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{{Geobox|River}}
Hogtown Creek is located in the northwest and southwest quadrants of Gainesville and is one of the largest watersheds in the area, encompassing approximately 20 square miles of urban and suburban Gainesville. The University of Florida and Gainesville High School are located within this basin. Hogtown Creek has numerous tributaries, with four of the largest being Possum Creek, Springstead Creek, Rattlesnake Branch, and Elizabeth Creek. These four tributaries all join the creek in the area between NW 39th Avenue and University Avenue. Relief is high in the watershed and in many areas the creek and tributaries are deeply incised. Phosphate pebbles and fossils, such as shark’s teeth, dugong rib bones, and shell molds and casts, are frequently found in the streambed. The creek flows through residential neighborhoods and commercial districts and then through forested wetlands where it ultimately recharges the Floridan Aquifer at Haile Sink.