Vasiliu is a Romanian surname. Notable people with the surname include:
- Constantin Dan Vasiliu (1951–2020), Romanian politician
- Grigore Vasiliu Birlic (1905–1970), Romanian actor
- George Vasiliu, pen name of George Bacovia (1881–1957), a Romanian symbolist poet
- Mircea Vasiliu (1920-2008), former Romanian diplomat, author
- Alin Vasiliu (1960-2016), Physicist, Engineer