Vascular endothelial zinc finger 1

Vascular endothelial zinc finger 1 is a protein that in humans is encoded by the VEZF1 gene.

VEZF1
Identifiers
Aliases	VEZF1, DB1, ZNF161, vascular endothelial zinc finger 1
External IDs	OMIM: 606747; MGI: 1313291; HomoloGene: 5175; GeneCards: VEZF1; OMA:VEZF1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q22 Start 57,971,547 bp End 57,988,259 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell internal globus pallidus ventricular zone bronchial epithelial cell ganglionic eminence germinal epithelium caput epididymis tail of epididymis Skeletal muscle tissue of rectus abdominis Skeletal muscle tissue of biceps brachii n/a More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding metal ion binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleoplasm nucleus Biological process regulation of transcription by RNA polymerase II cellular defense response regulation of transcription, DNA-templated transcription by RNA polymerase II endothelial cell development angiogenesis transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of endothelial cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7716 22344 Ensembl ENSG00000136451 ENSMUSG00000018377 UniProt Q14119 n/a RefSeq (mRNA) NM_007146 NM_001330393 NM_016686 RefSeq (protein) NP_001317322 NP_009077 n/a Location (UCSC) Chr 17: 57.97 – 57.99 Mb n/a PubMed search
Wikidata
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Function

Transcriptional regulatory proteins containing tandemly repeated zinc finger domains are thought to be involved in both normal and abnormal cellular proliferation and differentiation. ZNF161 is a C2H2-type zinc finger protein (Koyano-Nakagawa et al., 1994 [PubMed 8035792]). See MIM 603971 for general information on zinc finger proteins.

Further reading

• Gowher H, Brick K, Camerini-Otero RD, Felsenfeld G (2012). "Vezf1 protein binding sites genome-wide are associated with pausing of elongating RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. 109 (7): 2370–5. Bibcode:2012PNAS..109.2370G. doi:10.1073/pnas.1121538109. PMC 3289347. PMID 22308494.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.