VAT1

Synaptic vesicle membrane protein VAT-1 homolog is a protein that in humans is encoded by the VAT1 gene.

VAT1
Identifiers
Aliases	VAT1, VATI, vesicle amine transport 1
External IDs	OMIM: 604631; MGI: 1349450; HomoloGene: 36200; GeneCards: VAT1; OMA:VAT1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q21.31 Start 43,014,607 bp End 43,025,123 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 D Start 101,349,571 bp End 101,357,056 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex stromal cell of endometrium left adrenal cortex skin of leg tendon of biceps brachii canal of the cervix right lung islet of Langerhans left ovary right ovary Top expressed in lip dorsomedial hypothalamic nucleus ciliary body decidua aortic valve otic vesicle suprachiasmatic nucleus supraoptic nucleus gastrula ascending aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity zinc ion binding Cellular component cytoplasm integral component of membrane mitochondrial outer membrane extracellular exosome membrane mitochondrion extracellular region azurophil granule lumen Biological process negative regulation of mitochondrial fusion neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10493 26949 Ensembl ENSG00000108828 ENSMUSG00000034993 UniProt Q99536 Q62465 RefSeq (mRNA) NM_006373 NM_012037 RefSeq (protein) NP_006364 NP_006364.2 NP_036167 Location (UCSC) Chr 17: 43.01 – 43.03 Mb Chr 11: 101.35 – 101.36 Mb PubMed search
Wikidata
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Synaptic vesicles are responsible for regulating the storage and release of neurotransmitters in the nerve terminal. The protein encoded by this gene is an abundant integral membrane protein of cholinergic synaptic vesicles and is thought to be involved in vesicular transport. It belongs to the quinone oxidoreductase subfamily of zinc-containing alcohol dehydrogenase proteins.

In melanocytic cells VAT1 gene expression may be regulated by MITF.

See also

• Acetylcholine, the neurotransmitter in cholinergic synaptic vesicles

Further reading

• Miki Y, Swensen J, Shattuck-Eidens D, et al. (1994). "A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1". Science. 266 (5182): 66–71. Bibcode:1994Sci...266...66M. doi:10.1126/science.7545954. PMID 7545954.
• Harshman K, Bell R, Rosenthal J, et al. (1995). "Comparison of the positional cloning methods used to isolate the BRCA1 gene". Hum. Mol. Genet. 4 (8): 1259–66. doi:10.1093/hmg/4.8.1259. PMID 7581362.
• Friedman LS, Ostermeyer EA, Lynch ED, et al. (1995). "The search for BRCA1". Cancer Res. 54 (24): 6374–82. PMID 7987831.
• Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.