Vesnarinone

Vesnarinone
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	By mouth
ATC code	None;
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name 6-[4-(3,4-Dimethoxybenzoyl)piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one;
CAS Number	81840-15-5 ;
PubChem CID	5663;
ChemSpider	5461 ;
UNII	5COW40EV8M;
ChEMBL	ChEMBL17423 ;
CompTox Dashboard (EPA)	DTXSID80231411 ;
Chemical and physical data
Formula	C22H25N3O4
Molar mass	395.459 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COC1=C(C=C(C=C1)C(=O)N2CCN(CC2)C3=CC4=C(C=C3)NC(=O)CC4)OC;
	InChI InChI=1S/C22H25N3O4/c1-28-19-7-3-16(14-20(19)29-2)22(27)25-11-9-24(10-12-25)17-5-6-18-15(13-17)4-8-21(26)23-18/h3,5-7,13-14H,4,8-12H2,1-2H3,(H,23,26) ; Key:ZVNYJIZDIRKMBF-UHFFFAOYSA-N ;
	(what is this?) (verify)

Vesnarinone (INN) is a cardiotonic agent.^[1] A mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. Vesnarinone improves ventricular performance most in patients with the worst degree of heart failure.

References

^ Cavusoglu E, Frishman WH, Klapholz M (June 1995). "Vesnarinone: a new inotropic agent for treating congestive heart failure". Journal of Cardiac Failure. 1 (3): 249–257. doi:10.1016/1071-9164(95)90030-6. PMID 9420657.

External links

Media related to Vesnarinone at Wikimedia Commons

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[1] Cavusoglu E, Frishman WH, Klapholz M (June 1995). "Vesnarinone: a new inotropic agent for treating congestive heart failure". Journal of Cardiac Failure. 1 (3): 249–257. doi:10.1016/1071-9164(95)90030-6. PMID 9420657.

[1]

Clinical data

AHFS/Drugs.com	International Drug Names
Routes of administration	By mouth
ATC code	None
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name 6-[4-(3,4-Dimethoxybenzoyl)piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one
CAS Number	81840-15-5^Y
PubChem CID	5663
ChemSpider	5461^N
UNII	5COW40EV8M
ChEMBL	ChEMBL17423^N
CompTox Dashboard (EPA)	DTXSID80231411
Chemical and physical data
Formula	C₂₂H₂₅N₃O₄
Molar mass	395.459 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES COC1=C(C=C(C=C1)C(=O)N2CCN(CC2)C3=CC4=C(C=C3)NC(=O)CC4)OC
InChI InChI=1S/C22H25N3O4/c1-28-19-7-3-16(14-20(19)29-2)22(27)25-11-9-24(10-12-25)17-5-6-18-15(13-17)4-8-21(26)23-18/h3,5-7,13-14H,4,8-12H2,1-2H3,(H,23,26)^N Key:ZVNYJIZDIRKMBF-UHFFFAOYSA-N^N
^NY (what is this?) (verify)