Vellosimine dehydrogenase

In enzymology, a vellosimine dehydrogenase (EC 1.1.1.273) is an enzyme that catalyzes the chemical reaction

vellosimine dehydrogenase
Identifiers
EC no.1.1.1.273
CAS no.86777-26-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins
10-deoxysarpagine + NADP+ vellosimine + NADPH + H+

Thus, the two substrates of this enzyme are 10-deoxysarpagine and NADP+, whereas its 3 products are vellosimine, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 10-deoxysarpagine:NADP+ oxidoreductase. This enzyme participates in indole and ipecac alkaloid biosynthesis.

References

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  • Pfitzner A, Krausch B, Stockigt J (1984). "Characteristics of vellosimine reductase, a specific enzyme involved in the biosynthesis of the Rauwolfia alkaloid sarpagine". Tetrahedron. 40 (10): 1691–1699. doi:10.1016/S0040-4020(01)91118-4.