Very-long-chain enoyl-CoA reductase (EC 1.3.1.93, TSC13 (gene name), CER10 (gene)) is an enzyme with systematic name very-long-chain acyl-CoA:NADP+ oxidoreductase.[1][2][3][4] This enzyme catalyses the following chemical reaction
| Very-long-chain enoyl-CoA reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.3.1.93 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- a very-long-chain acyl-CoA + NADP+ a very-long-chain trans-2,3-dehydroacyl-CoA + NADPH + H+
This is the fourth component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA.
References
edit- ^ Kohlwein SD, Eder S, Oh CS, Martin CE, Gable K, Bacikova D, Dunn T (January 2001). "Tsc13p is required for fatty acid elongation and localizes to a novel structure at the nuclear-vacuolar interface in Saccharomyces cerevisiae". Molecular and Cellular Biology. 21 (1): 109–25. doi:10.1128/MCB.21.1.109-125.2001. PMC 88785. PMID 11113186.
- ^ Gable K, Garton S, Napier JA, Dunn TM (February 2004). "Functional characterization of the Arabidopsis thaliana orthologue of Tsc13p, the enoyl reductase of the yeast microsomal fatty acid elongating system". Journal of Experimental Botany. 55 (396): 543–5. doi:10.1093/jxb/erh061. PMID 14673020.
- ^ Kvam E, Gable K, Dunn TM, Goldfarb DS (September 2005). "Targeting of Tsc13p to nucleus-vacuole junctions: a role for very-long-chain fatty acids in the biogenesis of microautophagic vesicles". Molecular Biology of the Cell. 16 (9): 3987–98. doi:10.1091/mbc.E05-04-0290. PMC 1196313. PMID 15958487.
- ^ Zheng H, Rowland O, Kunst L (May 2005). "Disruptions of the Arabidopsis Enoyl-CoA reductase gene reveal an essential role for very-long-chain fatty acid synthesis in cell expansion during plant morphogenesis". The Plant Cell. 17 (5): 1467–81. doi:10.1105/tpc.104.030155. PMC 1091768. PMID 15829606.
External links
edit- Very-long-chain+enoyl-CoA+reductase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
