Verosudil

Verosudil
Identifiers
	IUPAC name 2-(dimethylamino)-N-(1-oxo-2H-isoquinolin-6-yl)-2-thiophen-3-ylacetamide;
CAS Number	1414854-42-4;
PubChem CID	66906051;
ChemSpider	32742441;
UNII	MAF34143WM;
KEGG	D10737;
ChEMBL	ChEMBL3545065;
CompTox Dashboard (EPA)	DTXSID801336680 ;
Chemical and physical data
Formula	C17H17N3O2S
Molar mass	327.40 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN(C)C(C1=CSC=C1)C(=O)NC2=CC3=C(C=C2)C(=O)NC=C3;
	InChI InChI=1S/C17H17N3O2S/c1-20(2)15(12-6-8-23-10-12)17(22)19-13-3-4-14-11(9-13)5-7-18-16(14)21/h3-10,15H,1-2H3,(H,18,21)(H,19,22); Key:VDYRZXYYQMMFJW-UHFFFAOYSA-N;

Verosudil (AR-12286) is a drug which acts as a potent and selective inhibitor of the enzyme Rho kinase, and has been investigated for the treatment of glaucoma.^[1]^[2]

References

^ Williams RD, Novack GD, van Haarlem T, Kopczynski C (November 2011). "Ocular hypotensive effect of the Rho kinase inhibitor AR-12286 in patients with glaucoma and ocular hypertension". American Journal of Ophthalmology. 152 (5): 834–41.e1. doi:10.1016/j.ajo.2011.04.012. PMID 21794845.
^ Skaat A, Jasien JV, Ritch R (September 2016). "Efficacy of Topically Administered Rho-Kinase Inhibitor AR-12286 in Patients With Exfoliation Syndrome and Ocular Hypertension or Glaucoma". Journal of Glaucoma. 25 (9): e807-14. doi:10.1097/IJG.0000000000000508. PMID 27552517. S2CID 2663391.

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[1] Williams RD, Novack GD, van Haarlem T, Kopczynski C (November 2011). "Ocular hypotensive effect of the Rho kinase inhibitor AR-12286 in patients with glaucoma and ocular hypertension". American Journal of Ophthalmology. 152 (5): 834–41.e1. doi:10.1016/j.ajo.2011.04.012. PMID 21794845.

[2] Skaat A, Jasien JV, Ritch R (September 2016). "Efficacy of Topically Administered Rho-Kinase Inhibitor AR-12286 in Patients With Exfoliation Syndrome and Ocular Hypertension or Glaucoma". Journal of Glaucoma. 25 (9): e807-14. doi:10.1097/IJG.0000000000000508. PMID 27552517. S2CID 2663391.

[1]

[2]

Identifiers

IUPAC name 2-(dimethylamino)-N-(1-oxo-2H-isoquinolin-6-yl)-2-thiophen-3-ylacetamide
CAS Number	1414854-42-4
PubChem CID	66906051
ChemSpider	32742441
UNII	MAF34143WM
KEGG	D10737
ChEMBL	ChEMBL3545065
CompTox Dashboard (EPA)	DTXSID801336680
Chemical and physical data
Formula	C₁₇H₁₇N₃O₂S
Molar mass	327.40 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CN(C)C(C1=CSC=C1)C(=O)NC2=CC3=C(C=C2)C(=O)NC=C3
InChI InChI=1S/C17H17N3O2S/c1-20(2)15(12-6-8-23-10-12)17(22)19-13-3-4-14-11(9-13)5-7-18-16(14)21/h3-10,15H,1-2H3,(H,18,21)(H,19,22) Key:VDYRZXYYQMMFJW-UHFFFAOYSA-N

Verosudil

See also

References