Truebreath

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Hello, Truebreath, and welcome to Wikipedia! Thank you for your contributions. I hope you like the place and decide to stay. Here are a few links to pages you might find helpful:

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Dabigatran

I am concerned that some of your additions to dabigatran are extrapolations from monitoring data that do not imply causality. Without stronger sources, one would not want to see this included in a general encyclopedia article. Could you respond to my message on Talk:Dabigatran before making further changes? Thank you. JFW | T@lk 10:05, 3 November 2013 (UTC)

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I have fixed this itemTruebreath (talk) 15:47, 7 November 2013 (UTC)

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Citation suggestion

Hi. Thanks for your contributions to the Dabigatran article. In case you haven't seen this yet, please check out User:Diberri's Wikipedia template filling tool (instructions). Given a PubMed ID, one can quickly produce a full citation that can be copied and pasted into a Wikipedia article. This tool can save you a lot of work and ensure that the citations are displayed in a consistent manner. Cheers. Boghog (talk) 22:50, 29 November 2013 (UTC)

Source selection

Hello Truebreath, I was wondering if I could draw your attention to an issue that affects your contributions to the NOAC articles. On Wikipedia, health-related articles are governed by a manual of style (which includes guidance on articles about medicines) and a sourcing guideline. You rely quite heavily on primary sources in your additions (e.g. the Bloch et al paper recently added to dabigatran), which effectively contravenes existing guidance. You are trying to write a huge comprehensive review of everything that can be said about these agents; that is not the purpose of an encyclopedia and I worry about introducing information that hasn't been reproduced or verified and may eventually be disproved. There is a risk that I will need to personally remove information that contravenes WP:MEDRS, but I prefer to give you an opportunity to fix this yourself. JFW | T@lk 12:33, 7 March 2014 (UTC)

You've been editing since I left my message. Can you acknowledge that you have received it? JFW | T@lk 22:00, 8 March 2014 (UTC)

I added a review about the woundproblems. I deleted the whole section about cost effectiveness; because most were original studies. I deleted things in dosing. So i am changing the references of original studies to references of secondary sources. --Truebreath (talk) 22:16, 8 March 2014 (UTC)

There are still lots of primary sources in the dabigatran article, such as doi:10.1016/j.amjmed.2013.12.005 (a cohort study). JFW | T@lk 11:06, 9 March 2014 (UTC)

Yes i know, but it confirms the association between dabigatran and myocard infarction in real life. So it is important. Systematic reviews of real life dabigatran events are lacking. We will not see any post approval trial in the near future that will show this.

I looked at the "good wiki article " about warfarin. adverse effects: osteoporosis; look at the extremely poor references. I think you should remove the whole section, because there is no reference to high level secondary source. Only original retrospective and prospective studies. Moreover a systematic review didn't find a relation between warfarin and osteoporosis, but this is not mentioned in the article. " Changes in bone density after exposure to oral anticoagulants: a meta-analysis PJ Caraballo, SE Gabriel, MR Castro… - Osteoporosis …, 1999 -" Look at the purple toe syndrome based on a study with 1 case. Look at the section interactions: almost all references don't come from high level secondary sources. Look at haemorrhages ref 18 is a prospective study; intracranial haemorrhages are lacking...which should be their biggest problem, according the new anticoagulant studies.

I looked at the "good wiki article " about bromazepam: side effects; references 6 to 22 are small trials, primary sources; half of the side effects part has no references.

I looked for "featured articles" about medecines; i didn't find any.

The problem is that harms are not so popular in trials; a systematic review states "in anticoagulant trials there are limited data about harms (exclusive bleedings) " .The harms have to be deducted from post approval, cheaper, phase 4 studies, that are almost always prospective or registry studies, with the good known biases. Maybe we should make a new heading for new potential dangerous medecines: "real world studies" and include all important studies about extern validity (generalisability). I agree that idealiter they should come from systematic reviews. The reason why there were serious doubts about warfarine in older people was the lack of studies about their generalisability. This is important for clinicians and for the patients. Could also Boghog give some input?

--Truebreath (talk) 15:01, 9 March 2014 (UTC)

Guidelines on Wikipedia

Please have a read of WP:MEDMOS. It provides some guidelines on writing style, wording and section headings. Best Doc James (talk · contribs · email) (if I write on your page reply on mine) 23:48, 15 March 2014 (UTC)

Extern validity; generalisability

So i see that all elements of extern validity were removed;"real world experiences""Pharmacovigilance" Cochrane should be disappointed.

So where do i put these things also found in other systematic reviews:

In the literature, reports of excess bleeding with dabigatran in elderly patients with renal dysfunction[40] raise doubts regarding whether the superior safety profile observed with dabigatran in clinical trials will be generalisable to clinical practice.

