V-set and immunoglobulin domain containing 4

V-set and immunoglobulin domain containing 4 is a protein that in humans is encoded by the VSIG4 gene.

VSIG4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ICC, 2ICE, 2ICF
Identifiers
Aliases	VSIG4, CRIg, Z39IG, V-set and immunoglobulin domain containing 4
External IDs	OMIM: 300353; MGI: 2679720; HomoloGene: 48515; GeneCards: VSIG4; OMA:VSIG4 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xq12 Start 66,021,738 bp End 66,040,125 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X C3 Start 95,290,809 bp End 95,337,044 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung lower lobe of lung gastric mucosa right coronary artery right adrenal cortex synovial membrane upper lobe of lung upper lobe of left lung synovial joint visceral pleura Top expressed in stroma of bone marrow ankle liver left lobe of liver myocardium of ventricle tibiofemoral joint granulocyte muscle of thigh aorta skin of external ear More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding complement component C3b binding Cellular component integral component of membrane membrane protein-containing complex Biological process innate immune response complement activation, alternative pathway immune system process negative regulation of interleukin-2 production negative regulation of T cell proliferation negative regulation of macrophage activation negative regulation of complement activation, alternative pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11326 278180 Ensembl ENSG00000155659 ENSMUSG00000044206 UniProt Q9Y279 F6TUL9 RefSeq (mRNA) NM_007268 NM_001100431 NM_001184830 NM_001184831 NM_001257403 NM_177789 RefSeq (protein) NP_001093901 NP_001171759 NP_001171760 NP_001244332 NP_009199 NP_808457 Location (UCSC) Chr X: 66.02 – 66.04 Mb Chr X: 95.29 – 95.34 Mb PubMed search
Wikidata
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Function

This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants.

Further reading

• Helmy KY, Katschke KJ, Gorgani NN, Kljavin NM, Elliott JM, Diehl L, Scales SJ, Ghilardi N, van Lookeren Campagne M (2006). "CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens". Cell. 124 (5): 915–27. doi:10.1016/j.cell.2005.12.039. PMID 16530040.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.