VPS45

Vacuolar protein sorting-associated protein 45 is a protein that in humans is encoded by the VPS45 gene.

VPS45
Identifiers
Aliases	VPS45, H1, H1SCN5, VPS45A, VPS45B, VPS54A, VSP45, VSP45A, vacuolar protein sorting 45 homolog
External IDs	OMIM: 610035; MGI: 891965; HomoloGene: 5250; GeneCards: VPS45; OMA:VPS45 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q21.2 Start 150,067,279 bp End 150,145,329 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3 F2.1|3 41.65 cM Start 95,907,144 bp End 95,965,778 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar cortex cerebellar hemisphere right hemisphere of cerebellum right adrenal cortex ganglionic eminence cerebellar vermis left adrenal gland monocyte left adrenal cortex Achilles tendon Top expressed in neural layer of retina neural tube facial motor nucleus dentate gyrus of hippocampal formation granule cell right kidney muscle of thigh ganglionic eminence Region I of hippocampus proper lens supraoptic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding molecular function Cellular component integral component of membrane endosome Golgi apparatus endosome membrane membrane Golgi membrane cellular component synaptic vesicle Biological process protein transport intracellular protein transport blood coagulation vesicle-mediated transport vesicle docking involved in exocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11311 22365 Ensembl ENSG00000136631 ENSMUSG00000015747 UniProt Q9NRW7 P97390 RefSeq (mRNA) NM_001279353 NM_001279354 NM_001279355 NM_007259 NM_013841 RefSeq (protein) NP_001266282 NP_001266283 NP_009190 NP_038869 Location (UCSC) Chr 1: 150.07 – 150.15 Mb Chr 3: 95.91 – 95.97 Mb PubMed search
Wikidata
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Function

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Tellam JT, James DE, Stevens TH, Piper RC (1997). "Identification of a mammalian Golgi Sec1p-like protein, mVps45". J. Biol. Chem. 272 (10): 6187–93. doi:10.1074/jbc.272.10.6187. PMID 9045632.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Rajasekariah P, Eyre HJ, Stanley KK, et al. (1999). "Molecular cloning and characterization of a cDNA encoding the human leucocyte vacuolar protein sorting (h1Vps45)". Int. J. Biochem. Cell Biol. 31 (6): 683–94. doi:10.1016/S1357-2725(99)00017-5. PMID 10404641.
• Nielsen E, Christoforidis S, Uttenweiler-Joseph S, et al. (2000). "Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain". J. Cell Biol. 151 (3): 601–12. doi:10.1083/jcb.151.3.601. PMC 2185588. PMID 11062261.
• de Renzis S, Sönnichsen B, Zerial M (2002). "Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes". Nat. Cell Biol. 4 (2): 124–33. doi:10.1038/ncb744. PMID 11788822. S2CID 6596498.
• Dulubova I, Yamaguchi T, Gao Y, et al. (2002). "How Tlg2p/syntaxin 16 'snares' Vps45". EMBO J. 21 (14): 3620–31. doi:10.1093/emboj/cdf381. PMC 126126. PMID 12110575.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kim BY, Ueda M, Kominami E, et al. (2004). "Identification of mouse Vps16 and biochemical characterization of mammalian class C Vps complex". Biochem. Biophys. Res. Commun. 311 (3): 577–82. doi:10.1016/j.bbrc.2003.10.030. PMID 14623309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.