Vesicle-associated membrane protein 7

Vesicle-associated membrane protein 7 (VAMP-7), is a protein that in humans is encoded by the VAMP7 gene also known as the SYBL1 gene.

VAMP7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DMW
Identifiers
Aliases	VAMP7, SYBL1, TI-VAMP, TIVAMP, VAMP-7, vesicle associated membrane protein 7
External IDs	OMIM: 300053; MGI: 1096399; HomoloGene: 4121; GeneCards: VAMP7; OMA:VAMP7 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xq28 and Yq12 Start 155,881,345 bp End 155,943,769 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte monocyte endothelial cell visceral pleura parietal pleura glomerulus trabecular bone kidney tubule metanephric glomerulus tibia n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SNARE binding SNAP receptor activity syntaxin binding protein binding Cellular component extracellular exosome transport vesicle pseudopodium cytoplasm transport vesicle membrane synapse integral component of membrane trans-Golgi network azurophil granule membrane Golgi apparatus cell junction platelet alpha granule intracellular membrane-bounded organelle lamellipodium apical part of cell neuron projection membrane cell surface phagocytic vesicle membrane endoplasmic reticulum perinuclear region of cytoplasm endoplasmic reticulum membrane secretory granule secretory granule membrane lysosome cytoplasmic vesicle late endosome membrane endosome phagocytic vesicle plasma membrane lysosomal membrane SNARE complex clathrin-coated vesicle membrane synaptic vesicle integral component of synaptic vesicle membrane hippocampal mossy fiber to CA3 synapse Biological process autophagosome maturation vesicle transport along microtubule vesicle fusion with Golgi apparatus Golgi to plasma membrane protein transport positive regulation of histamine secretion by mast cell SNARE complex assembly calcium-ion regulated exocytosis triglyceride transport endoplasmic reticulum to Golgi vesicle-mediated transport post-Golgi vesicle-mediated transport regulation of protein targeting to vacuolar membrane exocytosis natural killer cell degranulation phagocytosis, engulfment protein transport endosome to lysosome transport positive regulation of dendrite morphogenesis vesicle fusion vesicle-mediated transport neutrophil degranulation eosinophil degranulation endocytosis membrane organization transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6845 20955 Ensembl ENSG00000124333 ENSMUSG00000051412 UniProt P51809 P70280 RefSeq (mRNA) NM_001145149 NM_001185183 NM_005638 NM_001302138 NM_011515 NM_001359151 RefSeq (protein) NP_001138621 NP_001172112 NP_005629 NP_001289067 NP_035645 NP_001346080 Location (UCSC) Chr X: 155.88 – 155.94 Mb n/a PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

VAMP-7 is a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. VAMP-7 localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes.