The findings based on clinical trial populations may not be generalisable to clinical practice where patients tend to be older and have more comorbidities.

Current and New Oral Antithrombotics in Non-valvular Atrial Fibrillation A Network Meta-analysis of 79 808 Patients Ariel Dogliotti, Ernesto Paolasso, Robert P Giugliano http://www.medscape.com/viewarticle/820832_6

--Truebreath (talk) 22:47, 18 March 2014 (UTC)

Probably the best place to bring this up is on the talk page of the article in question. Exactly what content are you hoping to see returned? Doc James (talk · contribs · email) (if I write on your page reply on mine) 23:38, 18 March 2014 (UTC)

This "In the literature, reports of excess bleeding with dabigatran in elderly patients with renal dysfunction[40] raise doubts regarding whether the superior safety profile observed with dabigatran in clinical trials will be generalisable to clinical practice." should go in the section on adverse effects if based on a review. Doc James (talk · contribs · email) (if I write on your page reply on mine) 23:39, 18 March 2014 (UTC)

Thanks

Hello there. I just wanted to thank you for your efforts to contribute to Wikipedia in a way that follows our guidelines. I helped write DVT, for what it's worth, although I could probably use some new oral anticoagulant information. Best wishes. Biosthmors (talk) pls notify me (i.e. {{U}}) while signing a reply, thx 21:06, 19 March 2014 (UTC)

Thanks; i loved yours on DVT to.--Truebreath (talk) 20:29, 7 April 2014 (UTC)

Cite web

Template:Cite web is good for webpages rather than [1]. See Wikipedia:RefToolbar/2.0 of WP:MEDHOW. Best Doc James (talk · contribs · email) (if I write on your page reply on mine) 01:13, 20 March 2014 (UTC)

Legal cases

I am very concerned by this edit. Surely you would not ever open an encyclopedia to find a blatant recruitment message for class action legislation? Please rethink your strategy on how you present this kind of information.

You should also have noticed that your edits still need fixing by other editors. Currently your contributions to the thiazolidinedione articles are being tidied up by someone else. JFW | T@lk 18:36, 30 March 2014 (UTC)

I do my best.--Truebreath (talk) 20:27, 7 April 2014 (UTC)

April 2014

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Oseltamivir

No offense intended on the revert. But I think the CDC and meta analysis authors already considered the funding issue, and for us to add the funding source of the trials as a way of discrediting the research is probably WP:OR. Best Formerly 98 (talk) 23:35, 13 April 2014 (UTC)

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Copy and paste issues

In this edit [2] you copied and pasted this text "Claims about the effectiveness of Tamiflu against complications were a key factor in decisions made by governments around the world to stockpile these drugs in case of a pandemic. The US has spent more than $1.3 billion buying a strategic reserve of antivirals, while in the UK the government has spent almost £424 million for a stockpile of about 40 million doses" This is not allowed and I have reverted all you edits to this page as they all must now be checked. Doc James (talk · contribs · email) (if I write on your page reply on mine) 13:47, 16 April 2014 (UTC)

I will try to rewrite some parts, but my English is poor. I find the last rewriting of oseltamivir good quality. Thanks--Truebreath (talk) 08:07, 17 April 2014 (UTC)

Thanks. No worries. We must paraphrase else we run into copyright issues. Doc James (talk · contribs · email) (if I write on your page reply on mine) 12:34, 17 April 2014 (UTC)

Primary sources

You continue to use some primary sources such as here [3]. Wondering why you do not use secondary sources as recommended at WP:MEDRS? Doc James (talk · contribs · email) (if I write on your page reply on mine) 13:59, 16 April 2014 (UTC)

I don't like to delete text from other authors; this part was not mine; i added 15 meta analyses and systematic reviews in the part efficacy of ace inhibitors; i left this primary source not added by me. So now it is deleted

--Truebreath (talk) 22:42, 16 April 2014 (UTC)

Wonderful. Thanks. Doc James (talk · contribs · email) (if I write on your page reply on mine) 03:11, 17 April 2014 (UTC)

Generic names

Please use the generic rather than the brand / trade name. Doc James (talk · contribs · email) (if I write on your page reply on mine) 18:40, 17 April 2014 (UTC)

Where did it happen? --Truebreath (talk) 19:48, 17 April 2014 (UTC)

Popular press

Is not appropriate for references for medical content per WP:MEDRS. Thus trimmed. Doc James (talk · contribs · email) (if I write on your page reply on mine) 18:57, 17 April 2014 (UTC)

Why do you keep adding popular press sources? Doc James (talk · contribs · email) (if I write on your page reply on mine) 19:33, 17 April 2014 (UTC)

The whole Japanese text was already there previously. By mistake i deleted it and restored it. So don't shoot on me. --Truebreath (talk) 19:47, 17 April 2014 (UTC)

