VG-1 is a B cell line which was derived from primary effusion lymphoma (PEL) (Lu et al. 2009). It was first established in 2000 by David T. Scadden’s group at Massachusetts General Hospital. It is infected with Kaposi's sarcoma-associated herpesvirus (KSHV), but negative with Epstein–Barr virus (EBV) (Brander et al. 2000).
References
edit- Brander, C.; Suscovich, T.; Lee, Y.; Nguyen, P.T.; O'Connor, P.; Seebach, J.; Jones, N.G.; van Gorder, M.; Walker, B.D.; Scadden, D.T. (2000), "Impaired CTL Recognition of Cells Latently Infected with Kaposi's Sarcoma-Associated Herpes Virus", J Immunol, vol. 165, no. 4, pp. 2077–83, doi:10.4049/jimmunol.165.4.2077, PMID 10925292
- Lu, P.; Yang, C.; Guasparri, I.; Harrington, W.; Wang, Y.L.; Cesarman, E. (2009), "Early Events of B-cell Receptor Signaling are not Essential for the Proliferation and Viability of AIDS-Related Lymphoma", Leukemia, vol. 23, no. 4, pp. 807–10, doi:10.1038/leu.2008.304, PMID 18987659
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