Interactions

VAMP-7 has been shown to interact with SNAP23 and AP3D1.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Galli T, Zahraoui A, Vaidyanathan VV, Raposo G, Tian JM, Karin M, Niemann H, Louvard D (1998). "A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells". Mol. Biol. Cell. 9 (6): 1437–48. doi:10.1091/mbc.9.6.1437. PMC 25366. PMID 9614185.
• Advani RJ, Yang B, Prekeris R, Lee KC, Klumperman J, Scheller RH (1999). "VAMP-7 mediates vesicular transport from endosomes to lysosomes". J. Cell Biol. 146 (4): 765–76. doi:10.1083/jcb.146.4.765. PMC 2156136. PMID 10459012.
• Matarazzo MR, Cuccurese M, Strazzullo M, Vacca M, Curci A, Miano MG, Cocchia M, Mercadante G, Torino A, D'Urso M, Ciccodicola A, D'Esposito M (1999). "Human and mouse SYBL1 gene structure and expression". Gene. 240 (1): 233–8. doi:10.1016/S0378-1119(99)00375-3. PMID 10564831.
• Ciccodicola A, D'Esposito M, Esposito T, Gianfrancesco F, Migliaccio C, Miano MG, Matarazzo MR, Vacca M, Franzè A, Cuccurese M, Cocchia M, Curci A, Terracciano A, Torino A, Cocchia S, Mercadante G, Pannone E, Archidiacono N, Rocchi M, Schlessinger D, D'Urso M (2000). "Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region". Hum. Mol. Genet. 9 (3): 395–401. doi:10.1093/hmg/9.3.395. PMID 10655549.
• Ward DM, Pevsner J, Scullion MA, Vaughn M, Kaplan J (2000). "Syntaxin 7 and VAMP-7 are soluble N-ethylmaleimide-sensitive factor attachment protein receptors required for late endosome-lysosome and homotypic lysosome fusion in alveolar macrophages". Mol. Biol. Cell. 11 (7): 2327–33. doi:10.1091/mbc.11.7.2327. PMC 14922. PMID 10888671.
• Hartley JL, Temple GF, Brasch MA (2000). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Antonin W, Holroyd C, Fasshauer D, Pabst S, Von Mollard GF, Jahn R (2000). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function". EMBO J. 19 (23): 6453–64. doi:10.1093/emboj/19.23.6453. PMC 305878. PMID 11101518.
• Wade N, Bryant NJ, Connolly LM, Simpson RJ, Luzio JP, Piper RC, James DE (2001). "Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells". J. Biol. Chem. 276 (23): 19820–7. doi:10.1074/jbc.M010838200. PMID 11278762.
• Antonin W, Fasshauer D, Becker S, Jahn R, Schneider TR (2002). "Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs". Nat. Struct. Biol. 9 (2): 107–11. doi:10.1038/nsb746. hdl:11858/00-001M-0000-0012-F459-F. PMID 11786915. S2CID 17724790.
• Müller DJ, Schulze TG, Jahnes E, Cichon S, Krauss H, Kesper K, Held T, Maier W, Propping P, Nöthen MM, Rietschel M (2002). "Association between a polymorphism in the pseudoautosomal X-linked gene SYBL1 and bipolar affective disorder". Am. J. Med. Genet. 114 (1): 74–8. doi:10.1002/ajmg.10115. PMID 11840509.
• Bogdanovic A, Bennett N, Kieffer S, Louwagie M, Morio T, Garin J, Satre M, Bruckert F (2002). "Syntaxin 7, syntaxin 8, Vti1 and VAMP7 (vesicle-associated membrane protein 7) form an active SNARE complex for early macropinocytic compartment fusion in Dictyostelium discoideum". Biochem. J. 368 (Pt 1): 29–39. doi:10.1042/BJ20020845. PMC 1222979. PMID 12175335.
• Matarazzo MR, De Bonis ML, Gregory RI, Vacca M, Hansen RS, Mercadante G, D'Urso M, Feil R, D'Esposito M (2002). "Allelic inactivation of the pseudoautosomal gene SYBL1 is controlled by epigenetic mechanisms common to the X and Y chromosomes". Hum. Mol. Genet. 11 (25): 3191–8. doi:10.1093/hmg/11.25.3191. PMID 12444103.
• Martinez-Arca S, Rudge R, Vacca M, Raposo G, Camonis J, Proux-Gillardeaux V, Daviet L, Formstecher E, Hamburger A, Filippini F, D'Esposito M, Galli T (2003). "A dual mechanism controlling the localization and function of exocytic v-SNAREs". Proc. Natl. Acad. Sci. U.S.A. 100 (15): 9011–6. Bibcode:2003PNAS..100.9011M. doi:10.1073/pnas.1431910100. PMC 166429. PMID 12853575.
• Di Leva F, Ferrante MI, Demarchi F, Caravelli A, Matarazzo MR, Giacca M, D'Urso M, D'Esposito M, Franzé A (2004). "Human synaptobrevin-like 1 gene basal transcription is regulated through the interaction of selenocysteine tRNA gene transcription activating factor-zinc finger 143 factors with evolutionary conserved cis-elements" (PDF). J. Biol. Chem. 279 (9): 7734–9. doi:10.1074/jbc.M308140200. PMID 14672948.
• Rao SK, Huynh C, Proux-Gillardeaux V, Galli T, Andrews NW (2004). "Identification of SNAREs involved in synaptotagmin VII-regulated lysosomal exocytosis". J. Biol. Chem. 279 (19): 20471–9. doi:10.1074/jbc.M400798200. PMID 14993220.

External links

• Overview of all the structural information available in the PDB for UniProt: P51809 (Vesicle-associated membrane protein 7) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.