Wüst (or Wuest) is a surname that may refer to
- Craig Wuest, American keyboardist
- Georg Wüst (1890-1977), German oceanographer
- Hendrik Wüst (b. 1975), German politician
- Ireen Wüst (b. 1986), Dutch long track allround speed skater
- Josef Wüst (1925-2003), Austrian journalist, editor-in-chief and publisher
- Kenneth Wuest (1893-1962), New Testament Greek scholar
- Marcel Wüst (b. 1967), German road bicycle racer
- Markus Wüst (b. 1971), Swiss Nordic combined skier
- Ryan Wuest, (b. 1981), South African football player
- Walther Wüst (1901-1993), German Orientalist, President of the SS Ahnenerbe Research Institute