WW domain-binding protein 1 is a protein that in humans is encoded by the WBP1 gene.[5][6]

WBP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesWBP1, WBP-1, WW domain binding protein 1
External IDsOMIM: 606961; MGI: 104710; HomoloGene: 8267; GeneCards: WBP1; OMA:WBP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012477

NM_001083922
NM_001083923
NM_016757

RefSeq (protein)

NP_036609

NP_001077391
NP_001077392
NP_058037

Location (UCSC)Chr 2: 74.46 – 74.46 MbChr 6: 83.1 – 83.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands.

This gene encodes a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein by a conserved region: XPPXY motif. The function of this protein has not been determined.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000239779Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030035Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chen HI, Sudol M (Sep 1995). "The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules". Proc Natl Acad Sci U S A. 92 (17): 7819–23. Bibcode:1995PNAS...92.7819C. doi:10.1073/pnas.92.17.7819. PMC 41237. PMID 7644498.
  6. ^ a b "Entrez Gene: WBP1 WW domain binding protein 1".

Further reading

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