VPS11

Vacuolar protein sorting-associated protein 11 homolog is a protein that in humans is encoded by the VPS11 gene.

VPS11
Identifiers
Aliases	VPS11, END1, PEP5, RNF108, hHLD12, CORVET/HOPS core subunit, VPS11 core subunit of CORVET and HOPS complexes
External IDs	OMIM: 608549; MGI: 1918982; HomoloGene: 6673; GeneCards: VPS11; OMA:VPS11 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q23.3 Start 119,067,692 bp End 119,081,978 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A5.2 Start 44,259,046 bp End 44,272,967 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex Pituitary Gland apex of heart right frontal lobe anterior pituitary right hemisphere of cerebellum right adrenal gland primary visual cortex putamen right adrenal cortex Top expressed in interventricular septum granulocyte neural layer of retina dentate gyrus of hippocampal formation granule cell superior frontal gyrus primary visual cortex ankle muscle of thigh cerebellar cortex right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein-macromolecule adaptor activity protein domain specific binding metal ion binding protein binding syntaxin binding Cellular component HOPS complex endosome late endosome late endosome membrane membrane endocytic vesicle autophagosome lysosomal membrane early endosome lysosome cytoplasmic vesicle clathrin-coated vesicle Biological process endosomal vesicle fusion regulation of protein stability regulation of organelle assembly positive regulation of protein targeting to mitochondrion endosome to lysosome transport autophagy positive regulation of early endosome to late endosome transport protein transport intracellular protein transport vesicle-mediated transport regulation of SNARE complex assembly lysosome organization endosome organization vesicle docking involved in exocytosis transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55823 71732 Ensembl ENSG00000160695 ENSG00000280616 ENSMUSG00000032127 UniProt Q9H270 Q91W86 RefSeq (mRNA) NM_001290185 NM_021729 NM_027889 NM_001357393 RefSeq (protein) NP_001277114 NP_068375 NP_001365147 NP_001365148 NP_001365149 NP_001365150 NP_082165 NP_001344322 Location (UCSC) Chr 11: 119.07 – 119.08 Mb Chr 9: 44.26 – 44.27 Mb PubMed search
Wikidata
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Function

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.

Interactions

VPS11 has been shown to interact with VPS18, VPS33A and STX7.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Huizing M, Didier A, Walenta J, Anikster Y, Gahl WA, Krämer H (2001). "Molecular cloning and characterization of human VPS18, VPS 11, VPS16, and VPS33". Gene. 264 (2): 241–7. doi:10.1016/S0378-1119(01)00333-X. PMID 11250079.
• Kim BY, Krämer H, Yamamoto A, Kominami E, Kohsaka S, Akazawa C (2001). "Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7". J. Biol. Chem. 276 (31): 29393–402. doi:10.1074/jbc.M101778200. PMID 11382755.
• Kim BY, Ueda M, Kominami E, Akagawa K, Kohsaka S, Akazawa C (2004). "Identification of mouse Vps16 and biochemical characterization of mammalian class C Vps complex". Biochem. Biophys. Res. Commun. 311 (3): 577–82. doi:10.1016/j.bbrc.2003.10.030. PMID 14623309.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.