Vitamin D3 dihydroxylase

Vitamin D3 dihydroxylase
Vitamin D3 dihydroxylase
Identifiers
Organism	Streptomyces griseolus
Symbol	CYP105A1
Alt. symbols	VD3 hydroxylase, Cytochrome P450-SU1
UniProt	P18326
Other data
EC number	1.14.15.22
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Vitamin D3 dihydroxylase is a cytochrome P450 enzyme purified from the actinobacterium Streptomyces griseolus,^[1] with EC number EC 1.14.15.22 and CYP Symbol CYP105A1 (Cytochrome P450, family 105, member A1), catalyses oxidation of cholecalciferol(vitamin D3) to calcitriol.^[2]

References

^ O'Keefe DP, Romesser JA, Leto KJ (March 1988). "Identification of constitutive and herbicide inducible cytochromes P-450 in Streptomyces griseolus". Archives of Microbiology. 149 (5): 406–12. Bibcode:1988ArMic.149..406O. doi:10.1007/BF00425579. S2CID 35526991.
^ Sawada N, Sakaki T, Yoneda S, Kusudo T, Shinkyo R, Ohta M, Inouye K (July 2004). "Conversion of vitamin D3 to 1alpha,25-dihydroxyvitamin D3 by Streptomyces griseolus cytochrome P450SU-1". Biochemical and Biophysical Research Communications. 320 (1): 156–64. doi:10.1016/j.bbrc.2004.05.140. PMID 15207715.

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