This family represents the vascular endothelial growth factor (VEGF) internal ribosome entry site (IRES) A. VEGF is an endothelial cell mitogen with many crucial functions such as embryogenic development and wound healing. The 5' UTR of VEGF mRNA contains two IRES elements which are able to promote efficient translation at the AUG start codon, this family represents IRES A.[1]
| Vascular endothelial growth factor (VEGF) IRES A | |
|---|---|
 Predicted secondary structure and sequence conservation of IRES_VEGF_A | |
| Identifiers | |
| Symbol | IRES_VEGF_A |
| Rfam | RF00461 |
| Other data | |
| RNA type | Cis-reg; IRES |
| Domain(s) | Eukaryota |
| GO | GO:0043022 |
| SO | SO:0000243 |
| PDB structures | PDBe |
References
edit- ^ Huez I, Créancier L, Audigier S, Gensac MC, Prats AC, Prats H (November 1998). "Two independent internal ribosome entry sites are involved in translation initiation of vascular endothelial growth factor mRNA". Molecular and Cellular Biology. 18 (11): 6178–6190. doi:10.1128/mcb.18.11.6178. PMC 109205. PMID 9774635.
External links
edit | This molecular or cell biology article is a stub. You can help Wikipedia by expanding it. |