Yet you continue to add it here [4] which means I need to continue removing it. If you are unclear what a high quality secondary source is would be happy to explain in greater detail. Doc James (talk · contribs · email) (if I write on your page reply on mine) 07:08, 19 April 2014 (UTC)

Yes i added it after i deleted it myself by error. I completely agree with removing it. --Truebreath (talk) 11:46, 19 April 2014 (UTC)

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Copy and pasting

In this edit [5] you added "the US has spent more than $1.3 billion buying a strategic reserve of antivirals, while in the UK the government has spent almost £424 million for a stockpile of about 40 million doses." which has already been published before? What is up? Doc James (talk · contribs · email) (if I write on your page reply on mine) 20:48, 18 April 2014 (UTC)

Reuters cited "The United States has spent more than $1.3 billion buying a strategic reserve of antivirals including Tamiflu, while the British government has spent almost 424 million pounds ($703 million) on a stockpile of some 40 million Tamiflu doses." Press release bmj: The US has spent more than $1.3 billion buying a strategic reserve of antivirals, while in the UK the government has spent almost £424 million for a stockpile of about 40 million doses.

should i cite the quote like Reuters? "The United States has spent more than $1.3 billion buying a strategic reserve of antivirals including Tamiflu, while the British government has spent almost 424 million pounds ($703 million) on a stockpile of some 40 million Tamiflu doses."

Or like this? Buying a strategic reserve of Tamiflu the US has spent more than $1.3 billion. The British government has spent almost 424 million pounds ($703 million) on a stockpile of some 40 million Tamiflu doses. --Truebreath (talk) 21:21, 18 April 2014 (UTC)

Newspapers are allowed "fair use" of text. Thus they often use text word for word from sources. As we are under a CC BY SA license we are not allowed fair use. Thus we must paraphrase all ideas we use. There should never be more than a couple of words the same as the source. Doc James (talk · contribs · email) (if I write on your page reply on mine) 06:33, 19 April 2014 (UTC)

2009 Swine flu

Hi there, I see you have been doing a lot of good work on the vaccine section of the 2009 flu article. I just now pared it down, deleting out of date stuff and main article stuff, but it needs more work. Rather than plow into the recent information which you have clearly already done and already have a great deal of knowledge about (which I sure don't!), could you please attempt to bring the section up to date by paring down some more old stuff (and perhaps updating the main 2009 flu vaccine article as well)? It is so good to meet one of those rare individuals willing to take the time to update medical articles with rather mundane information. Gandydancer (talk) 15:14, 26 April 2014 (UTC)

Some stroopwafels for you!

Well done for improving the quality of your sourcing over the last few months. You are a very prolific editor, and I am sure that your contributions have an enduring positive impact on the articles. JFW | T@lk 18:10, 7 May 2014 (UTC)

A cup of coffee for you!

That you for the tremendous amount of content that you put into Surrogate endpoint. I am reading it now and like it a lot. Blue Rasberry (talk) 13:45, 12 May 2014 (UTC)

Thank you all --Truebreath (talk) 22:55, 24 June 2014 (UTC)

Teriparatide

Your addition of the statement "It did not reduce the risk of hip fractures" cites a study of HIV prevalence in Spanish seamen as source. Presumably this is some sort of cut and paste error? Formerly 98 (talk) 03:50, 21 June 2014 (UTC)

The addition of the spanish seamen was already there before my addition. --Truebreath (talk) 22:54, 24 June 2014 (UTC)

FDA approval

This is a US thing. We are not dividing sections based on FDA approval into "on label" and off-label uses. Doc James (talk · contribs · email) (if I write on your page reply on mine) 09:03, 20 July 2014 (UTC)

Refs

We need references to be used when you add text such as here [6] Doc James (talk · contribs · email) (if I write on your page reply on mine) 21:46, 20 July 2014 (UTC)

I deleted it; --Truebreath (talk) 22:07, 20 July 2014 (UTC)

Copy and pasting again

In this edit [7] you added the text:

there was no top tier evidence that was unequivocally unbiased. Second tier evidence showed that gabapentin was significantly better than placebo in postherpetic neuralgia (number needed to threat 8.0) and painful diabetic neuropathy (number needed to treat 6). Over half of those treated with gabapentin will not have worthwhile pain relief. Adverse events occurred significantly more often with gabapentin."

Ref says [8] "There was no top tier evidence that was unequivocally unbiased... Over half of those treated with gabapentin will not have worthwhile pain relief" "Adverse events occurred significantly more often with gabapentin"

You have been warned about copy and past issues before. As this is an ongoing issue I have blocked your account until it can be resolve. Doc James (talk · contribs · email) (if I write on your page reply on mine) 21:57, 20 July 2014 (UTC)

So i wrote to the editorial board of the cochrane collaboration if we could copy parts from there summaries. I wait for a response. I thought we should collaborate more with them as i read on your user page.

