323328/). Furthermore, the impact of Penicillium crustosum on the food industry can be discussed as important crops that are exported from select countries are infected by this fungus; link (http://www.tandfonline.com/doi/abs/10.1080/07060661.2016.1243582?journalCode=tcjp20). I hope this helps!--Juliaq (talk) 02:41, 28 October 2017 (UTC)