--Truebreath (talk) 22:04, 20 July 2014 (UTC)

No we may not copy and past part of their summaries until Wiley agrees to release them under a CC BY SA license. I need to see a clear understanding that you realize that you must paraphrase going forwards. I have removed your edits from gabapentin due to this copyright issue and posted here at WP:AN [9] Doc James (talk · contribs · email) (if I write on your page reply on mine) 22:05, 20 July 2014 (UTC)

I think the cochrane summaries are not copyrighted under Wiley. Their ip adress is http://summaries.cochrane.org/; the cochrane library with the systematic reviews has another adress: http://onlinelibrary.wiley.com/ On 12/7/2014 i have send this email to the editorial board of the cochrane collaboration:

"Is it permitted to copy/ past text from cochrane summaries in wikipedia English version?? with the right references. Wikipedian people say it is not permitted. And that you must rephrase. But the content of cochrane summaries is so easy to understand, that it is difficult to say it better, in other words.

A hepatitis c cochrane review was deleted, in the subject "surrogate outcome" English version because of copy pasting."

I wait for a response from the editorial board. I found this on the site: "The Review will be made Open Access under the terms of the Creative Commons Attribution License (CC BY), which permits use, distribution and reproduction in any medium, provided that the Review is properly cited and is not used for commercial purposes. For an understanding of what is meant by the terms of the Creative Commons License, please refer to Wiley's Open Access Terms and Conditions "

How can we resolve this issue? Can we not copy past from plos one? Could you answer to the unbalanced surrogate item? Sincerely yours --Truebreath (talk) 22:20, 20 July 2014 (UTC)

• We resolve by you never, ever copy and pasting anything, ever. You rewrite in your own words or you don't use. If you copy and paste then move the words around a bit, that is still plagiarism and will still get you blocked. Rewrite from scratch or don't edit. Dennis Brown | 2¢ | WER 23:14, 20 July 2014 (UTC)

Truebreath, remember that Wikipedia allows others to reuse Wikipedia articles, so long as they properly give credit. This can include putting several articles together as a book and selling it for a profit. The clause you said you found on the site "is not used for commercial purposes" conflicts with what is allowed here. Ravensfire (talk) 15:18, 21 July 2014 (UTC)

And since most of your 3500 edits contained issues and many to obviously commercial sources I would need a very clear display of understanding. Doc James (talk · contribs · email) (if I write on your page reply on mine) 15:24, 21 July 2014 (UTC)

July 2014

You have been blocked temporarily from editing for recurrent copy and paste issues. Once the block has expired, you are welcome to make useful contributions. If you think there are good reasons why you should be unblocked, you may appeal this block by adding the following text below this notice: {{unblock|reason=Your reason here ~~~~}}. However, you should read the guide to appealing blocks first.  Doc James (talk · contribs · email) (if I write on your page reply on mine) 22:04, 20 July 2014 (UTC)

WP:AN discussion notice

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More copy and pasting

Gah. In this edit

You added "When released in draft form for consultation, the guidance prompted the publication of a letter signed, among others,by the president of the Royal College of Physicians, and the former chairwoman of the Royal College of General Practitioners, warning of the risks of medicalising five million healthy people in Great Britain on the basis of drug company trials" [10]

Ref says "When released in draft form for consultation, the guidance prompted the publication of a letter signed, among others, by Richard Thompson, president of the Royal College of Physicians, and Clare Gerada, former chairwoman of the Royal College of General Practitioners, warning of the risks of medicalising five million healthy people on the basis of drug company trials." [11][12]

Thus will be reverting all your edits. Doc James (talk · contribs · email) (if I write on your page reply on mine) 00:04, 21 July 2014 (UTC)

Copy and paste violation found on acyclovir. Going through all your edits. Doc James (talk · contribs · email) (if I write on your page reply on mine) 00:12, 21 July 2014 (UTC)

Yup all more or less than same. Most all copyright violations. Doc James (talk · contribs · email) (if I write on your page reply on mine) 08:41, 21 July 2014 (UTC)

Your draft article, User:Truebreath/sandbox

Hello Truebreath. It has been over six months since you last edited your WP:AFC draft article submission, entitled "sandbox".

The page will shortly be deleted. If you plan on editing the page to address the issues raised when it was declined and resubmit it, simply and remove the {{db-afc}} or {{db-g13}} code. Please note that Articles for Creation is not for indefinite hosting of material deemed unsuitable for the encyclopedia mainspace.

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Thanks for your submission to Wikipedia, and happy editing. JMHamo (talk) 17:19, 24 January 2015 (UTC)